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Aliases for C14orf28 Gene

Aliases for C14orf28 Gene

  • Chromosome 14 Open Reading Frame 28 2 3 5
  • Dopamine Receptor Interacting Protein 1 2 3
  • DRIP1 3 4
  • Dopamine Receptor-Interacting Protein 1 4
  • Uncharacterized Protein C14orf28 3
  • C14_5270 3
  • DRIP-1 3

External Ids for C14orf28 Gene

Previous GeneCards Identifiers for C14orf28 Gene

  • GC14P039162
  • GC14P043356
  • GC14P044436
  • GC14P045366
  • GC14P025477

Summaries for C14orf28 Gene

GeneCards Summary for C14orf28 Gene

C14orf28 (Chromosome 14 Open Reading Frame 28) is a Protein Coding gene.

Additional gene information for C14orf28 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf28 Gene

Genomics for C14orf28 Gene

GeneHancer (GH) Regulatory Elements for C14orf28 Gene

Promoters and enhancers for C14orf28 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I044895 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 -0.3 -275 3.6 PKNOX1 ATF1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF48 YY1 GLIS2 C14orf28 ENSG00000258633 LINC02302 MIS18BP1 RRAGAP1 GC14P044608 GC14P044609 GC14P044610 GC14M044793 GC14P044549
GH14I045249 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 10.4 +354.7 354735 6 PKNOX1 SMAD1 FOXA2 MLX ARID4B NEUROD1 SIN3A DMAP1 ZNF2 IRF4 MIS18BP1 PRPF39 FANCM KLHL28 C14orf28 GC14M044793 GC14M045228 GC14P045107 GC14P045108
GH14I044940 Enhancer 0.2 ENCODE 11.3 +43.7 43693 0.8 GC14M044938 C14orf28 LINC02302 SNORD127 TOGARAM1 GC14P044911 KLHL28 GC14M044793 GC14P044608 GC14P044609
GH14I044944 Enhancer 0.2 ENCODE 11.2 +48.2 48182 1 C14orf28 SNORD127 GC14M044938 TOGARAM1 GC14P044911 KLHL28 GC14M044793 GC14P044608 GC14P044609 GC14P044610
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C14orf28 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C14orf28 gene promoter:

Genomic Locations for C14orf28 Gene

Genomic Locations for C14orf28 Gene
chr14:44,897,295-44,907,257
(GRCh38/hg38)
Size:
9,963 bases
Orientation:
Plus strand
chr14:45,366,498-45,376,460
(GRCh37/hg19)

Genomic View for C14orf28 Gene

Genes around C14orf28 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf28 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf28 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf28 Gene

Proteins for C14orf28 Gene

  • Protein details for C14orf28 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4W4Y0-CN028_HUMAN
    Recommended name:
    Uncharacterized protein C14orf28
    Protein Accession:
    Q4W4Y0

    Protein attributes for C14orf28 Gene

    Size:
    310 amino acids
    Molecular mass:
    36306 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C14orf28 Gene

Post-translational modifications for C14orf28 Gene

No Post-translational modifications

Other Protein References for C14orf28 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C14orf28 Gene

Domains & Families for C14orf28 Gene

Gene Families for C14orf28 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C14orf28 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C14orf28 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf28: view

No data available for UniProtKB/Swiss-Prot for C14orf28 Gene

Function for C14orf28 Gene

Phenotypes From GWAS Catalog for C14orf28 Gene

Phenotypes for C14orf28 Gene

GenomeRNAi human phenotypes for C14orf28:
genes like me logo Genes that share phenotypes with C14orf28: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf28 Gene

Localization for C14orf28 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf28 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C14orf28 Gene

Pathways & Interactions for C14orf28 Gene

SuperPathways for C14orf28 Gene

No Data Available

Interacting Proteins for C14orf28 Gene

Gene Ontology (GO) - Biological Process for C14orf28 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C14orf28 Gene

Drugs & Compounds for C14orf28 Gene

No Compound Related Data Available

Transcripts for C14orf28 Gene

Unigene Clusters for C14orf28 Gene

Chromosome 14 open reading frame 28:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf28 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b
SP1: -
SP2:

Relevant External Links for C14orf28 Gene

GeneLoc Exon Structure for
C14orf28
ECgene alternative splicing isoforms for
C14orf28

Expression for C14orf28 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C14orf28 Gene

NURSA nuclear receptor signaling pathways regulating expression of C14orf28 Gene:

C14orf28

SOURCE GeneReport for Unigene cluster for C14orf28 Gene:

Hs.82098
genes like me logo Genes that share expression patterns with C14orf28: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf28 Gene

Orthologs for C14orf28 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C14orf28 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf28 33
  • 99.68 (n)
C14orf28 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C14orf28 34
  • 98 (a)
OneToOne
C21H14orf28 33
  • 95 (n)
dog
(Canis familiaris)
Mammalia C14ORF28 34
  • 98 (a)
OneToOne
C8H14orf28 33
  • 96.45 (n)
oppossum
(Monodelphis domestica)
Mammalia C14orf28 34
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1307621 33
  • 94.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf28 34
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gm527 33 16 34
  • 93.87 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494240 33
  • 76.02 (n)
zebrafish
(Danio rerio)
Actinopterygii C14orf28 34
  • 64 (a)
OneToOne
LOC100333462 33
  • 62.03 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.7573 33
Species where no ortholog for C14orf28 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C14orf28 Gene

ENSEMBL:
Gene Tree for C14orf28 (if available)
TreeFam:
Gene Tree for C14orf28 (if available)

Paralogs for C14orf28 Gene

No data available for Paralogs for C14orf28 Gene

Variants for C14orf28 Gene

Sequence variations from dbSNP and Humsavar for C14orf28 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000012068 -- 44,898,402(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000308755 -- 44,904,253(+) C/A/T intron_variant
rs1000340555 -- 44,906,074(+) T/G 3_prime_UTR_variant
rs1000374803 -- 44,905,740(+) T/A 3_prime_UTR_variant
rs1000914335 -- 44,902,820(+) G/A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf28 Gene

Variant ID Type Subtype PubMed ID
nsv1053437 CNV loss 25217958
nsv1258 CNV insertion 18451855
nsv564642 CNV loss 21841781

Variation tolerance for C14orf28 Gene

Residual Variation Intolerance Score: 63.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.30; 62.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C14orf28 Gene

Human Gene Mutation Database (HGMD)
C14orf28
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C14orf28

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf28 Gene

Disorders for C14orf28 Gene

Additional Disease Information for C14orf28

No disorders were found for C14orf28 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf28 Gene

Publications for C14orf28 Gene

  1. C14orf28 downregulated by miR-519d contributes to oncogenicity and regulates apoptosis and EMT in colorectal cancer. (PMID: 28455792) Yang X … Tang H (Molecular and cellular biochemistry 2017) 2 3 58
  2. Altered expression and coregulation of dopamine signalling genes in schizophrenia and bipolar disorder. (PMID: 20874815) Zhan L … Nasir J (Neuropathology and applied neurobiology 2011) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Transcriptome analysis of human gastric cancer. (PMID: 16341674) Oh JH … Kim NS (Mammalian genome : official journal of the International Mammalian Genome Society 2005) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C14orf28 Gene

Sources for C14orf28 Gene

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