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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C15orf41 Gene

protein-coding GIFtS: 41
GCID: GC15P036871

chromosome 15 open reading frame 41

Explore 1 disease affiliated with
C15orf41 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 15 Open Reading Frame 41¹ ²
HH114¹ ²
FLJ22851¹
MGC11326¹
Uncharacterized Protein C15orf41²
Protein HH114³

External Ids:	HGNC: 26929¹	Entrez Gene: 84529²	Ensembl: ENSG00000186073⁷	UniProtKB: Q9Y2V0³

Export aliases for C15orf41 gene to outside databases

Previous GC identifers: GC15P034721 GC15P013717

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000015.9 NC_018926.1 NT_010194.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C15orf41 gene promoter:
Pax-5 FOXO3 FOXD3 Nkx2-5 E4BP4 Evi-1 c-Ets-1 GATA-2 c-Rel IRF-2
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for C15orf41

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C15orf41

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14 Ensembl cytogenetic band: 15q14 HGNC cytogenetic band: 15q14

C15orf41 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C15orf41 gene location

GeneLoc information about chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15P036871: view genomic region (about GC identifiers)

Start:	36,871,812 bp from pter	End:	37,102,449 bp from pter
Size:	230,638 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CO041_HUMAN, Q9Y2V0 (See protein sequence)

Recommended Name: Uncharacterized protein C15orf41

Size: 281 amino acids; 32264 Da

Sequence caution: Sequence=AAH06254.1; Type=Erroneous initiation;

Secondary accessions: B2RD87

Alternative splicing: 2 isoforms: Q9Y2V0-1 Q9Y2V0-2

Explore the universe of human proteins at neXtProt for C15orf41: NX_Q9Y2V0

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y2V0

C15orf41 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001123482.1 NP_115888.1

ENSEMBL proteins:

ENSP00000455397 ENSP00000457227 ENSP00000401362 ENSP00000456477 ENSP00000454831

ENSP00000456736 ENSP00000457854 ENSP00000454334 ENSP00000456240 ENSP00000342433

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9Y2V0

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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In Situ Assay
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1 GenomeRNAi human phenotype for C15orf41:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C15orf41

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for C15orf41 (Q9Y2V0³ ENSP00000401362⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
ASF1B	Q9NVP2³, ENSP00000263382⁴	I2D: score=3 STRING: ENSP00000263382
UBC	ENSP00000344818⁴	STRING: ENSP00000344818

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C15orf41
Search CenterWatch for drugs/clinical trials and news about C15orf41 / CO041

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C15orf41 gene (2 alternative transcripts):

NM_001130010.1 NM_032499.4

Unigene Cluster for C15orf41:

Chromosome 15 open reading frame 41

Hs.48348 [show with all ESTs]

Unigene Representative Sequence: BC042750

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000566621(uc001zje.4) ENST00000570265 ENST00000567573 ENST00000564586

ENST00000437989 ENST00000569302 ENST00000566807 ENST00000567389(uc010bbb.1 uc001zjf.3 uc010uci.2)

ENST00000562877 ENST00000565792 ENST00000562489 ENST00000566932 ENST00000566677

ENST00000563167 ENST00000338183

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		hsa-miR-582-3p hsa-miR-548j hsa-miR-4307 hsa-miR-4272 hsa-miR-765 hsa-miR-3916 hsa-miR-570 hsa-miR-629

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Additional cDNA sequence:

AF114263.1 AK026504.1 AK315446.1 BC006254.2 BC042750.1 BX647650.1

10 DOTS entries:

DT.100741169 DT.97839836 DT.75136171 DT.101969640 DT.40252406 DT.95166033 DT.91752097 DT.100732989

DT.121081689 DT.92427955

24/88 AceView cDNA sequences (see all 88):

BG201716 BM840002 BQ225672 AI208530 BC006254 CR612493 AA130117 BU690095

BG218005 AL572673 BG202232 AL526521 BE896259 BG213225 AI473354 AI652221

N76709 BP342706 BI756678 BG536012 AI016540 AI768950 CB956263 BG260062

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C15orf41 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

C15orf41 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Neural Tube

Mesencephalic Ventricular Zone

Neural Tube

Telencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

See C15orf41 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C15orf41

SOURCE GeneReport for Unigene cluster: Hs.48348

SABiosciences Custom PCR Arrays for C15orf41

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf41

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for C15orf41 gene from 6/22 species (see all 22) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	BC052040^{1 , 5}	cDNA sequence BC052040^{1, 5}	91.58(n)¹ 95.02(a)¹		2 (58.18 cM)⁵ 399568¹ NM_001145898.1¹ NP_001139370.1¹ 115581733⁵
chicken (Gallus gallus)	Aves	C5H15orf41¹	chromosome 5 open reading frame, human C15orf41	83.33(n) 82.59(a)		423293 NM_001031200.1 NP_001026371.1
lizard (Anolis carolinensis)	Reptilia	C15orf41⁶	--	79(a)	1 ↔ 1	1(31533648-31664936)
African clawed frog (Xenopus laevis)	Amphibia	Xl.22285²	Xenopus laevis transcribed sequence with moderate similarity more	74.67(n)		BU901623.1
zebrafish (Danio rerio)	Actinopterygii	wufb38f07²	Transcribed sequence with weak similarity to protein more	81.78(n)		BM265170.1
fruit fly (Drosophila melanogaster)	Insecta	CG12713¹	CG12713	45.53(n) 36.17(a)		39724 NM_140549.2 NP_648806.1

ENSEMBL Gene Tree for C15orf41 (if available)
TreeFam Gene Tree for C15orf41 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 15 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142240304^1,2		--	36869866(+)	`AGGAGA/TTTAAA`	1	--	us2k¹		0	--	--	--	--
rs183316177^1,2		--	36870052(+)	`GTAAAC/TGCCCT`	1	--	us2k¹		0	--	--	--	--
rs79411491^1,2	C,	--	36870114(+)	`CGCAGT/CTGCTC`	1	--	us2k¹		2		WA	120
rs4924084^1,2	C,F,A,H,	--	36870119(+)	`TTGCTT/CTTGCA`	1	--	us2k¹		13		NA WA CSA EA	380
rs12912029^1,2	C,F,A,H,	--	36870194(+)	`AGCCTG/ATTAAT`	1	--	us2k¹		26		NS EA NA WA CSA	2490
rs9972293^1,2	C,F,	--	36870255(+)	`TACTTT/CGGGAG`	1	--	us2k¹		11		NA WA CSA EA	374
rs151035202^1,2		--	36870335(+)	`TCTAGA/TGAAAA`	1	--	us2k¹		0	--	--	--	--
rs186615797^1,2		--	36870342(+)	`AAAAAC/TTTTAA`	1	--	us2k¹		0	--	--	--	--
rs191116668^1,2		--	36870345(+)	`AATTTA/TAAAAT`	1	--	us2k¹		0	--	--	--	--
rs182396882^1,2		--	36870382(+)	`TAGTCC/TCAACT`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for C15orf41 (36871812 - 37102449 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C15orf41: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C15orf41

DNA2.0 Custom Variant and Variant Library Synthesis for C15orf41

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C15orf41 for disorders About GeneDecksing

1 disease for C15orf41: About MalaCards

paraplegia

1 disease from the University of Copenhagen DISEASES database for C15orf41:

Paraplegia

Human Genome Epidemiology (HuGE) Navigator: C15orf41 (3 documents)

Export disorders for C15orf41 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C15orf41 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C15orf41)

Utopia: connect your pdf to the dynamic
world of online information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)¹ Bailey S.D....Anand S. (2010)
Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)¹ Talmud P.J.... . (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)¹ Ewing R.M.... Figeys D. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 84529	HGNC: 26929	AceView: HH114	Ensembl:ENSG00000186073	euGenes: HUgn84529
ECgene: C15orf41	H-InvDB: C15orf41

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C15orf41	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C15orf41 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C15orf41 gene:
Search GeneIP for patents involving C15orf41

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C15orf41
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C15orf41
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	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C15orf41
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C15orf41
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C15orf41

	GenScript Custom Purified and Recombinant Proteins Services for C15orf41		GenScript cDNA clones with any tag delivered in your preferred vector for C15orf41
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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	Regulatory tfbs in C15orf41 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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	Search for Antibodies for C15orf41 at Abcam
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf41

	SwitchGear 3'UTR luciferase reporter plasmids for C15orf41
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ThermoFisher Antibodies for C15orf41

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C15orf41

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C15orf41 gene at Home site.

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C15orf41 Gene

chromosome 15 open reading frame 41

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C15orf41 Gene

chromosome 15 open reading frame 41

Aliasesfor C15orf41 gene

Summariesfor C15orf41 gene

Genomic Viewsfor C15orf41 gene

Proteinsfor C15orf41 gene

Protein Domains /Familiesfor C15orf41 gene

Functionfor C15orf41 gene

Pathways & Interactionsfor C15orf41 gene

Drugs & Compoundsfor C15orf41 gene

Transcriptsfor C15orf41 gene

Expression for C15orf41 gene

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Genomic Variantsfor C15orf41 gene

Disorders / Diseasesfor C15orf41 gene

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External Searches for C15orf41 gene

Genome Databases showing C15orf41 gene

Other Databases showing C15orf41 gene

Specialized Databases showing C15orf41 gene

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Aliases
for C15orf41 gene

Summaries
for C15orf41 gene

Genomic Views
for C15orf41 gene

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for C15orf41 gene

Protein Domains /
Families
for C15orf41 gene

Function
for C15orf41 gene

Pathways & Interactions
for C15orf41 gene

Drugs & Compounds
for C15orf41 gene

Transcripts
for C15orf41 gene

Expression
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Orthologs
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Genomic Variants
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Disorders / Diseases
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Publications
for C15orf41 gene

Intellectual Property
for C15orf41 gene

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for C15orf41 gene