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Aliases for C14orf37 Gene

Aliases for C14orf37 Gene

  • Chromosome 14 Open Reading Frame 37 2 3 5
  • Uncharacterized Protein C14orf37 3
  • C14_5376 3

External Ids for C14orf37 Gene

Previous GeneCards Identifiers for C14orf37 Gene

  • GC14M052267
  • GC14M056460
  • GC14U900322
  • GC14M057540
  • GC14M058470
  • GC14M038636

Summaries for C14orf37 Gene

GeneCards Summary for C14orf37 Gene

C14orf37 (Chromosome 14 Open Reading Frame 37) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf37 Gene

Genomics for C14orf37 Gene

Regulatory Elements for C14orf37 Gene

Enhancers for C14orf37 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C14orf37 on UCSC Golden Path with GeneCards custom track

Promoters for C14orf37 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C14orf37 on UCSC Golden Path with GeneCards custom track

Genomic Location for C14orf37 Gene

57,993,531 bp from pter
58,298,139 bp from pter
304,609 bases
Minus strand

Genomic View for C14orf37 Gene

Genes around C14orf37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf37 Gene

Proteins for C14orf37 Gene

  • Protein details for C14orf37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C14orf37
    Protein Accession:
    Secondary Accessions:
    • A8K8Z8
    • Q6P5Q1
    • Q86TY1

    Protein attributes for C14orf37 Gene

    774 amino acids
    Molecular mass:
    84173 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C14orf37 Gene


neXtProt entry for C14orf37 Gene

Post-translational modifications for C14orf37 Gene

  • Glycosylation at Asn 57, Thr 96, Ser 135, Asn 189, and Ser 389
  • Modification sites at PhosphoSitePlus

Other Protein References for C14orf37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C14orf37 Gene

Domains & Families for C14orf37 Gene

Protein Domains for C14orf37 Gene


Suggested Antigen Peptide Sequences for C14orf37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf37: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C14orf37 Gene

Function for C14orf37 Gene

Phenotypes for C14orf37 Gene

genes like me logo Genes that share phenotypes with C14orf37: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf37 Gene

Localization for C14orf37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf37 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for C14orf37 Gene COMPARTMENTS Subcellular localization image for C14orf37 gene
Compartment Confidence
extracellular 2
plasma membrane 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for C14orf37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C14orf37: view

Pathways & Interactions for C14orf37 Gene

SuperPathways for C14orf37 Gene

No Data Available

Interacting Proteins for C14orf37 Gene

Gene Ontology (GO) - Biological Process for C14orf37 Gene


No data available for Pathways by source and SIGNOR curated interactions for C14orf37 Gene

Drugs & Compounds for C14orf37 Gene

No Compound Related Data Available

Transcripts for C14orf37 Gene

mRNA/cDNA for C14orf37 Gene

(5) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C14orf37 Gene

Chromosome 14 open reading frame 37:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf37 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP2: -

Relevant External Links for C14orf37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C14orf37 Gene

mRNA expression in normal human tissues for C14orf37 Gene

Protein differential expression in normal tissues from HIPED for C14orf37 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C14orf37 Gene

Protein tissue co-expression partners for C14orf37 Gene

NURSA nuclear receptor signaling pathways regulating expression of C14orf37 Gene:


SOURCE GeneReport for Unigene cluster for C14orf37 Gene:

genes like me logo Genes that share expression patterns with C14orf37: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C14orf37 Gene

Orthologs for C14orf37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C14orf37 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C10H14orf37 34
  • 82.14 (n)
  • 73.74 (a)
C14orf37 35
  • 73 (a)
(Canis familiaris)
Mammalia C8H14orf37 34
  • 83.68 (n)
  • 75.45 (a)
C14orf37 35
  • 69 (a)
(Mus musculus)
Mammalia 3632451O06Rik 34
  • 72.38 (n)
  • 57.5 (a)
3632451O06Rik 16
3632451O06Rik 35
  • 55 (a)
(Pan troglodytes)
Mammalia C14H14orf37 34
  • 99.01 (n)
  • 98.32 (a)
C14ORF37 35
  • 94 (a)
(Rattus norvegicus)
Mammalia RGD1310110 34
  • 71.52 (n)
  • 57.94 (a)
(Monodelphis domestica)
Mammalia C14orf37 35
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia C14orf37 35
  • 36 (a)
(Gallus gallus)
Aves C5H14ORF37 34
  • 54.11 (n)
  • 43.42 (a)
C14orf37 35
  • 37 (a)
(Anolis carolinensis)
Reptilia C14orf37 35
  • 88 (a)
Species where no ortholog for C14orf37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf37 Gene

Gene Tree for C14orf37 (if available)
Gene Tree for C14orf37 (if available)

Paralogs for C14orf37 Gene

No data available for Paralogs for C14orf37 Gene

Variants for C14orf37 Gene

Sequence variations from dbSNP and Humsavar for C14orf37 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs3829765 - 58,139,072(+) GCTGG(A/G)TTTCT nc-transcript-variant, reference, missense
rs1018504 - 58,138,187(+) TGAAA(A/G)CAGGT nc-transcript-variant, reference, missense
rs12886921 - 58,133,129(+) GACGA(A/C)TGTAG nc-transcript-variant, reference, missense
rs2273442 - 58,096,976(+) TTCTT(C/G)TCCCT nc-transcript-variant, reference, missense
rs1609698 -- 58,063,197(+) tgtca(A/G)tgtgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf37 Gene

Variant ID Type Subtype PubMed ID
esv2319201 CNV deletion 18987734
esv2657771 CNV deletion 23128226
esv2677940 CNV deletion 23128226
esv3412182 CNV insertion 20981092
esv34185 CNV loss 18971310
esv3634618 CNV loss 21293372
esv3634619 CNV loss 21293372
esv3634620 CNV loss 21293372
nsv1038569 CNV gain 25217958
nsv1042675 CNV gain 25217958
nsv1046422 CNV gain 25217958
nsv507752 OTHER sequence alteration 20534489
nsv826959 CNV loss 20364138

Variation tolerance for C14orf37 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.96; 97.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C14orf37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf37 Gene

Disorders for C14orf37 Gene

Relevant External Links for C14orf37

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C14orf37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf37 Gene

Publications for C14orf37 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 65
  2. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (PMID: 24925725) Chung S.A. … Langefeld C.D. (J. Am. Soc. Nephrol. 2014) 3 65
  3. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PMID: 21406692) Rigbolt K.T. … Blagoev B. (Sci. Signal. 2011) 4 65
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 65
  5. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PMID: 20235792) Uhl G.R. … MunafA^ M.R. (Pharmacogenomics 2010) 46 65

Products for C14orf37 Gene

Sources for C14orf37 Gene