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Aliases for C14orf39 Gene

Aliases for C14orf39 Gene

  • Chromosome 14 Open Reading Frame 39 2 3
  • Six6 Opposite Strand Transcript 1 3 4
  • Six6os1 3 4
  • Protein SIX6OS1 3

External Ids for C14orf39 Gene

Previous GeneCards Identifiers for C14orf39 Gene

  • GC14M054696
  • GC14M058853
  • GC14M058892
  • GC14M059972
  • GC14M060863
  • GC14M041066

Summaries for C14orf39 Gene

GeneCards Summary for C14orf39 Gene

C14orf39 (Chromosome 14 Open Reading Frame 39) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C14orf39 Gene

  • May be involved in eye development through regulation of the SIX6 transcription factor

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf39 Gene

Genomics for C14orf39 Gene

Regulatory Elements for C14orf39 Gene

Genomic Location for C14orf39 Gene

Start:
60,396,469 bp from pter
End:
60,515,543 bp from pter
Size:
119,075 bases
Orientation:
Minus strand

Genomic View for C14orf39 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C14orf39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf39 Gene

Proteins for C14orf39 Gene

  • Protein details for C14orf39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1H7-S6OS1_HUMAN
    Recommended name:
    Protein SIX6OS1
    Protein Accession:
    Q8N1H7
    Secondary Accessions:
    • Q08AQ4

    Protein attributes for C14orf39 Gene

    Size:
    587 amino acids
    Molecular mass:
    68166 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C14orf39 Gene

Proteomics data for C14orf39 Gene at MOPED

Post-translational modifications for C14orf39 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C14orf39 Gene

No data available for DME Specific Peptides for C14orf39 Gene

Domains for C14orf39 Gene

Protein Domains for C14orf39 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C14orf39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf39: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C14orf39 Gene

Function for C14orf39 Gene

Molecular function for C14orf39 Gene

UniProtKB/Swiss-Prot Function: May be involved in eye development through regulation of the SIX6 transcription factor

Gene Ontology (GO) - Molecular Function for C14orf39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C14orf39: view

Phenotypes for C14orf39 Gene

GenomeRNAi human phenotypes for C14orf39:
genes like me logo Genes that share phenotypes with C14orf39: view

miRNA for C14orf39 Gene

miRTarBase miRNAs that target C14orf39

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C14orf39 Gene

Localization for C14orf39 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C14orf39 Gene COMPARTMENTS Subcellular localization image for C14orf39 gene
Compartment Confidence
cytoskeleton 1
cytosol 1
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for C14orf39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with C14orf39: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C14orf39 Gene

Pathways for C14orf39 Gene

SuperPathways for C14orf39 Gene

No Data Available

Interacting Proteins for C14orf39 Gene

Gene Ontology (GO) - Biological Process for C14orf39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0051090 regulation of sequence-specific DNA binding transcription factor activity NAS 15703187
genes like me logo Genes that share ontologies with C14orf39: view

No data available for Pathways by source for C14orf39 Gene

Transcripts for C14orf39 Gene

mRNA/cDNA for C14orf39 Gene

(17) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C14orf39 Gene

Chromosome 14 open reading frame 39:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf39 Gene

No ASD Table

Relevant External Links for C14orf39 Gene

GeneLoc Exon Structure for
C14orf39
ECgene alternative splicing isoforms for
C14orf39

Expression for C14orf39 Gene

mRNA expression in normal human tissues for C14orf39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C14orf39 Gene

This gene is overexpressed in Pituitary (9.8), Testis (8.5), and Muscle - Skeletal (4.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for C14orf39 Gene

SOURCE GeneReport for Unigene cluster for C14orf39 Gene Hs.335754

mRNA Expression by UniProt/SwissProt for C14orf39 Gene

Q8N1H7-S6OS1_HUMAN
Tissue specificity: Highest expression in retina, skeletal muscle and colon.
genes like me logo Genes that share expressions with C14orf39: view

Orthologs for C14orf39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C14orf39 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf39 35
  • 99.38 (n)
  • 98.98 (a)
C14orf39 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C10H14orf39 35
  • 87.04 (n)
  • 77.4 (a)
C14orf39 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C14orf39 36
  • 79 (a)
OneToOne
C8H14orf39 35
  • 87.74 (n)
  • 78.87 (a)
mouse
(Mus musculus)
Mammalia 4930447C04Rik 35
  • 82.35 (n)
  • 70.21 (a)
4930447C04Rik 16
4930447C04Rik 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C14orf39 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf39 36
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Six6os1 35
  • 81.31 (n)
  • 69.97 (a)
chicken
(Gallus gallus)
Aves C14orf39 36
  • 41 (a)
OneToOne
LOC101748050 35
  • 63.14 (n)
  • 44.93 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486324 35
  • 53.53 (n)
  • 32.12 (a)
Species with no ortholog for C14orf39:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf39 Gene

ENSEMBL:
Gene Tree for C14orf39 (if available)
TreeFam:
Gene Tree for C14orf39 (if available)

Paralogs for C14orf39 Gene

Selected SIMAP similar genes for C14orf39 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with C14orf39: view

No data available for Paralogs for C14orf39 Gene

Variants for C14orf39 Gene

Sequence variations from dbSNP and Humsavar for C14orf39 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs958504 -- 60,483,022(+) TATTT(A/G)CACCA intron-variant
rs970042 -- 60,454,276(+) AATAT(A/T)ACTCA intron-variant
rs1024222 -- 60,459,240(+) gatgt(A/G)aagta intron-variant
rs1024223 -- 60,459,401(+) aggat(C/T)ggaac intron-variant
rs1024224 -- 60,460,224(+) CAGCA(C/G)GTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf39 Gene

Variant ID Type Subtype PubMed ID
dgv1942n71 CNV Loss 21882294
nsv901999 CNV Gain 21882294
nsv902000 CNV Loss 21882294
nsv1294 CNV Loss 18451855

Relevant External Links for C14orf39 Gene

HapMap Linkage Disequilibrium report
C14orf39
Human Gene Mutation Database (HGMD)
C14orf39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf39 Gene

Disorders for C14orf39 Gene

Relevant External Links for C14orf39

Genetic Association Database (GAD)
C14orf39
genes like me logo Genes that share disorders with C14orf39: view

No data available for UniProtKB/Swiss-Prot for C14orf39 Gene

Publications for C14orf39 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Natural antisense transcripts associated with genes involved in eye development. (PMID: 15703187) Alfano G. … Banfi S. (Hum. Mol. Genet. 2005) 3 4
  3. Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. (PMID: 23396134) Verhoeven V.J. … Hammond C.J. (Nat. Genet. 2013) 3
  4. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PMID: 23563607) Berndt S.I. … Ingelsson E. (Nat. Genet. 2013) 3
  5. Genome-wide association of echocardiographic dimensions, brachial artery endothelial function and treadmill exercise responses in the Framingham Heart Study. (PMID: 17903301) Vasan R.S. … Benjamin E.J. (BMC Med. Genet. 2007) 48

Products for C14orf39 Gene

Sources for C14orf39 Gene

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