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Aliases for C15orf40 Gene

Aliases for C15orf40 Gene

  • Chromosome 15 Open Reading Frame 40 2 3 5

External Ids for C15orf40 Gene

Previous GeneCards Identifiers for C15orf40 Gene

  • GC15M081465
  • GC15M083673
  • GC15M059921
  • GC15M083659

Summaries for C15orf40 Gene

GeneCards Summary for C15orf40 Gene

C15orf40 (Chromosome 15 Open Reading Frame 40) is a Protein Coding gene.

Additional gene information for C15orf40 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf40 Gene

Genomics for C15orf40 Gene

Regulatory Elements for C15orf40 Gene

Enhancers for C15orf40 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H083060 2 FANTOM5 Ensembl ENCODE dbSUPER 28 -52.4 -52425 7 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 C15orf40 SNHG21 BTBD1 TM6SF1 FAM103A1 AP3B2 GOLGA6L9 WHAMM MIR4515 GC15P083169
GH15H083010 1.1 ENCODE 43.1 +0.8 839 2 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766 FAM103A1 C15orf40 WHAMM EFL1 ENSG00000260579 HOMER2 BTBD1 CPEB1-AS1 CPEB1 AP3B2
GH15H083204 1 ENCODE 34.3 -194.5 -194501 4 HDGF SIN3A GLI4 ZNF2 ZBTB7B GTF3C2 GLIS2 GATA2 KLF7 RUNX3 WHAMM C15orf40 FAM103A1 RPL9P9 GOLGA6L9 EFL1 CSPG4P11 BTBD1 FABP5P8 AP3B2
GH15H082848 1.3 Ensembl ENCODE 21.8 +162.2 162232 2 HNRNPUL1 HDGF PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 FAM103A1 C15orf40 WHAMM HOMER2 FSD2 EFL1 GOLGA6L9 GC15M082841 GC15P082870
GH15H082708 1 ENCODE 28.3 +303.0 302967 2 ZNF133 ARID4B SIN3A ZNF766 GLIS2 ELK1 ZNF143 KLF7 SP3 MXD4 AP3B2 C15orf40 SAXO2 SNHG21 LINC01583 WHAMM RPL9P9 CPEB1 HDGFL3 EFL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C15orf40 on UCSC Golden Path with GeneCards custom track

Promoters for C15orf40 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000080269 898 1201 HDGF ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZNF766

Genomic Location for C15orf40 Gene

Chromosome:
15
Start:
82,988,308 bp from pter
End:
83,012,298 bp from pter
Size:
23,991 bases
Orientation:
Minus strand

Genomic View for C15orf40 Gene

Genes around C15orf40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf40 Gene

Proteins for C15orf40 Gene

  • Protein details for C15orf40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUR7-CO040_HUMAN
    Recommended name:
    UPF0235 protein C15orf40
    Protein Accession:
    Q8WUR7
    Secondary Accessions:
    • A6NIC9
    • B2R5E7
    • F5GX92
    • F8WD31
    • G5EA00

    Protein attributes for C15orf40 Gene

    Size:
    153 amino acids
    Molecular mass:
    16353 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C15orf40 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C15orf40 Gene

Post-translational modifications for C15orf40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C15orf40 Gene

Domains & Families for C15orf40 Gene

Gene Families for C15orf40 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C15orf40 Gene

Suggested Antigen Peptide Sequences for C15orf40 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUR7

UniProtKB/Swiss-Prot:

CO040_HUMAN :
  • Belongs to the UPF0235 family.
Family:
  • Belongs to the UPF0235 family.
genes like me logo Genes that share domains with C15orf40: view

Function for C15orf40 Gene

Phenotypes for C15orf40 Gene

genes like me logo Genes that share phenotypes with C15orf40: view

Animal Model Products

CRISPR Products

miRNA for C15orf40 Gene

miRTarBase miRNAs that target C15orf40

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf40 Gene

Localization for C15orf40 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C15orf40 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C15orf40 Gene

Pathways & Interactions for C15orf40 Gene

SuperPathways for C15orf40 Gene

No Data Available

Interacting Proteins for C15orf40 Gene

Gene Ontology (GO) - Biological Process for C15orf40 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C15orf40 Gene

Drugs & Compounds for C15orf40 Gene

No Compound Related Data Available

Transcripts for C15orf40 Gene

Unigene Clusters for C15orf40 Gene

Chromosome 15 open reading frame 40:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf40 Gene

No ASD Table

Relevant External Links for C15orf40 Gene

GeneLoc Exon Structure for
C15orf40
ECgene alternative splicing isoforms for
C15orf40

Expression for C15orf40 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C15orf40 Gene

Protein differential expression in normal tissues from HIPED for C15orf40 Gene

This gene is overexpressed in Blymphocyte (13.5), Bone marrow stromal cell (12.9), and Pancreas (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C15orf40 Gene



NURSA nuclear receptor signaling pathways regulating expression of C15orf40 Gene:

C15orf40

SOURCE GeneReport for Unigene cluster for C15orf40 Gene:

Hs.352541
genes like me logo Genes that share expression patterns with C15orf40: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C15orf40 Gene

Orthologs for C15orf40 Gene

This gene was present in the common ancestor of animals.

Orthologs for C15orf40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf40 33
  • 99.09 (n)
C15orf40 34
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C21H15orf40 33
  • 89.33 (n)
C21H15ORF40 34
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 3110040N11Rik 33 16 34
  • 83.48 (n)
rat
(Rattus norvegicus)
Mammalia RGD1305713 33
  • 83.48 (n)
dog
(Canis familiaris)
Mammalia C3H15orf40 33
  • 83.21 (n)
-- 34
  • 58 (a)
OneToMany
-- 34
  • 38 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia C15orf40 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10H15ORF40 33
  • 65.17 (n)
C15orf40 34
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C15orf40 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf40 33
  • 68.5 (n)
zebrafish
(Danio rerio)
Actinopterygii C25H15orf40 34
  • 36 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6971 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001528 33
  • 52.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14966 33 34
  • 50.63 (n)
worm
(Caenorhabditis elegans)
Secernentea W01A8.2 34
  • 28 (a)
OneToOne
Species where no ortholog for C15orf40 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C15orf40 Gene

ENSEMBL:
Gene Tree for C15orf40 (if available)
TreeFam:
Gene Tree for C15orf40 (if available)

Paralogs for C15orf40 Gene

Pseudogenes.org Pseudogenes for C15orf40 Gene

genes like me logo Genes that share paralogs with C15orf40: view

No data available for Paralogs for C15orf40 Gene

Variants for C15orf40 Gene

Sequence variations from dbSNP and Humsavar for C15orf40 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000039873 -- 82,997,229(+) TTTTT(A/T)AATTT intron-variant
rs1000065285 -- 83,007,226(+) GCTTC(C/T)CCTAG intron-variant
rs1000196119 -- 83,013,882(+) AGAAG(A/G)AAGTA upstream-variant-2KB
rs1000419391 -- 82,998,304(+) TGGCT(A/G)CCGGG intron-variant
rs1000443788 -- 83,010,648(+) TATTT(A/C)CAATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf40 Gene

Variant ID Type Subtype PubMed ID
esv28659 CNV loss 19812545
esv3637065 CNV gain 21293372
nsv1120052 OTHER inversion 24896259

Variation tolerance for C15orf40 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C15orf40 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C15orf40

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf40 Gene

Disorders for C15orf40 Gene

Relevant External Links for C15orf40

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C15orf40

No disorders were found for C15orf40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf40 Gene

Publications for C15orf40 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 60
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 60

Products for C15orf40 Gene

Sources for C15orf40 Gene

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