Aliases for C14orf180 Gene
Aliases for C14orf180 Gene
External Ids for C14orf180 Gene
- HGNC: 33795
- Entrez Gene: 400258
- Ensembl: ENSG00000184601
- UniProtKB: Q8N912
Previous HGNC Symbols for C14orf180 Gene
- C14orf77
Previous GeneCards Identifiers for C14orf180 Gene
- GC14P104118
- GC14P105046
- GC14P085242
Summaries for C14orf180 Gene
GeneCards Summary for C14orf180 Gene
C14orf180 (Chromosome 14 Open Reading Frame 180) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf180 Gene
Genomics for C14orf180 Gene
Regulatory Elements for C14orf180 Gene
Enhancers for C14orf180 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C14orf180 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the C14orf180 gene promoter:
Regulatory Element Products
Genomic Location for C14orf180 Gene
- Chromosome:
- 14
- Start:
- 104,579,684 bp from pter
- End:
- 104,590,515 bp from pter
- Size:
- 10,832 bases
- Orientation:
- Plus strand
Genomic View for C14orf180 Gene
Genes around C14orf180 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.33 by Ensembl
- 14q32.33 by Entrez Gene
- 14q32.33 by HGNC
C14orf180 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C14orf180 Gene
Proteins for C14orf180 Gene
-
Protein details for C14orf180 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N912-NRAC_HUMAN
- Recommended name:
- Nutritionally-regulated adipose and cardiac enriched protein homolog
- Protein Accession:
- Q8N912
Protein attributes for C14orf180 Gene
- Size:
- 160 amino acids
- Molecular mass:
- 18051 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for C14orf180 Gene
No Post-translational modifications
Other Protein References for C14orf180 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C14orf180
-
Abcam antibodies for C14orf180
- GeneTex C14orf180 antibody for C14orf180
Protein Products
-
OriGene Purified Proteins for C14orf180
- Search Origene for MassSpec and Protein Over-expression Lysates for C14orf180
- Origene Custom Protein Services for C14orf180
- Novus Biologicals lysates for C14orf180
- Search GeneTex for Proteins for C14orf180
Assay Products
No data available for DME Specific Peptides for C14orf180 Gene
Domains & Families for C14orf180 Gene
Suggested Antigen Peptide Sequences for C14orf180 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families and UniProtKB/Swiss-Prot for C14orf180 Gene
Function for C14orf180 Gene
Phenotypes for C14orf180 Gene
- GenomeRNAi human phenotypes for C14orf180:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C14orf180
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C14orf180 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf180 gene
- Search ViGene Biosciences for C14orf180
CRISPR Products
-
OriGene CRISPR knockouts for C14orf180
-
Santa Cruz Biotechnology (SCBT) CRISPR for C14orf180
- GenScript: Design CRISPR guide RNA sequences for C14orf180
miRNA for C14orf180 Gene
- miRTarBase miRNAs that target C14orf180
-
- hsa-mir-670-5p (MIRT642595)
- hsa-mir-642b-5p (MIRT642596)
- hsa-mir-139-3p (MIRT642597)
- hsa-mir-6754-3p (MIRT642598)
- hsa-mir-4786-5p (MIRT642599)
- hsa-mir-412-3p (MIRT642600)
- hsa-mir-6791-5p (MIRT642601)
- hsa-mir-1266-3p (MIRT642602)
- hsa-mir-4292 (MIRT642603)
- hsa-mir-6765-3p (MIRT642604)
- hsa-mir-3622b-3p (MIRT642605)
- hsa-mir-3622a-3p (MIRT642606)
- hsa-mir-1255b-2-3p (MIRT642607)
miRNA Products
- Search ViGene Biosciences for C14orf180
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C14orf180
- Browse OriGene Inhibitory RNA Products For C14orf180
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf180 gene
Clone Products
-
OriGene ORF clones in human for C14orf180
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C14orf180
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf180
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C14orf180
-
ViGene Biosciences adenoviral particle packaged cDNA for C14orf180 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C14orf180 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf180 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf180 Gene
Localization for C14orf180 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C14orf180 Gene
- Cell membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 4 |
| extracellular | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005886 | plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
Transcripts for C14orf180 Gene
mRNA/cDNA for C14orf180 Gene
- (5) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (15) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C14orf180 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C14orf180
-
Santa Cruz Biotechnology (SCBT) CRISPR for C14orf180
- GenScript: Design CRISPR guide RNA sequences for C14orf180
miRNA Products
- Search ViGene Biosciences for C14orf180
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C14orf180
- Browse OriGene Inhibitory RNA Products For C14orf180
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf180 gene
Clone Products
-
OriGene ORF clones in human for C14orf180
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C14orf180
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf180
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for C14orf180 Gene
mRNA differential expression in normal tissues according to GTEx for C14orf180 Gene
This gene is overexpressed in Heart - Left Ventricle (x15.0), Heart - Atrial Appendage (x13.3), Adipose - Visceral (Omentum) (x7.4), and Adipose - Subcutaneous (x5.1).
NURSA nuclear receptor signaling pathways regulating expression of C14orf180 Gene:
C14orf180SOURCE GeneReport for Unigene cluster for C14orf180 Gene:
Hs.153827Evidence on tissue expression from TISSUES for C14orf180 Gene
- Heart(4.3)
- Nervous system(4)
Primer Products
-
OriGene qPCR primer pairs for C14orf180
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf180 Gene
Orthologs for C14orf180 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C14H14orf180 34 |
|
||
| C14orf180 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | LOC612691 34 |
|
||
| C14orf180 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | NRAC 34 |
|
||
| C14orf180 35 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | LOC691485 34 |
|
||
| mouse (Mus musculus) |
Mammalia | A530016L24Rik 34 16 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | C14orf180 35 |
|
OneToOne |
- Species where no ortholog for C14orf180 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C14orf180 Gene
(1) SIMAP similar genes for C14orf180 Gene using alignment to 1 proteins:
No data available for Paralogs for C14orf180 Gene
Variants for C14orf180 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000182284 | -- | 104,578,699(+) | GGTGG(C/G)TTCCA | upstream-variant-2KB | |
| rs1000817289 | -- | 104,584,771(+) | TGATC(C/T)GGCGA | intron-variant | |
| rs1001037569 | -- | 104,584,950(+) | ACTGC(A/G)GTATC | intron-variant | |
| rs1001182520 | -- | 104,579,757(+) | GGGAC(A/G)AAGGC | upstream-variant-2KB, utr-variant-5-prime | |
| rs1001235503 | -- | 104,586,948(+) | ACTGC(C/T)AGGCT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2749222 | CNV | deletion | 23290073 |
| esv2749223 | CNV | deletion | 23290073 |
| esv2761599 | CNV | gain | 21179565 |
| esv3635623 | CNV | gain | 21293372 |
| nsv1054574 | CNV | loss | 25217958 |
| nsv456445 | CNV | loss | 19166990 |
| nsv470676 | CNV | loss | 18288195 |
| nsv566047 | CNV | loss | 21841781 |
| nsv952271 | CNV | deletion | 24416366 |
Gene Damage Index Score:
1.54;
29.92% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C14orf180 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C14orf180
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf180 Gene
Disorders for C14orf180 Gene
Relevant External Links for C14orf180
No disorders were found for C14orf180 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf180 Gene
Publications for C14orf180 Gene
- Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene. (PMID: 23029450) Zhang R. … Abou-Samra A.B. (PLoS ONE 2012) 2 3 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
Products for C14orf180 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
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- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for C14orf180
- Search Origene for MassSpec and Protein Over-expression Lysates for C14orf180
- Origene Custom Protein Services for C14orf180
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C14orf180
- Browse OriGene Inhibitory RNA Products For C14orf180
- OriGene qPCR primer pairs for C14orf180
- OriGene CRISPR knockouts for C14orf180
- OriGene ORF clones in human for C14orf180
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For C14orf180
- GenScript: Next-day shipping cDNA ORF clone for C14orf180 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for C14orf180
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- GenScript: Design CRISPR guide RNA sequences for C14orf180
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- Novus Biologicals Antibodies for C14orf180
- Novus Biologicals lysates for C14orf180
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for C14orf180 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C14orf180 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C14orf180 gene
- Search ViGene Biosciences for C14orf180
- Horizon Cell Lines for C14orf180
- Cyagen custom Knockout/knockin (KOKI) mouse models for C14orf180
- VectorBuilder custom plasmid, inducible vectors for C14orf180
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf180
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C14orf180 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
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- (122) diseasecard
- (123) NIH Rare Diseases
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- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer