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Aliases for C15orf48 Gene

Aliases for C15orf48 Gene

  • Chromosome 15 Open Reading Frame 48 2 3
  • NMES1 3 4 6
  • Normal Mucosa Of Esophagus Specific 1 2 3
  • Normal Mucosa Of Esophagus-Specific Gene 1 Protein 3
  • Protein FOAP-11 4
  • FOAP-11 3

External Ids for C15orf48 Gene

Summaries for C15orf48 Gene

Entrez Gene Summary for C15orf48 Gene

  • This gene was first identified in a study of human esophageal squamous cell carcinoma tissues. Levels of both the message and protein are reduced in carcinoma samples. In adult human tissues, this gene is expressed in the the esophagus, stomach, small intestine, colon and placenta. Alternatively spliced transcript variants that encode the same protein have been identified. [provided by RefSeq, Jun 2012]

GeneCards Summary for C15orf48 Gene

C15orf48 (Chromosome 15 Open Reading Frame 48) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf48 Gene

Genomics for C15orf48 Gene

Genomic Location for C15orf48 Gene

Start:
45,430,529 bp from pter
End:
45,448,761 bp from pter
Size:
18,233 bases
Orientation:
Plus strand

Genomic View for C15orf48 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C15orf48 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf48 Gene

Regulatory Elements for C15orf48 Gene

Proteins for C15orf48 Gene

  • Protein details for C15orf48 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C002-NMES1_HUMAN
    Recommended name:
    Normal mucosa of esophagus-specific gene 1 protein
    Protein Accession:
    Q9C002
    Secondary Accessions:

    Protein attributes for C15orf48 Gene

    Size:
    83 amino acids
    Molecular mass:
    9617 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C15orf48 Gene

Proteomics data for C15orf48 Gene at MOPED

Post-translational modifications for C15orf48 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C15orf48 Gene

No data available for DME Specific Peptides for C15orf48 Gene

Domains for C15orf48 Gene

Protein Domains for C15orf48 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

NMES1_HUMAN
Family:
  • Belongs to the complex I NDUFA4 subunit family.:
    • Q9C002
genes like me logo Genes that share domains with C15orf48: view

No data available for Gene Families for C15orf48 Gene

Function for C15orf48 Gene

Phenotypes for C15orf48 Gene

genes like me logo Genes that share phenotypes with C15orf48: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C15orf48 Gene

Localization for C15orf48 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C15orf48 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C15orf48 Gene COMPARTMENTS Subcellular localization image for C15orf48 gene
Compartment Confidence
nucleus 5
extracellular 3
mitochondrion 2
endoplasmic reticulum 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C15orf48 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 12209954
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with C15orf48: view

Pathways for C15orf48 Gene

SuperPathways for C15orf48 Gene

No Data Available

Interacting Proteins for C15orf48 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000341610%0d%0a9606.ENSP00000427562%0d%0a9606.ENSP00000362634%0d%0a
Selected Interacting proteins: ENSP00000341610 for C15orf48 Gene via STRING

Gene Ontology (GO) - Biological Process for C15orf48 Gene

None

No data available for Pathways by source for C15orf48 Gene

Transcripts for C15orf48 Gene

Unigene Clusters for C15orf48 Gene

Chromosome 15 open reading frame 48:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf48 Gene

No ASD Table

Relevant External Links for C15orf48 Gene

GeneLoc Exon Structure for
C15orf48
ECgene alternative splicing isoforms for
C15orf48

Expression for C15orf48 Gene

mRNA expression in normal human tissues for C15orf48 Gene

mRNA differential expression in normal tissues according to GTEx for C15orf48 Gene

This gene is overexpressed in Colon - Transverse (25.4), Esophagus - Mucosa (5.6), and Small Intestine - Terminal Ileum (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C15orf48 Gene

SOURCE GeneReport for Unigene cluster for C15orf48 Gene Hs.112242

mRNA Expression by UniProt/SwissProt for C15orf48 Gene

Q9C002-NMES1_HUMAN
Tissue specificity: Expressed mainly in stomach, placenta, small intestine and colon, as well as in normal mucosa of esophagus. Down-regulated in esophageal squamous cell carcinoma
genes like me logo Genes that share expressions with C15orf48: view

Orthologs for C15orf48 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf48 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf48 36
  • 100 (n)
  • 100 (a)
ptr-mir-147b 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia bta-mir-147 37
  • 83 (a)
OneToOne
C10H15orf48 36
  • 87.55 (n)
  • 83.13 (a)
dog
(Canis familiaris)
Mammalia C30H15orf48 36
  • 85.14 (n)
  • 83.13 (a)
cfa-mir-147 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AA467197 36
  • 76.71 (n)
  • 72.29 (a)
AA467197 16
AA467197 37
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 64 (a)
OneToMany
-- 37
  • 57 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia oan-mir-147 37
  • 18 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia MGC105649 36
  • 76.71 (n)
  • 71.08 (a)
chicken
(Gallus gallus)
Aves gga-mir-147 37
  • 60 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13119 36
zebrafish
(Danio rerio)
Actinopterygii C18H15orf48 37
  • 56 (a)
OneToOne
zgc:153317 36
  • 60.57 (n)
  • 58.54 (a)
Species with no ortholog for C15orf48:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf48 Gene

ENSEMBL:
Gene Tree for C15orf48 (if available)
TreeFam:
Gene Tree for C15orf48 (if available)

Paralogs for C15orf48 Gene

Selected SIMAP similar genes for C15orf48 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C15orf48: view

No data available for Paralogs for C15orf48 Gene

Variants for C15orf48 Gene

Sequence variations from dbSNP and Humsavar for C15orf48 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs1153846 -- 45,428,913(+) cagag(A/C)gagac upstream-variant-2KB
rs1288847 -- 45,429,377(+) ACCTG(C/T)GTTCT upstream-variant-2KB
rs1288848 -- 45,429,924(+) ACCCC(C/T)TTTTA upstream-variant-2KB
rs1288849 -- 45,433,639(+) TGGAG(A/G)TGAAT downstream-variant-500B
rs1629849 -- 45,430,927(+) AAATA(C/T)AGTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf48 Gene

Variant ID Type Subtype PubMed ID
nsv469721 CNV Complex 16826518

Relevant External Links for C15orf48 Gene

HapMap Linkage Disequilibrium report
C15orf48

Disorders for C15orf48 Gene

Relevant External Links for C15orf48

Human Genome Epidemiology (HuGE) Navigator
C15orf48
genes like me logo Genes that share disorders with C15orf48: view

No data available for UniProtKB/Swiss-Prot for C15orf48 Gene

Publications for C15orf48 Gene

  1. A novel gene, NMES1, downregulated in human esophageal squamous cell carcinoma. (PMID: 12209954) Zhou J. … Liu Z. (Int. J. Cancer 2002) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Discovery of novel methylation biomarkers in cervical carcinoma by global demethylation and microarray analysis. (PMID: 16434596) Sova P. … Kiviat N. (Cancer Epidemiol. Biomarkers Prev. 2006) 3
  4. Analysis of the methylation status of genes up-regulated by the demethylating agent, 5-aza-2'-deoxycytidine, in esophageal squamous cell carcinoma. (PMID: 18636205) Arai M. … Yokosuka O. (Oncol. Rep. 2008) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for C15orf48 Gene

Sources for C15orf48 Gene

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