C14orf166B Gene
protein-coding GIFtS : 40
GCID: GC14 P077292
chromosome 14 open reading frame 166B
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Aliasesfor C14orf166B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chromosome 14 Open Reading Frame 166B 1 2 Uncharacterized Protein C14orf166B2
Export aliases for C14orf166B gene to outside databases Previous GC identifers: GC14P075285 GC14P076362 GC14P057461
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Summariesfor C14orf166B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor C14orf166B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000014.8 NC_018925.1 NT_026437.12 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the C14orf166B gene promoter: COUP-TF1 COUP Olf-1 HNF-4alpha2 CUTL1 HNF-4alpha1 YY1 COUP-TF c-Myb aMEF-2 Other transcription factors Search SABiosciences Chromatin IP Primers for C14orf166B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf166B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3 C14orf166B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14P077292: view genomic region
(about GC identifiers )
Start:
77,292,715 bp from pter
End:
77,336,645 bp from pter
Size:
43,931 bases
Orientation:
plus strand
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Proteinsfor C14orf166B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CN16B_HUMAN, Q0VAA2 (See
protein sequence )Recommended Name: Uncharacterized protein C14orf166B Size : 488 amino acids; 54535 Da
Caution : It is uncertain whether Met-1 or Met-27 is the initiator
Sequence caution : Sequence=AAD44364.1; Type=Erroneous gene model prediction; Sequence=AAI21160.1; Type=Erroneousinitiation; Note=Translation N-terminally extended; Sequence=AAI21161.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=EAW81265.1; Type=Erroneous gene model prediction;
Secondary accessions : Q6ZUG6 Q9Y627Alternative splicing : 2 isoforms : Q0VAA2-1 Q0VAA2-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for C14orf166B: NX_Q0VAA2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q0VAA2 C14orf166B Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_919263.2 ENSEMBL proteins: ENSP00000377369 ENSP00000216450 ENSP00000452427 ENSP00000452348 ENSP00000451057 ENSP00000396260 ENSP00000216453 Human Recombinant Protein Products: C14orf166B Antibody Products: Assay Products for C14orf166B:
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Protein
Domains / Familiesfor C14orf166B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q0VAA2
UniProtKB/Swiss-Prot: CN16B_HUMAN, Q0VAA2 Similarity : Contains 8 LRR (leucine-rich) repeats
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Functionfor C14orf166B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C14orf166B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C14orf166BOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C14orf166B (NM_194287 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C14orf166B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C14orf166B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf166B
1 GenomeRNAi human phenotype for C14orf166B :
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Pathways & Interactionsfor C14orf166B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C14orf166B 5/24 Interacting proteins for C14orf166B (Q0VAA2 2 ) via UniProtKB, MINT, STRING, and/or I2D (see all 24 )About this table
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Drugs & Compoundsfor C14orf166B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for C14orf166B Search CenterWatch for drugs/clinical trials and news about C14orf166B / CN16B
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Transcriptsfor C14orf166B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for C14orf166B gene: NM_194287.2 Unigene Cluster for C14orf166B:
Chromosome 14 open reading frame 166B Hs.147276 [show with all ESTs ] Unigene Representative Sequence: AK125722 8 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000393774 (uc010tvh.1 ) ENST00000216450 (uc010asn.1 ) ENST00000557453 ENST00000484640 (uc010tvg.1 uc001xsx.2 uc001xsw.2 ) ENST00000555189 ENST00000460005 (uc010aso.1 ) ENST00000450042 ENST00000216453 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C14orf166B (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C14orf166BOriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C14orf166B (NM_194287 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C14orf166B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C14orf166B
Additional cDNA sequence: AK058106.1 AK125722.1 AK301762.1 BC062799.1 BC121159.2 BC121160.2 BC143896.1
5 DOTS entries : DT.65286598 DT.120770352
DT.101960237 DT.101976783 DT.40116043 11 AceView cDNA sequences :
BX106373 AI672518 AK058106 BC062799 AW593882 NM_194287 AK125722 AI206706 AW003278 BU854032 AA393602 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for C14orf166B About this scheme ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 SP1 :           -   -     -               -               SP2 :     -       -   -   -   -       -                       SP3 :                 -                             SP4 :     -                                         SP5 :                                            
ECgene alternative splicing isoforms for C14orf166B
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Expression for C14orf166B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section C14orf166B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GGCATTTGGG
About this image C14orf166B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table 1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Testis Seminiferous Tubules Spermatid Germ Cells, Male Gametocytes Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See C14orf166B Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for C14orf166B SOURCE GeneReport for Unigene cluster: Hs.147276 SABiosciences Custom PCR Arrays for C14orf166B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C14orf166BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat C14orf166B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C14orf166B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C14orf166B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf166B
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Orthologsfor C14orf166B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of eukaryotes.
Orthologs for C14orf166B gene from 6/21 species (see all 21 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
C14orf166B6
Uncharacterized protein
35(a)
1 ↔ 1
5(41319036-41332195)
lizard (Anolis carolinensis)
Reptilia
C14orf166B6
--
52(a)
1 ↔ 1
1(21328507-21358024)
zebrafish (Danio rerio)
Actinopterygii
AL935141.26
--
49(a)
1 ↔ 1
17(53128606-53137861)
honey bee (Apis mellifera)
Insecta
--
--
11(a)
1 → many
Group5.15(19031-21095)
thale cress (Arabidopsis thaliana)
eudicotyledons
emb20046
leucine-rich repeats-ribonuclease inhibitor domain...
13(a)
possible ortholog
1(3461635-3465786)
rice (Oryza sativa)
Liliopsida
--
peroxidase family protein, expressed
9(a)
possible ortholog
6(7147962-7157823)
ENSEMBL Gene Tree for C14orf166B (if available)TreeFam Gene Tree for C14orf166B (if available)
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Paralogsfor C14orf166B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for C14orf166B gene TCTE1 2 LRRC34 2 LOC400891 2 PPP1R37 2 LRRC45 2 1 SIMAP similar gene for C14orf166B using alignment to 6 protein entries: CN16B_HUMAN (see all proteins ):LOC400891
C14orf166B for paralogs About GeneDecksing
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Genomic Variantsfor C14orf166B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 14 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for C14orf166B (77292715 - 77336645 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for C14orf166B: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C14orf166B
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Disorders
/ Diseasesfor C14orf166B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section C14orf166B for disorders About MalaCards
C14orf166B for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: C14orf166B (2 documents) Export disorders for C14orf166B gene to outside databases
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Publicationsfor C14orf166B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for C14orf166B gene integrated from 9 sources : (articles sorted by number of sources associating them with C14orf166B) Utopia : connect your pdf to the dynamic world of online information
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614) 1 Rose J.E....Uhl G.R. (2010) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121) 2 Heilig R.... Weissenbach J. (2003) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for C14orf166B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing C14orf166B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing C14orf166B gene
(According to HUGE )
About This Section --
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Specialized Databases showing C14orf166B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for C14orf166B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for C14orf166B gene: Search GeneIP for patents involving C14orf166B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor C14orf166B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for C14orf166B OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for C14orf166B OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for C14orf166B OriGene Protein Over-expression Lysate for C14orf166B Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for C14orf166B Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for C14orf166B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for C14orf166B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for C14orf166B OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for C14orf166B OriGene Custom Protein Services for C14orf166B OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C14orf166B QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing C14orf166B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf166B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat C14orf166B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat C14orf166B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat C14orf166B
C14orf166B Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf166B
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat C14orf166B
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Expression for C14orf166B
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