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Aliases for C15orf38-AP3S2 Gene

Aliases for C15orf38-AP3S2 Gene

  • C15orf38-AP3S2 Readthrough 2 3 5

External Ids for C15orf38-AP3S2 Gene

Previous GeneCards Identifiers for C15orf38-AP3S2 Gene

  • GC15U901312
  • GC15M090378

Summaries for C15orf38-AP3S2 Gene

Entrez Gene Summary for C15orf38-AP3S2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring C15orf38 (chromosome 15 open reading frame 38) and AP3S2 (adaptor-related protein complex 3, sigma 2 subunit) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]

GeneCards Summary for C15orf38-AP3S2 Gene

C15orf38-AP3S2 (C15orf38-AP3S2 Readthrough) is a Protein Coding gene. GO annotations related to this gene include protein transporter activity. An important paralog of this gene is ARPIN.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf38-AP3S2 Gene

Genomics for C15orf38-AP3S2 Gene

Regulatory Elements for C15orf38-AP3S2 Gene

Enhancers for C15orf38-AP3S2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C15orf38-AP3S2 on UCSC Golden Path with GeneCards custom track

Promoters for C15orf38-AP3S2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for C15orf38-AP3S2 Gene

Chromosome:
15
Start:
89,830,599 bp from pter
End:
89,912,990 bp from pter
Size:
82,392 bases
Orientation:
Minus strand

Genomic View for C15orf38-AP3S2 Gene

Genes around C15orf38-AP3S2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf38-AP3S2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf38-AP3S2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf38-AP3S2 Gene

Proteins for C15orf38-AP3S2 Gene

  • Protein details for C15orf38-AP3S2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYH1
    Recommended name:
    Protein C15orf38-AP3S2
    Protein Accession:
    A0A0A6YYH1

    Protein attributes for C15orf38-AP3S2 Gene

    Size:
    394 amino acids
    Molecular mass:
    43882 Da
    Quaternary structure:
    No Data Available
  • Protein details for C15orf38-AP3S2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YL85
    Recommended name:
    Protein C15orf38-AP3S2
    Protein Accession:
    H0YL85

    Protein attributes for C15orf38-AP3S2 Gene

    Size:
    185 amino acids
    Molecular mass:
    20448 Da
    Quaternary structure:
    No Data Available
  • Protein details for C15orf38-AP3S2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YMK0
    Recommended name:
    Protein C15orf38-AP3S2
    Protein Accession:
    H0YMK0

    Protein attributes for C15orf38-AP3S2 Gene

    Size:
    184 amino acids
    Molecular mass:
    20721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C15orf38-AP3S2 Gene

Protein Expression for C15orf38-AP3S2 Gene

Post-translational modifications for C15orf38-AP3S2 Gene

No Post-translational modifications

Other Protein References for C15orf38-AP3S2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C15orf38-AP3S2 Gene

Domains & Families for C15orf38-AP3S2 Gene

Protein Domains for C15orf38-AP3S2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C15orf38-AP3S2: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C15orf38-AP3S2 Gene

Function for C15orf38-AP3S2 Gene

Phenotypes for C15orf38-AP3S2 Gene

GenomeRNAi human phenotypes for C15orf38-AP3S2:
genes like me logo Genes that share phenotypes with C15orf38-AP3S2: view

Animal Model Products

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf38-AP3S2 Gene

Localization for C15orf38-AP3S2 Gene

Gene Ontology (GO) - Cellular Components for C15orf38-AP3S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030117 membrane coat IEA --
genes like me logo Genes that share ontologies with C15orf38-AP3S2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for C15orf38-AP3S2 Gene

Pathways & Interactions for C15orf38-AP3S2 Gene

SuperPathways for C15orf38-AP3S2 Gene

No Data Available

Interacting Proteins for C15orf38-AP3S2 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000381377%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000381377 for C15orf38-AP3S2 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for C15orf38-AP3S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with C15orf38-AP3S2: view

No data available for Pathways by source and SIGNOR curated interactions for C15orf38-AP3S2 Gene

Drugs & Compounds for C15orf38-AP3S2 Gene

No Compound Related Data Available

Transcripts for C15orf38-AP3S2 Gene

mRNA/cDNA for C15orf38-AP3S2 Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf38-AP3S2 Gene

No ASD Table

Relevant External Links for C15orf38-AP3S2 Gene

GeneLoc Exon Structure for
C15orf38-AP3S2
ECgene alternative splicing isoforms for
C15orf38-AP3S2

Expression for C15orf38-AP3S2 Gene

mRNA expression in normal human tissues for C15orf38-AP3S2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from MOPED for C15orf38-AP3S2 Gene



genes like me logo Genes that share expression patterns with C15orf38-AP3S2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C15orf38-AP3S2 Gene

Orthologs for C15orf38-AP3S2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf38-AP3S2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia ARPIN 34
  • 88.39 (n)
  • 91.07 (a)
C21H15orf38 35
  • 90 (a)
OneToMany
dog
(Canis familiaris)
Mammalia C3H15orf38 34
  • 87.8 (n)
  • 87.5 (a)
C3H15orf38 35
  • 70 (a)
OneToMany
mouse
(Mus musculus)
Mammalia 2610034B18Rik 34
  • 84.37 (n)
  • 88.39 (a)
Arpin 16
2610034B18Rik 35
  • 88 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia LOC100170757 34
  • 98.96 (n)
  • 98.66 (a)
AP3S2 35
  • 99 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia RGD1311021 34
  • 85.57 (n)
  • 89.29 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 70 (a)
ManyToMany
-- 35
  • 73 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf38 34
  • 62.8 (n)
  • 64.73 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:112432 34
  • 58.93 (n)
  • 58.48 (a)
C18H15orf38 35
  • 58 (a)
OneToMany
Species where no ortholog for C15orf38-AP3S2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf38-AP3S2 Gene

ENSEMBL:
Gene Tree for C15orf38-AP3S2 (if available)
TreeFam:
Gene Tree for C15orf38-AP3S2 (if available)

Paralogs for C15orf38-AP3S2 Gene

Paralogs for C15orf38-AP3S2 Gene

(10) SIMAP similar genes for C15orf38-AP3S2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C15orf38-AP3S2: view

Variants for C15orf38-AP3S2 Gene

Structural Variations from Database of Genomic Variants (DGV) for C15orf38-AP3S2 Gene

Variant ID Type Subtype PubMed ID
esv1678655 CNV deletion 17803354
esv2667255 CNV deletion 23128226
esv2750010 CNV deletion 23290073
esv3637203 CNV loss 21293372
esv3637204 CNV loss 21293372
esv3637205 CNV gain 21293372
esv3637206 CNV loss 21293372
nsv1661 CNV insertion 18451855
nsv570389 CNV loss 21841781

Variation tolerance for C15orf38-AP3S2 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C15orf38-AP3S2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C15orf38-AP3S2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for C15orf38-AP3S2 Gene

Disorders for C15orf38-AP3S2 Gene

Relevant External Links for C15orf38-AP3S2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C15orf38-AP3S2

No disorders were found for C15orf38-AP3S2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf38-AP3S2 Gene

Publications for C15orf38-AP3S2 Gene

  1. Genome-wide association study identifies three novel loci for type 2 diabetes. (PMID: 23945395) Hara K. … Kadowaki T. (Hum. Mol. Genet. 2014) 3 65
  2. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. (PMID: 24509480) . … Morris A.P. (Nat. Genet. 2014) 3 65
  3. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PMID: 21874001) Kooner J.S. … Chambers J.C. (Nat. Genet. 2011) 3 65
  4. Web-based, participant-driven studies yield novel genetic associations for common traits. (PMID: 20585627) Eriksson N. … Mountain J. (PLoS Genet. 2010) 3 65
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 65

Products for C15orf38-AP3S2 Gene

Sources for C15orf38-AP3S2 Gene

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