Aliases for C14orf178 Gene
External Ids for C14orf178 Gene
- HGNC: 26385
- Entrez Gene: 283579
- Ensembl: ENSG00000197734
- UniProtKB: Q8N769
Previous GeneCards Identifiers for C14orf178 Gene
- GC14P077297
- GC14P078226
- GC14P058393
Summaries for C14orf178 Gene
GeneCards Summary for C14orf178 Gene
C14orf178 (Chromosome 14 Open Reading Frame 178) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf178 Gene
Genomics for C14orf178 Gene
Regulatory Elements for C14orf178 Gene
Enhancers for C14orf178 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH14G077799 | 1.1 | ENCODE | 19.6 | +39.5 | 39455 | 1.5 | HNRNPUL1 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 | C14orf178 RPL21P10 ADCK1 GC14M077822 ENSG00000199440 |
| GH14G077759 | 1 | ENCODE | 21.4 | +0.1 | 109 | 2.5 | PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207 ZNF143 | C14orf178 RPL21P10 ADCK1 SNW1 |
| GH14G077795 | 1 | Ensembl ENCODE | 17.6 | +35.4 | 35423 | 1.5 | GTF2F1 TEAD1 JUN HLF MAX CEBPB CEBPG EP300 TEAD3 JUND | C14orf178 SLIRP ADCK1 SNW1 |
| GH14G077729 | 0.6 | ENCODE | 26.5 | -29.9 | -29940 | 2.0 | PAF1 CTCF NFIC NFIB SMC3 RAD21 MAFK | ADCK1 C14orf178 SNW1 SLIRP ALKBH1 RPL21P10 |
| GH14G077663 | 1.1 | FANTOM5 Ensembl ENCODE | 13.4 | -97.1 | -97128 | 0.9 | PKNOX1 ESRRA CEBPB MNT CTBP1 ZFHX2 FOS FOSL2 EGR2 | ADCK1 C14orf178 SLIRP SNW1 RPL21P10 GC14P077671 COX6CP11 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C14orf178 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for C14orf178 Gene
- Chromosome:
- 14
- Start:
- 77,760,830 bp from pter
- End:
- 77,769,742 bp from pter
- Size:
- 8,913 bases
- Orientation:
- Plus strand
Genomic View for C14orf178 Gene
Genes around C14orf178 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q24.3 by Ensembl
- 14q24.3 by Entrez Gene
- 14q24.3 by HGNC
C14orf178 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C14orf178 Gene
Proteins for C14orf178 Gene
-
Protein details for C14orf178 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N769-CN178_HUMAN
- Recommended name:
- Uncharacterized protein C14orf178
- Protein Accession:
- Q8N769
- Q2HIX2
- Q3KNR7
Protein attributes for C14orf178 Gene
- Size:
- 122 amino acids
- Molecular mass:
- 13377 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for C14orf178 Gene
No Post-translational modifications
Other Protein References for C14orf178 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C14orf178
- Invitrogen Antibodies for C14orf178
- Search GeneTex for Antibodies for C14orf178
Protein Products
-
OriGene Purified Proteins for C14orf178
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- Novus Biologicals proteins for C14orf178
- Search GeneTex for Proteins for C14orf178
Assay Products
No data available for DME Specific Peptides for C14orf178 Gene
Domains & Families for C14orf178 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C14orf178 Gene
Function for C14orf178 Gene
Phenotypes for C14orf178 Gene
- GenomeRNAi human phenotypes for C14orf178:
Animal Model Products
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for C14orf178 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf178 gene
- Search ViGene Biosciences for C14orf178
CRISPR Products
-
OriGene CRISPR knockouts for C14orf178
-
Santa Cruz Biotechnology (SCBT) CRISPR for C14orf178
- GenScript: Design CRISPR guide RNA sequences for C14orf178
miRNA for C14orf178 Gene
- miRTarBase miRNAs that target C14orf178
miRNA Products
- Search ViGene Biosciences for C14orf178
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C14orf178
- Browse OriGene Inhibitory RNA Products For C14orf178
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf178 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for C14orf178
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C14orf178
-
ViGene Biosciences adenoviral particle packaged cDNA for C14orf178 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C14orf178 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf178 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf178 Gene
Localization for C14orf178 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 2 |
| nucleus | 2 |
| peroxisome | 1 |
| cytosol | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C14orf178 Gene
Pathways & Interactions for C14orf178 Gene
No Data Available
Interacting Proteins for C14orf178 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| SETX |
No data available for Pathways by source and SIGNOR curated interactions for C14orf178 Gene
Transcripts for C14orf178 Gene
mRNA/cDNA for C14orf178 Gene
- (2) REFSEQ mRNAs :
- (2) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for C14orf178
-
Santa Cruz Biotechnology (SCBT) CRISPR for C14orf178
- GenScript: Design CRISPR guide RNA sequences for C14orf178
miRNA Products
- Search ViGene Biosciences for C14orf178
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C14orf178
- Browse OriGene Inhibitory RNA Products For C14orf178
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf178 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for C14orf178
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf178
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for C14orf178 Gene
mRNA differential expression in normal tissues according to GTEx for C14orf178 Gene
This gene is overexpressed in Testis (x9.8).
NURSA nuclear receptor signaling pathways regulating expression of C14orf178 Gene:
C14orf178SOURCE GeneReport for Unigene cluster for C14orf178 Gene:
Hs.375834Primer Products
-
OriGene qPCR primer pairs for C14orf178
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf178 Gene
Orthologs for C14orf178 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C14H14orf178 34 |
|
||
| C14orf178 35 |
|
OneToOne |
- Species where no ortholog for C14orf178 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C14orf178 Gene
(20) SIMAP similar genes for C14orf178 Gene using alignment to 2 proteins:
No data available for Paralogs for C14orf178 Gene
Variants for C14orf178 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000131949 | -- | 77,768,943(+) | ACAAG(A/G)TATTC | intron-variant | |
| rs1000324914 | -- | 77,769,859(+) | GACGG(A/G)CACAG | downstream-variant-500B | |
| rs1000367442 | -- | 77,763,762(+) | ACTGA(C/T)TTTAA | intron-variant | |
| rs1000503936 | -- | 77,769,276(+) | GGTGC(A/G)ATCAC | intron-variant | |
| rs1000886780 | -- | 77,763,405(+) | ATAGA(A/G)CGTCC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2759998 | CNV | gain | 17122850 |
Residual Variation Intolerance Score:
64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.65;
56.85% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C14orf178 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C14orf178
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf178 Gene
Disorders for C14orf178 Gene
Relevant External Links for C14orf178
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- C14orf178
No disorders were found for C14orf178 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf178 Gene
Publications for C14orf178 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 64
Products for C14orf178 Gene
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- OriGene qPCR primer pairs for C14orf178
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- Novus Biologicals Antibodies for C14orf178
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- Invitrogen Antibodies for C14orf178
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- Horizon Cell Lines for C14orf178
- Cyagen custom Knockout/knockin (KOKI) mouse models for C14orf178
- VectorBuilder custom plasmid, inducible vectors for C14orf178
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf178
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C14orf178 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
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- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (135) Gene Damage Index
- (136) ViGene Biosciences
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer