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Aliases for C14orf2 Gene

Aliases for C14orf2 Gene

  • Chromosome 14 Open Reading Frame 2 2 3 5
  • MP68 3 4
  • 6.8 KDa Mitochondrial Proteolipid 2
  • PLPM 3

External Ids for C14orf2 Gene

Previous GeneCards Identifiers for C14orf2 Gene

  • GC14M101769
  • GC14M098194
  • GC14M102368
  • GC14M103448
  • GC14M104378
  • GC14M084559

Summaries for C14orf2 Gene

GeneCards Summary for C14orf2 Gene

C14orf2 (Chromosome 14 Open Reading Frame 2) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf2 Gene

Genomics for C14orf2 Gene

Regulatory Elements for C14orf2 Gene

Genomic Location for C14orf2 Gene

Chromosome:
14
Start:
103,912,288 bp from pter
End:
103,928,269 bp from pter
Size:
15,982 bases
Orientation:
Minus strand

Genomic View for C14orf2 Gene

Genes around C14orf2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf2 Gene

Proteins for C14orf2 Gene

  • Protein details for C14orf2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P56378-68MP_HUMAN
    Recommended name:
    6.8 kDa mitochondrial proteolipid
    Protein Accession:
    P56378
    Secondary Accessions:
    • B2R588
    • G3V5Q3
    • Q86TT7

    Protein attributes for C14orf2 Gene

    Size:
    58 amino acids
    Molecular mass:
    6662 Da
    Quaternary structure:
    • Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.
    SequenceCaution:
    • Sequence=EAW81849.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C14orf2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C14orf2 Gene

Proteomics data for C14orf2 Gene at MOPED

Post-translational modifications for C14orf2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C14orf2 Gene

No data available for DME Specific Peptides for C14orf2 Gene

Domains & Families for C14orf2 Gene

Protein Domains for C14orf2 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for C14orf2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P56378

UniProtKB/Swiss-Prot:

68MP_HUMAN :
  • Belongs to the small mitochondrial proteolipid family.
Family:
  • Belongs to the small mitochondrial proteolipid family.
genes like me logo Genes that share domains with C14orf2: view

No data available for Gene Families for C14orf2 Gene

Function for C14orf2 Gene

Molecular function for C14orf2 Gene

GENATLAS Biochemistry:
chromosome 14 open reading frame 2
genes like me logo Genes that share phenotypes with C14orf2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C14orf2

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf2 Gene

Localization for C14orf2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf2 Gene

Mitochondrion. Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C14orf2 Gene COMPARTMENTS Subcellular localization image for C14orf2 gene
Compartment Confidence
mitochondrion 5
cytosol 4
extracellular 2
nucleus 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for C14orf2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with C14orf2: view

Pathways & Interactions for C14orf2 Gene

SuperPathways for C14orf2 Gene

No Data Available

Interacting Proteins for C14orf2 Gene

Gene Ontology (GO) - Biological Process for C14orf2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C14orf2 Gene

Drugs & Compounds for C14orf2 Gene

No Compound Related Data Available

Transcripts for C14orf2 Gene

Unigene Clusters for C14orf2 Gene

Chromosome 14 open reading frame 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: -
SP4:
SP5:

Relevant External Links for C14orf2 Gene

GeneLoc Exon Structure for
C14orf2
ECgene alternative splicing isoforms for
C14orf2

Expression for C14orf2 Gene

mRNA expression in normal human tissues for C14orf2 Gene

Protein differential expression in normal tissues from HIPED for C14orf2 Gene

This gene is overexpressed in Stomach (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C14orf2 Gene



SOURCE GeneReport for Unigene cluster for C14orf2 Gene Hs.109052

genes like me logo Genes that share expression patterns with C14orf2: view

Protein tissue co-expression partners for C14orf2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C14orf2 Gene

Orthologs for C14orf2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C14orf2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C21H14orf2 35
  • 85.63 (n)
  • 81.03 (a)
MP68 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C8H14orf2 35
  • 83.63 (n)
  • 75.44 (a)
mouse
(Mus musculus)
Mammalia 2010107E04Rik 35
  • 81.03 (n)
  • 72.41 (a)
2010107E04Rik 16
2010107E04Rik 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf2 35
  • 99.56 (n)
  • 98.67 (a)
C14orf2 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C14orf2 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf2 36
  • 73 (a)
OneToOne
Species with no ortholog for C14orf2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf2 Gene

ENSEMBL:
Gene Tree for C14orf2 (if available)
TreeFam:
Gene Tree for C14orf2 (if available)

Paralogs for C14orf2 Gene

(5) SIMAP similar genes for C14orf2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for C14orf2 Gene

genes like me logo Genes that share paralogs with C14orf2: view

No data available for Paralogs for C14orf2 Gene

Variants for C14orf2 Gene

Sequence variations from dbSNP and Humsavar for C14orf2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs8095 -- 103,912,515(-) ATGCA(C/T)TGCTA utr-variant-3-prime
rs1053419 -- 103,915,165(-) AAAAC(A/G/T)TATGG reference, missense
rs1008312 -- 103,914,469(-) GTTTT(C/T)TTAGG intron-variant
rs1018535 -- 103,922,620(-) TTTCA(C/G)TCTTG upstream-variant-2KB
rs2269186 -- 103,913,575(-) GGACT(A/G)CAGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf2 Gene

Variant ID Type Subtype PubMed ID
dgv658e1 CNV Complex 17122850
nsv902318 CNV Loss 21882294
nsv902319 CNV Gain 21882294
dgv1997n71 CNV Loss 21882294

Variation tolerance for C14orf2 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C14orf2 Gene

HapMap Linkage Disequilibrium report
C14orf2
Human Gene Mutation Database (HGMD)
C14orf2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf2 Gene

Disorders for C14orf2 Gene

Relevant External Links for C14orf2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C14orf2

No disorders were found for C14orf2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf2 Gene

Publications for C14orf2 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 67
  2. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Population of ATP synthase molecules in mitochondria is limited by available 6.8-kDa proteolipid protein (MLQ). (PMID: 24330338) Fujikawa M. … Yoshida M. (Genes Cells 2014) 3
  5. Mapping of transcription start sites of human retina expressed genes. (PMID: 17286855) Roni V. … Wissinger B. (BMC Genomics 2007) 3

Products for C14orf2 Gene

Sources for C14orf2 Gene

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