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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C15orf39 Gene

protein-coding   GIFtS: 41
GCID: GC15P075491

chromosome 15 open reading frame 39

(Previous name: chromosome 15 open reading frame 38~Name Same As HGNC:28782...)
  Search for C15orf39
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for C15orf39    

Aliases
for C15orf39 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Chromosome 15 Open Reading Frame 391 2
DKFZP434H1321
FLJ463371
Chromosome 15 Open Reading Frame 38~Name Same As HGNC:287821
Uncharacterized Protein C15orf392

External Ids:    HGNC: 244971   Entrez Gene: 569052   Ensembl: ENSG000001671737   UniProtKB: Q6ZRI63   

Export aliases for C15orf39 gene to outside databases

Previous GC identifers: GC15P073279 GC15P052290


Summaries
for C15orf39 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for C15orf39 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C15orf39 gene promoter:
         GR   Max1   ER-alpha   Bach2   C/EBPalpha   YY1   GCNF-1   c-Myb   GR-alpha   GCNF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C15orf39

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C15orf39


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q23

C15orf39 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C15orf39 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P075491:  view genomic region     (about GC identifiers)

Start:
 75,487,984 bp from pter      End:
 75,504,510 bp from pter
Size:
 16,527 bases      Orientation:
 plus strand

Proteins
for C15orf39 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CO039_HUMAN, Q6ZRI6 (See protein sequence)
Recommended Name: Uncharacterized protein C15orf39  
Size: 1047 amino acids; 110673 Da
Sequence caution: Sequence=AAQ06680.1; Type=Frameshift; Positions=267; Sequence=CAB55985.3; Type=Erroneous initiation;
Note=Translation N-terminally shortened; Sequence=CAD39045.1; Type=Frameshift; Positions=900;
Secondary accessions: B3KWI3 C9J888 Q71JB1 Q7L3S0 Q8N3F2 Q96FB6 Q9NTU5
Alternative splicing: 3 isoforms:  Q6ZRI6-1   Q6ZRI6-2   Q6ZRI6-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C15orf39: NX_Q6ZRI6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZRI6

    • C15orf39 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_056307.2  
    ENSEMBL proteins: 
     ENSP00000454677   ENSP00000457045   ENSP00000353854   ENSP00000378438   ENSP00000456381  
     ENSP00000458025   ENSP00000454405  

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    Uscn Proteins for C15orf39


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    Uscn ELISAs and CLIAs for C15orf39

    Protein Domains /
    Families
    for C15orf39 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6ZRI6


    Function
    for C15orf39 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
    Products:            		 OriGene 3'-UTR Clone: C15orf39
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C15orf39
    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate C15orf39 (see all 17):
    hsa-miR-3194-5p hsa-miR-125a-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-miR-125b hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmid: C15orf39 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    2 GenomeRNAi human phenotypes for C15orf39:
     Decreased viability with pacli  Increased gamma-H2AX phosphory 


    Pathways & Interactions
    for C15orf39 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C15orf39

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/6 Interacting proteins for C15orf39 (Q6ZRI62, 3 ENSP000003538544) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RPLP1P053862, 3MINT-65142 I2D: score=4 
    SUMO2ENSP000004059654STRING: ENSP00000405965
    GPSM2ENSP000002641264STRING: ENSP00000264126
    WLSENSP000003468294STRING: ENSP00000346829
    CTBP2ENSP000003118254STRING: ENSP00000311825
    About this table

    Drugs & Compounds
    for C15orf39 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C15orf39
    Search CenterWatch for drugs/clinical trials and news about C15orf39 / CO039 

    Transcripts
    for C15orf39 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for C15orf39 gene: 
    NM_015492.4  

    Unigene Cluster for C15orf39:

    Chromosome 15 open reading frame 39
    Hs.17936  [show with all ESTs]
    Unigene Representative Sequence: AK128205
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000563905 ENST00000562637 ENST00000360639(uc002azp.4) ENST00000394987(uc002azq.4)
    ENST00000564848 ENST00000567617(uc002azr.4) ENST00000565074(uc021sqm.1)


    miRNA
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    8/17 QIAGEN miScript miRNA Assays for microRNAs that regulate C15orf39 (see all 17):
    hsa-miR-3194-5p hsa-miR-125a-5p hsa-let-7d hsa-miR-202 hsa-let-7c hsa-let-7g hsa-miR-125b hsa-let-7a
    SwitchGear 3'UTR luciferase reporter plasmid: C15orf39 3' UTR sequence
    Inhib. RNA
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    Clone
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    Additional cDNA sequence: 

    AF063593.1 AF143881.1 AK056589.1 AK057025.1 AK125111.1 AK125604.1 AK128205.1 AK304663.1 
    AL117540.1 AL360143.1 AL834382.1 BC000540.2 BC001762.1 BC006207.2 BC011379.1 BC011905.2 
    BC051235.1 BC069049.1 BC109195.1 BC110367.1 CR533482.1 

    8 DOTS entries:

    DT.97846282  DT.100836517  DT.95340879  DT.411567  DT.95114355  DT.100665455  DT.91953161  DT.92438808 

    24/174 AceView cDNA sequences (see all 174):

    BM466630 BM548989 BM799616 BQ227238 AL109730 AW964124 BM553795 BM797205 
    CB242732 BG055732 AA459421 Z38749 AW516789 BI089086 BX115322 BC051235 
    BG231821 BQ369175 BF036362 BM009944 BG912793 BE269651 BG744027 BG490444 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for C15orf39 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
    SP1:              -                                                                     
    SP2:                                                                                    
    SP3:                                                                                    
    SP4:                                                                    -               
    SP5:              -     -                                                               


    ECgene alternative splicing isoforms for C15orf39

    Expression
    for C15orf39 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C15orf39 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    C15orf39 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See C15orf39 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C15orf39

    SOURCE GeneReport for Unigene cluster: Hs.17936
        SABiosciences Custom PCR Arrays for C15orf39
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    In Situ
    Assay Products:     
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    Orthologs
    for C15orf39 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for C15orf39 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia 1700017B05Rik1 , 5 RIKEN cDNA 1700017B05 gene1, 5 79.95(n)1
    78.79(a)1    		   9 (30.89 cM)5
    742111  NM_028820.21  NP_083096.11 
     572523225 
    chicken
    (Gallus gallus)    		 Aves LOC1008573641 uncharacterized LOC100857364 51.56(n)
    42.95(a)    		   100857364  XM_003641811.1  XP_003641859.1 
    lizard
    (Anolis carolinensis)    		 Reptilia C15orf396
    		 --
    		 45(a)
    		 1 ↔ 1
    		 GL343492.1(422340-423974)
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.144012 Transcribed sequences 76.53(n)    CF998588.1 


    ENSEMBL Gene Tree for C15orf39 (if available)
    TreeFam Gene Tree for C15orf39 (if available) 

    Paralogs
    for C15orf39 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C15orf39 gene

    C15orf39 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for C15orf39
    PGOHUM00000243995


    Genomic Variants
    for C15orf39 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for C15orf39
         1 Inversion: 37170
    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C15orf39
    DNA2.0 Custom Variant and Variant Library Synthesis for C15orf39

    Disorders / Diseases
    for C15orf39 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for C15orf39 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C15orf39 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with C15orf39)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)1, 2 Wan D....Gu J. (2004)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
    5. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    8. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    9. System-wide changes to SUMO modifications in response to heat shock. (PubMed id 19471022)1 Golebiowski F....Hay R.T. (2009)
    10. Lysine acetylation targets protein complexes and co-regulates major cellular functions. (PubMed id 19608861)2 Choudhary C.... Mann M. (2009)

    External Searches for C15orf39 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing C15orf39 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56905 HGNC: 24497 AceView: DKFZP434H132 Ensembl:ENSG00000167173 euGenes: HUgn56905
    ECgene: C15orf39 H-InvDB: C15orf39

    Other Databases showing C15orf39 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing C15orf39 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C15orf39 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for C15orf39 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for C15orf39 gene:
    Search GeneIP for patents involving C15orf39

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for C15orf39 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
    In Situ Hybridization Assays from
    Advanced Cell Diagnostics
    About This Section

     
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    VWF
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    von Willebrand factor
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