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Aliases for C14orf180 Gene

Aliases for C14orf180 Gene

  • Chromosome 14 Open Reading Frame 180 2 3 5
  • C14orf77 3 4
  • NRAC 3 4
  • Nutritionally-Regulated Adipose And Cardiac-Enriched 2
  • Chromosome 14 Open Reading Frame 77 2
  • Transmembrane Protein C14orf180 3

External Ids for C14orf180 Gene

Previous HGNC Symbols for C14orf180 Gene

  • C14orf77

Previous GeneCards Identifiers for C14orf180 Gene

  • GC14P104118
  • GC14P105046
  • GC14P085242

Summaries for C14orf180 Gene

GeneCards Summary for C14orf180 Gene

C14orf180 (Chromosome 14 Open Reading Frame 180) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf180 Gene

Genomics for C14orf180 Gene

Regulatory Elements for C14orf180 Gene

Genomic Location for C14orf180 Gene

Chromosome:
14
Start:
104,579,684 bp from pter
End:
104,590,515 bp from pter
Size:
10,832 bases
Orientation:
Plus strand

Genomic View for C14orf180 Gene

Genes around C14orf180 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf180 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf180 Gene

Proteins for C14orf180 Gene

  • Protein details for C14orf180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N912-NRAC_HUMAN
    Recommended name:
    Nutritionally-regulated adipose and cardiac enriched protein homolog
    Protein Accession:
    Q8N912

    Protein attributes for C14orf180 Gene

    Size:
    160 amino acids
    Molecular mass:
    18051 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C14orf180 Gene

Proteomics data for C14orf180 Gene at MOPED

Post-translational modifications for C14orf180 Gene

No Post-translational modifications

Other Protein References for C14orf180 Gene

No data available for DME Specific Peptides for C14orf180 Gene

Domains & Families for C14orf180 Gene

Protein Domains for C14orf180 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C14orf180 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf180: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C14orf180 Gene

Function for C14orf180 Gene

Phenotypes for C14orf180 Gene

GenomeRNAi human phenotypes for C14orf180:
genes like me logo Genes that share phenotypes with C14orf180: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf180 Gene

Localization for C14orf180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf180 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C14orf180 Gene COMPARTMENTS Subcellular localization image for C14orf180 gene
Compartment Confidence
plasma membrane 4
cytosol 1
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C14orf180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with C14orf180: view

Pathways & Interactions for C14orf180 Gene

SuperPathways for C14orf180 Gene

No Data Available

Interacting Proteins for C14orf180 Gene

Gene Ontology (GO) - Biological Process for C14orf180 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C14orf180 Gene

Drugs & Compounds for C14orf180 Gene

No Compound Related Data Available

Transcripts for C14orf180 Gene

mRNA/cDNA for C14orf180 Gene

Unigene Clusters for C14orf180 Gene

Chromosome 14 open reading frame 180:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf180 Gene

No ASD Table

Relevant External Links for C14orf180 Gene

GeneLoc Exon Structure for
C14orf180
ECgene alternative splicing isoforms for
C14orf180

Expression for C14orf180 Gene

mRNA expression in normal human tissues for C14orf180 Gene

mRNA differential expression in normal tissues according to GTEx for C14orf180 Gene

This gene is overexpressed in Heart - Left Ventricle (x15.0), Heart - Atrial Appendage (x13.3), Adipose - Visceral (Omentum) (x7.4), and Adipose - Subcutaneous (x5.1).

SOURCE GeneReport for Unigene cluster for C14orf180 Gene Hs.153827

genes like me logo Genes that share expression patterns with C14orf180: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for C14orf180 Gene

Orthologs for C14orf180 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C14orf180 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia NRAC 35
  • 75.47 (n)
  • 61.64 (a)
C14orf180 36
  • 60 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC612691 35
  • 77.85 (n)
  • 67.09 (a)
C14orf180 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia A530016L24Rik 35
  • 67.1 (n)
  • 50.65 (a)
A530016L24Rik 16
A530016L24Rik 36
  • 48 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf180 35
  • 98.54 (n)
  • 97.5 (a)
C14orf180 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC691485 35
  • 69.37 (n)
  • 55 (a)
oppossum
(Monodelphis domestica)
Mammalia C14orf180 36
  • 43 (a)
OneToOne
Species with no ortholog for C14orf180:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf180 Gene

ENSEMBL:
Gene Tree for C14orf180 (if available)
TreeFam:
Gene Tree for C14orf180 (if available)

Paralogs for C14orf180 Gene

(1) SIMAP similar genes for C14orf180 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C14orf180: view

No data available for Paralogs for C14orf180 Gene

Variants for C14orf180 Gene

Sequence variations from dbSNP and Humsavar for C14orf180 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1134959 -- 104,589,768(+) CCGAC(C/G)ATCCA utr-variant-3-prime
rs3803318 -- 104,589,022(-) CTCAC(A/G)TGGAC utr-variant-3-prime
rs4270105 -- 104,582,205(+) GCCAG(C/T)GGGCG intron-variant
rs3840007 -- 104,589,336(-) GGGGG(-/G)TCAGA utr-variant-3-prime
rs3840008 -- 104,588,955(-) CCCCC(-/C)ATGTC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for C14orf180 Gene

Variant ID Type Subtype PubMed ID
nsv902371 CNV Loss 21882294
nsv902372 CNV Loss 21882294
nsv902373 CNV Loss 21882294
nsv470676 CNV Loss 18288195
nsv456445 CNV Loss 19166990
dgv2007n71 CNV Gain 21882294
esv2749222 CNV Deletion 23290073
esv2749223 CNV Deletion 23290073

Variation tolerance for C14orf180 Gene

Gene Damage Index Score: 1.54; 29.92% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C14orf180 Gene

HapMap Linkage Disequilibrium report
C14orf180

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf180 Gene

Disorders for C14orf180 Gene

Relevant External Links for C14orf180

Genetic Association Database (GAD)
C14orf180
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C14orf180

No disorders were found for C14orf180 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf180 Gene

Publications for C14orf180 Gene

  1. Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene. (PMID: 23029450) Zhang R. … Abou-Samra A.B. (PLoS ONE 2012) 2 3 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C14orf180 Gene

Sources for C14orf180 Gene

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