Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



C14orf169 Gene

protein-coding   GIFtS: 40
GCID: GC14P073958

Chromosome 14 Open Reading Frame 169

  Search for C14orf169
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Chromosome 14 Open Reading Frame 1691 2     ROX2 3
Myc-Associated Protein With JmjC Domain1 2 3     hsNO662 3
Nucleolar Protein 661 2 3     NO662 5
MAPJD2 3 5     Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase NO662
Histone Lysine Demethylase NO662 3     Lysine-Specific Demethylase NO662
Ribosomal Oxygenase NO662 3     EC 1.14.11.-3
60S Ribosomal Protein L8 Histidine Hydroxylase2 3     EC 1.14.11.273

External Ids:    HGNC: 209681   Entrez Gene: 796972   Ensembl: ENSG000002552427   OMIM: 6119195   UniProtKB: Q9H6W33   

Export aliases for C14orf169 gene to outside databases

Previous GC identifers: GC14P071948 GC14P071949 GC14P073027 GC14P054124


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for C14orf169 Gene:
C14orf169 (chromosome 14 open reading frame 169) is a protein-coding gene. GO annotations related to this gene include iron ion binding and histone demethylase activity (H3-K36 specific).

UniProtKB/Swiss-Prot: NO66_HUMAN, Q9H6W3
Function: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role
in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4'
(H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the
hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its
interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter
activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of
certain heterochromatic region. Participates in MYC-induced transcriptional activation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the C14orf169 gene promoter:
         USF1   Pax-2b   USF-1   Nkx2-2   Pax-6   Pax-2   Pax-2a   ITF-2   Tal-1beta   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C14orf169

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C14orf169


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.3

C14orf169 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf169 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P073958:  view genomic region     (about GC identifiers)

Start:
73,957,644 bp from pter      End:
73,960,105 bp from pter
Size:
2,462 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: NO66_HUMAN, Q9H6W3 (See protein sequence)
Recommended Name: Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66  
Size: 641 amino acids; 71086 Da
Cofactor: Binds 1 Fe(2+) ion per subunit (By similarity)
Subunit: Interacts with SP7/OSX; the interaction is direct (By similarity). Interacts with MYC. Interacts with
PHF19; leading to its recruitment to H3K36me3 sites
2 PDB 3D structures from and Proteopedia for C14orf169:
4DIQ (3D)        4E4H (3D)    
Secondary accessions: B4DT02
Alternative splicing: 2 isoforms:  Q9H6W3-1   Q9H6W3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C14orf169: NX_Q9H6W3

Explore proteomics data for C14orf169 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C14orf169 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_078920.2  

    C14orf169 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for C14orf169
    GenScript Custom Purified and Recombinant Proteins Services for C14orf169
    Novus Biologicals C14orf169 Protein
    Novus Biologicals C14orf169 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for C14orf169 

    C14orf169 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of C14orf169
    Browse R&D Systems for Antibodies
    OriGene Antibodies for C14orf169
    OriGene Custom Antibody Services for C14orf169
    Novus Biologicals C14orf169 Antibodies
    Abcam antibodies for C14orf169
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for C14orf169
    LSBio Antibodies in human, mouse, rat for C14orf169

    C14orf169 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for C14orf169
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for C14orf169
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for C14orf169 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR013109 NO66/MINA
     IPR003347 JmjC_dom

    Graphical View of Domain Structure for InterPro Entry Q9H6W3

    ProtoNet protein and cluster: Q9H6W3

    2 Blocks protein domains:
    IPB003347 Transcription factor jumonji
    IPB013109 Cupin 4


    UniProtKB/Swiss-Prot: NO66_HUMAN, Q9H6W3
    Similarity: Belongs to the MINA53/NO66 family. NO66 subfamily
    Similarity: Contains 1 JmjC domain


    Find genes that share domains with C14orf169           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: NO66_HUMAN, Q9H6W3
    Function: Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.
    Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role
    in histone code. Preferentially demethylates trimethylated H3 'Lys-4' (H3K4me3) and monomethylated H3 'Lys-4'
    (H3K4me1) residues, while it has weaker activity for dimethylated H3 'Lys-36' (H3K36me2). Also catalyzes the
    hydroxylation of 60S ribosomal protein L8 on 'His-216'. Acts as a regulator of osteoblast differentiation via its
    interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter
    activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of
    certain heterochromatic region. Participates in MYC-induced transcriptional activation
    Catalytic activity: Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine +
    succinate + formaldehyde + CO(2)
    Catalytic activity: Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate +
    formaldehyde + CO(2)
    Catalytic activity: L-histidine-[60S ribosomal protein L8] + 2-oxoglutarate + O(2) =
    (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L8] + succinate + CO(2)

         Enzyme Numbers (IUBMB): EC 1.14.11.-1 EC 1.14.11.271

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005506iron ion binding ISS--
    GO:0005515protein binding IPI19927124
    GO:0016706oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors ISS--
    GO:0032453histone demethylase activity (H3-K4 specific) ISS--
    GO:0051864histone demethylase activity (H3-K36 specific) ISS--
         
    Find genes that share ontologies with C14orf169           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for C14orf169:
     Decreased viability with TRAIL 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C14orf169
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C14orf169

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C14orf169
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C14orf169

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat C14orf169 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate C14orf169:
    hsa-miR-146a* hsa-miR-495 hsa-miR-1271 hsa-miR-485-3p hsa-miR-514b-5p hsa-miR-513c hsa-miR-96 hsa-miR-3907
    SwitchGear 3'UTR luciferase reporter plasmidC14orf169 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for C14orf169
    Predesigned siRNA for gene silencing in human, mouse, rat C14orf169

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for C14orf169

    Clone
    Products:
         
    OriGene clones in human, mouse for C14orf169 (see all 6)
    OriGene ORF clones in mouse, rat for C14orf169
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C14orf169 (NM_024644)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C14orf169
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf169

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for C14orf169
    Browse ESI BIO Cell Lines and PureStem Progenitors for C14orf169 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf169


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    NO66_HUMAN, Q9H6W3: Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Granular part of nucleoli. Nucleoplasm,
    nucleoplasmic foci, some of them associated with nucleoli

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ISS--
    GO:0005654nucleoplasm IEA--
    GO:0005730nucleolus IEA--

    Find genes that share ontologies with C14orf169           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C14orf169
    Interactions:

        Search GeneGlobe Interaction Network for C14orf169

    Selected Interacting proteins for C14orf169 (Q9H6W31, 2, 3) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP2CAP677753I2D: score=2 
    TRAPPC6BQ86SZ23I2D: score=2 
    USP42Q9H9J43I2D: score=2 
    BCAR1P569453I2D: score=1 
    KAT5Q929933I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0034720histone H3-K4 demethylation ISS--
    GO:0045668negative regulation of osteoblast differentiation ISS--
    GO:0045892negative regulation of transcription, DNA-templated ISS--
    GO:0070544histone H3-K36 demethylation ISS--

    Find genes that share ontologies with C14orf169           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C14orf169 (NO66)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for C14orf169 gene: 
    NM_024644.4  

    Unigene Cluster for C14orf169:

    Chromosome 14 open reading frame 169
    Hs.509916  [show with all ESTs]
    Unigene Representative Sequence: NM_024644
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000531973(processed_transcript)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat C14orf169 using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate C14orf169:
    hsa-miR-146a* hsa-miR-495 hsa-miR-1271 hsa-miR-485-3p hsa-miR-514b-5p hsa-miR-513c hsa-miR-96 hsa-miR-3907
    SwitchGear 3'UTR luciferase reporter plasmidC14orf169 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for C14orf169
    Predesigned siRNA for gene silencing in human, mouse, rat C14orf169
    Clone
    Products:
         
    OriGene clones in human, mouse for C14orf169 (see all 6)
    OriGene ORF clones in mouse, rat for C14orf169
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C14orf169 (NM_024644)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C14orf169
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf169
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for C14orf169
    OriGene qSTAR qPCR primer pairs in human, mouse for C14orf169
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C14orf169
      QuantiTect SYBR Green Assays in human, mouse, rat C14orf169
      QuantiFast Probe-based Assays in human, mouse, rat C14orf169

    Additional mRNA sequence: 

    AK025455.1 AK299994.1 AY390535.1 BC011350.1 BC071954.1 

    4 DOTS entries:

    DT.408891  DT.120758296  DT.102842734  DT.91687878 

    Selected AceView cDNA sequences (see all 57):

    BI257802 BG107618 Z40969 BQ924940 BF221583 BM923853 BG108325 BG610839 
    BE784665 AI904506 BC071954 BC011350 NM_024644 BQ018771 AI904509 AA576870 
    CB528504 BX384677 CF131678 BX342600 BX390965 BF194857 BI913225 BF000100 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    C14orf169 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCGGGTCGG
    C14orf169 Expression
    About this image

    C14orf169 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C14orf169 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.509916

    UniProtKB/Swiss-Prot: NO66_HUMAN, Q9H6W3
    Tissue specificity: Widely expressed. Overexpressed in lung carcinomas

        Custom PCR Arrays for C14orf169
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for C14orf169
    OriGene qSTAR qPCR primer pairs in human, mouse for C14orf169
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C14orf169
    QuantiTect SYBR Green Assays in human, mouse, rat C14orf169
    QuantiFast Probe-based Assays in human, mouse, rat C14orf169
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf169

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for C14orf169 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2410016O06Rik1 , 5 RIKEN cDNA 2410016O06 gene1, 5 81.91(n)1
    83.25(a)1
      12 (38.97 cM)5
    719521  NM_023633.31  NP_076122.21 
     839506085 
    chicken
    (Gallus gallus)
    Aves C5H14ORF1691 chromosome 5 open reading frame, human C14orf169 64.03(n)
    60.08(a)
      423249  NM_001031196.1  NP_001026367.1 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004882461 bifunctional lysine-specific demethylase and histidyl-hydroxylase more 59.12(n)
    54.29(a)
      100488246  XM_002933865.2  XP_002933911.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.43342 Transcribed sequence with weak similarity to protein more 74.54(n)    CB360227.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG29821 CG2982 51.89(n)
    41.76(a)
      31374  NM_131932.3  NP_572160.1 


    ENSEMBL Gene Tree for C14orf169 (if available)
    TreeFam Gene Tree for C14orf169 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus
    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for C14orf169:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv510643CNV Loss20534489
    dgv1958n71CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing C14orf169
    DNA2.0 Custom Variant and Variant Library Synthesis for C14orf169

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 611919    OMIM disorders: --


    Find genes that share disorders with C14orf169           About GenesLikeMe


    Export disorders for C14orf169 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for C14orf169 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with C14orf169)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer. (PubMed id 17308053)1, 2, 3 Suzuki C.... Daigo Y. (Mol. Cancer Ther. 2007)
    2. Purification, crystallization and preliminary crystallographic analysis of histone lysine demethylase NO66 from Homo sapiens. (PubMed id 22750859)1, 3 Zhou X....Zang J. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2012)
    3. Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. (PubMed id 19927124)1, 3 Sinha K.M....de Crombrugghe B. (EMBO J. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. NO66, a highly conserved dual location protein in the nucleolus and in a special type of synchronously replicating chromatin. (PubMed id 14742713)1, 2 Eilbracht J.... Schmidt-Zachmann M.S. (Mol. Biol. Cell 2004)
    7. Structural insights into histone demethylase NO66 in interaction with osteoblast-specific transcription factor osterix and gene repression. (PubMed id 23620590)1 Tao Y....Zang J. (J. Biol. Chem. 2013)
    8. Oxygenase-catalyzed ribosome hydroxylation occurs in prokaryotes and humans. (PubMed id 23103944)2 Ge W....Schofield C.J. (Nat. Chem. Biol. 2012)
    9. Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation. (PubMed id 23160351)2 Brien G.L.... Bracken A.P. (Nat. Struct. Mol. Biol. 2012)
    10. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 79697 HGNC: 20968 AceView: C14orf169 Ensembl:ENSG00000255242 euGenes: HUgn79697
    ECgene: C14orf169 H-InvDB: C14orf169

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for C14orf169 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for C14orf169 gene:
    Search GeneIP for patents involving C14orf169

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of C14orf169
     Browse Kits and Assays available from EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for C14orf169   OriGene RNAi products in human, mouse, rat for C14orf169  
     OriGene qPCR primer pairs and template standards for C14orf169   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for C14orf169  
     OriGene qSTAR qPCR primer pairs in human, mouse for C14orf169   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for C14orf169   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for C14orf169   OriGene Custom Protein Services for C14orf169  

     
     
     Block miRNA regulation of human, mouse, rat C14orf169 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing C14orf169
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C14orf169 Predesigned siRNA for gene silencing in human, mouse, rat C14orf169
     QuantiFast Probe-based Assays in human, mouse, rat C14orf169 QuantiTect SYBR Green Assays in human, mouse, rat C14orf169
     Custom PCR Arrays for C14orf169 Search Chromatin IP Primers for C14orf169
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C14orf169  Search GeneGlobe Interaction Network for C14orf169
     Regulatory tfbs in C14orf169 promoter
     GenScript Custom Purified and Recombinant Proteins Services for C14orf169 GenScript cDNA clones with any tag delivered in your preferred vector for C14orf169
     GenScript Custom Assay Services for C14orf169 GenScript Custom overexpressing Cell Line Services for C14orf169
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for C14orf169 (NO66)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     C14orf169 antibodies
     C14orf169 proteins
     C14orf169 lysates
     Antibodies for C14orf169
     See all of Abcam's Antibodies, Kits and Proteins for C14orf169
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for C14orf169
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf169
     SwitchGear 3'UTR luciferase reporter plasmids for C14orf169
     Browse SwitchGear Promoter luciferase reporter plasmids for C14orf169
     ThermoFisher Antibodies for C14orf169
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf169
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C14orf169
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C14orf169
     LSBio Antibodies in human, mouse, rat for C14orf169
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for C14orf169
      Search eBioscience for proteins for C14orf169
      Search eBioscience for elisas for C14orf169
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      C14orf169 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4