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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C15orf27 Gene

protein-coding   GIFtS: 41
GCID: GC15P076352

Chromosome 15 Open Reading Frame 27

  Search for C15orf27
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 15 Open Reading Frame 271 2
Transmembrane Protein C15orf272

External Ids:    HGNC: 267631   Entrez Gene: 1235912   Ensembl: ENSG000001697587   UniProtKB: Q2M3C63   

Export aliases for C15orf27 gene to outside databases

Previous GC identifers: GC15P074069 GC15P074139 GC15P053183


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C15orf27 Gene: 
C15orf27 (chromosome 15 open reading frame 27) is a protein-coding gene. An important paralog of this gene is HVCN1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C15orf27 gene promoter:
         Nkx3-1   ISGF-3   Nkx3-1 v4   Nkx3-1 v1   GATA-1   Nkx3-1 v2   FOXO4   FOXO1a   Nkx3-1 v3   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C15orf27

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C15orf27


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.2   Ensembl cytogenetic band:  15q24.2   HGNC cytogenetic band: 15q23-q24.1

C15orf27 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C15orf27 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P076352:  view genomic region     (about GC identifiers)

Start:
76,352,178 bp from pter      End:
76,521,462 bp from pter
Size:
169,285 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CO027_HUMAN, Q2M3C6 (See protein sequence)
Recommended Name: Transmembrane protein C15orf27  
Size: 531 amino acids; 58444 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAI04954.1; Type=Erroneous initiation; Sequence=AAI04956.1; Type=Erroneous initiation;
Sequence=BAB71676.1; Type=Erroneous initiation; Sequence=BAC04562.1; Type=Frameshift; Positions=13, 93;
Secondary accessions: Q8N993 Q96LL5
Alternative splicing: 2 isoforms:  Q2M3C6-1   Q2M3C6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C15orf27: NX_Q2M3C6

Explore proteomics data for C15orf27 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q2M3C6

  • C15orf27 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C15orf27 Protein Expression
    REFSEQ proteins: NP_689548.2  
    ENSEMBL proteins: 
     ENSP00000373594   ENSP00000435049   ENSP00000453957  

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    Cloud-Clone Corp. Proteins for C15orf27 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    C15orf27 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for C15orf27


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR027359 K_channel_four-helix_dom

    Graphical View of Domain Structure for InterPro Entry Q2M3C6

    ProtoNet protein and cluster: Q2M3C6


    C15orf27 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for C15orf27 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C15orf27 
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    SwitchGear 3'UTR luciferase reporter plasmidC15orf27 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf27


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C15orf27

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C15orf27 (CO027)

    Search CenterWatch for drugs/clinical trials and news about C15orf27 / CO027

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C15orf27 gene: 
    NM_152335.2  

    Unigene Cluster for C15orf27:

    Chromosome 15 open reading frame 27
    Hs.661411  [show with all ESTs]
    Unigene Representative Sequence: NM_152335
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000388942(uc002bbq.3 uc002bbr.3) ENST00000484722 ENST00000559079
    ENST00000561302(uc010bkp.3) ENST00000558249(uc002bbs.3)
    miRNA
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    8/25 QIAGEN miScript miRNA Assays for microRNAs that regulate C15orf27 (see all 25):
    hsa-miR-1178 hsa-miR-4254 hsa-miR-148b hsa-miR-128 hsa-miR-29c hsa-miR-29a hsa-miR-512-3p hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidC15orf27 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C15orf27
    Clone
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    OriGene clones in human, mouse for C15orf27 (see all 9)
    OriGene ORF clones in mouse, rat for C15orf27
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C15orf27 (NM_152335)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C15orf27
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C15orf27
    Sirion Biotech Customized lentivirus for stable overexpression of C15orf27 
                         Customized lentivirus expression plasmids for stable overexpression of C15orf27 
    Primer
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    OriGene qPCR primer pairs and template standards for C15orf27
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C15orf27
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C15orf27

    Additional mRNA sequence: 

    AK054866.1 AK056777.1 AK058126.1 AK095509.1 AK308676.1 BC104953.1 BC104955.1 

    4 DOTS entries:

    DT.100844519  DT.433943  DT.97822402  DT.97774959 

    13 AceView cDNA sequences:

    NM_152335 AK095509 BX398159 AK054866 AA232331 AK058126 BQ009396 BX377202 
    BQ009353 AK056777 BP369654 AL699780 AA633991 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for C15orf27    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
    SP1:              -     -                                               -                     
    SP2:                                                                                          
    SP3:                                                                                          


    ECgene alternative splicing isoforms for C15orf27

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C15orf27 expression in normal human tissues (normalized intensities)      C15orf27 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGCGTTTCTG
    C15orf27 Expression
    About this image


    C15orf27 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Brain (Nervous System)
             cerebellum   

    See C15orf27 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C15orf27

    SOURCE GeneReport for Unigene cluster: Hs.661411
        SABiosciences Custom PCR Arrays for C15orf27
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C15orf27

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C15orf27 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia AI1180781 , 5 expressed sequence AI1180781, 5 88.18(n)1
    88.87(a)1
      9 (29.98 cM)5
    2448861  NM_172923.31  NP_766511.11 
     553269135 
    chicken
    (Gallus gallus)
    Aves C10H15orf271 chromosome 10 open reading frame, human C15orf27 74.55(n)
    75.76(a)
      770288  XM_001233622.2  XP_001233623.2 
    lizard
    (Anolis carolinensis)
    Reptilia C15ORF276
    Uncharacterized protein
    58(a)
    1 ↔ 1
    AAWZ02041122(21-4712)
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.144932 Transcribed sequences 80.95(n)    BQ077807.1 


    ENSEMBL Gene Tree for C15orf27 (if available)
    TreeFam Gene Tree for C15orf27 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C15orf27 gene
    HVCN12  

    C15orf27 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3064 SNPs in C15orf27 are shown (see all 3064)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1427459291,2
    C--76350325(+) AAATT-/TCTC  
            
    TCAGC
    1 -- us2k10--------
    rs1868524961,2
    --76350335(+) CAGCAA/GGTTTC 1 -- us2k10--------
    rs29598511,2
    C,F,A,H--76350447(+) GAGTGG/CATAAC 1 -- us2k18Minor allele frequency- C:0.08NS EA WA CSA NA 656
    rs14981981,2
    C,F,A,H--76350516(-) CAGTCA/GGTGAC 1 -- us2k1 tfbs313Minor allele frequency- G:0.20NS EA NA WA CSA 1495
    rs1168177821,2
    F--76350620(+) AGAAAT/CGTAGA 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1386177841,2
    --76350633(+) AATCCA/TTTGGC 1 -- us2k10--------
    rs1906985021,2
    --76350655(+) CTTCCA/GCAAGT 1 -- us2k10--------
    rs1825286571,2
    --76350734(+) AAGGCA/GAAGGA 1 -- us2k10--------
    rs1871784781,2
    --76350754(+) GAAATC/TTTACA 1 -- us2k10--------
    rs14981971,2
    C,F--76350773(-) TGGCAA/CACTGA 1 -- us2k14Minor allele frequency- C:0.12WA CSA NA 242

    HapMap Linkage Disequilibrium report for C15orf27 (76352178 - 76521462 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for C15orf27:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2669418CNV Deletion23128226
    esv2749895CNV Deletion23290073
    esv2660944CNV Deletion23128226
    esv2665159CNV Deletion23128226
    esv2749898CNV Deletion23290073
    esv274972CNV Loss21479260
    nsv833057CNV Loss17160897
    nsv1617CNV Loss18451855
    nsv904398CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C15orf27 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C15orf27)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2, 3 Ota T.... Sugano S. (2004)
    2. Aspartatea88112 is the selectivity filter of the human voltage-gated proton channel. (PubMed id 22020278)1, 3 Musset B....Decoursey T.E. (2011)
    3. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    6. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 123591 HGNC: 26763 AceView: C15orf27 Ensembl:ENSG00000169758 euGenes: HUgn123591
    ECgene: C15orf27 H-InvDB: C15orf27

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C15orf27 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C15orf27 gene:
    Search GeneIP for patents involving C15orf27

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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