Aliases for C14orf177 Gene
External Ids for C14orf177 Gene
- HGNC: 26375
- Entrez Gene: 283598
- Ensembl: ENSG00000176605
- UniProtKB: Q52M58
Previous GeneCards Identifiers for C14orf177 Gene
- GC14P098250
- GC14P099177
- GC14P079360
Summaries for C14orf177 Gene
GeneCards Summary for C14orf177 Gene
C14orf177 (Chromosome 14 Open Reading Frame 177) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf177 Gene
Genomics for C14orf177 Gene
Regulatory Elements for C14orf177 Gene
Enhancers for C14orf177 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH14G098682 | 0.4 | ENCODE | 12.1 | -29.4 | -29375 | 0.2 | ATF2 | C14orf177 GC14M098582 |
| GH14G099190 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 1.4 | +480.3 | 480279 | 2.5 | HDGF GLI4 ZNF2 ZNF416 YY2 REST ZNF610 ZSCAN16 ZNF658 MYNN | HHIPL1 ENSG00000234648 RPL3P4 BCL11B C14orf177 GC14M099194 GC14M099192 GC14P099185 |
| GH14G098684 | 0.2 | ENCODE | 12.1 | -27.0 | -26955 | 0.2 | C14orf177 GC14M098582 | |
| GH14G098274 | 0.3 | FANTOM5 | 1.3 | -436.9 | -436908 | 0.0 | C14orf177 LOC105370656 RN7SL714P | |
| GH14G098798 | 0.7 | ENCODE | 0.2 | +86.6 | 86646 | 0.2 | PKNOX1 FEZF1 ZBTB8A ATF2 OSR2 ZFP69B CTBP1 PRDM6 ZNF544 GLI2 | GC14P098810 C14orf177 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C14orf177 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the C14orf177 gene promoter:
Regulatory Element Products
Genomic Location for C14orf177 Gene
- Chromosome:
- 14
- Start:
- 98,711,613 bp from pter
- End:
- 98,717,766 bp from pter
- Size:
- 6,154 bases
- Orientation:
- Plus strand
Genomic View for C14orf177 Gene
Genes around C14orf177 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q32.2 by Ensembl
- 14q32.2 by Entrez Gene
- 14q32.2 by HGNC
C14orf177 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C14orf177 Gene
Proteins for C14orf177 Gene
-
Protein details for C14orf177 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q52M58-CN177_HUMAN
- Recommended name:
- Putative uncharacterized protein C14orf177
- Protein Accession:
- Q52M58
- Q8N7D2
Protein attributes for C14orf177 Gene
- Size:
- 125 amino acids
- Molecular mass:
- 13861 Da
- Quaternary structure:
- No Data Available
Post-translational modifications for C14orf177 Gene
Other Protein References for C14orf177 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for C14orf177
- Novus Biologicals Antibodies for C14orf177
-
Abcam antibodies for C14orf177
- Invitrogen Antibodies for C14orf177
- Search GeneTex for Antibodies for C14orf177
Protein Products
-
OriGene Purified Proteins for C14orf177
- Search Origene for MassSpec and Protein Over-expression Lysates for C14orf177
- Origene Custom Protein Services for C14orf177
- Search GeneTex for Proteins for C14orf177
Assay Products
No data available for DME Specific Peptides for C14orf177 Gene
Domains & Families for C14orf177 Gene
Protein Domains for C14orf177 Gene
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C14orf177 Gene
Function for C14orf177 Gene
Phenotypes for C14orf177 Gene
- GenomeRNAi human phenotypes for C14orf177:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C14orf177
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C14orf177 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf177 gene
- Search ViGene Biosciences for C14orf177
CRISPR Products
-
OriGene CRISPR knockouts for C14orf177
-
Santa Cruz Biotechnology (SCBT) CRISPR for C14orf177
- GenScript: Design CRISPR guide RNA sequences for C14orf177
miRNA Products
- Search ViGene Biosciences for C14orf177
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C14orf177
- Browse OriGene Inhibitory RNA Products For C14orf177
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf177 gene
Clone Products
-
OriGene ORF clones in human for C14orf177
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- VectorBuilder custom plasmid, inducible vectors for C14orf177
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf177
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C14orf177
-
ViGene Biosciences adenoviral particle packaged cDNA for C14orf177 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C14orf177 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf177 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C14orf177 Gene
Localization for C14orf177 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| extracellular | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| peroxisome | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C14orf177 Gene
Transcripts for C14orf177 Gene
mRNA/cDNA for C14orf177 Gene
- (3) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (4) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C14orf177 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C14orf177
-
Santa Cruz Biotechnology (SCBT) CRISPR for C14orf177
- GenScript: Design CRISPR guide RNA sequences for C14orf177
miRNA Products
- Search ViGene Biosciences for C14orf177
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C14orf177
- Browse OriGene Inhibitory RNA Products For C14orf177
-
ViGene Biosciences ready-to-package AAV shRNAs for C14orf177 gene
Clone Products
-
OriGene ORF clones in human for C14orf177
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C14orf177
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf177
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: |
Expression for C14orf177 Gene
mRNA differential expression in normal tissues according to GTEx for C14orf177 Gene
This gene is overexpressed in Testis (x50.0).
NURSA nuclear receptor signaling pathways regulating expression of C14orf177 Gene:
C14orf177SOURCE GeneReport for Unigene cluster for C14orf177 Gene:
Hs.448754Primer Products
-
OriGene qPCR primer pairs for C14orf177
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf177 Gene
Orthologs for C14orf177 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C14orf177 35 |
|
OneToOne | |
| C14H14orf177 34 |
|
- Species where no ortholog for C14orf177 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C14orf177 Gene
No data available for Paralogs for C14orf177 Gene
Variants for C14orf177 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000215979 | -- | 98,713,745(+) | GCAGA(C/G)TTTGC | intron-variant | |
| rs1000298787 | -- | 98,711,043(+) | CAGGC(A/T)GGAGT | upstream-variant-2KB | |
| rs1000315136 | -- | 98,713,457(+) | CTGTA(A/C)TCCAG | intron-variant | |
| rs1000416042 | -- | 98,716,672(+) | CATGA(C/T)TGACG | intron-variant | |
| rs1000473314 | -- | 98,716,874(+) | GCATT(C/T)GATAG | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1968n100 | CNV | loss | 25217958 |
| dgv3870n54 | CNV | loss | 21841781 |
| dgv3871n54 | CNV | loss | 21841781 |
| dgv419e214 | CNV | loss | 21293372 |
| esv2665034 | CNV | deletion | 23128226 |
| esv2761555 | CNV | loss | 21179565 |
| esv3552032 | CNV | deletion | 23714750 |
| esv3581403 | CNV | loss | 25503493 |
| esv3635469 | CNV | gain | 21293372 |
| esv3635472 | CNV | gain | 21293372 |
| nsv456417 | CNV | loss | 19166990 |
| nsv516436 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.00;
49.85% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C14orf177 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C14orf177
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf177 Gene
Disorders for C14orf177 Gene
Relevant External Links for C14orf177
No disorders were found for C14orf177 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf177 Gene
Publications for C14orf177 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy. (PMID: 23118302) Chu A.Y. … Ridker P.M. (Circ Cardiovasc Genet 2012) 3 64
- Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
Products for C14orf177 Gene
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- Custom Antibody ServicesOriGene Antibodies for C14orf177
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- OriGene Purified Proteins for C14orf177
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- OriGene qPCR primer pairs for C14orf177
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- Novus Biologicals Antibodies for C14orf177
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- Invitrogen Antibodies for C14orf177
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for C14orf177 gene
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- Search ViGene Biosciences for C14orf177
- Horizon Cell Lines for C14orf177
- Cyagen custom Knockout/knockin (KOKI) mouse models for C14orf177
- VectorBuilder custom plasmid, inducible vectors for C14orf177
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf177
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C14orf177 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
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- (118) ClinicalTrials
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- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
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- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
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- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
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- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer