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Aliases for C14orf93 Gene

Aliases for C14orf93 Gene

  • Chromosome 14 Open Reading Frame 93 2 3 5
  • Regulator Of Thyroid Function And Cancer 2 3
  • Uncharacterized Protein C14orf93 3
  • EC 2.4.2.18 61
  • EC 2.4.2.21 61
  • RTFC 3

External Ids for C14orf93 Gene

Previous GeneCards Identifiers for C14orf93 Gene

  • GC14M017243
  • GC14M021446
  • GC14M022525
  • GC14M023456
  • GC14M003573

Summaries for C14orf93 Gene

GeneCards Summary for C14orf93 Gene

C14orf93 (Chromosome 14 Open Reading Frame 93) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf93 Gene

Genomics for C14orf93 Gene

Regulatory Elements for C14orf93 Gene

Enhancers for C14orf93 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G022976 1.9 FANTOM5 ENCODE dbSUPER 11.3 +30.3 30296 7.6 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 PRMT5 HAUS4 LOC102724814 MMP14 PSMB5 C14orf119 CDH24 C14orf93 PSMB11 PABPN1
GH14G022504 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.2 +472.0 472014 66.7 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YBX1 YY1 SLC30A9 ZNF143 MMP14 ABHD4 OXA1L EFS BCL2L2-PABPN1 DAD1 LOC105370399 TRAC C14orf119 OR6J1
GH14G023067 1.6 Ensembl ENCODE dbSUPER 11 -60.3 -60262 5.9 HDGF PKNOX1 MLX ARNT ZFP64 WRNIP1 SIN3A ARID4B DMAP1 YBX1 PSMB11 PSMB5 C14orf119 ACIN1 C14orf93 CEBPE AJUBA HAUS4 SLC7A8 RNF212B
GH14G023085 1.6 FANTOM5 ENCODE dbSUPER 10.7 -75.9 -75857 1.3 HDGF ATF1 ARID4B SIN3A ZNF2 YY1 SLC30A9 GLIS2 ZNF143 ZNF207 CDH24 C14orf93 SLC7A8 RNF212B RBM23 SLC7A7 ACIN1 C14orf119
GH14G023145 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.9 -136.4 -136351 2.8 PKNOX1 ATF1 ARNT YBX1 ZNF2 TCF12 ZNF766 ELK1 GATA2 JUNB SLC7A8 RNF212B CEBPE ACIN1 SLC22A17 C14orf93 DHRS4 RNU6-1138P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C14orf93 on UCSC Golden Path with GeneCards custom track

Promoters for C14orf93 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000066675 101 1401 MLX CREB3L1 ARNT ZFP64 SIN3A ARID4B FEZF1 DMAP1 DEK ZNF263

Genomic Location for C14orf93 Gene

Chromosome:
14
Start:
22,985,908 bp from pter
End:
23,010,201 bp from pter
Size:
24,294 bases
Orientation:
Minus strand

Genomic View for C14orf93 Gene

Genes around C14orf93 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf93 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf93 Gene

Proteins for C14orf93 Gene

  • Protein details for C14orf93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H972-CN093_HUMAN
    Recommended name:
    Uncharacterized protein C14orf93
    Protein Accession:
    Q9H972
    Secondary Accessions:
    • B7WP03
    • D3DS38
    • D3DS39
    • Q86SE6
    • Q96CF7
    • Q9HA68

    Protein attributes for C14orf93 Gene

    Size:
    538 amino acids
    Molecular mass:
    58697 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C14orf93 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C14orf93 Gene

Selected DME Specific Peptides for C14orf93 Gene

Q9H972:
  • LNAAAAL
  • LGAASVG

Post-translational modifications for C14orf93 Gene

  • Ubiquitination at posLast=7171
  • Modification sites at PhosphoSitePlus

Domains & Families for C14orf93 Gene

Protein Domains for C14orf93 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf93: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C14orf93 Gene

Function for C14orf93 Gene

Enzyme Numbers (IUBMB) for C14orf93 Gene

Gene Ontology (GO) - Molecular Function for C14orf93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 22658674
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C14orf93: view
genes like me logo Genes that share phenotypes with C14orf93: view

Animal Model Products

CRISPR Products

miRNA for C14orf93 Gene

miRTarBase miRNAs that target C14orf93

Inhibitory RNA Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf93 Gene

Localization for C14orf93 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf93 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf93 gene
Compartment Confidence
extracellular 4
nucleus 3
plasma membrane 2
cytosol 2

Gene Ontology (GO) - Cellular Components for C14orf93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C14orf93: view

Pathways & Interactions for C14orf93 Gene

SuperPathways for C14orf93 Gene

No Data Available

Interacting Proteins for C14orf93 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000299088%0d%0a9606.ENSP00000318352%0d%0a
Selected Interacting proteins: Q9H972-CN093_HUMAN ENSP00000299088 for C14orf93 Gene via IID STRING UniProtKB

Gene Ontology (GO) - Biological Process for C14orf93 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C14orf93 Gene

Drugs & Compounds for C14orf93 Gene

No Compound Related Data Available

Transcripts for C14orf93 Gene

Unigene Clusters for C14orf93 Gene

Chromosome 14 open reading frame 93:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf93 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^
SP1:
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - -
SP12: - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - -
SP16: - - - - - - - -

ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for C14orf93 Gene

GeneLoc Exon Structure for
C14orf93
ECgene alternative splicing isoforms for
C14orf93

Expression for C14orf93 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C14orf93 Gene

Protein differential expression in normal tissues from HIPED for C14orf93 Gene

This gene is overexpressed in Tlymphocyte (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C14orf93 Gene



Protein tissue co-expression partners for C14orf93 Gene

NURSA nuclear receptor signaling pathways regulating expression of C14orf93 Gene:

C14orf93

SOURCE GeneReport for Unigene cluster for C14orf93 Gene:

Hs.255874

Evidence on tissue expression from TISSUES for C14orf93 Gene

  • Nervous system(3)
genes like me logo Genes that share expression patterns with C14orf93: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf93 Gene

Orthologs for C14orf93 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C14orf93 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14orf93 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C14orf93 35
  • 92 (a)
OneToOne
C8H14orf93 34
  • 90.89 (n)
cow
(Bos Taurus)
Mammalia C10H14ORF93 35
  • 91 (a)
OneToOne
C10H14orf93 34
  • 88.97 (n)
oppossum
(Monodelphis domestica)
Mammalia C14orf93 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565222 34
  • 85.14 (n)
mouse
(Mus musculus)
Mammalia 4931414P19Rik 34 16 35
  • 84.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf93 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C14orf93 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c14orf93 34
  • 59.29 (n)
Str.14071 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3310 34
Species where no ortholog for C14orf93 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf93 Gene

ENSEMBL:
Gene Tree for C14orf93 (if available)
TreeFam:
Gene Tree for C14orf93 (if available)

Paralogs for C14orf93 Gene

No data available for Paralogs for C14orf93 Gene

Variants for C14orf93 Gene

Sequence variations from dbSNP and Humsavar for C14orf93 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000046493 -- 22,986,528(+) ACAAA(A/G)CTGTG intron-variant, downstream-variant-500B
rs1000055919 -- 22,994,387(+) AAGTC(G/T)GTAAT intron-variant, downstream-variant-500B
rs1000086226 -- 22,993,434(+) GGACC(A/G)TTATT intron-variant
rs1000131023 -- 23,011,504(+) CAACA(C/T)GAATT upstream-variant-2KB
rs1000267319 -- 23,011,999(+) TGCCG(A/G)GCCAA upstream-variant-2KB

Variation tolerance for C14orf93 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C14orf93 Gene

Human Gene Mutation Database (HGMD)
C14orf93
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C14orf93

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C14orf93 Gene

Disorders for C14orf93 Gene

Relevant External Links for C14orf93

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C14orf93

No disorders were found for C14orf93 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf93 Gene

Publications for C14orf93 Gene

  1. Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function. (PMID: 28230092) Yu Y. … Chen L. (Sci Rep 2017) 2 3 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. C14orf93 (RTFC) is identified as a novel susceptibility gene for familial nonmedullary thyroid cancer. (PMID: 27864143) Liu C. … Chen L. (Biochem. Biophys. Res. Commun. 2016) 3 64
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64

Products for C14orf93 Gene

Sources for C14orf93 Gene

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