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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C14orf169 Gene

protein-coding   GIFtS: 41
GCID: GC14P073958

Chromosome 14 Open Reading Frame 169

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 14 Open Reading Frame 1691 2     ROX2 3
Myc-Associated Protein With JmjC Domain1 2 3     hsNO662 3
Nucleolar Protein 661 2 3     NO662 5
MAPJD2 3 5     Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase NO662
Histone Lysine Demethylase NO662 3     Lysine-Specific Demethylase NO662
Ribosomal Oxygenase NO662 3     EC 1.14.11.-3
60S Ribosomal Protein L8 Histidine Hydroxylase2 3     EC 1.14.11.273

External Ids:    HGNC: 209681   Entrez Gene: 796972   Ensembl: ENSG000002552427   OMIM: 6119195   UniProtKB: Q9H6W33   

Export aliases for C14orf169 gene to outside databases

Previous GC identifers: GC14P071948 GC14P071949 GC14P073027 GC14P054124


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C14orf169 Gene: 
C14orf169 (chromosome 14 open reading frame 169) is a protein-coding gene. Diseases associated with C14orf169 include lung cancer. GO annotations related to this gene include oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors and iron ion binding.

UniProtKB/Swiss-Prot: NO66_HUMAN, Q9H6W3
Function: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role
in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4'
(H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the
hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its
interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter
activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of
certain heterochromatic region. Participates in MYC-induced transcriptional activation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C14orf169 gene promoter:
         USF1   Pax-2b   USF-1   Nkx2-2   Pax-6   Pax-2   Pax-2a   ITF-2   Tal-1beta   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C14orf169

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf169


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

C14orf169 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf169 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P073958:  view genomic region     (about GC identifiers)

Start:
73,957,644 bp from pter      End:
73,960,105 bp from pter
Size:
2,462 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: NO66_HUMAN, Q9H6W3 (See protein sequence)
Recommended Name: Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66  
Size: 641 amino acids; 71086 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subunit: Interacts with SP7/OSX; the interaction is direct (By similarity). Interacts with MYC. Interacts with
PHF19; leading to its recruitment to H3K36me3 sites
Subcellular location: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Granular part of nucleoli. Nucleoplasm,
nucleoplasmic foci, some of them associated with nucleoli
2 PDB 3D structures from and Proteopedia for C14orf169:
4DIQ (3D)        4E4H (3D)    
Secondary accessions: B4DT02
Alternative splicing: 2 isoforms:  Q9H6W3-1   Q9H6W3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C14orf169: NX_Q9H6W3

Explore proteomics data for C14orf169 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9H6W3

  • C14orf169 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C14orf169 Protein Expression
    REFSEQ proteins: NP_078920.2  
    Human Recombinant Protein Products for C14orf169: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IEA--

    C14orf169 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR003347 JmjC_dom
     IPR013109 NO66/MINA

    Graphical View of Domain Structure for InterPro Entry Q9H6W3

    ProtoNet protein and cluster: Q9H6W3

    2 Blocks protein domains:
    IPB003347 Transcription factor jumonji
    IPB013109 Cupin 4


    UniProtKB/Swiss-Prot: NO66_HUMAN, Q9H6W3
    Similarity: Belongs to the MINA53/NO66 family. NO66 subfamily
    Similarity: Contains 1 JmjC domain


    C14orf169 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NO66_HUMAN, Q9H6W3
    Function: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
    Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role
    in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4'
    (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the
    hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its
    interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter
    activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of
    certain heterochromatic region. Participates in MYC-induced transcriptional activation
    Catalytic activity: Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine +
    succinate + formaldehyde + CO(2)
    Catalytic activity: Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate +
    formaldehyde + CO(2)
    Catalytic activity: L-histidine-[60S ribosomal protein L8] + 2-oxoglutarate + O(2) =
    (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L8] + succinate + CO(2)

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.11.271

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding ISS--
    GO:0005515protein binding IPI19927124
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ISS--
    GO:0032453histone demethylase activity (H3-K4 specific) ISS--
    GO:0051864histone demethylase activity (H3-K36 specific) ISS--
         
    C14orf169 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for C14orf169:
     Decreased viability with TRAIL 

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidC14orf169 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C14orf169

    5/9 Interacting proteins for C14orf169 (Q9H6W32, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CAP677753I2D: score=2 
    TRAPPC6BQ86SZ23I2D: score=2 
    USP42Q9H9J43I2D: score=2 
    BCAR1P569453I2D: score=1 
    KAT5Q929933I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0034720histone H3-K4 demethylation ISS--
    GO:0045668negative regulation of osteoblast differentiation ISS--
    GO:0045892negative regulation of transcription, DNA-dependent ISS--
    GO:0070544histone H3-K36 demethylation ISS--

    C14orf169 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C14orf169 (NO66)

    Search CenterWatch for drugs/clinical trials and news about C14orf169 / NO66

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C14orf169 gene: 
    NM_024644.3  

    Unigene Cluster for C14orf169:

    Chromosome 14 open reading frame 169
    Hs.509916  [show with all ESTs]
    Unigene Representative Sequence: NM_024644
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000531973
    miRNA
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    Additional mRNA sequence: 

    AK025455.1 AK299994.1 AY390535.1 BC011350.1 BC071954.1 

    4 DOTS entries:

    DT.408891  DT.120758296  DT.102842734  DT.91687878 

    24/57 AceView cDNA sequences (see all 57):

    Z40969 BI257802 BG108325 BM923853 BQ924940 BF221583 BG610839 BE784665 
    BG107618 AW769847 AI904506 AY390535 BF194857 CB528504 BX363489 BC011350 
    NM_024644 BX390965 BQ018771 AI904509 BM040984 BF000100 BX342600 AK025455 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C14orf169 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCGGGTCGG
    C14orf169 Expression
    About this image


    See C14orf169 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C14orf169

    SOURCE GeneReport for Unigene cluster: Hs.509916

    UniProtKB/Swiss-Prot: NO66_HUMAN, Q9H6W3
    Tissue specificity: Widely expressed. Overexpressed in lung carcinomas

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for C14orf169 gene from 5/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2410016O06Rik1 , 5 RIKEN cDNA 2410016O06 gene1, 5 81.97(n)1
    83.33(a)1
      12 (38.97 cM)5
    719521  NM_023633.31  NP_076122.21 
     839506085 
    chicken
    (Gallus gallus)
    Aves C5H14orf1691 chromosome 5 open reading frame, human C14orf169 62.31(n)
    58.22(a)
      423249  NM_001031196.1  NP_001026367.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.43342 Transcribed sequence with weak similarity to protein more 74.54(n)    CB360227.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29821 CG2982 51.7(n)
    41.44(a)
      31374  NM_131932.3  NP_572160.1 
    worm
    (Caenorhabditis elegans)
    Secernentea jmjc-11 Protein JMJC-1 46.56(n)
    37.56(a)
      171932  NM_001026473.3  NP_001021644.1 


    ENSEMBL Gene Tree for C14orf169 (if available)
    TreeFam Gene Tree for C14orf169 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section
    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for C14orf169:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv510643CNV Loss20534489
    dgv1958n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 611919    OMIM disorders: --

    2 diseases for C14orf169:    About MalaCards
    lung cancer    


    C14orf169 for disorders           About GeneDecksing


    Export disorders for C14orf169 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C14orf169 gene, integrated from 9 sources (see all 14):
    (articles sorted by number of sources associating them with C14orf169)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer. (PubMed id 17308053)1, 2, 3 Suzuki C....Daigo Y. (2007)
    2. Purification, crystallization and preliminary crystall ographic analysis of histone lysine demethylase NO66 from Homo sapiens. (PubMed id 22750859)1, 3 Zhou X....Zang J. (2012)
    3. Regulation of the osteoblast-specific transcription f actor Osterix by NO66, a Jumonji family histone demethylase. (PubMed id 19927124)1, 3 Sinha K.M....de Crombrugghe B. (2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin. (PubMed id 14742713)1, 2 Eilbracht J.... Schmidt-Zachmann M.S. (2004)
    7. Structural insights into histone demethylase NO66 in i nteraction with osteoblast-specific transcription factor osterix and gene repres sion. (PubMed id 23620590)1 Tao Y....Zang J. (2013)
    8. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. (PubMed id 23103944)2 Ge W....Schofield C.J. (2012)
    9. Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation. (PubMed id 23160351)2 Brien G.L.... Bracken A.P. (2012)
    10. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79697 HGNC: 20968 AceView: C14orf169 Ensembl:ENSG00000255242 euGenes: HUgn79697
    ECgene: C14orf169 H-InvDB: C14orf169

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C14orf169 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C14orf169 gene:
    Search GeneIP for patents involving C14orf169

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