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Aliases for C14orf80 Gene

Aliases for C14orf80 Gene

  • Chromosome 14 Open Reading Frame 80 2 3 5

External Ids for C14orf80 Gene

Previous GeneCards Identifiers for C14orf80 Gene

  • GC14P099948
  • GC14P103927
  • GC14P103928
  • GC14P105027
  • GC14P105953
  • GC14P086154
  • GC14P105956

Summaries for C14orf80 Gene

GeneCards Summary for C14orf80 Gene

C14orf80 (Chromosome 14 Open Reading Frame 80) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf80 Gene

Genomics for C14orf80 Gene

Regulatory Elements for C14orf80 Gene

Enhancers for C14orf80 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C14orf80 on UCSC Golden Path with GeneCards custom track

Promoters for C14orf80 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C14orf80 on UCSC Golden Path with GeneCards custom track

Genomic Location for C14orf80 Gene

Chromosome:
14
Start:
105,489,855 bp from pter
End:
105,499,575 bp from pter
Size:
9,721 bases
Orientation:
Plus strand

Genomic View for C14orf80 Gene

Genes around C14orf80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf80 Gene

Proteins for C14orf80 Gene

  • Protein details for C14orf80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SX3-CN080_HUMAN
    Recommended name:
    Uncharacterized protein C14orf80
    Protein Accession:
    Q86SX3
    Secondary Accessions:
    • B5MDG3
    • E9PAQ4
    • Q86TT3
    • Q86TT4
    • Q86TT5
    • Q96B41
    • Q9H7H4

    Protein attributes for C14orf80 Gene

    Size:
    495 amino acids
    Molecular mass:
    54231 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD62351.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62363.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62611.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for C14orf80 Gene

neXtProt entry for C14orf80 Gene

Proteomics data for C14orf80 Gene at MOPED

Post-translational modifications for C14orf80 Gene

  • Ubiquitination at Lys 43, Lys 83, Lys 195, and Lys 409
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C14orf80 Gene

Domains & Families for C14orf80 Gene

Protein Domains for C14orf80 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf80: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C14orf80 Gene

Function for C14orf80 Gene

Phenotypes for C14orf80 Gene

GenomeRNAi human phenotypes for C14orf80:
genes like me logo Genes that share phenotypes with C14orf80: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf80 Gene

Localization for C14orf80 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C14orf80 Gene COMPARTMENTS Subcellular localization image for C14orf80 gene
Compartment Confidence
cytosol 3
golgi apparatus 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C14orf80 Gene

Pathways & Interactions for C14orf80 Gene

SuperPathways for C14orf80 Gene

No Data Available

Interacting Proteins for C14orf80 Gene

Gene Ontology (GO) - Biological Process for C14orf80 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C14orf80 Gene

Drugs & Compounds for C14orf80 Gene

No Compound Related Data Available

Transcripts for C14orf80 Gene

Unigene Clusters for C14orf80 Gene

Chromosome 14 open reading frame 80:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf80 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: -
SP8: - -
SP9: - - - - - - - - - -
SP10: - -
SP11: - - - - -
SP12: -
SP13: - - - - - - - - -
SP14: - -
SP15: - - - - - - -
SP16:
SP17:

ExUns: 12a · 12b · 12c · 12d ^ 13a · 13b · 13c ^ 14a · 14b
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: -
SP7: -
SP8: - -
SP9:
SP10: -
SP11: -
SP12: - -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for C14orf80 Gene

GeneLoc Exon Structure for
C14orf80
ECgene alternative splicing isoforms for
C14orf80

Expression for C14orf80 Gene

mRNA expression in normal human tissues for C14orf80 Gene

Protein differential expression in normal tissues from HIPED for C14orf80 Gene

This gene is overexpressed in Adipocyte (31.0), Lung (28.3), and Testis (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C14orf80 Gene



SOURCE GeneReport for Unigene cluster for C14orf80 Gene Hs.720306

genes like me logo Genes that share expression patterns with C14orf80: view

Protein tissue co-expression partners for C14orf80 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C14orf80 Gene

Orthologs for C14orf80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C14orf80 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia C8H14orf80 35
  • 77.89 (n)
  • 69.55 (a)
C14orf80 36
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930427A07Rik 35
  • 74.32 (n)
  • 69.38 (a)
4930427A07Rik 16
4930427A07Rik 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC453219 35
  • 99.37 (n)
  • 99.53 (a)
C14orf80 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC690422 35
  • 73.35 (n)
  • 67.3 (a)
cow
(Bos Taurus)
Mammalia C14orf80 36
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C14orf80 36
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves C14ORF80 35
  • 55.61 (n)
  • 46.02 (a)
C14orf80 36
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C14orf80 36
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485326 35
  • 46.23 (n)
  • 38.44 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC570574 35
  • 46.93 (n)
  • 36.58 (a)
C17H14orf80 36
  • 25 (a)
OneToOne
Species with no ortholog for C14orf80:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C14orf80 Gene

ENSEMBL:
Gene Tree for C14orf80 (if available)
TreeFam:
Gene Tree for C14orf80 (if available)

Paralogs for C14orf80 Gene

No data available for Paralogs for C14orf80 Gene

Variants for C14orf80 Gene

Sequence variations from dbSNP and Humsavar for C14orf80 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7492357 -- 105,496,322(+) GCCCC(A/G)GCACC intron-variant
rs7494205 -- 105,495,720(+) CAGAG(C/G)AGAGG intron-variant
rs7494247 -- 105,490,171(+) ggggg(C/G)cccga intron-variant, upstream-variant-2KB
rs7494350 -- 105,495,897(+) GGAGC(C/T)GCCCA intron-variant
rs7494717 -- 105,496,032(+) GCAGC(A/G)CCCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf80 Gene

Variant ID Type Subtype PubMed ID
dgv2020n71 CNV Loss 21882294
nsv902424 CNV Loss 21882294
nsv470679 CNV Loss 18288195
dgv2024n71 CNV Loss 21882294
dgv2025n71 CNV Loss 21882294
nsv517055 CNV Gain+Loss 19592680
dgv2032n71 CNV Loss 21882294
dgv2033n71 CNV Loss 21882294
dgv2034n71 CNV Loss 21882294
dgv2035n71 CNV Loss 21882294
nsv902480 CNV Loss 21882294
nsv902481 CNV Loss 21882294
dgv2036n71 CNV Loss 21882294
dgv2037n71 CNV Loss 21882294
nsv902490 CNV Loss 21882294
nsv827088 CNV Gain 20364138

Variation tolerance for C14orf80 Gene

Gene Damage Index Score: 5.46; 71.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C14orf80 Gene

HapMap Linkage Disequilibrium report
C14orf80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf80 Gene

Disorders for C14orf80 Gene

Relevant External Links for C14orf80

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C14orf80

No disorders were found for C14orf80 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf80 Gene

Publications for C14orf80 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3

Products for C14orf80 Gene

Sources for C14orf80 Gene

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