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Aliases for C14orf2 Gene

Aliases for C14orf2 Gene

  • Chromosome 14 Open Reading Frame 2 2 3 5
  • 6.8-KDa Proteolipid With N-Terminal Sequence Met-Leu-Gln (MLQ) 2 3
  • 6.8 KDa Mitochondrial Proteolipid 2 3
  • MP68 3 4
  • 6.8PL 3
  • PLPM 3
  • MLQ 3

External Ids for C14orf2 Gene

Previous GeneCards Identifiers for C14orf2 Gene

  • GC14M101769
  • GC14M098194
  • GC14M102368
  • GC14M103448
  • GC14M104378
  • GC14M084559

Summaries for C14orf2 Gene

GeneCards Summary for C14orf2 Gene

C14orf2 (Chromosome 14 Open Reading Frame 2) is a Protein Coding gene.

Additional gene information for C14orf2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf2 Gene

Genomics for C14orf2 Gene

Regulatory Elements for C14orf2 Gene

Enhancers for C14orf2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H103887 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.5 +38.4 38355 4.1 ELF3 ATF1 FOXA2 ARID4B DMAP1 RARA YY1 EGR1 FOS RCOR1 PPP1R13B C14orf2 KLC1 TDRD9 LOC105370690 ENSG00000269958 TRMT61A GC14P103903
GH14H103909 1.4 Ensembl ENCODE dbSUPER 10.2 +17.8 17814 1.2 PKNOX1 ARID4B SIN3A ZNF76 KLF17 NFXL1 ZNF2 RAD21 RFX5 YY1 PPP1R13B ENSG00000202275 C14orf2 ASPG TDRD9 GC14P103906 GC14M103922 GC14M103921
GH14H103931 1.3 FANTOM5 Ensembl ENCODE 10.6 -4.5 -4532 3.2 ELF3 SOX13 FOXA2 SAP130 CEBPG RARA ZNF7 TEAD3 POLR2A SOX5 TDRD9 C14orf2 ENSG00000202275 RD3L
GH14H103879 1.5 Ensembl ENCODE dbSUPER 9 +47.2 47214 4.4 PKNOX1 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 YY1 TCF12 SLC30A9 TDRD9 KLC1 C14orf2 LOC105370690 GC14P103903
GH14H103920 1.1 ENCODE 10.3 +7.0 6994 1.8 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207 ZNF143 SP3 SP5 XRCC3 TDRD9 BAG5 LINC00638 C14orf2 GC14M103922 GC14M103921 GC14P103906
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C14orf2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C14orf2 Gene

Genomic Locations for C14orf2 Gene
15,982 bases
Minus strand

Genomic View for C14orf2 Gene

Genes around C14orf2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf2 Gene

Proteins for C14orf2 Gene

  • Protein details for C14orf2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    6.8 kDa mitochondrial proteolipid
    Protein Accession:
    Secondary Accessions:
    • B2R588
    • G3V5Q3
    • Q86TT7

    Protein attributes for C14orf2 Gene

    58 amino acids
    Molecular mass:
    6662 Da
    Quaternary structure:
    • Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.
    • Sequence=EAW81849.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for C14orf2 Gene


neXtProt entry for C14orf2 Gene

Post-translational modifications for C14orf2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C14orf2 Gene

No data available for DME Specific Peptides for C14orf2 Gene

Domains & Families for C14orf2 Gene

Gene Families for C14orf2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for C14orf2 Gene


Suggested Antigen Peptide Sequences for C14orf2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small mitochondrial proteolipid family.
  • Belongs to the small mitochondrial proteolipid family.
genes like me logo Genes that share domains with C14orf2: view

Function for C14orf2 Gene

Molecular function for C14orf2 Gene

GENATLAS Biochemistry:
chromosome 14 open reading frame 2

Phenotypes From GWAS Catalog for C14orf2 Gene

Gene Ontology (GO) - Molecular Function for C14orf2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C14orf2: view
genes like me logo Genes that share phenotypes with C14orf2: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf2 Gene

Localization for C14orf2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf2 Gene

Mitochondrion. Mitochondrion membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf2 gene
Compartment Confidence
mitochondrion 5
cytosol 4
plasma membrane 2
extracellular 2
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (3)
  • Nucleoli fibrillar center (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C14orf2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
GO:0005753 mitochondrial proton-transporting ATP synthase complex ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C14orf2: view

Pathways & Interactions for C14orf2 Gene

SuperPathways for C14orf2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C14orf2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C14orf2: view

No data available for Pathways by source and SIGNOR curated interactions for C14orf2 Gene

Drugs & Compounds for C14orf2 Gene

No Compound Related Data Available

Transcripts for C14orf2 Gene

Unigene Clusters for C14orf2 Gene

Chromosome 14 open reading frame 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf2 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for C14orf2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C14orf2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C14orf2 Gene

Protein differential expression in normal tissues from HIPED for C14orf2 Gene

This gene is overexpressed in Stomach (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C14orf2 Gene

Protein tissue co-expression partners for C14orf2 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C14orf2 Gene:


SOURCE GeneReport for Unigene cluster for C14orf2 Gene:


Evidence on tissue expression from TISSUES for C14orf2 Gene

  • Blood(4.3)
  • Lung(4.3)
  • Nervous system(3.2)
  • Heart(2.2)
  • Muscle(2.2)
genes like me logo Genes that share expression patterns with C14orf2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf2 Gene

Orthologs for C14orf2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C14orf2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C14H14orf2 33
  • 99.56 (n)
C14orf2 34
  • 99 (a)
(Bos Taurus)
Mammalia C21H14orf2 33
  • 85.63 (n)
MP68 34
  • 77 (a)
(Canis familiaris)
Mammalia C8H14orf2 33
  • 83.63 (n)
(Mus musculus)
Mammalia 2010107E04Rik 33 16 34
  • 81.03 (n)
(Monodelphis domestica)
Mammalia C14orf2 34
  • 75 (a)
(Ornithorhynchus anatinus)
Mammalia C14orf2 34
  • 73 (a)
Species where no ortholog for C14orf2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf2 Gene

Gene Tree for C14orf2 (if available)
Gene Tree for C14orf2 (if available)

Paralogs for C14orf2 Gene

(5) SIMAP similar genes for C14orf2 Gene using alignment to 1 proteins: Pseudogenes for C14orf2 Gene

genes like me logo Genes that share paralogs with C14orf2: view

No data available for Paralogs for C14orf2 Gene

Variants for C14orf2 Gene

Sequence variations from dbSNP and Humsavar for C14orf2 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000300711 -- 103,918,979(+) ATTGC(A/G)CCACT intron-variant
rs1000332545 -- 103,912,911(+) ACAGC(A/G)CAAAG intron-variant
rs1000517685 -- 103,919,070(+) CCTAG(C/T)GCCTG intron-variant
rs1000574277 -- 103,918,829(+) CATCC(G/T)GGCTA intron-variant
rs1001677731 -- 103,918,607(+) TGCCC(A/G)CCTCG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf2 Gene

Variant ID Type Subtype PubMed ID
esv2760013 CNV loss 17122850
nsv1054574 CNV loss 25217958

Variation tolerance for C14orf2 Gene

Residual Variation Intolerance Score: 65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.41; 54.44% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C14orf2 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf2 Gene

Disorders for C14orf2 Gene

Relevant External Links for C14orf2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C14orf2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf2 Gene

Publications for C14orf2 Gene

  1. Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning. (PMID: 9653160) Mao M … Chen Z (Proceedings of the National Academy of Sciences of the United States of America 1998) 2 3 4 60
  2. Organization of Subunits in the Membrane Domain of the Bovine F-ATPase Revealed by Covalent Cross-linking. (PMID: 25851905) Lee J … Walker JE (The Journal of biological chemistry 2015) 2 3 60
  3. Population of ATP synthase molecules in mitochondria is limited by available 6.8-kDa proteolipid protein (MLQ). (PMID: 24330338) Fujikawa M … Yoshida M (Genes to cells : devoted to molecular & cellular mechanisms 2014) 2 3 60
  4. Identification of two proteins associated with mammalian ATP synthase. (PMID: 17575325) Meyer B … Schägger H (Molecular & cellular proteomics : MCP 2007) 2 3 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for C14orf2 Gene

Sources for C14orf2 Gene

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