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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C14orf28 Gene

protein-coding   GIFtS: 38
GCID: GC14P045366

Chromosome 14 Open Reading Frame 28

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 14 Open Reading Frame 281 2     DRIP-12
Dopamine Receptor Interacting Protein 11 2     c14_52702
Dopamine Receptor-Interacting Protein 12 3     Uncharacterized Protein C14orf282
DRIP12 3     

External Ids:    HGNC: 198341   Entrez Gene: 1225252   Ensembl: ENSG000001794767   UniProtKB: Q4W4Y03   

Export aliases for C14orf28 gene to outside databases

Previous GC identifers: GC14P039162 GC14P043356 GC14P044436 GC14P025477


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C14orf28 Gene: 
C14orf28 (chromosome 14 open reading frame 28) is a protein-coding gene. Diseases associated with C14orf28 include bipolar disorder, and schizophrenia.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C14orf28 gene promoter:
         HSF1 (long)   POU6F1 (c2)   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   c-Ets-1   SRY   FOXO1a   HSF1short   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C14orf28

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf28


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q21.2   Ensembl cytogenetic band:  14q21.2   HGNC cytogenetic band: 14q21.2

C14orf28 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf28 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P045366:  view genomic region     (about GC identifiers)

Start:
45,366,498 bp from pter      End:
45,376,460 bp from pter
Size:
9,963 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CN028_HUMAN, Q4W4Y0 (See protein sequence)
Recommended Name: Uncharacterized protein C14orf28  
Size: 310 amino acids; 36306 Da

Explore the universe of human proteins at neXtProt for C14orf28: NX_Q4W4Y0

Explore proteomics data for C14orf28 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q4W4Y0

  • C14orf28 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C14orf28 Protein Expression
    REFSEQ proteins: NP_001017923.1  
    ENSEMBL proteins: 
     ENSP00000326846   ENSP00000451791  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q4W4Y0


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C14orf28

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C14orf28 (CN028)

    Search CenterWatch for drugs/clinical trials and news about C14orf28 / CN028

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C14orf28 gene: 
    NM_001017923.1  

    Unigene Cluster for C14orf28:

    Chromosome 14 open reading frame 28
    Hs.82098  [show with all ESTs]
    Unigene Representative Sequence: NM_001017923
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000325192(uc001wvo.3) ENST00000557112 ENST00000555826(uc001wvp.1)
    ENST00000553841
    miRNA
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    Additional mRNA sequence: 

    AF250395.1 BC030258.1 BC105030.1 BC105032.1 

    2 DOTS entries:

    DT.99970323  DT.100674134 

    24/44 AceView cDNA sequences (see all 44):

    AA257029 AI339742 AA256324 AA256452 AI741798 CR602151 BM697310 BX113814 
    AI377372 AA906110 AA022589 BU624091 BM849739 AI480365 BU182551 BI826488 
    AA255798 AA022590 CD511435 CD248747 BC030258 BM667946 BG104938 AK126985 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for C14orf28    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
    SP1:        -                                 
    SP2:                                          


    ECgene alternative splicing isoforms for C14orf28

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C14orf28 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTAATAAAAA
    C14orf28 Expression
    About this image


    See C14orf28 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C14orf28

    SOURCE GeneReport for Unigene cluster: Hs.82098
        SABiosciences Custom PCR Arrays for C14orf28
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf28

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C14orf28 gene from 2/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Gm5271 , 5 predicted gene 5271, 5 93.87(n)1
    96.45(a)1
      12 (27.21 cM)5
    2176481  NM_001025605.11  NP_001020776.11 
     649179115 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1003334621 uncharacterized protein C14orf28 homolog 62.03(n)
    66.02(a)
      100333462  XM_002667674.2  XP_002667720.1 


    ENSEMBL Gene Tree for C14orf28 (if available)
    TreeFam Gene Tree for C14orf28 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/249 SNPs in C14orf28 are shown (see all 249)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1888268661,2
    --45364532(+) GAGGCC/TGAGGT 1 -- us2k10--------
    rs1929435371,2
    --45364634(+) TGGTGA/GTGCAC 1 -- us2k10--------
    rs1849071181,2
    --45364685(+) ACTCTA/TGATCC 1 -- us2k10--------
    rs2018321601,2
    C--45364793(-) CTCTGC/TCTTTT 1 -- us2k10--------
    rs1411224221,2
    --45364808(+) GGGGCA/GGTAGG 1 -- us2k10--------
    rs733471581,2
    C,F--45364920(+) ATGCTC/GTATAT 1 -- us2k13Minor allele frequency- G:0.17WA CSA 122
    rs1498190011,2
    C--45364997(+) GAAGAC/TGGTGG 1 -- us2k10--------
    rs171156811,2
    C,F,H--45365009(+) AAAGAT/CGCAGA 1 -- us2k117Minor allele frequency- C:0.08NA NS EA WA CSA 1912
    rs101506461,2
    C,F,A,H--45365089(+) CTCCAT/GCTAGC 1 -- us2k120Minor allele frequency- G:0.32NS EA NA WA CSA 2338
    rs740465291,2
    C,F--45365106(+) TCGGCA/GGAGTT 1 -- us2k12Minor allele frequency- G:0.27WA 120

    HapMap Linkage Disequilibrium report for C14orf28 (45366498 - 45376460 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for C14orf28:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv1258CNV Insertion18451855
    nsv901841CNV Loss21882294
    nsv901832CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    3 diseases for C14orf28:    About MalaCards
    bipolar disorder    schizophrenia    gastric cancer


    C14orf28 for disorders           About GeneDecksing


    Export disorders for C14orf28 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C14orf28 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C14orf28)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Altered expression and coregulation of dopamine signa lling genes in schizophrenia and bipolar disorder. (PubMed id 20874815)1 Zhan L....Nasir J. (2011)
    3. Transcriptome analysis of human gastric cancer. (PubMed id 16341674)1 Oh J.H....Kim N.S. (2005)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 122525 HGNC: 19834 AceView: C14orf28 Ensembl:ENSG00000179476 euGenes: HUgn122525
    ECgene: C14orf28 H-InvDB: C14orf28

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C14orf28 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C14orf28 gene:
    Search GeneIP for patents involving C14orf28

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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