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C14orf64 Gene

protein-coding   GIFtS: 24
GCID: GC14M098391

Chromosome 14 Open Reading Frame 64

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 14 Open Reading Frame 641 2

External Ids:    HGNC: 201111   Entrez Gene: 3880112   Ensembl: ENSG000002462237   UniProtKB: H0YJ134   UniProtKB: H0YJ234   
UniProtKB: H0YJ284   UniProtKB: H0YJB04   UniProtKB: H0YJM94   UniProtKB: H0YJQ24   

Export aliases for C14orf64 gene to outside databases

Previous GC identifers: GC14U900157 GC14M078575


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C14orf64 Gene:
C14orf64 (chromosome 14 open reading frame 64) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the C14orf64 gene promoter:
         STAT1   STAT1beta   STAT1alpha   E47   HNF-1A   STAT2   HNF-1   STAT3   Sox9   Hand1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C14orf64

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C14orf64


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

C14orf64 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf64 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M098391:  view genomic region     (about GC identifiers)

Start:
98,391,947 bp from pter      End:
98,444,461 bp from pter
Size:
52,515 bases      Orientation:
minus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for C14orf64

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/TrEMBL: H0YJ13 (See protein sequence)
Recommended Name: Protein C14orf64  
Size: 89 amino acids; 9709 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H0YJ23 (See protein sequence)

Recommended Name: Protein C14orf64  
Size: 137 amino acids; 14984 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H0YJ28 (See protein sequence)

Recommended Name: Protein C14orf64  
Size: 132 amino acids; 14433 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H0YJB0 (See protein sequence)

Recommended Name: Protein C14orf64  
Size: 111 amino acids; 12343 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H0YJM9 (See protein sequence)

Recommended Name: Protein C14orf64  
Size: 133 amino acids; 14570 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data

UniProtKB/TrEMBL: H0YJQ2 (See protein sequence)

Recommended Name: Protein C14orf64  
Size: 118 amino acids; 13190 Da
Caution: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered
as preliminary data


ENSEMBL proteins: 
 ENSP00000450685   ENSP00000450631   ENSP00000451817   ENSP00000450702   ENSP00000451120  
 ENSP00000451954  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: H0YJ13


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C14orf64
Interactions:

    Search GeneGlobe Interaction Network for C14orf64

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
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Browse Tocris compounds for C14orf64



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Unigene Cluster for C14orf64:

Chromosome 14 open reading frame 64
Hs.651477  [show with all ESTs]
Unigene Representative Sequence: AK091668
6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000499006(uc001yfw.2) ENST00000556462(uc001yfx.2) ENST00000502187(uc001yfy.2 uc010avq.2)
ENST00000512901 ENST00000554822 ENST00000556138
miRNA
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Additional mRNA sequence: 

AK091668.1 AK097943.1 BC043585.1 BX647564.1 JX073283.1 NR_015430.1 

6 DOTS entries:

DT.101978367  DT.75100840  DT.100021056  DT.75165145  DT.427747  DT.91751809 

23 AceView cDNA sequences:

AA418739 AA356385 AK097943 AI424963 BI772351 BX109572 AA486654 AK091668 
BI834723 AW137548 BC043585 AA418794 BX647564 AI246285 BV205945 AA486557 
AI140993 AW054808 AV707761 AI275518 AW243292 CD686762 AI766277 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C14orf64 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
C14orf64 Expression
About this image

C14orf64 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.651477
    Custom PCR Arrays for C14orf64
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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ENSEMBL Gene Tree for C14orf64 (if available)
TreeFam Gene Tree for C14orf64 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C14orf64 (see all 1255)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs96461771,2
C,F,H--79382887(+) GATGAT/ACAAAC 1 -- int110Minor allele frequency- A:0.33NS EA NA WA 774
rs1385115901,2
--79382951(+) ATACCA/GTTATT 1 -- int10--------
rs96461391,2
C,F,H--79383019(+) CTGCCG/AGAAGC 1 -- int115Minor allele frequency- A:0.33NS EA NA WA 1204
rs1415425771,2
--79383040(+) CATGAC/TGAAAT 1 -- int10--------
rs1461993511,2
--79383042(+) TGATGA/TAATGT 1 -- int10--------
rs1379678431,2
--79383164(+) CCTCAC/GCATCT 1 -- int10--------
rs26049781,2
C,F,A,H--79383345(-) AAAAAG/TGTGGC 1 -- nc-transcript-variant12Minor allele frequency- T:0.47NA WA CSA EA 510
rs1493995481,2
--79383350(+) CTTTTC/TTGTTT 1 -- nc-transcript-variant0--------
rs801414611,2
--79383369(+) TTTTTG/TAGACT 1 -- nc-transcript-variant1Minor allele frequency- T:0.50NA 2
rs1122462921,2
F--79383409(+) ATCTCA/C/GGCTCA 2 -- nc-transcript-variant1CSA 2

HapMap Linkage Disequilibrium report for C14orf64 (98391947 - 98444461 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for C14orf64:    About this table    
Variant IDTypeSubtypePubMed ID
esv2669181CNV Deletion23128226
nsv832868CNV Gain+Loss17160897

Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing C14orf64
DNA2.0 Custom Variant and Variant Library Synthesis for C14orf64

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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Find genes that share disorders with C14orf64           About GenesLikeMe

Genetic Association Database (GAD): C14orf64

Export disorders for C14orf64 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C14orf64 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C14orf64)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis. (PubMed id 23612905)1 Zhao S.X....Song H.D. (Hum. Mol. Genet. 2013)
  2. Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression. (PubMed id 22445761)4 Kurose K....Saito Y. (Psychiatry Res 2012)
  3. Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium. (PubMed id 22068335)4 Mitchell G.F....Witteman J.C. (Circ Cardiovasc Genet 2012)
  4. Genomewide association study of movement-related adverse antipsychotic effects. (PubMed id 19875103)4 Aberg K....van den Oord E.J. (Biol. Psychiatry 2010)
  5. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PubMed id 19430480)4 Barrett J.C....Rich S.S. (Nat. Genet. 2009)
  6. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. (PubMed id 17903299)4 Kathiresan S....Cupples L.A. (BMC Med. Genet. 2007)
  7. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
  8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 388011 HGNC: 20111 AceView: LOC388011 Ensembl:ENSG00000246223 euGenes: HUgn388011
ECgene: C14orf64 H-InvDB: C14orf64

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C14orf64 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C14orf64 gene:
Search GeneIP for patents involving C14orf64

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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