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Aliases for C15orf39 Gene

Aliases for C15orf39 Gene

  • Chromosome 15 Open Reading Frame 39 2 3 5

External Ids for C15orf39 Gene

Previous GeneCards Identifiers for C15orf39 Gene

  • GC15P073279
  • GC15P075491
  • GC15P052290

Summaries for C15orf39 Gene

GeneCards Summary for C15orf39 Gene

C15orf39 (Chromosome 15 Open Reading Frame 39) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf39 Gene

Genomics for C15orf39 Gene

Regulatory Elements for C15orf39 Gene

Enhancers for C15orf39 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G075041 2.1 FANTOM5 Ensembl ENCODE dbSUPER 39 -149.8 -149757 8.2 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 SCAMP5 C15orf39 RPP25 DNM1P35 ENSG00000203392 PPCDC EDC3 ULK3 SIN3A CSK
GH15G075198 2 FANTOM5 Ensembl ENCODE dbSUPER 29.1 +6.2 6193 7.1 CREB3L1 ZFP64 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 C15orf39 RPP25 MAN2C1 CSK PPCDC SIN3A SCAMP2 PIR52818
GH15G075069 1.8 FANTOM5 Ensembl ENCODE dbSUPER 29.4 -125.8 -125838 1.6 TBP PKNOX1 TBL1XR1 ZFP64 RAD21 RELB ETV6 IKZF2 CREM ZNF280D SCAMP5 C15orf39 SIN3A RPP25 CSK MAN2C1 CLK3 SCAMP2 GC15P075113 PPCDC
GH15G075072 1.6 FANTOM5 Ensembl ENCODE dbSUPER 31.8 -122.2 -122224 1.0 ZNF263 SMARCE1 CTCF ATF1 ZNF394 ATF2 JUND ZFHX2 IKZF1 CREB1 C15orf39 SCAMP2 RPP25 CSK SIN3A MAN2C1 CLK3 GC15P075113 PPCDC
GH15G074775 2.1 FANTOM5 Ensembl ENCODE dbSUPER 23.9 -407.5 -407470 26.0 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 TBX21 MEF2D GLIS1 RCOR2 ULK3 C15orf39 DNM1P35 EDC3 ENSG00000203392 CSK RPP25 CPLX3 LMAN1L ENSG00000260274
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C15orf39 on UCSC Golden Path with GeneCards custom track

Genomic Location for C15orf39 Gene

Chromosome:
15
Start:
75,195,643 bp from pter
End:
75,212,169 bp from pter
Size:
16,527 bases
Orientation:
Plus strand

Genomic View for C15orf39 Gene

Genes around C15orf39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf39 Gene

Proteins for C15orf39 Gene

  • Protein details for C15orf39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRI6-CO039_HUMAN
    Recommended name:
    Uncharacterized protein C15orf39
    Protein Accession:
    Q6ZRI6
    Secondary Accessions:
    • B3KWI3
    • C9J888
    • Q71JB1
    • Q7L3S0
    • Q8N3F2
    • Q96FB6
    • Q9NTU5

    Protein attributes for C15orf39 Gene

    Size:
    1047 amino acids
    Molecular mass:
    110673 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ06680.1; Type=Frameshift; Positions=267; Evidence={ECO:0000305}; Sequence=CAB55985.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD39045.1; Type=Frameshift; Positions=900; Evidence={ECO:0000305};

    Alternative splice isoforms for C15orf39 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C15orf39 Gene

Post-translational modifications for C15orf39 Gene

  • Ubiquitination at Lys620 and Lys898
  • Modification sites at PhosphoSitePlus

Other Protein References for C15orf39 Gene

No data available for DME Specific Peptides for C15orf39 Gene

Domains & Families for C15orf39 Gene

Protein Domains for C15orf39 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C15orf39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C15orf39: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C15orf39 Gene

Function for C15orf39 Gene

genes like me logo Genes that share phenotypes with C15orf39: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf39 Gene

Localization for C15orf39 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C15orf39 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for C15orf39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with C15orf39: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C15orf39 Gene

Pathways & Interactions for C15orf39 Gene

SuperPathways for C15orf39 Gene

No Data Available

Interacting Proteins for C15orf39 Gene

Gene Ontology (GO) - Biological Process for C15orf39 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C15orf39 Gene

Drugs & Compounds for C15orf39 Gene

No Compound Related Data Available

Transcripts for C15orf39 Gene

Unigene Clusters for C15orf39 Gene

Chromosome 15 open reading frame 39:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf39 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2:
SP3:
SP4: -
SP5: - -
SP6:

Relevant External Links for C15orf39 Gene

GeneLoc Exon Structure for
C15orf39
ECgene alternative splicing isoforms for
C15orf39

Expression for C15orf39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C15orf39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C15orf39 Gene

This gene is overexpressed in Whole Blood (x9.9) and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for C15orf39 Gene

This gene is overexpressed in Saliva (28.9), Pancreatic juice (21.4), Heart (11.7), and Placenta (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C15orf39 Gene



Protein tissue co-expression partners for C15orf39 Gene

NURSA nuclear receptor signaling pathways regulating expression of C15orf39 Gene:

C15orf39

SOURCE GeneReport for Unigene cluster for C15orf39 Gene:

Hs.17936

Evidence on tissue expression from TISSUES for C15orf39 Gene

  • Spleen(4.2)
  • Muscle(4.1)
  • Eye(4)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with C15orf39: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C15orf39 Gene

Orthologs for C15orf39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf39 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf39 34
  • 99.01 (n)
C15orf39 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C21H15orf39 34
  • 81.82 (n)
C15orf39 35
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C30H15orf39 34
  • 79.99 (n)
C15orf39 35
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1305464 34
  • 79.55 (n)
mouse
(Mus musculus)
Mammalia 1700017B05Rik 34 16 35
  • 78.48 (n)
oppossum
(Monodelphis domestica)
Mammalia C15orf39 35
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves C15orf39 35
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C15orf39 35
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C18H15orf39 35
  • 22 (a)
OneToOne
Dr.14401 34
Species where no ortholog for C15orf39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf39 Gene

ENSEMBL:
Gene Tree for C15orf39 (if available)
TreeFam:
Gene Tree for C15orf39 (if available)

Paralogs for C15orf39 Gene

Pseudogenes.org Pseudogenes for C15orf39 Gene

genes like me logo Genes that share paralogs with C15orf39: view

No data available for Paralogs for C15orf39 Gene

Variants for C15orf39 Gene

Sequence variations from dbSNP and Humsavar for C15orf39 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000487914 -- 75,211,934(+) TCAGG(A/G)ACTGG utr-variant-3-prime
rs1000505129 -- 75,200,446(+) TAAGA(A/C)CACAG upstream-variant-2KB
rs1000532700 -- 75,200,004(+) CAGAG(C/G)CTTCA upstream-variant-2KB
rs1000868442 -- 75,203,365(+) CTGAG(C/T)CTGCT intron-variant
rs1000978321 -- 75,203,676(+) CATGG(G/T)CTGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf39 Gene

Variant ID Type Subtype PubMed ID
dgv2621n100 CNV gain 25217958
dgv4627n54 CNV loss 21841781
esv3636921 CNV gain 21293372
nsv1121512 CNV deletion 24896259
nsv833056 CNV gain 17160897
nsv951995 CNV deletion 24416366

Variation tolerance for C15orf39 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.94; 83.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C15orf39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C15orf39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf39 Gene

Disorders for C15orf39 Gene

Relevant External Links for C15orf39

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C15orf39

No disorders were found for C15orf39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf39 Gene

Publications for C15orf39 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64
  4. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for C15orf39 Gene

Sources for C15orf39 Gene

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