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Aliases for C14orf2 Gene

Aliases for C14orf2 Gene

  • Chromosome 14 Open Reading Frame 2 2 3
  • MP68 3 4 6
  • 6.8 KDa Mitochondrial Proteolipid 2 3
  • PLPM 3

External Ids for C14orf2 Gene

Previous GeneCards Identifiers for C14orf2 Gene

  • GC14M101769
  • GC14M098194
  • GC14M102368
  • GC14M103448
  • GC14M104378
  • GC14M084559

Summaries for C14orf2 Gene

GeneCards Summary for C14orf2 Gene

C14orf2 (Chromosome 14 Open Reading Frame 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf2 Gene

Genomics for C14orf2 Gene

Regulatory Elements for C14orf2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C14orf2 Gene

Start:
103,912,288 bp from pter
End:
103,928,269 bp from pter
Size:
15,982 bases
Orientation:
Minus strand

Genomic View for C14orf2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C14orf2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf2 Gene

Proteins for C14orf2 Gene

  • Protein details for C14orf2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56378-68MP_HUMAN
    Recommended name:
    6.8 kDa mitochondrial proteolipid
    Protein Accession:
    P56378
    Secondary Accessions:
    • B2R588
    • G3V5Q3
    • Q86TT7

    Protein attributes for C14orf2 Gene

    Size:
    58 amino acids
    Molecular mass:
    6662 Da
    Quaternary structure:
    • Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.
    SequenceCaution:
    • Sequence=EAW81849.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C14orf2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C14orf2 Gene

Proteomics data for C14orf2 Gene at MOPED

Post-translational modifications for C14orf2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C14orf2 Gene

No data available for DME Specific Peptides for C14orf2 Gene

Domains for C14orf2 Gene

Protein Domains for C14orf2 Gene

InterPro:
Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

P56378

UniProtKB/Swiss-Prot:

68MP_HUMAN :
  • P56378
Family:
  • Belongs to the small mitochondrial proteolipid family.
genes like me logo Genes that share domains with C14orf2: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for C14orf2 Gene

Function for C14orf2 Gene

Molecular function for C14orf2 Gene

GENATLAS Biochemistry: chromosome 14 open reading frame 2

Gene Ontology (GO) - Molecular Function for C14orf2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C14orf2: view

Phenotypes for C14orf2 Gene

GenomeRNAi human phenotypes for C14orf2:
genes like me logo Genes that share phenotypes with C14orf2: view

Animal Model Products

CRISPR Products

miRNA for C14orf2 Gene

miRTarBase miRNAs that target C14orf2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C14orf2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C14orf2 Gene

Localization for C14orf2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf2 Gene

Mitochondrion. Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C14orf2 Gene COMPARTMENTS Subcellular localization image for C14orf2 gene
Compartment Confidence
mitochondrion 5
cytosol 2
extracellular 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for C14orf2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion --
GO:0005753 mitochondrial proton-transporting ATP synthase complex ISS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C14orf2: view

Pathways for C14orf2 Gene

SuperPathways for C14orf2 Gene

No Data Available

Interacting Proteins for C14orf2 Gene

Gene Ontology (GO) - Biological Process for C14orf2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C14orf2: view

No data available for Pathways by source for C14orf2 Gene

Transcripts for C14orf2 Gene

Unigene Clusters for C14orf2 Gene

Chromosome 14 open reading frame 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C14orf2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for C14orf2 Gene

GeneLoc Exon Structure for
C14orf2
ECgene alternative splicing isoforms for
C14orf2

Expression for C14orf2 Gene

mRNA expression in normal human tissues for C14orf2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C14orf2 Gene

SOURCE GeneReport for Unigene cluster for C14orf2 Gene Hs.109052

genes like me logo Genes that share expressions with C14orf2: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C14orf2 Gene

Orthologs for C14orf2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C14orf2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf2 35
  • 99.56 (n)
  • 98.67 (a)
C14orf2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C21H14orf2 35
  • 85.63 (n)
  • 81.03 (a)
MP68 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C8H14orf2 35
  • 83.63 (n)
  • 75.44 (a)
mouse
(Mus musculus)
Mammalia 2010107E04Rik 35
  • 81.03 (n)
  • 72.41 (a)
2010107E04Rik 16
2010107E04Rik 36
  • 72 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C14orf2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf2 36
  • 73 (a)
OneToOne
Species with no ortholog for C14orf2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf2 Gene

ENSEMBL:
Gene Tree for C14orf2 (if available)
TreeFam:
Gene Tree for C14orf2 (if available)

Paralogs for C14orf2 Gene

Selected SIMAP similar genes for C14orf2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for C14orf2 Gene

genes like me logo Genes that share paralogs with C14orf2: view

No data available for Paralogs for C14orf2 Gene

Variants for C14orf2 Gene

Sequence variations from dbSNP and Humsavar for C14orf2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs8095 -- 103,912,515(-) ATGCA(C/T)TGCTA utr-variant-3-prime
rs1008312 -- 103,914,469(-) GTTTT(C/T)TTAGG intron-variant
rs1018535 -- 103,922,620(-) TTTCA(C/G)TCTTG upstream-variant-2KB
rs1053419 -- 103,915,165(-) AAAAC(A/G/T)TATGG reference, missense
rs1475008 -- 103,914,858(-) CTTTT(C/T)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf2 Gene

Variant ID Type Subtype PubMed ID
dgv658e1 CNV Complex 17122850
nsv902318 CNV Loss 21882294
nsv902319 CNV Gain 21882294
dgv1997n71 CNV Loss 21882294

Relevant External Links for C14orf2 Gene

HapMap Linkage Disequilibrium report
C14orf2
Human Gene Mutation Database (HGMD)
C14orf2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf2 Gene

Disorders for C14orf2 Gene

No disorders were found for C14orf2 Gene.

No data available for UniProtKB/Swiss-Prot for C14orf2 Gene

Publications for C14orf2 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PMID: 16712791) Wang A.G. … Kim N.S. (Biochem. Biophys. Res. Commun. 2006) 3
  5. Mapping of transcription start sites of human retina expressed genes. (PMID: 17286855) Roni V. … Wissinger B. (BMC Genomics 2007) 3

Products for C14orf2 Gene

Sources for C14orf2 Gene

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