Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C15orf38-AP3S2 Gene

Aliases for C15orf38-AP3S2 Gene

  • C15orf38-AP3S2 Readthrough 2 3 5

External Ids for C15orf38-AP3S2 Gene

Previous GeneCards Identifiers for C15orf38-AP3S2 Gene

  • GC15U901312
  • GC15M090378

Summaries for C15orf38-AP3S2 Gene

Entrez Gene Summary for C15orf38-AP3S2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring C15orf38 (chromosome 15 open reading frame 38) and AP3S2 (adaptor-related protein complex 3, sigma 2 subunit) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]

GeneCards Summary for C15orf38-AP3S2 Gene

C15orf38-AP3S2 (C15orf38-AP3S2 Readthrough) is a Protein Coding gene. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is ARPIN.

Additional gene information for C15orf38-AP3S2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf38-AP3S2 Gene

Genomics for C15orf38-AP3S2 Gene

Regulatory Elements for C15orf38-AP3S2 Gene

Enhancers for C15orf38-AP3S2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H089855 1.2 ENCODE dbSUPER 12.1 +51.8 51772 10 ELF3 PKNOX1 FOXA2 ZFP64 ARID4B THRB RAD21 RARA YY1 ZNF366 AP3S2 RNU6-1111P RNU7-111P ARPIN C15orf38-AP3S2 MESP2 MESP1 ZNF710 PLIN1 ANPEP
GH15H089910 1.2 FANTOM5 ENCODE 0.7 +0.5 477 3 HDGF FOXA2 ZSCAN4 ARID4B SIN3A ZNF2 GLIS2 ELK1 SCRT2 SP3 ARPIN C15orf38-AP3S2 GC15P089898
GH15H089898 1.4 FANTOM5 Ensembl ENCODE 0.4 +13.7 13700 1 CTCF RB1 FEZF1 RAD21 RFX5 CC2D1A ZNF121 ZFHX2 EED SCRT2 AP3S2 ANPEP ARPIN GC15P089898 C15orf38-AP3S2
GH15H089917 0.7 ENCODE 0.4 -5.1 -5074 0 ESRRA JUN CTBP1 GATA3 FOSL2 FOS TCF7L2 SMARCE1 SMARCC1 CEBPB ARPIN C15orf38-AP3S2 LOC100421368
GH15H089936 0.4 ENCODE 0.3 -23.4 -23399 0 ZSCAN4 GABPA LOC100421368 C15orf38-AP3S2 ARPIN
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C15orf38-AP3S2 on UCSC Golden Path with GeneCards custom track

Promoters for C15orf38-AP3S2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000080978 290 1001 HDGF ARID4B SIN3A ZNF2 RAD21 GLIS2 ELK1 SP3 ZNF398 ZNF341

Genomic Location for C15orf38-AP3S2 Gene

Chromosome:
15
Start:
89,830,599 bp from pter
End:
89,912,990 bp from pter
Size:
82,392 bases
Orientation:
Minus strand

Genomic View for C15orf38-AP3S2 Gene

Genes around C15orf38-AP3S2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf38-AP3S2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf38-AP3S2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf38-AP3S2 Gene

Proteins for C15orf38-AP3S2 Gene

  • Protein details for C15orf38-AP3S2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYH1
    Recommended name:
    Protein C15orf38-AP3S2
    Protein Accession:
    A0A0A6YYH1

    Protein attributes for C15orf38-AP3S2 Gene

    Size:
    394 amino acids
    Molecular mass:
    43882 Da
    Quaternary structure:
    No Data Available
  • Protein details for C15orf38-AP3S2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YL85
    Recommended name:
    C15orf38-AP3S2 readthrough
    Protein Accession:
    H0YL85

    Protein attributes for C15orf38-AP3S2 Gene

    Size:
    185 amino acids
    Molecular mass:
    20448 Da
    Quaternary structure:
    No Data Available
  • Protein details for C15orf38-AP3S2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YMK0
    Recommended name:
    C15orf38-AP3S2 readthrough
    Protein Accession:
    H0YMK0

    Protein attributes for C15orf38-AP3S2 Gene

    Size:
    184 amino acids
    Molecular mass:
    20721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C15orf38-AP3S2 Gene

Protein Expression for C15orf38-AP3S2 Gene

Post-translational modifications for C15orf38-AP3S2 Gene

No Post-translational modifications

Other Protein References for C15orf38-AP3S2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C15orf38-AP3S2 Gene

Domains & Families for C15orf38-AP3S2 Gene

Gene Families for C15orf38-AP3S2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C15orf38-AP3S2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C15orf38-AP3S2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C15orf38-AP3S2 Gene

Function for C15orf38-AP3S2 Gene

Gene Ontology (GO) - Molecular Function for C15orf38-AP3S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with C15orf38-AP3S2: view

Phenotypes for C15orf38-AP3S2 Gene

GenomeRNAi human phenotypes for C15orf38-AP3S2:
genes like me logo Genes that share phenotypes with C15orf38-AP3S2: view

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for C15orf38-AP3S2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf38-AP3S2 Gene

Localization for C15orf38-AP3S2 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C15orf38-AP3S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030117 membrane coat IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with C15orf38-AP3S2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for C15orf38-AP3S2 Gene

Pathways & Interactions for C15orf38-AP3S2 Gene

SuperPathways for C15orf38-AP3S2 Gene

No Data Available

Interacting Proteins for C15orf38-AP3S2 Gene

Gene Ontology (GO) - Biological Process for C15orf38-AP3S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with C15orf38-AP3S2: view

No data available for Pathways by source and SIGNOR curated interactions for C15orf38-AP3S2 Gene

Drugs & Compounds for C15orf38-AP3S2 Gene

No Compound Related Data Available

Transcripts for C15orf38-AP3S2 Gene

mRNA/cDNA for C15orf38-AP3S2 Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for C15orf38-AP3S2
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf38-AP3S2 Gene

No ASD Table

Relevant External Links for C15orf38-AP3S2 Gene

GeneLoc Exon Structure for
C15orf38-AP3S2
ECgene alternative splicing isoforms for
C15orf38-AP3S2

Expression for C15orf38-AP3S2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C15orf38-AP3S2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb and MOPED for C15orf38-AP3S2 Gene



genes like me logo Genes that share expression patterns with C15orf38-AP3S2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C15orf38-AP3S2 Gene

Orthologs for C15orf38-AP3S2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf38-AP3S2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP3S2 34
  • 99 (a)
OneToMany
LOC100170757 33
  • 98.96 (n)
cow
(Bos Taurus)
Mammalia C21H15orf38 34
  • 90 (a)
OneToMany
ARPIN 33
  • 88.39 (n)
dog
(Canis familiaris)
Mammalia C3H15orf38 33 34
  • 87.8 (n)
rat
(Rattus norvegicus)
Mammalia RGD1311021 33
  • 85.57 (n)
mouse
(Mus musculus)
Mammalia 2610034B18Rik 33 34
  • 84.37 (n)
Arpin 16
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
ManyToMany
-- 34
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf38 33
  • 62.8 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:112432 33
  • 58.93 (n)
C18H15orf38 34
  • 58 (a)
OneToMany
Species where no ortholog for C15orf38-AP3S2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf38-AP3S2 Gene

ENSEMBL:
Gene Tree for C15orf38-AP3S2 (if available)
TreeFam:
Gene Tree for C15orf38-AP3S2 (if available)

Paralogs for C15orf38-AP3S2 Gene

Paralogs for C15orf38-AP3S2 Gene

(10) SIMAP similar genes for C15orf38-AP3S2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C15orf38-AP3S2: view

Variants for C15orf38-AP3S2 Gene

Sequence variations from dbSNP and Humsavar for C15orf38-AP3S2 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000019756 -- 89,891,660(+) GAGGG(-/A)AAAAA intron-variant
rs1000050564 -- 89,886,454(+) TTTTT(G/T)TTTCT intron-variant
rs1000141168 -- 89,832,450(+) ACAAA(A/G)AAAGG nc-transcript-variant, utr-variant-3-prime
rs1000162925 -- 89,857,524(+) TTATT(C/G)TGTTA intron-variant
rs1000183807 -- 89,908,099(+) ACGGG(G/T)ATCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf38-AP3S2 Gene

Variant ID Type Subtype PubMed ID
esv1678655 CNV deletion 17803354
esv2667255 CNV deletion 23128226
esv2750010 CNV deletion 23290073
esv3637203 CNV loss 21293372
esv3637204 CNV loss 21293372
esv3637205 CNV gain 21293372
esv3637206 CNV loss 21293372
nsv1661 CNV insertion 18451855
nsv570389 CNV loss 21841781

Variation tolerance for C15orf38-AP3S2 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C15orf38-AP3S2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C15orf38-AP3S2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf38-AP3S2 Gene

Disorders for C15orf38-AP3S2 Gene

Relevant External Links for C15orf38-AP3S2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C15orf38-AP3S2

No disorders were found for C15orf38-AP3S2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf38-AP3S2 Gene

Publications for C15orf38-AP3S2 Gene

  1. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. (PMID: 24509480) DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium … Morris AP (Nature genetics 2014) 3 60
  2. Genome-wide association study identifies three novel loci for type 2 diabetes. (PMID: 23945395) Hara K … Kadowaki T (Human molecular genetics 2014) 3 60
  3. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PMID: 21874001) Kooner JS … Chambers JC (Nature genetics 2011) 3 60
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 60
  5. Web-based, participant-driven studies yield novel genetic associations for common traits. (PMID: 20585627) Eriksson N … Mountain J (PLoS genetics 2010) 3 60

Products for C15orf38-AP3S2 Gene

Sources for C15orf38-AP3S2 Gene

Content
Loading form....