C14orf2 Gene
protein-coding GIFtS: 48
GCID: GC14M104378
|
|
chromosome 14 open reading frame 2
| |
Aliases
for C14orf2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 14 Open Reading Frame 21 2 | | MP681 2 5 | | 6.8 KDa Mitochondrial Proteolipid2 | | PLPM2 |
Export aliases for C14orf2 gene to outside databasesPrevious GC identifers: GC14M101769 GC14M098194 GC14M102368 GC14M103448 GC14M084559 |
Summaries
for C14orf2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C14orf2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C14orf2 gene promoter:
STAT5B STAT1 STAT4 STAT6 STAT1beta STAT5A STAT1alpha Egr-2 STAT2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for C14orf2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q32.33 Ensembl cytogenetic band: 14q32.33 HGNC cytogenetic band: 14q32.33C14orf2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M104378: view genomic region
(about GC identifiers)
Start:
|
104,378,625 bp from pter |
End:
|
104,394,606 bp from pter |
Size:
|
15,982 bases |
Orientation:
|
minus strand |
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Proteins
for C14orf2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: 68MP_HUMAN, P56378 (See
protein sequence)Recommended Name: 6.8 kDa mitochondrial proteolipid Size: 58 amino acids; 6662 Da
Subunit: Component of an ATP synthase complex composed of ATP5F1, ATP5G1, ATP5E, ATP5H, ATP5I, ATP5J, ATP5J2, MT-ATP6,MT-ATP8, ATP5A1, ATP5B, ATP5D, ATP5C1, ATP5O, ATP5L, USMG5 and MP68 (By similarity)
Subcellular location: Mitochondrion (By similarity). Mitochondrion membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=CAD61878.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: B2R588 Q86TT7Explore the universe of human proteins at neXtProt for C14orf2: NX_P56378
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P56378
C14orf2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001120865.1 NP_004885.1
ENSEMBL proteins: ENSP00000286953 ENSP00000452133 ENSP00000452186 ENSP00000401770 ENSP00000452462 ENSP00000450894 ENSP00000451500
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- | | GO:0005739 | mitochondrion |
-- | -- | | GO:0005753 | mitochondrial proton-transporting ATP synthase complex |
ISS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
C14orf2 for ontologies About GeneDecksing
C14orf2 Antibody Products:
Assay Products for C14orf2: |
Protein
Domains /
Families
for C14orf2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C14orf2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P56378ProtoNet protein and cluster: P56378 1 Blocks protein family: IPB012574 Mitochondrial proteolipid
UniProtKB/Swiss-Prot: 68MP_HUMAN, P56378Similarity: Belongs to the small mitochondrial proteolipid family |
Function
for C14orf2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for C14orf2:chromosome 14 open reading frame 2
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for C14orf2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
C14orf2 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for C14orf2:
|
Pathways & Interactions
for C14orf2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C14orf2
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/48 Interacting proteins for C14orf2 (ENSP000004017704) via UniProtKB, MINT, STRING, and/or I2D (see all 48)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
C14orf2 for ontologies About GeneDecksing
|
Drugs & Compounds
for C14orf2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C14orf2
Search CenterWatch for drugs/clinical trials and news about C14orf2 / 68MP
|
Transcripts
for C14orf2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C14orf2 gene (2 alternative transcripts): NM_001127393.1 NM_004894.2 Unigene Cluster for C14orf2: Chromosome 14 open reading frame 2 Hs.109052 [show with all ESTs]Unigene Representative Sequence: AK09277912 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000286953(uc001yoi.4) ENST00000554880 ENST00000555030 ENST00000414262(uc001yoj.4)
ENST00000553430(uc010aww.2 uc001yok.3) ENST00000554287 ENST00000557040
ENST00000553449 ENST00000554089 ENST00000554713 ENST00000557260 ENST00000554528
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): C14orf2 (NM_004894) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C14orf2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf2 |
Additional cDNA sequence: AF054175.1 AF116639.1 AK092779.1 AK309355.1 AK309499.1 AK310120.1 AK312099.1 BC000429.2 BC001944.1 BC047289.1 BC063419.1 BX161388.1 22 DOTS entries: DT.218411 DT.99980551 DT.91656015 DT.120750461 DT.101985711 DT.91756579 DT.120750462 DT.100059537 DT.40215838 DT.120750454 DT.91937107 DT.97856195 DT.100059538 DT.100809981 DT.120750456 DT.95152010 DT.100804777 DT.100853250 DT.120750476 DT.40280154 DT.91756580 DT.120750442 24/404 AceView cDNA sequences (see all 404): BC001944 CA431434 CB125195 AA548236 BX331524 AI264957 AA554533 BC000429 AK092779 AA557186 CB113879 AA635717 AJ712543 CB126437 BI259741 CB106550 AW592487 AV734517 BF219959 BE048299 BM714851 BM763790 BE791161 AI419753
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for C14orf2 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b |
|---|
|
| SP1: | | | | | | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | - | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C14orf2
|
Expression
for C14orf2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C14orf2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAATGGA
About this image
See C14orf2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C14orf2
SOURCE GeneReport for Unigene cluster: Hs.109052
SABiosciences Custom PCR Arrays for C14orf2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C14orf2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat C14orf2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C14orf2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C14orf2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf2 |
Orthologs
for C14orf2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of human and mouse.
Orthologs for C14orf2 gene from 1/7 species (see all 7) About this table
ENSEMBL Gene Tree for C14orf2 (if available)
TreeFam Gene Tree for C14orf2 (if available) |
Paralogs
for C14orf2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C14orf2 gene
5 SIMAP similar genes for C14orf2 using alignment to 2 protein entries: G3V556_HUMAN (see all proteins):MP68 MEFV APCDD1 BCKDHA ZNF195
C14orf2 for paralogs About GeneDecksing
4 Pseudogenes.org Pseudogenes for C14orf2
PGOHUM00000257858 PGOHUM00000244032 PGOHUM00000246594 PGOHUM00000249759
|
Genomic Variants
for C14orf2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C14orf2 (104378625 - 104394606 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C14orf2
1 CNV: 3949 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C14orf2 |
|
Disorders
/ Diseases
for C14orf2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C14orf2 for disorders About GeneDecksing
OMIM gene information: 604573
OMIM disorders: --
2  diseases for C14orf2: About MalaCardsintrahepatic cholangiocarcinoma cholangiocarcinoma
Export disorders for C14orf2 gene to outside databases
|
Publications
for C14orf2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C14orf2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C14orf2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full- length cDNA cloning. (PubMed id 9653160)1, 2, 3 Mao M.... Chen Z. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mapping of transcription start sites of human retina expressed genes. (PubMed id 17286855)1 Roni V.... Wissinger B. (2007)
- Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)1 Wang A.G....Kim N.S. (2006)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1 Zhang Q.-H.... Chen Z. (2000)
|
External Searches for C14orf2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C14orf2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C14orf2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C14orf2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C14orf2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C14orf2 gene:
Search GeneIP for patents involving C14orf2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C14orf2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C14orf2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C14orf2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C14orf2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C14orf2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C14orf2 |
| |
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| | | | Search Tocris compounds for C14orf2 |
| |  |  |  |  | | | | |
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 | | | C14orf2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf2 |
|  |  |  | | | | Search ThermoFisher Antibodies for C14orf2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf2 |
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