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Aliases for C14orf177 Gene

Aliases for C14orf177 Gene

  • Chromosome 14 Open Reading Frame 177 2 3 5

External Ids for C14orf177 Gene

Previous GeneCards Identifiers for C14orf177 Gene

  • GC14P098250
  • GC14P099177
  • GC14P079360

Summaries for C14orf177 Gene

GeneCards Summary for C14orf177 Gene

C14orf177 (Chromosome 14 Open Reading Frame 177) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf177 Gene

Genomics for C14orf177 Gene

Regulatory Elements for C14orf177 Gene

Enhancers for C14orf177 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F099190 1.5 FANTOM5 Ensembl ENCODE 16 +480.3 480303 2.6 HDGF INSM2 KLF17 GLI4 ZNF2 RAD21 ZNF354C ZNF366 SCRT2 ZNF416 ENSG00000229402 ENSG00000258383 ENSG00000237342 ENSG00000258672 ENSG00000258560 ENSG00000259097 C14orf177 ENSG00000234648 RPL3P4 BCL11B
GH14F099550 1.3 Ensembl ENCODE 16.2 +841.8 841772 6.0 MLX ZNF493 ARID4B DMAP1 ZNF48 YY1 ZNF143 FOS ZNF263 SP5 ENSG00000258672 ENSG00000258383 ENSG00000229402 ENSG00000258560 ENSG00000237342 RN7SL523P C14orf177 MIR6764 WDR25 CCDC85C
GH14F098684 0.2 ENCODE 12.1 -27.0 -26955 0.2 C14orf177 GC14M098582
GH14F098682 0.2 ENCODE 12.1 -29.4 -29375 0.2 C14orf177 GC14M098582
GH14F098274 0.3 FANTOM5 1.3 -436.9 -436908 0.0 C14orf177 LOC105370656 RN7SL714P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C14orf177 on UCSC Golden Path with GeneCards custom track

Genomic Location for C14orf177 Gene

98,711,613 bp from pter
98,717,766 bp from pter
6,154 bases
Plus strand

Genomic View for C14orf177 Gene

Genes around C14orf177 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf177 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf177 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf177 Gene

Proteins for C14orf177 Gene

  • Protein details for C14orf177 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative uncharacterized protein C14orf177
    Protein Accession:
    Secondary Accessions:
    • Q8N7D2

    Protein attributes for C14orf177 Gene

    125 amino acids
    Molecular mass:
    13861 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C14orf177 Gene

Post-translational modifications for C14orf177 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C14orf177 Gene

No data available for DME Specific Peptides for C14orf177 Gene

Domains & Families for C14orf177 Gene

Protein Domains for C14orf177 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf177: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C14orf177 Gene

Function for C14orf177 Gene

genes like me logo Genes that share phenotypes with C14orf177: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C14orf177 Gene

Localization for C14orf177 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf177 gene
Compartment Confidence
nucleus 3
extracellular 2
plasma membrane 1
mitochondrion 1
peroxisome 1
cytosol 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C14orf177 Gene

Pathways & Interactions for C14orf177 Gene

SuperPathways for C14orf177 Gene

No Data Available

Interacting Proteins for C14orf177 Gene

Gene Ontology (GO) - Biological Process for C14orf177 Gene


No data available for Pathways by source and SIGNOR curated interactions for C14orf177 Gene

Transcripts for C14orf177 Gene

mRNA/cDNA for C14orf177 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C14orf177 Gene

Chromosome 14 open reading frame 177:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf177 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -

Relevant External Links for C14orf177 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C14orf177 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C14orf177 Gene

mRNA differential expression in normal tissues according to GTEx for C14orf177 Gene

This gene is overexpressed in Testis (x50.0).

NURSA nuclear receptor signaling pathways regulating expression of C14orf177 Gene:


SOURCE GeneReport for Unigene cluster for C14orf177 Gene:

genes like me logo Genes that share expression patterns with C14orf177: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C14orf177 Gene

Orthologs for C14orf177 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C14orf177 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C14orf177 35
  • 98 (a)
C14H14orf177 34
  • 97.87 (n)
Species where no ortholog for C14orf177 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf177 Gene

Gene Tree for C14orf177 (if available)
Gene Tree for C14orf177 (if available)

Paralogs for C14orf177 Gene

No data available for Paralogs for C14orf177 Gene

Variants for C14orf177 Gene

Sequence variations from dbSNP and Humsavar for C14orf177 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10139538 -- 98,718,176(+) gcgga(A/T)cacct downstream-variant-500B
rs10140386 -- 98,714,967(+) AAGAC(A/C)AGCGC intron-variant
rs111296774 -- 98,718,222(+) GGGAA(A/T)CTACG downstream-variant-500B
rs111421144 -- 98,715,078(+) TCCAG(A/G)ATCCA intron-variant
rs111546908 -- 98,711,186(+) AGACA(C/G)GGTTT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C14orf177 Gene

Variant ID Type Subtype PubMed ID
dgv1968n100 CNV loss 25217958
dgv3870n54 CNV loss 21841781
dgv3871n54 CNV loss 21841781
dgv419e214 CNV loss 21293372
esv2665034 CNV deletion 23128226
esv2761555 CNV loss 21179565
esv3552032 CNV deletion 23714750
esv3581403 CNV loss 25503493
esv3635469 CNV gain 21293372
esv3635472 CNV gain 21293372
nsv456417 CNV loss 19166990
nsv516436 CNV loss 19592680

Variation tolerance for C14orf177 Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C14orf177 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf177 Gene

Disorders for C14orf177 Gene

Relevant External Links for C14orf177

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C14orf177 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf177 Gene

Publications for C14orf177 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy. (PMID: 23118302) Chu A.Y. … Ridker P.M. (Circ Cardiovasc Genet 2012) 3 64
  5. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64

Products for C14orf177 Gene

Sources for C14orf177 Gene

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