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Aliases for C15orf27 Gene

Aliases for C15orf27 Gene

  • Chromosome 15 Open Reading Frame 27 2 3

External Ids for C15orf27 Gene

Previous GeneCards Identifiers for C15orf27 Gene

  • GC15P074069
  • GC15P074139
  • GC15P076352
  • GC15P053183

Summaries for C15orf27 Gene

GeneCards Summary for C15orf27 Gene

C15orf27 (Chromosome 15 Open Reading Frame 27) is a Protein Coding gene. An important paralog of this gene is HVCN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf27 Gene

Genomics for C15orf27 Gene

Regulatory Elements for C15orf27 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C15orf27 Gene

Start:
76,059,837 bp from pter
End:
76,229,121 bp from pter
Size:
169,285 bases
Orientation:
Plus strand

Genomic View for C15orf27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C15orf27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf27 Gene

Proteins for C15orf27 Gene

  • Protein details for C15orf27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M3C6-CO027_HUMAN
    Recommended name:
    Transmembrane protein C15orf27
    Protein Accession:
    Q2M3C6
    Secondary Accessions:
    • Q8N993
    • Q96LL5

    Protein attributes for C15orf27 Gene

    Size:
    531 amino acids
    Molecular mass:
    58444 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI04954.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04956.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71676.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04562.1; Type=Frameshift; Positions=13, 93; Evidence={ECO:0000305};

    Alternative splice isoforms for C15orf27 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C15orf27 Gene

Proteomics data for C15orf27 Gene at MOPED

Post-translational modifications for C15orf27 Gene

  • Glycosylation at Asn8, Asn363, and Asn380
  • Modification sites at PhosphoSitePlus

Other Protein References for C15orf27 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C15orf27 Gene

Domains for C15orf27 Gene

Protein Domains for C15orf27 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C15orf27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C15orf27: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C15orf27 Gene

Function for C15orf27 Gene

Gene Ontology (GO) - Molecular Function for C15orf27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005245 voltage-gated calcium channel activity IBA --
genes like me logo Genes that share ontologies with C15orf27: view

Animal Model Products

CRISPR Products

miRNA for C15orf27 Gene

miRTarBase miRNAs that target C15orf27

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C15orf27

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for C15orf27 Gene

Localization for C15orf27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C15orf27 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C15orf27 Gene COMPARTMENTS Subcellular localization image for C15orf27 gene
Compartment Confidence
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for C15orf27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C15orf27: view

Pathways for C15orf27 Gene

SuperPathways for C15orf27 Gene

No Data Available

Interacting Proteins for C15orf27 Gene

Gene Ontology (GO) - Biological Process for C15orf27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070509 calcium ion import IBA --
GO:0070588 calcium ion transmembrane transport IBA --
GO:0086010 membrane depolarization during action potential IBA --
genes like me logo Genes that share ontologies with C15orf27: view

No data available for Pathways by source for C15orf27 Gene

Transcripts for C15orf27 Gene

mRNA/cDNA for C15orf27 Gene

Unigene Clusters for C15orf27 Gene

Chromosome 15 open reading frame 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C15orf27

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf27 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: - - -
SP2:
SP3:

Relevant External Links for C15orf27 Gene

GeneLoc Exon Structure for
C15orf27
ECgene alternative splicing isoforms for
C15orf27

Expression for C15orf27 Gene

mRNA expression in normal human tissues for C15orf27 Gene

mRNA differential expression in normal tissues according to GTEx for C15orf27 Gene

This gene is overexpressed in Brain - Cerebellum (14.5) and Brain - Cerebellar Hemisphere (13.6).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C15orf27 Gene

SOURCE GeneReport for Unigene cluster for C15orf27 Gene Hs.661411

genes like me logo Genes that share expressions with C15orf27: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C15orf27 Gene

Orthologs for C15orf27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf27 35
  • 99.31 (n)
  • 99.44 (a)
C15orf27 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C15orf27 36
  • 88 (a)
OneToOne
C21H15orf27 35
  • 88.76 (n)
  • 87.9 (a)
dog
(Canis familiaris)
Mammalia C15orf27 36
  • 76 (a)
OneToOne
LOC487670 35
  • 86.27 (n)
  • 84.71 (a)
mouse
(Mus musculus)
Mammalia AI118078 35
  • 87.36 (n)
  • 88.11 (a)
AI118078 16
AI118078 36
  • 86 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C15orf27 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C15orf27 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562084 35
  • 88.23 (n)
  • 88.29 (a)
chicken
(Gallus gallus)
Aves C15ORF27 35
  • 74.61 (n)
  • 76.55 (a)
C15orf27 36
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C15orf27 36
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C25H15orf27 36
  • 60 (a)
OneToOne
Dr.14493 35
zgc:158624 35
  • 68.05 (n)
  • 64.16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
OneToOne
Species with no ortholog for C15orf27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf27 Gene

ENSEMBL:
Gene Tree for C15orf27 (if available)
TreeFam:
Gene Tree for C15orf27 (if available)

Paralogs for C15orf27 Gene

Paralogs for C15orf27 Gene

genes like me logo Genes that share paralogs with C15orf27: view

Variants for C15orf27 Gene

Sequence variations from dbSNP and Humsavar for C15orf27 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs868576 -- 76,153,348(-) CCTTC(A/G)TGCCT intron-variant
rs868577 -- 76,153,018(-) AGCAC(A/G)CTCCT intron-variant
rs869452 -- 76,202,747(-) TCAGC(A/G)TTATT intron-variant
rs870294 -- 76,202,335(+) CTCGG(C/G)CTGGC intron-variant
rs870295 -- 76,202,534(+) AATTG(A/G)AAGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf27 Gene

Variant ID Type Subtype PubMed ID
esv2749895 CNV Deletion 23290073
esv2749898 CNV Deletion 23290073
nsv904398 CNV Gain 21882294
nsv1617 CNV Loss 18451855
esv2669418 CNV Deletion 23128226
nsv833057 CNV Loss 17160897
esv2665159 CNV Deletion 23128226
esv2660944 CNV Deletion 23128226
esv274972 CNV Loss 21479260

Relevant External Links for C15orf27 Gene

HapMap Linkage Disequilibrium report
C15orf27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf27 Gene

Disorders for C15orf27 Gene

No disorders were found for C15orf27 Gene.

No data available for UniProtKB/Swiss-Prot for C15orf27 Gene

Publications for C15orf27 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. Aspartatea88112 is the selectivity filter of the human voltage-gated proton channel. (PMID: 22020278) Musset B. … Decoursey T.E. (Nature 2011) 2 3 4
  3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for C15orf27 Gene

  • antibodies-online peptides for C15orf27
  • antibodies-online antibodies for C15orf27
  • antibodies-online kits for C15orf27

Sources for C15orf27 Gene

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