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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C14orf177 Gene

protein-coding   GIFtS: 38
GCID: GC14P099177          (predicted)

Chromosome 14 Open Reading Frame 177

  Search for C14orf177
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 14 Open Reading Frame 1771 2
Putative Uncharacterized Protein C14orf1772

External Ids:    HGNC: 263751   Entrez Gene: 2835982   Ensembl: ENSG000001766057   UniProtKB: Q52M583   

Export aliases for C14orf177 gene to outside databases

Previous GC identifers: GC14P098250 GC14P079360


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C14orf177 Gene: 
C14orf177 (chromosome 14 open reading frame 177) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C14orf177 gene promoter:
         Sox5   POU3F2 (N-Oct-5a)   CUTL1   POU3F2   E47   Evi-1   Nkx6-1   FOXJ2 (long isoform)   FOXJ2   Pax-4a   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C14orf177

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf177


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

C14orf177 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf177 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P099177:  view genomic region     (about GC identifiers)

Start:
99,177,950 bp from pter      End:
99,184,103 bp from pter
Size:
6,154 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CN177_HUMAN, Q52M58 (See protein sequence)
Recommended Name: Putative uncharacterized protein C14orf177  
Size: 125 amino acids; 13861 Da
Secondary accessions: Q8N7D2

Explore the universe of human proteins at neXtProt for C14orf177: NX_Q52M58

Explore proteomics data for C14orf177 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q52M58

  • C14orf177 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C14orf177 Protein Expression
    REFSEQ proteins: NP_872366.2  
    ENSEMBL proteins: 
     ENSP00000321360   ENSP00000440687  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q52M58


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         2 GenomeRNAi human phenotypes for C14orf177:
     Increased gamma-H2AX phosphory  Increased number of cells in m 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for C14orf177 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C14orf177

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C14orf177 (CN177)

    Search CenterWatch for drugs/clinical trials and news about C14orf177 / CN177

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C14orf177 gene: 
    NM_182560.2  

    Unigene Cluster for C14orf177:

    Chromosome 14 open reading frame 177
    Hs.448754  [show with all ESTs]
    Unigene Representative Sequence: NM_182560
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000325812(uc001yfz.2) ENST00000541516 ENST00000546029
    miRNA
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    Additional mRNA sequence: 

    AK098639.1 BC093661.1 

    2 DOTS entries:

    DT.75164330  DT.40279264 

    4 AceView cDNA sequences:

    NM_182560 AK098639 AA436123 AI130802 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for C14orf177    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
    SP1:                    -                     
    SP2:                                          


    ECgene alternative splicing isoforms for C14orf177

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C14orf177 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGTAATAGC
    C14orf177 Expression
    About this image


    See C14orf177 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.448754
        SABiosciences Custom PCR Arrays for C14orf177
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf177

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and chimp.

    Orthologs for C14orf177 gene from 1 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia C14H14orf1771 chromosome 14 open reading frame, human C14orf177 97.87(n)
    98.4(a)
      742332  XM_001156575.1  XP_001156575.1 


    ENSEMBL Gene Tree for C14orf177 (if available)
    TreeFam Gene Tree for C14orf177 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/237 SNPs in C14orf177 are shown (see all 237)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs80088981,2
    C,F,A,H--99175956(+) AATCTG/TCAGAG 1 -- us2k118Minor allele frequency- T:0.34NA NS EA WA CSA 930
    rs1139917611,2
    F--99175988(+) TCCTCC/TCCATT 1 -- us2k12Minor allele frequency- T:0.06CSA WA 120
    rs175311321,2
    C,F--99176022(+) CCAGCT/ATGTTT 1 -- us2k14Minor allele frequency- A:0.02NA 262
    rs1928902771,2
    --99176070(+) ATCAAA/GTAATA 1 -- us2k10--------
    rs1844853251,2
    --99176138(+) CATATA/TTCTTT 1 -- us2k10--------
    rs1893631051,2
    --99176152(+) CTAAAA/GTACAT 1 -- us2k10--------
    rs1807614901,2
    --99176179(+) TTTTCG/TGGTTA 1 -- us2k10--------
    rs1467727511,2
    --99176363(+) TTCATC/TTGTCA 1 -- us2k10--------
    rs1489312631,2
    C--99176386(+) ACTTAC/TTTGAT 1 -- us2k10--------
    rs767796981,2
    --99176421(+) AAATCC/TATTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C14orf177 (99177950 - 99184103 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for C14orf177:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2665034CNV Deletion23128226
    nsv516436CNV Loss19592680
    nsv456417CNV Loss19166990

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    C14orf177 for disorders           About MalaCards

    C14orf177 for disorders           About GeneDecksing

    Genetic Association Database (GAD): C14orf177

    Export disorders for C14orf177 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C14orf177 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C14orf177)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    5. Genome-wide association study evaluating lipoprotein-a ssociated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy. (PubMed id 23118302)1 Chu A.Y....Ridker P.M. (2012)
    6. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)1 Yang Q....O'Donnell C.J. (2007)
    7. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PubMed id 17903307)4 Wilk J.B....O'Connor G.T. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 283598 HGNC: 26375 AceView: FLJ25773 Ensembl:ENSG00000176605 euGenes: HUgn283598
    ECgene: C14orf177 H-InvDB: C14orf177

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C14orf177 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C14orf177 gene:
    Search GeneIP for patents involving C14orf177

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Proteins for C14orf177
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     Gene Synthesis
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf177
     SwitchGear 3'UTR luciferase reporter plasmids for C14orf177
     Browse SwitchGear Promoter luciferase reporter plasmids for C14orf177
     Search ThermoFisher Antibodies for C14orf177
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf177
     inGenious Targeting Laboratory - Custom generated mouse model solutions for C14orf177
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C14orf177
    Customized:
     lentivirus for stable overexpression of C14orf177
     lentivirus expression plasmids for stable overexpression of C14orf177
     adenovirus for overexpression of C14orf177
     LSBio Antibodies in human, mouse, rat for C14orf177
    Customized transgenic rodents for:
     Humanization
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
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