Aliases for C14orf2 Gene
Aliases for C14orf2 Gene
External Ids for C14orf2 Gene
- HGNC: 1188
- Entrez Gene: 9556
- Ensembl: ENSG00000156411
- OMIM: 604573
- UniProtKB: P56378
Previous GeneCards Identifiers for C14orf2 Gene
- GC14M101769
- GC14M098194
- GC14M102368
- GC14M103448
- GC14M104378
- GC14M084559
Summaries for C14orf2 Gene
GeneCards Summary for C14orf2 Gene
C14orf2 (Chromosome 14 Open Reading Frame 2) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf2 Gene
Genomics for C14orf2 Gene
Regulatory Elements for C14orf2 Gene
Enhancers for C14orf2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C14orf2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the C14orf2 gene promoter:
Regulatory Element Products
Genomic Location for C14orf2 Gene
- Chromosome:
- 14
- Start:
- 103,912,288 bp from pter
- End:
- 103,928,269 bp from pter
- Size:
- 15,982 bases
- Orientation:
- Minus strand
Genomic View for C14orf2 Gene
Genes around C14orf2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.33 by Ensembl
- 14q32.33 by Entrez Gene
- 14q32.33 by HGNC
C14orf2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C14orf2 Gene
Proteins for C14orf2 Gene
-
Protein details for C14orf2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P56378-68MP_HUMAN
- Recommended name:
- 6.8 kDa mitochondrial proteolipid
- Protein Accession:
- P56378
- B2R588
- G3V5Q3
- Q86TT7
Protein attributes for C14orf2 Gene
- Size:
- 58 amino acids
- Molecular mass:
- 6662 Da
- Quaternary structure:
-
- Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6, MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68.
- SequenceCaution:
-
- Sequence=EAW81849.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for C14orf2 Gene
Post-translational modifications for C14orf2 Gene
Other Protein References for C14orf2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for C14orf2
- Novus Biologicals Antibodies for C14orf2
-
Abcam antibodies for C14orf2
- Invitrogen Antibodies for C14orf2
- GeneTex C14orf2 antibody for C14orf2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for C14orf2
- Origene Custom Protein Services for C14orf2
- Novus Biologicals proteins for C14orf2
- Search GeneTex for Proteins for C14orf2
Assay Products
No data available for DME Specific Peptides for C14orf2 Gene
Domains & Families for C14orf2 Gene
Protein Domains for C14orf2 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for C14orf2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P56378- Family:
-
- Belongs to the small mitochondrial proteolipid family.
No data available for Gene Families for C14orf2 Gene
Function for C14orf2 Gene
Molecular function for C14orf2 Gene
- GENATLAS Biochemistry:
- chromosome 14 open reading frame 2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003674 | molecular_function | ND | -- |
Phenotypes for C14orf2 Gene
- GenomeRNAi human phenotypes for C14orf2:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C14orf2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C14orf2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf2 gene
- Search ViGene Biosciences for C14orf2
CRISPR Products
-
OriGene CRISPR knockouts for C14orf2
-
Santa Cruz Biotechnology (SCBT) CRISPR for C14orf2
- GenScript: Design CRISPR guide RNA sequences for C14orf2
miRNA for C14orf2 Gene
- miRTarBase miRNAs that target C14orf2
-
- hsa-mir-26b-5p (MIRT028884)
- hsa-mir-6516-5p (MIRT451645)
- hsa-mir-1273e (MIRT451646)
- hsa-mir-455-3p (MIRT451647)
- hsa-mir-6807-5p (MIRT451648)
- hsa-mir-25-5p (MIRT451649)
- hsa-mir-3202 (MIRT451650)
- hsa-mir-4533 (MIRT451651)
- hsa-mir-658 (MIRT451652)
- hsa-mir-6499-3p (MIRT451653)
- hsa-mir-6086 (MIRT451654)
- hsa-mir-377-5p (MIRT451655)
- hsa-mir-219b-3p (MIRT451656)
- hsa-mir-302f (MIRT451657)
- hsa-mir-490-3p (MIRT451658)
- hsa-mir-4468 (MIRT543164)
- hsa-mir-936 (MIRT543165)
- hsa-mir-4461 (MIRT543166)
- hsa-mir-381-3p (MIRT543167)
- hsa-mir-300 (MIRT543168)
- hsa-mir-6882-5p (MIRT543169)
miRNA Products
- Search ViGene Biosciences for C14orf2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C14orf2
- Browse OriGene Inhibitory RNA Products For C14orf2
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C14orf2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C14orf2
-
ViGene Biosciences adenoviral particle packaged cDNA for C14orf2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C14orf2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf2 Gene
Localization for C14orf2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C14orf2 Gene
- Mitochondrion. Mitochondrion membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytosol | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| nucleus | 2 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005575 | cellular_component | ND | -- |
| GO:0005739 | mitochondrion | IEA | -- |
| GO:0005753 | mitochondrial proton-transporting ATP synthase complex | ISS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for C14orf2 Gene
No Data Available
Interacting Proteins for C14orf2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0008150 | biological_process | ND | -- |
No data available for Pathways by source and SIGNOR curated interactions for C14orf2 Gene
Transcripts for C14orf2 Gene
mRNA/cDNA for C14orf2 Gene
- (2) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (404) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C14orf2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C14orf2
-
Santa Cruz Biotechnology (SCBT) CRISPR for C14orf2
- GenScript: Design CRISPR guide RNA sequences for C14orf2
miRNA Products
- Search ViGene Biosciences for C14orf2
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C14orf2
- Browse OriGene Inhibitory RNA Products For C14orf2
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C14orf2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||
| SP2: | - | - | - | ||||||||||||||
| SP3: | - | ||||||||||||||||
| SP4: | |||||||||||||||||
| SP5: |
Expression for C14orf2 Gene
This gene is overexpressed in Stomach (20.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C14orf2 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of C14orf2 Gene:
C14orf2SOURCE GeneReport for Unigene cluster for C14orf2 Gene:
Hs.109052Evidence on tissue expression from TISSUES for C14orf2 Gene
- Blood(4.3)
- Lung(4.3)
- Nervous system(3.2)
- Heart(2.2)
- Muscle(2.2)
Primer Products
-
OriGene qPCR primer pairs for C14orf2
-
OriGene qPCR primer pairs and template standards for C14orf2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf2 Gene
Orthologs for C14orf2 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C14H14orf2 34 |
|
||
| C14orf2 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C21H14orf2 34 |
|
||
| MP68 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C8H14orf2 34 |
|
||
| mouse (Mus musculus) |
Mammalia | 2010107E04Rik 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | C14orf2 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | C14orf2 35 |
|
OneToOne |
- Species where no ortholog for C14orf2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C14orf2 Gene
(5) SIMAP similar genes for C14orf2 Gene using alignment to 1 proteins:
Pseudogenes.org Pseudogenes for C14orf2 Gene
No data available for Paralogs for C14orf2 Gene
Variants for C14orf2 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000300711 | -- | 103,918,979(+) | ATTGC(A/G)CCACT | intron-variant | |
| rs1000332545 | -- | 103,912,911(+) | ACAGC(A/G)CAAAG | intron-variant | |
| rs1000517685 | -- | 103,919,070(+) | CCTAG(C/T)GCCTG | intron-variant | |
| rs1000574277 | -- | 103,918,829(+) | CATCC(G/T)GGCTA | intron-variant | |
| rs1001677731 | -- | 103,918,607(+) | TGCCC(A/G)CCTCG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2760013 | CNV | loss | 17122850 |
| nsv1054574 | CNV | loss | 25217958 |
Residual Variation Intolerance Score:
65.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.41;
54.44% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C14orf2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf2 Gene
Disorders for C14orf2 Gene
Relevant External Links for C14orf2
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- C14orf2
No disorders were found for C14orf2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf2 Gene
Publications for C14orf2 Gene
- Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PMID: 9653160) Mao M. … Chen Z. (Proc. Natl. Acad. Sci. U.S.A. 1998) 2 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64
- Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J. … Shi Y. (Genes Dev. 2015) 3 64
Products for C14orf2 Gene
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- Browse R&D Systems for biochemical assays
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- Custom Antibody ServicesOriGene Antibodies for C14orf2
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- OriGene qPCR primer pairs and template standards for C14orf2
- OriGene qPCR primer pairs for C14orf2
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- GenScript: Design CRISPR guide RNA sequences for C14orf2
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- Novus Biologicals Antibodies for C14orf2
- Novus Biologicals proteins for C14orf2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for C14orf2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C14orf2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C14orf2 gene
- Search ViGene Biosciences for C14orf2
- Horizon Cell Lines for C14orf2
- Cyagen custom Knockout/knockin (KOKI) mouse models for C14orf2
- VectorBuilder custom plasmid, inducible vectors for C14orf2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C14orf2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer