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Aliases for C15orf27 Gene

Aliases for C15orf27 Gene

  • Chromosome 15 Open Reading Frame 27 2 3

External Ids for C15orf27 Gene

Previous GeneCards Identifiers for C15orf27 Gene

  • GC15P074069
  • GC15P074139
  • GC15P076352
  • GC15P053183

Summaries for C15orf27 Gene

GeneCards Summary for C15orf27 Gene

C15orf27 (Chromosome 15 Open Reading Frame 27) is a Protein Coding gene. An important paralog of this gene is HVCN1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf27 Gene

Genomics for C15orf27 Gene

Regulatory Elements for C15orf27 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C15orf27 Gene

76,059,837 bp from pter
76,229,121 bp from pter
169,285 bases
Plus strand

Genomic View for C15orf27 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C15orf27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf27 Gene

Proteins for C15orf27 Gene

  • Protein details for C15orf27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein C15orf27
    Protein Accession:
    Secondary Accessions:
    • Q8N993
    • Q96LL5

    Protein attributes for C15orf27 Gene

    531 amino acids
    Molecular mass:
    58444 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI04954.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04956.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB71676.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04562.1; Type=Frameshift; Positions=13, 93; Evidence={ECO:0000305};

    Alternative splice isoforms for C15orf27 Gene


neXtProt entry for C15orf27 Gene

Proteomics data for C15orf27 Gene at MOPED

Post-translational modifications for C15orf27 Gene

  • Glycosylation at Asn8, Asn363, and Asn380
  • Modification sites at PhosphoSitePlus

Other Protein References for C15orf27 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for C15orf27 Gene

Domains for C15orf27 Gene

Protein Domains for C15orf27 Gene


Suggested Antigen Peptide Sequences for C15orf27 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C15orf27: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C15orf27 Gene

Function for C15orf27 Gene

Gene Ontology (GO) - Molecular Function for C15orf27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005245 voltage-gated calcium channel activity IBA --
genes like me logo Genes that share ontologies with C15orf27: view

Animal Model Products

CRISPR Products

miRNA for C15orf27 Gene

miRTarBase miRNAs that target C15orf27

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C15orf27

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf27 Gene

Localization for C15orf27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C15orf27 Gene

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for C15orf27 Gene COMPARTMENTS Subcellular localization image for C15orf27 gene
Compartment Confidence
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for C15orf27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C15orf27: view

Pathways for C15orf27 Gene

SuperPathways for C15orf27 Gene

No Data Available

Interacting Proteins for C15orf27 Gene

Gene Ontology (GO) - Biological Process for C15orf27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070509 calcium ion import IBA --
GO:0070588 calcium ion transmembrane transport IBA --
GO:0086010 membrane depolarization during action potential IBA --
genes like me logo Genes that share ontologies with C15orf27: view

No data available for Pathways by source for C15orf27 Gene

Transcripts for C15orf27 Gene

mRNA/cDNA for C15orf27 Gene

Unigene Clusters for C15orf27 Gene

Chromosome 15 open reading frame 27:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C15orf27

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf27 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13
SP1: - - -

Relevant External Links for C15orf27 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C15orf27 Gene

mRNA expression in normal human tissues for C15orf27 Gene

mRNA differential expression in normal tissues according to GTEx for C15orf27 Gene

This gene is overexpressed in Brain - Cerebellum (14.5) and Brain - Cerebellar Hemisphere (13.6).

Protein differential expression in normal tissues for C15orf27 Gene

This gene is overexpressed in Plasma (58.3) and Bone marrow stromal cell (7.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C15orf27 Gene

SOURCE GeneReport for Unigene cluster for C15orf27 Gene Hs.661411

genes like me logo Genes that share expressions with C15orf27: view

Expression partners for C15orf27 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C15orf27 Gene

Orthologs for C15orf27 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf27 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C21H15orf27 35
  • 88.76 (n)
  • 87.9 (a)
C15orf27 36
  • 88 (a)
(Canis familiaris)
Mammalia LOC487670 35
  • 86.27 (n)
  • 84.71 (a)
C15orf27 36
  • 76 (a)
(Mus musculus)
Mammalia AI118078 35
  • 87.36 (n)
  • 88.11 (a)
AI118078 16
AI118078 36
  • 86 (a)
(Pan troglodytes)
Mammalia C15H15orf27 35
  • 99.31 (n)
  • 99.44 (a)
C15orf27 36
  • 99 (a)
(Rattus norvegicus)
Mammalia RGD1562084 35
  • 88.23 (n)
  • 88.29 (a)
(Monodelphis domestica)
Mammalia C15orf27 36
  • 74 (a)
(Ornithorhynchus anatinus)
Mammalia C15orf27 36
  • 77 (a)
(Gallus gallus)
Aves C15ORF27 35
  • 74.61 (n)
  • 76.55 (a)
C15orf27 36
  • 72 (a)
(Anolis carolinensis)
Reptilia C15orf27 36
  • 35 (a)
(Danio rerio)
Actinopterygii Dr.14493 35
zgc:158624 35
  • 68.05 (n)
  • 64.16 (a)
C25H15orf27 36
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 25 (a)
Species with no ortholog for C15orf27:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf27 Gene

Gene Tree for C15orf27 (if available)
Gene Tree for C15orf27 (if available)

Paralogs for C15orf27 Gene

Paralogs for C15orf27 Gene

genes like me logo Genes that share paralogs with C15orf27: view

Variants for C15orf27 Gene

Sequence variations from dbSNP and Humsavar for C15orf27 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs868576 -- 76,153,348(-) CCTTC(A/G)TGCCT intron-variant
rs868577 -- 76,153,018(-) AGCAC(A/G)CTCCT intron-variant
rs869452 -- 76,202,747(-) TCAGC(A/G)TTATT intron-variant
rs870294 -- 76,202,335(+) CTCGG(C/G)CTGGC intron-variant
rs2959825 -- 76,118,895(-) CTAAC(A/T)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf27 Gene

Variant ID Type Subtype PubMed ID
esv2749895 CNV Deletion 23290073
esv2749898 CNV Deletion 23290073
nsv904398 CNV Gain 21882294
nsv1617 CNV Loss 18451855
esv2669418 CNV Deletion 23128226
nsv833057 CNV Loss 17160897
esv2665159 CNV Deletion 23128226
esv2660944 CNV Deletion 23128226
esv274972 CNV Loss 21479260

Relevant External Links for C15orf27 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf27 Gene

Disorders for C15orf27 Gene

No disorders were found for C15orf27 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for C15orf27 Gene

Publications for C15orf27 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4
  2. Aspartatea88112 is the selectivity filter of the human voltage-gated proton channel. (PMID: 22020278) Musset B. … Decoursey T.E. (Nature 2011) 2 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody M.C. … Nusbaum C. (Nature 2006) 3 4
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for C15orf27 Gene

Sources for C15orf27 Gene

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