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Aliases for C14orf169 Gene

Aliases for C14orf169 Gene

  • Chromosome 14 Open Reading Frame 169 2 3 5
  • Nucleolar Protein 66 2 3 4
  • 60S Ribosomal Protein L8 Histidine Hydroxylase 3 4
  • Myc-Associated Protein With JmjC Domain 2 4
  • Histone Lysine Demethylase NO66 3 4
  • Ribosomal Oxygenase NO66 3 4
  • HsNO66 3 4
  • MAPJD 3 4
  • ROX 3 4
  • Bifunctional Lysine-Specific Demethylase And Histidyl-Hydroxylase NO66 3
  • MYC-Associated Protein With JmjC Domain 3
  • Lysine-Specific Demethylase NO66 3
  • Up-Regulated In Lung Cancer 2 3
  • EC 1.14.11.27 4
  • EC 1.14.11.- 4
  • URLC2 3
  • NO66 3

External Ids for C14orf169 Gene

Previous GeneCards Identifiers for C14orf169 Gene

  • GC14P071948
  • GC14P071949
  • GC14P073027
  • GC14P073958
  • GC14P054124

Summaries for C14orf169 Gene

GeneCards Summary for C14orf169 Gene

C14orf169 (Chromosome 14 Open Reading Frame 169) is a Protein Coding gene. GO annotations related to this gene include iron ion binding and histone demethylase activity (H3-K36 specific). An important paralog of this gene is MINA.

UniProtKB/Swiss-Prot for C14orf169 Gene

  • Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates Lys-4 (H3K4me) and Lys-36 (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 Lys-4 (H3K4me3) and monomethylated H3 Lys-4 (H3K4me1) residues, while it has weaker activity for dimethylated H3 Lys-36 (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on His-216. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf169 Gene

Genomics for C14orf169 Gene

Regulatory Elements for C14orf169 Gene

Enhancers for C14orf169 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F073748 1.1 FANTOM5 ENCODE 4 +266.7 266692 17.4 HDGF PKNOX1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ELMSAN1 PNMA1 ZNF410 LOC100420966 LOC100506476 FCF1 RBM25 PTGR2 ENSG00000223300 ENSG00000259005
GH14F073768 1.4 FANTOM5 ENCODE 3.1 +280.9 280886 7.3 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 ZNF207 PTGR2 LOC100506476 PNMA1 ENSG00000223300 ELMSAN1 LOC100506498 ACOT1 ENTPD5 C14orf169 ZNF410
GH14F073226 1.3 FANTOM5 Ensembl ENCODE 1.4 -263.1 -263124 3.3 HDGF ZNF493 ZFP64 SIN3A ZEB1 ZNF121 GLIS2 ZNF138 KLF7 FOS RBM25 ELMSAN1 LOC100420966 ENSG00000258891 PNMA1 LIN52 PSEN1 LOC101928123 NUMB DPF3
GH14F073489 0.9 ENCODE 0.8 -1.0 -964 0.2 GATA3 C14orf169 GC14M073418
GH14F073485 0.3 FANTOM5 0.4 -5.6 -5630 0.2 PRDM10 ZNF384 C14orf169 GC14M073418
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C14orf169 on UCSC Golden Path with GeneCards custom track

Promoters for C14orf169 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001023727 267 2000 PKNOX1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 SP3

Genomic Location for C14orf169 Gene

Chromosome:
14
Start:
73,490,934 bp from pter
End:
73,493,401 bp from pter
Size:
2,468 bases
Orientation:
Plus strand

Genomic View for C14orf169 Gene

Genes around C14orf169 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf169 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf169 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf169 Gene

Proteins for C14orf169 Gene

  • Protein details for C14orf169 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H6W3-NO66_HUMAN
    Recommended name:
    Bifunctional lysine-specific demethylase and histidyl-hydroxylase NO66
    Protein Accession:
    Q9H6W3
    Secondary Accessions:
    • B4DT02

    Protein attributes for C14orf169 Gene

    Size:
    641 amino acids
    Molecular mass:
    71086 Da
    Cofactor:
    Name=Fe(2+); Xref=ChEBI:CHEBI:29033;
    Quaternary structure:
    • Interacts with SP7/OSX; the interaction is direct (By similarity). Interacts with MYC. Interacts with PHF19; leading to its recruitment to H3K36me3 sites.

    Three dimensional structures from OCA and Proteopedia for C14orf169 Gene

    Alternative splice isoforms for C14orf169 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C14orf169 Gene

Post-translational modifications for C14orf169 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C14orf169 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for C14orf169 Gene

Domains & Families for C14orf169 Gene

Protein Domains for C14orf169 Gene

Suggested Antigen Peptide Sequences for C14orf169 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H6W3

UniProtKB/Swiss-Prot:

NO66_HUMAN :
  • Contains 1 JmjC domain.
  • Belongs to the ROX family. NO66 subfamily.
Domain:
  • Contains 1 JmjC domain.
Family:
  • Belongs to the ROX family. NO66 subfamily.
genes like me logo Genes that share domains with C14orf169: view

No data available for Gene Families for C14orf169 Gene

Function for C14orf169 Gene

Molecular function for C14orf169 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Protein N(6),N(6)-dimethyl-L-lysine + 2-oxoglutarate + O(2) = protein N(6)-methyl-L-lysine + succinate + formaldehyde + CO(2).
UniProtKB/Swiss-Prot CatalyticActivity:
Protein N(6)-methyl-L-lysine + 2-oxoglutarate + O(2) = protein L-lysine + succinate + formaldehyde + CO(2).
UniProtKB/Swiss-Prot CatalyticActivity:
L-histidine-[60S ribosomal protein L8] + 2-oxoglutarate + O(2) = (3S)-3-hydroxy-L-histidine-[60S ribosomal protein L8] + succinate + CO(2).
UniProtKB/Swiss-Prot Function:
Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates Lys-4 (H3K4me) and Lys-36 (H3K36me) of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 Lys-4 (H3K4me3) and monomethylated H3 Lys-4 (H3K4me1) residues, while it has weaker activity for dimethylated H3 Lys-36 (H3K36me2). Also catalyzes the hydroxylation of 60S ribosomal protein L8 on His-216. Acts as a regulator of osteoblast differentiation via its interaction with SP7/OSX by demethylating H3K4me and H3K36me, thereby inhibiting SP7/OSX-mediated promoter activation (By similarity). May also play a role in ribosome biogenesis and in the replication or remodeling of certain heterochromatic region. Participates in MYC-induced transcriptional activation.

Enzyme Numbers (IUBMB) for C14orf169 Gene

Gene Ontology (GO) - Molecular Function for C14orf169 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005506 iron ion binding ISS --
GO:0005515 protein binding IPI 19927124
GO:0016491 oxidoreductase activity IEA --
GO:0016706 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors IEA,ISS --
GO:0032453 histone demethylase activity (H3-K4 specific) IEA,ISS --
genes like me logo Genes that share ontologies with C14orf169: view
genes like me logo Genes that share phenotypes with C14orf169: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C14orf169 Gene

Localization for C14orf169 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf169 Gene

Nucleus, nucleolus. Nucleus, nucleoplasm. Note=Granular part of nucleoli. Nucleoplasm, nucleoplasmic foci, some of them associated with nucleoli.

Gene Ontology (GO) - Cellular Components for C14orf169 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
GO:0005654 nucleoplasm IEA --
GO:0005730 nucleolus IEA --
genes like me logo Genes that share ontologies with C14orf169: view

No data available for Subcellular locations from COMPARTMENTS for C14orf169 Gene

Pathways & Interactions for C14orf169 Gene

SuperPathways for C14orf169 Gene

No Data Available

Interacting Proteins for C14orf169 Gene

Gene Ontology (GO) - Biological Process for C14orf169 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006338 chromatin remodeling IBA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0016569 covalent chromatin modification IEA --
GO:0018193 peptidyl-amino acid modification IBA --
genes like me logo Genes that share ontologies with C14orf169: view

No data available for Pathways by source and SIGNOR curated interactions for C14orf169 Gene

Drugs & Compounds for C14orf169 Gene

(3) Drugs for C14orf169 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Formaldehyde Approved, Vet_approved Pharma 84
Oxygen Approved, Vet_approved Pharma 0
Succinic acid Approved Nutra Full agonist, Agonist 0

(1) Additional Compounds for C14orf169 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Oxoglutaric acid
  • 2-Ketoglutarate
  • 2-Ketoglutaric acid
  • 2-Oxo-1,5-pentanedioate
  • 2-Oxo-1,5-pentanedioic acid
  • 2-Oxoglutarate
328-50-7
genes like me logo Genes that share compounds with C14orf169: view

Transcripts for C14orf169 Gene

mRNA/cDNA for C14orf169 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(57) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C14orf169 Gene

Chromosome 14 open reading frame 169:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf169 Gene

No ASD Table

Relevant External Links for C14orf169 Gene

GeneLoc Exon Structure for
C14orf169
ECgene alternative splicing isoforms for
C14orf169

Expression for C14orf169 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C14orf169 Gene

Protein differential expression in normal tissues from HIPED for C14orf169 Gene

This gene is overexpressed in Lung (21.3), Testis (17.6), and CD8 Tcells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C14orf169 Gene



Protein tissue co-expression partners for C14orf169 Gene

NURSA nuclear receptor signaling pathways regulating expression of C14orf169 Gene:

C14orf169

SOURCE GeneReport for Unigene cluster for C14orf169 Gene:

Hs.509916

mRNA Expression by UniProt/SwissProt for C14orf169 Gene:

Q9H6W3-NO66_HUMAN
Tissue specificity: Widely expressed. Overexpressed in lung carcinomas.
genes like me logo Genes that share expression patterns with C14orf169: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for C14orf169 Gene

Orthologs for C14orf169 Gene

This gene was present in the common ancestor of animals.

Orthologs for C14orf169 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia C8H14orf169 34
  • 89.83 (n)
cow
(Bos Taurus)
Mammalia NO66 34
  • 87.47 (n)
rat
(Rattus norvegicus)
Mammalia RGD1307704 34
  • 82.94 (n)
mouse
(Mus musculus)
Mammalia 2410016O06Rik 34 16
  • 81.91 (n)
chicken
(Gallus gallus)
Aves C5H14ORF169 34
  • 64.03 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488246 34
  • 59.12 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:162967 34
  • 56.92 (n)
Dr.4334 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001938 34
  • 54.17 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG2982 34
  • 51.89 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4160 34
Species where no ortholog for C14orf169 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C14orf169 Gene

ENSEMBL:
Gene Tree for C14orf169 (if available)
TreeFam:
Gene Tree for C14orf169 (if available)

Paralogs for C14orf169 Gene

Paralogs for C14orf169 Gene

genes like me logo Genes that share paralogs with C14orf169: view

Variants for C14orf169 Gene

Sequence variations from dbSNP and Humsavar for C14orf169 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10144461 -- 73,490,977(+) CTTCG(C/G)CCCCG intron-variant, utr-variant-5-prime
rs10144469 -- 73,491,067(+) GCCGA(A/G)GCGCC intron-variant, upstream-variant-2KB, reference, missense
rs10147070 -- 73,491,397(+) TTCCG(C/T)GCCGC intron-variant, upstream-variant-2KB, reference, missense
rs10148812 -- 73,493,587(+) AATCC(C/T)AGCAC intron-variant, upstream-variant-2KB
rs111230413 -- 73,491,872(+) GCCGC(C/T)GCGTG intron-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for C14orf169 Gene

Variant ID Type Subtype PubMed ID
esv3892561 CNV gain 25118596
nsv1035460 CNV gain 25217958
nsv510643 CNV deletion 20534489

Relevant External Links for C14orf169 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C14orf169

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for C14orf169 Gene

Disorders for C14orf169 Gene

Relevant External Links for C14orf169

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C14orf169

No disorders were found for C14orf169 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf169 Gene

Publications for C14orf169 Gene

  1. Identification of Myc-associated protein with JmjC domain as a novel therapeutic target oncogene for lung cancer. (PMID: 17308053) Suzuki C. … Daigo Y. (Mol. Cancer Ther. 2007) 2 3 4 64
  2. Structure-function relationships of human JmjC oxygenases-demethylases versus hydroxylases. (PMID: 27309310) Markolovic S. … Schofield C.J. (Curr. Opin. Struct. Biol. 2016) 2 3 64
  3. Purification, crystallization and preliminary crystallographic analysis of histone lysine demethylase NO66 from Homo sapiens. (PMID: 22750859) Zhou X. … Zang J. (Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 2012) 2 3 64
  4. Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation. (PMID: 23160351) Brien G.L. … Bracken A.P. (Nat. Struct. Mol. Biol. 2012) 3 4 64
  5. Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. (PMID: 19927124) Sinha K.M. … de Crombrugghe B. (EMBO J. 2010) 2 3 64

Products for C14orf169 Gene

Sources for C14orf169 Gene

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