Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C14orf93 Gene

Aliases for C14orf93 Gene

  • Chromosome 14 Open Reading Frame 93 2 3 5
  • EC 2.4.2.18 61
  • EC 2.4.2.21 61

External Ids for C14orf93 Gene

Previous GeneCards Identifiers for C14orf93 Gene

  • GC14M017243
  • GC14M021446
  • GC14M022525
  • GC14M023456
  • GC14M003573

Summaries for C14orf93 Gene

GeneCards Summary for C14orf93 Gene

C14orf93 (Chromosome 14 Open Reading Frame 93) is a Protein Coding gene. GO annotations related to this gene include poly(A) RNA binding.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf93 Gene

Genomics for C14orf93 Gene

Regulatory Elements for C14orf93 Gene

Enhancers for C14orf93 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F022976 1.4 FANTOM5 ENCODE 11.3 +30.3 30296 7.6 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 PRMT5 HAUS4 LOC102724814 PABPN1 MMP14 LOC105370399 RN7SKP205 LOC105370409 TRAV37 LINC00596
GH14F023060 0.2 ENCODE 11 -52.6 -52570 4.3 PKNOX1 KLF17 SIN3A PLRG1 ZBTB40 DNMT3B ZNF2 RFX5 GLIS2 ZNF366 EFS PSMB11 PSMB5 ACIN1 C14orf93 C14orf119 AJUBA HAUS4 MIR4707 RNF212B
GH14F023067 0.9 Ensembl ENCODE 11 -60.3 -60262 5.9 HDGF PKNOX1 ARNT MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 YBX1 PSMB11 PSMB5 C14orf119 ACIN1 C14orf93 CEBPE AJUBA HAUS4 MIR4707 SLC7A8
GH14F023085 1.1 FANTOM5 ENCODE 10.7 -75.9 -75857 1.3 HDGF ATF1 ARID4B SIN3A ZNF2 YY1 SLC30A9 GLIS2 ZNF143 ZNF207 MMP14 CDH24 C14orf93 ENSG00000258457 RNF212B SLC7A8 RBM23 SLC7A7 ACIN1 C14orf119
GH14F022955 0.4 ENCODE 10.6 +53.6 53597 2.6 HDGF PKNOX1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 HAUS4 C14orf119 AJUBA PSMB5 PSMB11 CDH24 C14orf93 LOC102724814 ACIN1 MIR4707
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C14orf93 on UCSC Golden Path with GeneCards custom track

Promoters for C14orf93 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000239773 201 1601 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF263 SP3 NFYC ZHX2

Genomic Location for C14orf93 Gene

Chromosome:
14
Start:
22,985,908 bp from pter
End:
23,010,201 bp from pter
Size:
24,294 bases
Orientation:
Minus strand

Genomic View for C14orf93 Gene

Genes around C14orf93 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf93 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf93 Gene

Proteins for C14orf93 Gene

  • Protein details for C14orf93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H972-CN093_HUMAN
    Recommended name:
    Uncharacterized protein C14orf93
    Protein Accession:
    Q9H972
    Secondary Accessions:
    • B7WP03
    • D3DS38
    • D3DS39
    • Q86SE6
    • Q96CF7
    • Q9HA68

    Protein attributes for C14orf93 Gene

    Size:
    538 amino acids
    Molecular mass:
    58697 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C14orf93 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C14orf93 Gene

Selected DME Specific Peptides for C14orf93 Gene

Q9H972:
  • LNAAAAL
  • LGAASVG

Post-translational modifications for C14orf93 Gene

  • Ubiquitination at Lys 71
  • Modification sites at PhosphoSitePlus

Domains & Families for C14orf93 Gene

Protein Domains for C14orf93 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf93: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C14orf93 Gene

Function for C14orf93 Gene

Enzyme Numbers (IUBMB) for C14orf93 Gene

Gene Ontology (GO) - Molecular Function for C14orf93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with C14orf93: view
genes like me logo Genes that share phenotypes with C14orf93: view

Animal Model Products

miRNA for C14orf93 Gene

miRTarBase miRNAs that target C14orf93

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf93 Gene

Localization for C14orf93 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf93 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C14orf93 Gene COMPARTMENTS Subcellular localization image for C14orf93 gene
Compartment Confidence
extracellular 4
nucleus 3
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for C14orf93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C14orf93: view

Pathways & Interactions for C14orf93 Gene

SuperPathways for C14orf93 Gene

No Data Available

Interacting Proteins for C14orf93 Gene

Gene Ontology (GO) - Biological Process for C14orf93 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C14orf93 Gene

Transcripts for C14orf93 Gene

Unigene Clusters for C14orf93 Gene

Chromosome 14 open reading frame 93:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf93 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^
SP1:
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - -
SP12: - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - -
SP16: - - - - - - - -

ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:

Relevant External Links for C14orf93 Gene

GeneLoc Exon Structure for
C14orf93
ECgene alternative splicing isoforms for
C14orf93

Expression for C14orf93 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C14orf93 Gene

Protein differential expression in normal tissues from HIPED for C14orf93 Gene

This gene is overexpressed in Tlymphocyte (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C14orf93 Gene



Protein tissue co-expression partners for C14orf93 Gene

NURSA nuclear receptor signaling pathways regulating expression of C14orf93 Gene:

C14orf93

SOURCE GeneReport for Unigene cluster for C14orf93 Gene:

Hs.255874
genes like me logo Genes that share expression patterns with C14orf93: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C14orf93 Gene

Orthologs for C14orf93 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C14orf93 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14orf93 35
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C14orf93 35
  • 92 (a)
OneToOne
C8H14orf93 34
  • 90.89 (n)
cow
(Bos Taurus)
Mammalia C10H14ORF93 35
  • 91 (a)
OneToOne
C10H14orf93 34
  • 88.97 (n)
oppossum
(Monodelphis domestica)
Mammalia C14orf93 35
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1565222 34
  • 85.14 (n)
mouse
(Mus musculus)
Mammalia 4931414P19Rik 34 16 35
  • 84.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf93 35
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C14orf93 35
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c14orf93 34
  • 59.29 (n)
Str.14071 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.3310 34
Species where no ortholog for C14orf93 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf93 Gene

ENSEMBL:
Gene Tree for C14orf93 (if available)
TreeFam:
Gene Tree for C14orf93 (if available)

Paralogs for C14orf93 Gene

No data available for Paralogs for C14orf93 Gene

Variants for C14orf93 Gene

Sequence variations from dbSNP and Humsavar for C14orf93 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10132820 -- 23,012,199(+) ttttt(A/T)ttttt upstream-variant-2KB
rs10143838 -- 22,999,481(+) AATGG(G/T)ACTGC intron-variant, utr-variant-5-prime
rs10144467 -- 23,002,606(+) gtaag(G/T)cacct intron-variant, upstream-variant-2KB
rs10147573 -- 22,987,824(+) TCTCA(G/T)ATGCC intron-variant
rs1043675 -- 22,987,106(-) AAAGC(A/G)AATTT intron-variant, utr-variant-3-prime

Variation tolerance for C14orf93 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.89% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C14orf93 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C14orf93

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C14orf93 Gene

Disorders for C14orf93 Gene

Relevant External Links for C14orf93

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C14orf93

No disorders were found for C14orf93 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf93 Gene

Publications for C14orf93 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. C14orf93 (RTFC) is identified as a novel susceptibility gene for familial nonmedullary thyroid cancer. (PMID: 27864143) Liu C. … Chen L. (Biochem. Biophys. Res. Commun. 2016) 3 64
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  5. The variant Polycomb Repressor Complex 1 component PCGF1 interacts with a pluripotency sub-network that includes DPPA4, a regulator of embryogenesis. (PMID: 26687479) Oliviero G. … Cagney G. (Sci. Rep. 2015) 3 64

Products for C14orf93 Gene

Sources for C14orf93 Gene

Content
Loading form....