Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C15orf38-AP3S2 Gene

Aliases for C15orf38-AP3S2 Gene

  • C15orf38-AP3S2 Readthrough 2 3 5

External Ids for C15orf38-AP3S2 Gene

Previous GeneCards Identifiers for C15orf38-AP3S2 Gene

  • GC15U901312
  • GC15M090378

Summaries for C15orf38-AP3S2 Gene

Entrez Gene Summary for C15orf38-AP3S2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring C15orf38 (chromosome 15 open reading frame 38) and AP3S2 (adaptor-related protein complex 3, sigma 2 subunit) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]

GeneCards Summary for C15orf38-AP3S2 Gene

C15orf38-AP3S2 (C15orf38-AP3S2 Readthrough) is a Protein Coding gene. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is ARPIN.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf38-AP3S2 Gene

Genomics for C15orf38-AP3S2 Gene

Regulatory Elements for C15orf38-AP3S2 Gene

Enhancers for C15orf38-AP3S2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C15orf38-AP3S2 on UCSC Golden Path with GeneCards custom track

Promoters for C15orf38-AP3S2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C15orf38-AP3S2 on UCSC Golden Path with GeneCards custom track

Genomic Location for C15orf38-AP3S2 Gene

Chromosome:
15
Start:
89,830,599 bp from pter
End:
89,912,990 bp from pter
Size:
82,392 bases
Orientation:
Minus strand

Genomic View for C15orf38-AP3S2 Gene

Genes around C15orf38-AP3S2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf38-AP3S2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf38-AP3S2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf38-AP3S2 Gene

Proteins for C15orf38-AP3S2 Gene

  • Protein details for C15orf38-AP3S2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYH1
    Recommended name:
    Protein C15orf38-AP3S2
    Protein Accession:
    A0A0A6YYH1

    Protein attributes for C15orf38-AP3S2 Gene

    Size:
    394 amino acids
    Molecular mass:
    43882 Da
    Quaternary structure:
    No Data Available
  • Protein details for C15orf38-AP3S2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YL85
    Recommended name:
    Protein C15orf38-AP3S2
    Protein Accession:
    H0YL85

    Protein attributes for C15orf38-AP3S2 Gene

    Size:
    185 amino acids
    Molecular mass:
    20448 Da
    Quaternary structure:
    No Data Available
  • Protein details for C15orf38-AP3S2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YMK0
    Recommended name:
    Protein C15orf38-AP3S2
    Protein Accession:
    H0YMK0

    Protein attributes for C15orf38-AP3S2 Gene

    Size:
    184 amino acids
    Molecular mass:
    20721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C15orf38-AP3S2 Gene

Proteomics data for C15orf38-AP3S2 Gene at MOPED

Protein Expression for C15orf38-AP3S2 Gene

Post-translational modifications for C15orf38-AP3S2 Gene

No Post-translational modifications

Other Protein References for C15orf38-AP3S2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C15orf38-AP3S2 Gene

Domains & Families for C15orf38-AP3S2 Gene

Protein Domains for C15orf38-AP3S2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C15orf38-AP3S2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C15orf38-AP3S2 Gene

Function for C15orf38-AP3S2 Gene

Phenotypes for C15orf38-AP3S2 Gene

GenomeRNAi human phenotypes for C15orf38-AP3S2:
genes like me logo Genes that share phenotypes with C15orf38-AP3S2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf38-AP3S2 Gene

Localization for C15orf38-AP3S2 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C15orf38-AP3S2 Gene

Pathways & Interactions for C15orf38-AP3S2 Gene

SuperPathways for C15orf38-AP3S2 Gene

No Data Available

Interacting Proteins for C15orf38-AP3S2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381377%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000381377 for C15orf38-AP3S2 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for C15orf38-AP3S2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C15orf38-AP3S2 Gene

Drugs & Compounds for C15orf38-AP3S2 Gene

No Compound Related Data Available

Transcripts for C15orf38-AP3S2 Gene

mRNA/cDNA for C15orf38-AP3S2 Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf38-AP3S2 Gene

No ASD Table

Relevant External Links for C15orf38-AP3S2 Gene

GeneLoc Exon Structure for
C15orf38-AP3S2
ECgene alternative splicing isoforms for
C15orf38-AP3S2

Expression for C15orf38-AP3S2 Gene

mRNA expression in normal human tissues for C15orf38-AP3S2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from for C15orf38-AP3S2 Gene



genes like me logo Genes that share expression patterns with C15orf38-AP3S2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C15orf38-AP3S2 Gene

Orthologs for C15orf38-AP3S2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf38-AP3S2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARPIN 35
  • 88.39 (n)
  • 91.07 (a)
C21H15orf38 36
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia C3H15orf38 35
  • 87.8 (n)
  • 87.5 (a)
C3H15orf38 36
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 2610034B18Rik 35
  • 84.37 (n)
  • 88.39 (a)
Arpin 16
2610034B18Rik 36
  • 88 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC100170757 35
  • 98.96 (n)
  • 98.66 (a)
AP3S2 36
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1311021 35
  • 85.57 (n)
  • 89.29 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 70 (a)
ManyToMany
-- 36
  • 73 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf38 35
  • 62.8 (n)
  • 64.73 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:112432 35
  • 58.93 (n)
  • 58.48 (a)
C18H15orf38 36
  • 58 (a)
OneToMany
Species with no ortholog for C15orf38-AP3S2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf38-AP3S2 Gene

ENSEMBL:
Gene Tree for C15orf38-AP3S2 (if available)
TreeFam:
Gene Tree for C15orf38-AP3S2 (if available)

Paralogs for C15orf38-AP3S2 Gene

Paralogs for C15orf38-AP3S2 Gene

(10) SIMAP similar genes for C15orf38-AP3S2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C15orf38-AP3S2: view

Variants for C15orf38-AP3S2 Gene

Structural Variations from Database of Genomic Variants (DGV) for C15orf38-AP3S2 Gene

Variant ID Type Subtype PubMed ID
nsv1661 CNV Insertion 18451855
esv2667255 CNV Deletion 23128226
esv1678655 CNV Deletion 17803354
esv2750010 CNV Deletion 23290073

Variation tolerance for C15orf38-AP3S2 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.65% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations from dbSNP and Humsavar and Relevant External Links for C15orf38-AP3S2 Gene

Disorders for C15orf38-AP3S2 Gene

Relevant External Links for C15orf38-AP3S2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C15orf38-AP3S2

No disorders were found for C15orf38-AP3S2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf38-AP3S2 Gene

Publications for C15orf38-AP3S2 Gene

  1. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. (PMID: 24509480) . … Morris A.P. (Nat. Genet. 2014) 3 67
  2. Genome-wide association study identifies three novel loci for type 2 diabetes. (PMID: 23945395) Hara K. … Kadowaki T. (Hum. Mol. Genet. 2014) 3
  3. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PMID: 21874001) Kooner J.S. … Chambers J.C. (Nat. Genet. 2011) 3
  4. Web-based, participant-driven studies yield novel genetic associations for common traits. (PMID: 20585627) Eriksson N. … Mountain J. (PLoS Genet. 2010) 3
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3

Products for C15orf38-AP3S2 Gene

Sources for C15orf38-AP3S2 Gene

Content