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Aliases for C15orf40 Gene

Aliases for C15orf40 Gene

  • Chromosome 15 Open Reading Frame 40 2 3 5

External Ids for C15orf40 Gene

Previous GeneCards Identifiers for C15orf40 Gene

  • GC15M081465
  • GC15M083673
  • GC15M059921
  • GC15M083659

Summaries for C15orf40 Gene

GeneCards Summary for C15orf40 Gene

C15orf40 (Chromosome 15 Open Reading Frame 40) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf40 Gene

Genomics for C15orf40 Gene

Regulatory Elements for C15orf40 Gene

Enhancers for C15orf40 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15F083010 1.1 ENCODE 40.5 +0.8 839 2.8 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 DEK C15orf40 FAM103A1 SNHG21 RPL9P9 CPEB1 CPEB1-AS1 EFL1 AP3B2 WHAMM ENSG00000260579
GH15F083060 1.2 FANTOM5 ENCODE 19.9 -52.4 -52425 7.5 HDGF PKNOX1 WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 C15orf40 BTBD1 TM6SF1 FAM103A1 AP3B2 GOLGA6L9 WHAMM MIR4515 GC15P083147
GH15F083498 0.6 ENCODE 16.4 -486.8 -486810 1.1 BRD4 CBX3 JUND BCL11A ZNF26 TEAD4 CUX1 FOS ETS1 C15orf40 GOLGA6L4 WHAMM GC15P083534 GC15M083457
GH15F083377 1.2 FANTOM5 Ensembl ENCODE 16.2 -366.9 -366860 3.9 HDGF CTCF ZNF146 PKNOX1 TAF1 JUN CEBPG ZIC2 RAD21 ZKSCAN1 BNC1 C15orf40 FAM103A1 GOLGA6L9 LOC105370934 SH3GL3
GH15F082646 1 ENCODE 13.6 +364.6 364556 1.5 ATF1 CREB3L1 SIN3A GLIS2 ZNF202 SP3 REST SMARCA4 GLIS1 KDM1A CSPG4P10 WHAMM C15orf40 GOLGA6L9 CPEB1-AS1 GC15P082650
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C15orf40 on UCSC Golden Path with GeneCards custom track

Promoters for C15orf40 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001454496 998 1401 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 DEK

Genomic Location for C15orf40 Gene

Chromosome:
15
Start:
82,988,308 bp from pter
End:
83,012,298 bp from pter
Size:
23,991 bases
Orientation:
Minus strand

Genomic View for C15orf40 Gene

Genes around C15orf40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf40 Gene

Proteins for C15orf40 Gene

  • Protein details for C15orf40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUR7-CO040_HUMAN
    Recommended name:
    UPF0235 protein C15orf40
    Protein Accession:
    Q8WUR7
    Secondary Accessions:
    • A6NIC9
    • B2R5E7
    • F5GX92
    • F8WD31
    • G5EA00

    Protein attributes for C15orf40 Gene

    Size:
    153 amino acids
    Molecular mass:
    16353 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C15orf40 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C15orf40 Gene

Post-translational modifications for C15orf40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C15orf40 Gene

Domains & Families for C15orf40 Gene

Protein Domains for C15orf40 Gene

Suggested Antigen Peptide Sequences for C15orf40 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUR7

UniProtKB/Swiss-Prot:

CO040_HUMAN :
  • Belongs to the UPF0235 family.
Family:
  • Belongs to the UPF0235 family.
genes like me logo Genes that share domains with C15orf40: view

No data available for Gene Families for C15orf40 Gene

Function for C15orf40 Gene

Phenotypes for C15orf40 Gene

genes like me logo Genes that share phenotypes with C15orf40: view

Animal Model Products

miRNA for C15orf40 Gene

miRTarBase miRNAs that target C15orf40

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf40 Gene

Localization for C15orf40 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C15orf40 Gene COMPARTMENTS Subcellular localization image for C15orf40 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C15orf40 Gene

Pathways & Interactions for C15orf40 Gene

SuperPathways for C15orf40 Gene

No Data Available

Interacting Proteins for C15orf40 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000403987%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000248420%0d%0a
Selected Interacting proteins: Q8WUR7-CO040_HUMAN ENSP00000403987 for C15orf40 Gene via IID STRING

Gene Ontology (GO) - Biological Process for C15orf40 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C15orf40 Gene

Transcripts for C15orf40 Gene

Unigene Clusters for C15orf40 Gene

Chromosome 15 open reading frame 40:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf40 Gene

No ASD Table

Relevant External Links for C15orf40 Gene

GeneLoc Exon Structure for
C15orf40
ECgene alternative splicing isoforms for
C15orf40

Expression for C15orf40 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C15orf40 Gene

Protein differential expression in normal tissues from HIPED for C15orf40 Gene

This gene is overexpressed in Blymphocyte (13.5), Bone marrow stromal cell (12.9), and Pancreas (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C15orf40 Gene



NURSA nuclear receptor signaling pathways regulating expression of C15orf40 Gene:

C15orf40

SOURCE GeneReport for Unigene cluster for C15orf40 Gene:

Hs.352541
genes like me logo Genes that share expression patterns with C15orf40: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C15orf40 Gene

Orthologs for C15orf40 Gene

This gene was present in the common ancestor of animals.

Orthologs for C15orf40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf40 34
  • 99.09 (n)
C15orf40 35
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C21H15orf40 34
  • 89.33 (n)
C21H15ORF40 35
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 3110040N11Rik 34 16 35
  • 83.48 (n)
rat
(Rattus norvegicus)
Mammalia LOC100363116 34
  • 83.48 (n)
dog
(Canis familiaris)
Mammalia C3H15orf40 34
  • 83.21 (n)
-- 35
  • 58 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 66 (a)
OneToMany
-- 35
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia C15orf40 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10H15ORF40 34
  • 65.17 (n)
C15orf40 35
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C15orf40 35
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf40 34
  • 68.5 (n)
zebrafish
(Danio rerio)
Actinopterygii C25H15orf40 35
  • 36 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6971 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001528 34
  • 52.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14966 34 35
  • 50.63 (n)
worm
(Caenorhabditis elegans)
Secernentea W01A8.2 35
  • 28 (a)
OneToOne
Species where no ortholog for C15orf40 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C15orf40 Gene

ENSEMBL:
Gene Tree for C15orf40 (if available)
TreeFam:
Gene Tree for C15orf40 (if available)

Paralogs for C15orf40 Gene

Pseudogenes.org Pseudogenes for C15orf40 Gene

genes like me logo Genes that share paralogs with C15orf40: view

No data available for Paralogs for C15orf40 Gene

Variants for C15orf40 Gene

Sequence variations from dbSNP and Humsavar for C15orf40 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs10083713 -- 83,004,403(+) ATCAG(A/C)AAAGG intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1037403 -- 82,995,439(-) CAAAT(C/G)TTTAA intron-variant
rs111290173 -- 82,996,425(+) CACGA(A/G)GTCAG intron-variant
rs111311452 -- 82,988,836(+) GTCTC(-/A)AAAAA intron-variant
rs111369223 -- 82,993,333(+) TAGTG(C/T)TGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf40 Gene

Variant ID Type Subtype PubMed ID
esv28659 CNV loss 19812545
esv3637065 CNV gain 21293372
nsv1120052 OTHER inversion 24896259

Variation tolerance for C15orf40 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C15orf40 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C15orf40

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf40 Gene

Disorders for C15orf40 Gene

Relevant External Links for C15orf40

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C15orf40

No disorders were found for C15orf40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf40 Gene

Publications for C15orf40 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X. … Vidal M. (Cell 2016) 3 64
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for C15orf40 Gene

Sources for C15orf40 Gene

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