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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C14orf37 Gene

protein-coding   GIFtS: 41
GCID: GC14M058470          (predicted)

Chromosome 14 Open Reading Frame 37

  Search for C14orf37
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 14 Open Reading Frame 371 2
c14_53762
Uncharacterized Protein C14orf372

External Ids:    HGNC: 198461   Entrez Gene: 1454072   Ensembl: ENSG000001399717   UniProtKB: Q86TY33   

Export aliases for C14orf37 gene to outside databases

Previous GC identifers: GC14M052267 GC14M056460 GC14U900322 GC14M057540 GC14M038636


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C14orf37 Gene: 
C14orf37 (chromosome 14 open reading frame 37) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C14orf37 gene promoter:
         USF1   POU2F1   POU2F1a   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C14orf37

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf37


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q23.1

C14orf37 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf37 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M058470:  view genomic region     (about GC identifiers)

Start:
58,466,453 bp from pter      End:
58,764,857 bp from pter
Size:
298,405 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CN037_HUMAN, Q86TY3 (See protein sequence)
Recommended Name: Uncharacterized protein C14orf37 precursor  
Size: 774 amino acids; 84173 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: A8K8Z8 Q6P5Q1 Q86TY1
Alternative splicing: 3 isoforms:  Q86TY3-1   Q86TY3-2   Q86TY3-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C14orf37: NX_Q86TY3

Explore proteomics data for C14orf37 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86TY3

  • C14orf37 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C14orf37 Protein Expression
    REFSEQ proteins: NP_001001872.2  
    ENSEMBL proteins: 
     ENSP00000267485  

    Human Recombinant Protein Products for C14orf37: 
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    Cloud-Clone Corp. Proteins for C14orf37 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    C14orf37 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q86TY3


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C14orf37 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C14orf37

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C14orf37 (CN037)

    Search CenterWatch for drugs/clinical trials and news about C14orf37 / CN037

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C14orf37 gene: 
    NM_001001872.2  

    Unigene Cluster for C14orf37:

    Chromosome 14 open reading frame 37
    Hs.535420  [show with all ESTs]
    Unigene Representative Sequence: BX649130
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556788 ENST00000267485(uc001xdd.3 uc001xdc.3 uc010tro.2)
    ENST00000557175 ENST00000334342(uc001xde.3) ENST00000555101 ENST00000554218

    miRNA
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    hsa-miR-767-3p
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C14orf37

    Additional mRNA sequence: 

    AK292513.1 AK292605.1 AK294599.1 BC013707.1 BC062772.1 BC113051.1 BC146861.1 BX161411.1 
    BX161448.1 BX649130.1 

    6 DOTS entries:

    DT.304540  DT.101969129  DT.100717379  DT.40120010  DT.100668993  DT.91751752 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for C14orf37    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
    SP1:                                                                  
    SP2:                          -                                       
    SP3:                                                                  


    ECgene alternative splicing isoforms for C14orf37

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C14orf37 expression in normal human tissues (normalized intensities)      C14orf37 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTACATACTG
    C14orf37 Expression
    About this image


    C14orf37 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 22 entries
             Thalamus
             Septum   
     
     Spinal Cord (Nervous System)    fully expand to see all 2 entries
             Dorsal Horn   

     -- (Muscoskeletal System)
             mouse/vertebral axis muscle system   

    See C14orf37 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C14orf37

    SOURCE GeneReport for Unigene cluster: Hs.535420
        SABiosciences Custom PCR Arrays for C14orf37
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf37

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C14orf37 gene from 3/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 3632451O06Rik1 , 5 RIKEN cDNA 3632451O06 gene1, 5 72.78(n)1
    58.43(a)1
      14 (25.78 cM)5
    674191  NM_026142.41  NP_080418.21 
     496815605 
    chicken
    (Gallus gallus)
    Aves C5H14orf371 chromosome 5 open reading frame, human C14orf37 53.02(n)
    41.06(a)
      423545  XM_421438.3  XP_421438.3 
    lizard
    (Anolis carolinensis)
    Reptilia C14ORF376
    Uncharacterized protein
    90(a)
    1 ↔ 1
    GL343325.1(474795-508304)


    ENSEMBL Gene Tree for C14orf37 (if available)
    TreeFam Gene Tree for C14orf37 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2921 SNPs in C14orf37 are shown (see all 2921)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1846943931,2
    --58470316(+) TTGTAC/TAGGGC 1 -- ds50010--------
    rs27471041,2
    C,F,O,H--58470403(+) GGCTGG/ATTTCC 1 -- ds500128Minor allele frequency- A:0.30NA NS EA WA CSA 2904
    rs1900082221,2
    --58470422(+) CTGTTA/GTTCAC 1 -- ds50010--------
    rs1441168741,2
    --58470442(+) GGCCAC/TTGGGC 1 -- ds50010--------
    rs1486958101,2
    C--58470455(+) ACAAAC/TGATAG 1 -- ds50010--------
    rs1928966821,2
    --58470456(+) CAAACA/GATAGA 1 -- ds50010--------
    rs19556301,2
    C,F,O,A,H--58470524(+) GTGGAG/ATCCAC 1 -- ds500118Minor allele frequency- A:0.46NS EA NA WA CSA 936
    rs733084251,2
    C,F--58470594(+) AAATGG/ACAGAC 1 -- ds50012Minor allele frequency- A:0.03WA 120
    rs677116191,2
    C,F--58470622(+) TTACCT/GACCCT 1 -- ds50017Minor allele frequency- G:0.07NA WA EA 366
    rs1853020161,2
    --58470662(+) TTCTCA/GGCAAA 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for C14orf37 (58466453 - 58716453 bp, first 250kb of C14orf37)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for C14orf37:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2657771CNV Deletion23128226
    esv2677940CNV Deletion23128226
    esv2319201CNV Deletion18987734
    nsv507752CNV Insertion20534489
    nsv826959CNV Loss20364138
    esv34185CNV Loss18971310

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C14orf37 for disorders           About MalaCards

    C14orf37 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C14orf37
    Human Genome Epidemiology (HuGE) Navigator: C14orf37 (1 document)

    Export disorders for C14orf37 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C14orf37 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C14orf37)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    3. Genome-wide association for smoking cessation success: participants in the Patch in Practice trial of nicotine replacement. (PubMed id 20235792)4 Uhl G.R....Munafo M.R. (2010)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 145407 HGNC: 19846 Ensembl:ENSG00000139971 euGenes: HUgn145407 ECgene: C14orf37
    H-InvDB: C14orf37

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C14orf37 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C14orf37 gene:
    Search GeneIP for patents involving C14orf37

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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