Aliases for C14orf37 Gene
Aliases for C14orf37 Gene
External Ids for C14orf37 Gene
- HGNC: 19846
- Entrez Gene: 145407
- Ensembl: ENSG00000139971
- UniProtKB: Q86TY3
Previous GeneCards Identifiers for C14orf37 Gene
- GC14M052267
- GC14M056460
- GC14U900322
- GC14M057540
- GC14M058470
- GC14M038636
Summaries for C14orf37 Gene
GeneCards Summary for C14orf37 Gene
C14orf37 (Chromosome 14 Open Reading Frame 37) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf37 Gene
Genomics for C14orf37 Gene
Regulatory Elements for C14orf37 Gene
Enhancers for C14orf37 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH14G058242 | 1.4 | ENCODE dbSUPER | 12.6 | +53.5 | 53541 | 3.6 | HDGF PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B | RNU6-341P C14orf37 ARID4A ENSG00000259969 PSMA3-AS1 ENSG00000258682 TRK-CTT1-1 PSMA3 |
| GH14G058081 | 1 | Ensembl ENCODE | 10.6 | +215.8 | 215762 | 1.9 | JUN BACH1 FOSL1 ZNF316 ZNF600 FOS NFE2 MAFK NFE2L2 MAFG | C14orf37 LOC100420347 GC14M058040 |
| GH14G058076 | 1 | FANTOM5 Ensembl ENCODE | 10.5 | +219.8 | 219835 | 2.6 | ZNF146 JUND | C14orf37 LOC100420347 GC14M058040 |
| GH14G058238 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 5.4 | +58.6 | 58630 | 3.0 | PKNOX1 FOXA2 ARID4B E2F7 SIN3A BRCA1 YY1 ZNF121 GTF3C2 ZNF766 | PSMA3-AS1 ENSG00000258682 HMGB1P14 C14orf37 ARID4A TRK-CTT1-1 ACTR10 |
| GH14G058151 | 0.9 | ENCODE | 10.5 | +146.1 | 146060 | 1.7 | FUS SIN3A GLIS2 EGR1 EGR2 ZNF263 SP3 MTA1 ZNF341 GLIS1 | C14orf37 GC14P058142 RN7SL598P |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C14orf37 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the C14orf37 gene promoter:
Regulatory Element Products
Genomic Location for C14orf37 Gene
- Chromosome:
- 14
- Start:
- 57,993,531 bp from pter
- End:
- 58,298,139 bp from pter
- Size:
- 304,609 bases
- Orientation:
- Minus strand
Genomic View for C14orf37 Gene
Genes around C14orf37 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q23.1 by Ensembl
- 14q23.1 by Entrez Gene
- 14q23.1 by HGNC
C14orf37 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C14orf37 Gene
Proteins for C14orf37 Gene
-
Protein details for C14orf37 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86TY3-CN037_HUMAN
- Recommended name:
- Uncharacterized protein C14orf37
- Protein Accession:
- Q86TY3
- A8K8Z8
- Q6P5Q1
- Q86TY1
Protein attributes for C14orf37 Gene
- Size:
- 774 amino acids
- Molecular mass:
- 84173 Da
- Quaternary structure:
- No Data Available
Protein Expression for C14orf37 Gene
Post-translational modifications for C14orf37 Gene
Other Protein References for C14orf37 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for C14orf37
- Novus Biologicals Antibodies for C14orf37
-
Abcam antibodies for C14orf37
- Invitrogen Antibodies for C14orf37
- GeneTex C14orf37 antibody for C14orf37
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for C14orf37
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- Novus Biologicals proteins for C14orf37
- Search GeneTex for Proteins for C14orf37
Assay Products
No data available for DME Specific Peptides for C14orf37 Gene
Domains & Families for C14orf37 Gene
Suggested Antigen Peptide Sequences for C14orf37 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for C14orf37 Gene
Function for C14orf37 Gene
Phenotypes for C14orf37 Gene
- GenomeRNAi human phenotypes for C14orf37:
Animal Model Products
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- Cyagen custom Knockout/knockin (KOKI) mouse models for C14orf37
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C14orf37 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf37 gene
- Search ViGene Biosciences for C14orf37
CRISPR Products
-
OriGene CRISPR knockouts for C14orf37
-
Santa Cruz Biotechnology (SCBT) CRISPR for C14orf37
- GenScript: Design CRISPR guide RNA sequences for C14orf37
miRNA for C14orf37 Gene
- miRTarBase miRNAs that target C14orf37
-
- hsa-mir-335-5p (MIRT017759)
- hsa-mir-26a-5p (MIRT050134)
- hsa-mir-580-3p (MIRT447548)
- hsa-mir-526b-5p (MIRT447549)
- hsa-mir-4465 (MIRT447550)
- hsa-mir-26b-5p (MIRT447551)
- hsa-mir-1297 (MIRT447552)
- hsa-mir-4451 (MIRT447553)
- hsa-mir-6770-5p (MIRT447554)
- hsa-mir-1253 (MIRT447555)
- hsa-mir-5697 (MIRT447556)
- hsa-mir-196b-5p (MIRT447557)
- hsa-mir-6831-5p (MIRT447558)
- hsa-mir-196a-5p (MIRT447559)
- hsa-mir-3927-3p (MIRT447560)
- hsa-mir-676-3p (MIRT714861)
- hsa-mir-4777-3p (MIRT714862)
- hsa-mir-6834-3p (MIRT714863)
miRNA Products
- Search ViGene Biosciences for C14orf37
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C14orf37
- Browse OriGene Inhibitory RNA Products For C14orf37
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf37 gene
Clone Products
-
OriGene ORF clones in human for C14orf37
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- VectorBuilder custom plasmid, inducible vectors for C14orf37
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf37
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C14orf37
-
ViGene Biosciences adenoviral particle packaged cDNA for C14orf37 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C14orf37 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf37 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf37 Gene
Localization for C14orf37 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C14orf37 Gene
- Membrane; Single-pass type I membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 2 |
| extracellular | 2 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
Transcripts for C14orf37 Gene
mRNA/cDNA for C14orf37 Gene
- (5) REFSEQ mRNAs :
- (10) Additional mRNA sequences :
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C14orf37 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C14orf37
-
Santa Cruz Biotechnology (SCBT) CRISPR for C14orf37
- GenScript: Design CRISPR guide RNA sequences for C14orf37
miRNA Products
- Search ViGene Biosciences for C14orf37
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C14orf37
- Browse OriGene Inhibitory RNA Products For C14orf37
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf37 gene
Clone Products
-
OriGene ORF clones in human for C14orf37
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C14orf37
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf37
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||
| SP3: |
Expression for C14orf37 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
This gene is overexpressed in Serum (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C14orf37 Gene
NURSA nuclear receptor signaling pathways regulating expression of C14orf37 Gene:
C14orf37SOURCE GeneReport for Unigene cluster for C14orf37 Gene:
Hs.535420Evidence on tissue expression from TISSUES for C14orf37 Gene
- Kidney(4.3)
- Intestine(3.8)
- Stomach(3.6)
- Lung(2.7)
- Nervous system(2.5)
Primer Products
-
OriGene qPCR primer pairs for C14orf37
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf37 Gene
Orthologs for C14orf37 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C14H14orf37 34 |
|
||
| C14ORF37 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C8H14orf37 34 |
|
||
| C14orf37 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C10H14orf37 34 |
|
||
| C14orf37 35 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | 3632451O06Rik 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | RGD1310110 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | C14orf37 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | C14orf37 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C5H14ORF37 34 |
|
||
| C14orf37 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | C14orf37 35 |
|
OneToOne |
- Species where no ortholog for C14orf37 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C14orf37 Gene
No data available for Paralogs for C14orf37 Gene
Variants for C14orf37 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000004846 | -- | 58,149,035(+) | TTTTG(C/T)GTCTT | intron-variant | |
| rs1000036507 | -- | 58,080,889(+) | TTGAG(G/T)CCAGG | intron-variant | |
| rs1000043790 | -- | 58,124,448(+) | TATCT(A/G)AAGCA | intron-variant | |
| rs1000050068 | -- | 58,107,256(+) | GCAGG(A/G)AGATC | intron-variant | |
| rs1000060433 | -- | 57,997,585(+) | AATAC(C/T)TAGCA | intron-variant, nc-transcript-variant, utr-variant-3-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2319201 | CNV | deletion | 18987734 |
| esv2657771 | CNV | deletion | 23128226 |
| esv2677940 | CNV | deletion | 23128226 |
| esv3412182 | CNV | insertion | 20981092 |
| esv34185 | CNV | loss | 18971310 |
| esv3634618 | CNV | loss | 21293372 |
| esv3634619 | CNV | loss | 21293372 |
| esv3634620 | CNV | loss | 21293372 |
| nsv1038569 | CNV | gain | 25217958 |
| nsv1042675 | CNV | gain | 25217958 |
| nsv1046422 | CNV | gain | 25217958 |
| nsv507752 | OTHER | sequence alteration | 20534489 |
| nsv826959 | CNV | loss | 20364138 |
Residual Variation Intolerance Score:
89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
15.96;
97.46% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C14orf37 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C14orf37
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf37 Gene
Disorders for C14orf37 Gene
Relevant External Links for C14orf37
No disorders were found for C14orf37 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf37 Gene
Publications for C14orf37 Gene
- Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. (PMID: 26927669) Lee D. … Scadden D.T. (J. Clin. Invest. 2016) 2 3 64
- Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors. (PMID: 25418727) Lee D. … Scadden D.T. (Stem Cell Reports 2014) 2 3 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (PMID: 24925725) Chung S.A. … Langefeld C.D. (J. Am. Soc. Nephrol. 2014) 3 64
- System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 64
Products for C14orf37 Gene
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- OriGene qPCR primer pairs for C14orf37
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- Novus Biologicals Antibodies for C14orf37
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- Novus Biologicals
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- Horizon Cell Lines for C14orf37
- Cyagen custom Knockout/knockin (KOKI) mouse models for C14orf37
- VectorBuilder custom plasmid, inducible vectors for C14orf37
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf37
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C14orf37 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
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- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer