C15orf27 Gene
protein-coding GIFtS : 40
GCID: GC15 P076352
chromosome 15 open reading frame 27
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Aliasesfor C15orf27 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chromosome 15 Open Reading Frame 27 1 2 FLJ381901 Transmembrane Protein C15orf272
Export aliases for C15orf27 gene to outside databases Previous GC identifers: GC15P074069 GC15P074139 GC15P053183
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Summariesfor C15orf27 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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Genomic Viewsfor C15orf27 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000015.9 NC_018926.1 NT_010194.17 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the C15orf27 gene promoter: Nkx3-1 ISGF-3 Nkx3-1 v4 Nkx3-1 v1 GATA-1 Nkx3-1 v2 FOXO4 FOXO1a Nkx3-1 v3 FOXO1 Other transcription factors Search SABiosciences Chromatin IP Primers for C15orf27 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat C15orf27
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 15q24.2 Ensembl cytogenetic band: 15q24.2 HGNC cytogenetic band: 15q23-q24.1 C15orf27 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 15 GeneLoc Exon Structure
GeneLoc location for GC15P076352: view genomic region
(about GC identifiers )
Start:
76,352,178 bp from pter
End:
76,521,462 bp from pter
Size:
169,285 bases
Orientation:
plus strand
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Proteinsfor C15orf27 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CO027_HUMAN, Q2M3C6 (See
protein sequence )Recommended Name: Transmembrane protein C15orf27 Size : 531 amino acids; 58444 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Sequence caution : Sequence=AAI04954.1; Type=Erroneous initiation; Sequence=AAI04956.1; Type=Erroneous initiation;Sequence=BAB71676.1; Type=Erroneous initiation; Sequence=BAC04562.1; Type=Frameshift; Positions=13, 93;
Secondary accessions : Q8N993 Q96LL5Alternative splicing : 2 isoforms : Q2M3C6-1 Q2M3C6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C15orf27: NX_Q2M3C6 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q2M3C6 C15orf27 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_689548.2 ENSEMBL proteins: ENSP00000373594 ENSP00000435049 ENSP00000453957 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
C15orf27 for ontologies About GeneDecksing C15orf27 Antibody Products: Assay Products for C15orf27:
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Protein
Domains / Familiesfor C15orf27 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q2M3C6
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Functionfor C15orf27 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C15orf27 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C15orf27 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C15orf27 (NM_152335 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C15orf27 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C15orf27
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf27
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Pathways & Interactionsfor C15orf27 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C15orf27
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Drugs & Compoundsfor C15orf27 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for C15orf27 Search CenterWatch for drugs/clinical trials and news about C15orf27 / CO027
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Transcriptsfor C15orf27 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
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siRNAs from
OriGene ,
QIAGEN ,
shRNA from
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microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
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GenScript ,
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Primers from
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QIAGEN
)About This Section REFSEQ mRNAs for C15orf27 gene: NM_152335.2 Unigene Cluster for C15orf27:
Chromosome 15 open reading frame 27 Hs.661411 [show with all ESTs ] Unigene Representative Sequence: NM_152335 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000388942 (uc002bbq.3 uc002bbr.3 ) ENST00000484722 ENST00000559079 ENST00000561302 (uc010bkp.3 ) ENST00000558249 (uc002bbs.3 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C15orf27 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C15orf27 (see all 2 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C15orf27 (NM_152335 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C15orf27 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C15orf27
Additional cDNA sequence: AK054866.1 AK056777.1 AK058126.1 AK095509.1 AK308676.1 BC104953.1 BC104955.1
4 DOTS entries : DT.100844519 DT.433943
DT.97822402 DT.97774959 13 AceView cDNA sequences :
NM_152335 AK095509 BX398159 AK056777 AA232331 BX377202 BQ009396 AK054866 BP369654 AK058126 BQ009353 AL699780 AA633991 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for C15orf27 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 SP1 :     -   -                 -         SP2 :                               SP3 :                              
ECgene alternative splicing isoforms for C15orf27
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Expression for C15orf27 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section C15orf27 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: AGCGTTTCTG
About this image C15orf27 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See C15orf27 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for C15orf27 SOURCE GeneReport for Unigene cluster: Hs.661411 SABiosciences Custom PCR Arrays for C15orf27 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C15orf27Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat C15orf27 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C15orf27 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C15orf27 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf27
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Orthologsfor C15orf27 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for C15orf27 gene from 4/14 species (see all 14 ) About this table
ENSEMBL Gene Tree for C15orf27 (if available)TreeFam Gene Tree for C15orf27 (if available)
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Paralogsfor C15orf27 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for C15orf27 gene HVCN1 2
C15orf27 for paralogs About GeneDecksing
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Genomic Variantsfor C15orf27 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 15 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for C15orf27 (76352178 - 76521462 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 2 variations for C15orf27 2 CNVs : 35343 35342
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C15orf27
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Disorders
/ Diseasesfor C15orf27 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor C15orf27 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for C15orf27 gene integrated from 9 sources : (articles sorted by number of sources associating them with C15orf27) Utopia : connect your pdf to the dynamic world of online information
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 , 3 Ota T.... Sugano S. (2004) Aspartatea88112 is the selectivity filter of the human voltage-gated proton channel. (PubMed id 22020278) 1 , 3 Musset B....Decoursey T.E. (2011) Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171) 1 , 2 Zody M.C....Nusbaum C. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556) 1 Suzuki Y.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for C15orf27 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing C15orf27 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing C15orf27 gene
(According to HUGE )
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Specialized Databases showing C15orf27 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for C15orf27 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for C15orf27 gene: Search GeneIP for patents involving C15orf27 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor C15orf27 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for C15orf27 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for C15orf27 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C15orf27 OriGene Protein Over-expression Lysate for C15orf27 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for C15orf27 OriGene 3'-UTR Clone for C15orf27 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C15orf27 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C15orf27 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for C15orf27 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for C15orf27 OriGene Custom Protein Services for C15orf27 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C15orf27 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C15orf27 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat C15orf27 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat C15orf27 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C15orf27 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C15orf27
C15orf27 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf27
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C15orf27
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Genomic Views for C15orf27
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