Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C14orf80 Gene

Aliases for C14orf80 Gene

  • Chromosome 14 Open Reading Frame 80 2 3 5

External Ids for C14orf80 Gene

Previous GeneCards Identifiers for C14orf80 Gene

  • GC14P099948
  • GC14P103927
  • GC14P103928
  • GC14P105027
  • GC14P105953
  • GC14P086154
  • GC14P105956

Summaries for C14orf80 Gene

GeneCards Summary for C14orf80 Gene

C14orf80 (Chromosome 14 Open Reading Frame 80) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf80 Gene

Genomics for C14orf80 Gene

Regulatory Elements for C14orf80 Gene

Enhancers for C14orf80 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F105290 1.4 FANTOM5 Ensembl ENCODE 11 -197.0 -196955 5.0 HDGF CTCF MXI1 SIN3A MAX BMI1 EBF1 ZIC2 RAD21 ZFHX2 BRF1 BTBD6 C14orf80 GPR132 PACS2 GC14P105252
GH14F105058 1.4 FANTOM5 ENCODE 1.8 -426.7 -426670 10.0 HDGF PKNOX1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZNF143 ZNF207 ZNF548 GPR132 AHNAK2 CDCA4 JAG2 NUDT14 ENSG00000257270 C14orf79 C14orf80 PLD4 BRF1
GH14F105497 0.8 Ensembl ENCODE 0.4 +9.6 9551 3.9 ELF3 MLX ZFP64 ARID4B ZNF48 RARA GLIS2 CREM MIXL1 EGR2 TMEM121 IGHV3-15 C14orf80
GH14F105511 0.6 ENCODE 0.3 +21.9 21894 0.2 PKNOX1 ZNF76 KLF17 KLF7 EGR2 YY2 ZEB2 TSHZ1 ZNF843 SP1 ENSG00000257270 TMEM121 C14orf80
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C14orf80 on UCSC Golden Path with GeneCards custom track

Promoters for C14orf80 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000424710 945 2401 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143

Genomic Location for C14orf80 Gene

Chromosome:
14
Start:
105,489,855 bp from pter
End:
105,499,575 bp from pter
Size:
9,721 bases
Orientation:
Plus strand

Genomic View for C14orf80 Gene

Genes around C14orf80 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf80 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf80 Gene

Proteins for C14orf80 Gene

  • Protein details for C14orf80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86SX3-CN080_HUMAN
    Recommended name:
    Uncharacterized protein C14orf80
    Protein Accession:
    Q86SX3
    Secondary Accessions:
    • B5MDG3
    • E9PAQ4
    • Q86TT3
    • Q86TT4
    • Q86TT5
    • Q96B41
    • Q9H7H4

    Protein attributes for C14orf80 Gene

    Size:
    495 amino acids
    Molecular mass:
    54231 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD62351.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62363.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD62611.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for C14orf80 Gene

neXtProt entry for C14orf80 Gene

Post-translational modifications for C14orf80 Gene

  • Ubiquitination at Lys 43, Lys 83, Lys 195, and Lys 409
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C14orf80 Gene

Domains & Families for C14orf80 Gene

Protein Domains for C14orf80 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf80: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C14orf80 Gene

Function for C14orf80 Gene

Phenotypes for C14orf80 Gene

GenomeRNAi human phenotypes for C14orf80:
genes like me logo Genes that share phenotypes with C14orf80: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf80 Gene

Localization for C14orf80 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C14orf80 Gene COMPARTMENTS Subcellular localization image for C14orf80 gene
Compartment Confidence
cytosol 3
golgi apparatus 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C14orf80 Gene

Pathways & Interactions for C14orf80 Gene

SuperPathways for C14orf80 Gene

No Data Available

Interacting Proteins for C14orf80 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000376307%0d%0a9606.ENSP00000447803%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000234170%0d%0a9606.ENSP00000338160%0d%0a
Selected Interacting proteins: ENSP00000376307 Q86SX3-CN080_HUMAN for C14orf80 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C14orf80 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C14orf80 Gene

Transcripts for C14orf80 Gene

Unigene Clusters for C14orf80 Gene

Chromosome 14 open reading frame 80:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf80 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: -
SP4: - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - - - - - - - - -
SP7: -
SP8: - -
SP9: - - - - - - - - - -
SP10: - -
SP11: - - - - -
SP12: -
SP13: - - - - - - - - -
SP14: - -
SP15: - - - - - - -
SP16:
SP17:

ExUns: 12a · 12b · 12c · 12d ^ 13a · 13b · 13c ^ 14a · 14b
SP1: - -
SP2: - -
SP3: - -
SP4: - -
SP5: -
SP6: -
SP7: -
SP8: - -
SP9:
SP10: -
SP11: -
SP12: - -
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for C14orf80 Gene

GeneLoc Exon Structure for
C14orf80
ECgene alternative splicing isoforms for
C14orf80

Expression for C14orf80 Gene

mRNA expression in normal human tissues for C14orf80 Gene

Protein differential expression in normal tissues from HIPED for C14orf80 Gene

This gene is overexpressed in Adipocyte (31.0), Lung (28.3), and Testis (9.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C14orf80 Gene



Protein tissue co-expression partners for C14orf80 Gene

NURSA nuclear receptor signaling pathways regulating expression of C14orf80 Gene:

C14orf80

SOURCE GeneReport for Unigene cluster for C14orf80 Gene:

Hs.720306
genes like me logo Genes that share expression patterns with C14orf80: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C14orf80 Gene

Orthologs for C14orf80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C14orf80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14orf80 35
  • 100 (a)
OneToOne
LOC453219 34
  • 99.37 (n)
dog
(Canis familiaris)
Mammalia C8H14orf80 34
  • 77.89 (n)
C14orf80 35
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930427A07Rik 34 16 35
  • 74.32 (n)
rat
(Rattus norvegicus)
Mammalia LOC690422 34
  • 73.35 (n)
cow
(Bos Taurus)
Mammalia C14orf80 35
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C14orf80 35
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves C14ORF80 34
  • 55.61 (n)
C14orf80 35
  • 40 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C14orf80 35
  • 35 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485326 34
  • 46.23 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC570574 34
  • 46.93 (n)
C17H14orf80 35
  • 25 (a)
OneToOne
Species where no ortholog for C14orf80 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C14orf80 Gene

ENSEMBL:
Gene Tree for C14orf80 (if available)
TreeFam:
Gene Tree for C14orf80 (if available)

Paralogs for C14orf80 Gene

No data available for Paralogs for C14orf80 Gene

Variants for C14orf80 Gene

Sequence variations from dbSNP and Humsavar for C14orf80 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10135326 -- 105,489,331(+) TGTGC(A/G)TCCTC upstream-variant-2KB
rs10143851 -- 105,487,998(+) GATGT(C/T)CCCCT intron-variant, upstream-variant-2KB
rs111318600 -- 105,494,020(+) TGGGG(A/G)CGGGG intron-variant
rs111367300 -- 105,495,517(+) CCTGA(C/T)GCCTG intron-variant
rs111624243 -- 105,488,119(+) GTAGG(C/T)GCCGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C14orf80 Gene

Variant ID Type Subtype PubMed ID
dgv3987n54 CNV loss 21841781
dgv3998n54 CNV loss 21841781
nsv1054190 CNV gain 25217958
nsv470679 CNV loss 18288195
nsv517055 CNV gain+loss 19592680
nsv566206 CNV loss 21841781
nsv827088 CNV gain 20364138
nsv952282 CNV deletion 24416366

Variation tolerance for C14orf80 Gene

Gene Damage Index Score: 5.46; 71.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C14orf80 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C14orf80

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf80 Gene

Disorders for C14orf80 Gene

Relevant External Links for C14orf80

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C14orf80

No disorders were found for C14orf80 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf80 Gene

Publications for C14orf80 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
  4. A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning. (PMID: 26673895) KA+rlA+ K. … GAPrlich D. (Elife 2015) 3 64
  5. A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways. (PMID: 25036637) Taipale M. … Lindquist S. (Cell 2014) 3 64

Products for C14orf80 Gene

Sources for C14orf80 Gene

Content
Loading form....