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C14orf37 Gene

protein-coding   GIFtS: 45
GCID: GC14M058470          (predicted)

Chromosome 14 Open Reading Frame 37

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 14 Open Reading Frame 371 2
c14_53762
Uncharacterized Protein C14orf372

External Ids:    HGNC: 198461   Entrez Gene: 1454072   Ensembl: ENSG000001399717   UniProtKB: Q86TY33   
ORGUL members:         

Export aliases for C14orf37 gene to outside databases

Previous GC identifers: GC14M052267 GC14M056460 GC14U900322 GC14M057540 GC14M038636


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C14orf37 Gene:
C14orf37 (chromosome 14 open reading frame 37) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C14orf37 gene promoter:
         USF1   POU2F1   POU2F1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C14orf37

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C14orf37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q23.1

C14orf37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf37 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M058470:  view genomic region     (about GC identifiers)

Start:
58,466,453 bp from pter      End:
58,764,857 bp from pter
Size:
298,405 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CN037_HUMAN, Q86TY3 (See protein sequence)
Recommended Name: Uncharacterized protein C14orf37 precursor  
Size: 774 amino acids; 84173 Da
Secondary accessions: A8K8Z8 Q6P5Q1 Q86TY1
Alternative splicing: 3 isoforms:  Q86TY3-1   Q86TY3-2   Q86TY3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C14orf37: NX_Q86TY3

Explore proteomics data for C14orf37 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn57, Ser91, Thr96, Ser135, Ser138, Asn189, Ser389
  • Modification sites at PhosphoSitePlus

  • See C14orf37 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001001872.2  
    ENSEMBL proteins: 
     ENSP00000267485  

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    antibodies-online peptides for C14orf37

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q86TY3


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for C14orf37

    miRNA
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    miRTarBase miRNAs that target C14orf37:
    hsa-mir-26a-5p (MIRT050134), hsa-mir-335-5p (MIRT017759)

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    1 qRT-PCR Assays for microRNA that regulate C14orf37:
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    SwitchGear 3'UTR luciferase reporter plasmidC14orf37 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CN037_HUMAN, Q86TY3: Membrane; Single-pass type I membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane2
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with C14orf37           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C14orf37
    Interactions:

        Search GeneGlobe Interaction Network for C14orf37

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C14orf37 (CN037)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C14orf37 gene: 
    NM_001001872.2  

    Unigene Cluster for C14orf37:

    Chromosome 14 open reading frame 37
    Hs.535420  [show with all ESTs]
    Unigene Representative Sequence: BX649130
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556788 ENST00000267485(uc001xdd.3 uc001xdc.3 uc010tro.2)
    ENST00000557175 ENST00000334342(uc001xde.3) ENST00000555101 ENST00000554218

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate C14orf37:
    hsa-miR-767-3p
    SwitchGear 3'UTR luciferase reporter plasmidC14orf37 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat C14orf37

    Additional mRNA sequence: 

    AK292513.1 AK292605.1 AK294599.1 BC013707.1 BC062772.1 BC113051.1 BC146861.1 BX161411.1 
    BX161448.1 BX649130.1 

    6 DOTS entries:

    DT.304540  DT.101969129  DT.100717379  DT.40120010  DT.100668993  DT.91751752 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for C14orf37    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                                  
    SP2:                          -                                       
    SP3:                                                                  


    ECgene alternative splicing isoforms for C14orf37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C14orf37 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACATACTG
    C14orf37 Expression
    About this image


    C14orf37 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Brain (Nervous System)    fully expand to see all 22 entries
             Thalamus
             Septum   
    C14orf37 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C14orf37 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.535420
        Custom PCR Arrays for C14orf37
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf37

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C14orf37 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 3632451O06Rik1 , 5 RIKEN cDNA 3632451O06 gene1, 5 72.38(n)1
    57.5(a)1
      14 (25.78 cM)5
    674191  NM_026142.41  NP_080418.21 
     496815605 
    chicken
    (Gallus gallus)
    Aves C5H14ORF371 chromosome 5 open reading frame, human C14orf37 54.11(n)
    43.42(a)
      423545  XM_004936467.1  XP_004936524.1 
    lizard
    (Anolis carolinensis)
    Reptilia C14orf376
    chromosome 14 open reading frame 37
    88(a)
    1 ↔ 1
    GL343325.1(474795-508304)


    ENSEMBL Gene Tree for C14orf37 (if available)
    TreeFam Gene Tree for C14orf37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C14orf37 (see all 2921)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846943931,2
    --58470316(+) TTGTAC/TAGGGC 1 -- ds50010--------
    rs27471041,2
    C,F,O,H--58470403(+) GGCTGG/ATTTCC 1 -- ds500128Minor allele frequency- A:0.30NA NS EA WA CSA 2904
    rs1900082221,2
    --58470422(+) CTGTTA/GTTCAC 1 -- ds50010--------
    rs1441168741,2
    --58470442(+) GGCCAC/TTGGGC 1 -- ds50010--------
    rs1486958101,2
    C--58470455(+) ACAAAC/TGATAG 1 -- ds50010--------
    rs1928966821,2
    --58470456(+) CAAACA/GATAGA 1 -- ds50010--------
    rs19556301,2
    C,F,O,A,H--58470524(+) GTGGAG/ATCCAC 1 -- ds500118Minor allele frequency- A:0.46NS EA NA WA CSA 936
    rs733084251,2
    C,F--58470594(+) AAATGG/ACAGAC 1 -- ds50012Minor allele frequency- A:0.03WA 120
    rs677116191,2
    C,F--58470622(+) TTACCT/GACCCT 1 -- ds50017Minor allele frequency- G:0.07NA WA EA 366
    rs1853020161,2
    --58470662(+) TTCTCA/GGCAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for C14orf37 (58466453 - 58716453 bp, first 250kb of C14orf37)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for C14orf37:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2657771CNV Deletion23128226
    esv2677940CNV Deletion23128226
    esv2319201CNV Deletion18987734
    nsv507752CNV Insertion20534489
    nsv826959CNV Loss20364138
    esv34185CNV Loss18971310

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with C14orf37           About GenesLikeMe

    Genetic Association Database (GAD): C14orf37
    Human Genome Epidemiology (HuGE) Navigator: C14orf37 (1 document)

    Export disorders for C14orf37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C14orf37 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C14orf37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    3. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....MunafA^ M.R. (Pharmacogenomics 2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 145407 HGNC: 19846 Ensembl:ENSG00000139971 euGenes: HUgn145407 ECgene: C14orf37
    H-InvDB: C14orf37

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C14orf37 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C14orf37 gene:
    Search GeneIP for patents involving C14orf37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

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