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C15orf32 Gene

protein-coding   GIFtS: 40
GCID: GC15P093014          (predicted)

Chromosome 15 Open Reading Frame 32

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 15 Open Reading Frame 321 2
Uncharacterized Protein C15orf322

External Ids:    HGNC: 265491   Entrez Gene: 1458582   Ensembl: ENSG000001836437   UniProtKB: Q32M923   

Export aliases for C15orf32 gene to outside databases

Previous GC identifers: GC15P090816 GC15P069151


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C15orf32 Gene:
C15orf32 (chromosome 15 open reading frame 32) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C15orf32 gene promoter:
         C/EBPbeta   Pax-5   POU2F1   POU2F1a   Hand1   E47   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C15orf32


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q26.1   Ensembl cytogenetic band:  15q26.1   HGNC cytogenetic band: 15q26.1

C15orf32 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C15orf32 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P093014:  view genomic region     (about GC identifiers)

Start:
93,014,884 bp from pter      End:
93,044,347 bp from pter
Size:
29,464 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CO032_HUMAN, Q32M92 (See protein sequence)
Recommended Name: Uncharacterized protein C15orf32  
Size: 178 amino acids; 20262 Da
Secondary accessions: C5HTZ8 Q96M45
Alternative splicing: 2 isoforms:  Q32M92-1   Q32M92-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C15orf32: NX_Q32M92

Explore proteomics data for C15orf32 at MOPED


See C15orf32 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_694585.1  
ENSEMBL proteins: 
 ENSP00000330267   ENSP00000456342  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q32M92


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for C15orf32

miRNA
Products:
    
miRTarBase miRNAs that target C15orf32:
hsa-mir-335-5p (MIRT017671)

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Selected qRT-PCR Assays for microRNAs that regulate C15orf32 (see all 13):
hsa-miR-365 hsa-miR-668 hsa-miR-634 hsa-miR-330-5p hsa-miR-4268 hsa-miR-1261 hsa-miR-4267 hsa-miR-374a*
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
cytosol1
nucleus1
peroxisome1
plasma membrane1

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C15orf32
Interactions:

    Search GeneGlobe Interaction Network for C15orf32

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C15orf32 (CO032)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C15orf32 gene: 
NM_153040.2  

Unigene Cluster for C15orf32:

Chromosome 15 open reading frame 32
Hs.367879  [show with all ESTs]
Unigene Representative Sequence: AK057393
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000333334(uc002brc.1 uc010bod.1) ENST00000556865
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SwitchGear 3'UTR luciferase reporter plasmidC15orf32 3' UTR sequence
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Additional mRNA sequence: 

AK057393.1 BC109252.2 BC109253.1 

1 DOTS entry:

DT.95146519 

Selected AceView cDNA sequences (see all 47):

BC069584 AI093905 AY358091 BM669836 U33551 NM_006011 AW157425 AA339648 
BX101574 C15130 AL134628 BM699174 NM_153040 AK057393 AI879502 AW161242 
AI815631 T07570 BM723674 BI914060 BX283248 BX537981 BM011899 AW161777 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for C15orf32    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b
SP1:                    -               
SP2:                                    


ECgene alternative splicing isoforms for C15orf32

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: GCAACCTTCC

C15orf32 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C15orf32 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.367879
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for C15orf32 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf321 chromosome 15 open reading frame, human C15orf32 99.63(n)
99.44(a)
  746351  XM_001170366.1  XP_001170366.1 


ENSEMBL Gene Tree for C15orf32 (if available)
TreeFam Gene Tree for C15orf32 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C15orf32 (see all 554)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 15 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs124414041,2
C,F,H--93016912(+) ACAGGG/AAGACA 1 -- int122Minor allele frequency- A:0.43NS EA NA WA CSA 2346
rs764281291,2
C,F--93016946(+) GGCCTA/GGAAAC 1 -- int11Minor allele frequency- G:0.02NA 120
rs1848661171,2
--93016969(+) TCAAGC/GCAAAC 1 -- int10--------
rs735339041,2
C,F--93017020(+) CCCACA/CGTTGC 1 -- int15Minor allele frequency- C:0.14WA CSA EA 244
rs1397350461,2
C--93017030(+) CTGTCC/GCCACA 1 -- int10--------
rs1497767421,2
C--93017087(+) TCCACC/TCAGTG 1 -- int10--------
rs1456963341,2
--93017170(+) CTTTCA/GAATTT 1 -- int10--------
rs1157119711,2
F--93017234(+) TCTGAG/AGATGA 1 -- int11Minor allele frequency- A:0.03WA 118
rs1489107441,2
--93017368(+) AAATGG/TGCTGC 1 -- int10--------
rs1130071411,2
C,F--93017385(+) GCAGGG/ACATTG 1 -- int11Minor allele frequency- A:0.50WA 2

HapMap Linkage Disequilibrium report for C15orf32 (93014884 - 93044347 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for C15orf32:    About this table    
Variant IDTypeSubtypePubMed ID
nsv519402CNV Gain19592680
nsv904499CNV Gain21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with C15orf32           About GenesLikeMe

Genetic Association Database (GAD): C15orf32

Export disorders for C15orf32 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C15orf32 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C15orf32)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genome-wide association study of bipolar I disorder in the Han Chinese population. (PubMed id 20386566)1, 4 Lee M.T....Cheng A.T. (Mol. Psychiatry 2011)
  2. A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. (PubMed id 21529783)1, 4 Heath A.C....Montgomery G.W. (Biol. Psychiatry 2011)
  3. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)1, 4 Wilk J.B....O'Connor G.T. (BMC Med. Genet. 2007)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 145858 HGNC: 26549 AceView: SIAT8BandFLJ32831 Ensembl:ENSG00000183643 euGenes: HUgn145858
ECgene: C15orf32 H-InvDB: C15orf32

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C15orf32 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C15orf32 gene:
Search GeneIP for patents involving C15orf32

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes      Disease genes      C15orf32 gene at Home site.
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