C15orf40 Gene
protein-coding GIFtS: 41
GCID: GC15M083673
|
|
chromosome 15 open reading frame 40
| |
Aliases
for C15orf40 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 15 Open Reading Frame 401 2 | | MGC299371 | | UPF0235 Protein C15orf402 |
Export aliases for C15orf40 gene to outside databasesPrevious GC identifers: GC15M081465 GC15M059921 |
Summaries
for C15orf40 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C15orf40 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_077661.3
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C15orf40 gene promoter:
Nkx3-1 Nkx3-1 v4 Nkx3-1 v1 RelA NF-kappaB LCR-F1 Nkx3-1 v2 ARP-1 Nkx3-1 v3 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C15orf40
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C15orf40 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q25.2 Ensembl cytogenetic band: 15q25.2 HGNC cytogenetic band: 15q25.2C15orf40 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M083673: view genomic region
(about GC identifiers)
Start:
|
83,657,193 bp from pter |
End:
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83,680,393 bp from pter |
Size:
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23,201 bases |
Orientation:
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minus strand |
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Proteins
for C15orf40 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CO040_HUMAN, Q8WUR7 (See
protein sequence)Recommended Name: UPF0235 protein C15orf40 Size: 126 amino acids; 13322 Da
Secondary accessions: A6NIC9 B2R5E7Explore the universe of human proteins at neXtProt for C15orf40: NX_Q8WUR7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WUR7
C15orf40 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (5 alternative transcripts):
NP_001153585.1 NP_001153586.1 NP_001153587.1 NP_001153588.1 NP_653198.2
ENSEMBL proteins: ENSP00000426639 ENSP00000441077 ENSP00000423436 ENSP00000424167 ENSP00000403987 ENSP00000424666 ENSP00000454502 ENSP00000454276 ENSP00000456006 ENSP00000307071
Human Recombinant Protein Products:
C15orf40 Antibody Products:
Assay Products for C15orf40: |
Protein
Domains /
Families
for C15orf40 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C15orf40 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WUR7ProtoNet protein and cluster: Q8WUR7 1 Blocks protein family: IPB003746 Protein of unknown function DUF167
UniProtKB/Swiss-Prot: CO040_HUMAN, Q8WUR7Similarity: Belongs to the UPF0235 family |
Function
for C15orf40 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf40 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf40 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 5): C15orf40 (NM_001160113) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C15orf40 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C15orf40 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf40 |
|
Pathways & Interactions
for C15orf40 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C15orf40
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for C15orf40 (ENSP000003070714) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C15orf40 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C15orf40
Search CenterWatch for drugs/clinical trials and news about C15orf40 / CO040
|
Transcripts
for C15orf40 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C15orf40 gene (5 alternative transcripts): NM_001160113.1 NM_001160114.1 NM_001160115.1 NM_001160116.1 NM_144597.2 Unigene Cluster for C15orf40: Chromosome 15 open reading frame 40 Hs.352541 [show with all ESTs]Unigene Representative Sequence: NM_14459713 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000514272 ENST00000538348(uc010uon.2) ENST00000510873 ENST00000512638
ENST00000451195(uc010uoo.1) ENST00000513601 ENST00000508990 ENST00000563387
ENST00000565712 ENST00000505341 ENST00000506912(uc010uor.1) ENST00000565725
ENST00000304177(uc002bjm.3 uc010uoq.2 uc010uop.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf40 (see all 7)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf40 (see all 6)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 5): C15orf40 (NM_001160113) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C15orf40 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C15orf40 |
Additional cDNA sequence: AK311484.1 AK312160.1 BC019820.1 NR_027649.1 NR_027650.1 9 DOTS entries: DT.95207146 DT.99960115 DT.91852738 DT.97833148 DT.86850992 DT.91898854 DT.100783432 DT.100842777 DT.91939047 24/58 AceView cDNA sequences (see all 58): BM698394 CK905216 CR614786 AK125586 BQ674378 AA070587 AA071054 BG398905 BM313878 BQ185982 AW105048 BM509433 AI239480 BM820066 AW082859 NM_144597 BF055305 BE906569 BX645524 BU736145 AA931467 BU173801 BC019820 AI203393
GeneLoc Exon Structure
|
Expression
for C15orf40 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C15orf40 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACTTGTAATT
About this image
See C15orf40 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C15orf40
SOURCE GeneReport for Unigene cluster: Hs.352541
SABiosciences Custom PCR Arrays for C15orf40
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C15orf40
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C15orf40 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C15orf40 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C15orf40 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf40 |
Orthologs
for C15orf40 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for C15orf40 gene from 8/19 species (see all 19) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
3110040N11Rik1 , 5 |
RIKEN cDNA 3110040N11 gene1, 5 |
82.4(n)1
85.6(a)1 |
|
7 (45.71 cM)5
672901 NM_026077.31 NP_080353.11
817821825 |
chicken
(Gallus gallus) |
Aves |
C10H15orf401 |
chromosome 10 open reading frame, human C15orf40 |
61.5(n)
62.02(a) |
|
415460 XM_413838.3 XP_413838.2 |
lizard
(Anolis carolinensis) |
Reptilia |
C15orf406 |
-- |
58(a) |
1 ↔ 1 |
GL343836.1(170067-172718) |
rainbow trout
(Oncorhynchus mykiss) |
Actinopterygii |
Omy.69712 |
Oncorhynchus mykiss transcribed sequence with weak more |
75.13(n) |
|
BX301250.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG149661 |
CG14966 |
48.09(n)
47.54(a) |
|
38390 NM_139527.2 NP_647784.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
W01A8.26 |
-- |
26(a) |
1 ↔ 1 |
I(7055356-7056874) |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT1G491706 |
uncharacterized protein |
29(a) |
1 ↔ 1 |
1(18183266-18184443) |
rice
(Oryza sativa) |
Liliopsida |
-- |
uncharacterized ACR, YggU family COG1872 containin... |
26(a) |
1 ↔ 1 |
4(34899197-34901165) |
ENSEMBL Gene Tree for C15orf40 (if available)
TreeFam Gene Tree for C15orf40 (if available) |
Paralogs
for C15orf40 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C15orf40 gene
15 SIMAP similar genes for C15orf40 using alignment to 10 protein entries: CO040_HUMAN (see all proteins):CLEC1A NDUFS7 C19orf47 CNOT2 NSD1 C11orf80
KIAA1651 ATL2 LRTOMT FANCA GNPTAB SERF1B
ZNHIT3 NPAT NSRP1
C15orf40 for paralogs About GeneDecksing
3 Pseudogenes.org Pseudogenes for C15orf40
PGOHUM00000249933 PGOHUM00000243068 PGOHUM00000260195
|
Genomic Variants
for C15orf40 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C15orf40 (83657193 - 83680393 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for C15orf40
1 CNV: 66852
1 Indel: 66851 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C15orf40 |
|
Disorders
/ Diseases
for C15orf40 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C15orf40 for disorders About GeneDecksing
1  disease for C15orf40: About MalaCardsmalaria
Export disorders for C15orf40 gene to outside databases
|
Publications
for C15orf40 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C15orf40 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with C15orf40) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
- Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (2006)
- Genomic annotation of 15,809 ESTs identified from pooled early gestation human eyes. (PubMed id 16368877)1 Choy K.W....Pang C.P. (2006)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
|
External Searches for C15orf40 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C15orf40 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C15orf40 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C15orf40 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C15orf40 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C15orf40 gene:
Search GeneIP for patents involving C15orf40
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C15orf40 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for C15orf40 | | OriGene shRNA RFP for C15orf40 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C15orf40 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C15orf40 | | | OriGene Protein Over-expression Lysate for C15orf40 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C15orf40 | | OriGene 3'-UTR Clone for C15orf40 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf40 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C15orf40 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C15orf40 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C15orf40 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C15orf40 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C15orf40 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C15orf40 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C15orf40 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C15orf40 |
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 | | | C15orf40 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf40 |
|  |  |  | | | | Search ThermoFisher Antibodies for C15orf40 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C15orf40 |
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