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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C14orf166 Gene

protein-coding   GIFtS: 49
GCID: GC14P052456

Chromosome 14 Open Reading Frame 166

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 14 Open Reading Frame 1661 2     CLE72
RLL Motif Containing 11 2     LCRP3692
CLE2 3     RLLM12
CLE7 Homolog2 3     UPF0568 Protein C14orf1662
CGI992 5     

External Ids:    HGNC: 231691   Entrez Gene: 516372   Ensembl: ENSG000000873027   OMIM: 6108585   UniProtKB: Q9Y2243   

Export aliases for C14orf166 gene to outside databases

Previous GC identifers: GC14P050446 GC14P051525 GC14P032616


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C14orf166 Gene: 
C14orf166 (chromosome 14 open reading frame 166) is a protein-coding gene. Diseases associated with C14orf166 include endocarditis, and influenza. GO annotations related to this gene include RNA polymerase II core binding and identical protein binding.

UniProtKB/Swiss-Prot: CN166_HUMAN, Q9Y224
Function: Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus
A, is involved in viral replication

Gene Wiki entry for C14orf166 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C14orf166 gene promoter:
         FOXO3   IRF-1   CUTL1   FOXO3b   Meis-1b   Arnt   AREB6   FOXO3a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC14orf166 promoter sequence
   Search SABiosciences Chromatin IP Primers for C14orf166

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf166


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q22.1

C14orf166 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf166 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P052456:  view genomic region     (about GC identifiers)

Start:
52,456,193 bp from pter      End:
52,471,420 bp from pter
Size:
15,228 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CN166_HUMAN, Q9Y224 (See protein sequence)
Recommended Name: UPF0568 protein C14orf166  
Size: 244 amino acids; 28068 Da
Subunit: Homodimer (Probable). Interacts with NIN; which may prevent phosphorylation of NIN. Interacts with
POLR2A. Component of a tRNA-splicing ligase complex. Interacts with influenza A virus RNA polymerase subunits PA,
PB1 and PB2, and nucleocapsid NP. Interacts with hepatitis C virus core protein p19
Subcellular location: Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing
center, centrosome. Note=May localize at the centrosome during mitosis

Explore the universe of human proteins at neXtProt for C14orf166: NX_Q9Y224

Explore proteomics data for C14orf166 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y224

  • C14orf166 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C14orf166 Protein Expression
    REFSEQ proteins: NP_057123.1  
    ENSEMBL proteins: 
     ENSP00000261700   ENSP00000451751   ENSP00000451715   ENSP00000451153  

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    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0048471perinuclear region of cytoplasm IEA--
    GO:0072669tRNA-splicing ligase complex IDA--

    C14orf166 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019265 UPF0568

    Graphical View of Domain Structure for InterPro Entry Q9Y224

    ProtoNet protein and cluster: Q9Y224

    UniProtKB/Swiss-Prot: CN166_HUMAN, Q9Y224
    Similarity: Belongs to the UPF0568 family


    C14orf166 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CN166_HUMAN, Q9Y224
    Function: Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus
    A, is involved in viral replication

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000993RNA polymerase II core binding IDA16950395
    GO:0005515protein binding IPI11507205
    GO:0042802identical protein binding IPI15147888
         
    C14orf166 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for C14orf166:
     Decreased viability  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased gamma-H2AX phosphory 

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C14orf166

    STRING Interaction Network Preview (showing 5 interactants - click image to see 15)

    5/32 Interacting proteins for C14orf166 (Q9Y2241, 2, 3 ENSP000002617004) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NINQ8N4C61, 3, ENSP000002454414EBI-1104547,EBI-1164022 I2D: score=3 STRING: ENSP00000245441
    YWHAZP631042, 3, ENSP000003095034MINT-3307487 I2D: score=1 STRING: ENSP00000309503
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    MAP3K3Q997593I2D: score=2 
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0019048modulation by virus of host morphology or physiology IEA--
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IMP16950395

    C14orf166 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C14orf166 (CN166)

    Search CenterWatch for drugs/clinical trials and news about C14orf166 / CN166

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C14orf166 gene: 
    NM_016039.2  

    Unigene Cluster for C14orf166:

    Chromosome 14 open reading frame 166
    Hs.534457  [show with all ESTs]
    Unigene Representative Sequence: AK129516
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261700(uc010aod.3) ENST00000557553 ENST00000556760 ENST00000553362
    ENST00000553707 ENST00000555319 ENST00000553479
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    hsa-miR-186 hsa-miR-3133
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    Additional mRNA sequence: 

    AF087877.1 AF100755.1 AF151857.1 AK129516.1 AK312004.1 AY817175.1 BC001722.1 DQ525179.1 

    15 DOTS entries:

    DT.100874513  DT.454678  DT.87017563  DT.100667260  DT.92424619  DT.99966737  DT.120978501  DT.95175083 
    DT.65285945  DT.100667252  DT.100667254  DT.75153399  DT.92456733  DT.95175089  DT.102834399 

    24/458 AceView cDNA sequences (see all 458):

    BQ671180 BU630030 BQ918671 BQ061428 BM851218 AA148661 CK724872 AA969840 
    AI739318 CB163135 BG941895 BE161776 BM793590 AA353065 CA942446 BQ926251 
    AA354435 AI093071 BU189808 BX401614 AI380551 BG122292 BU069914 AI524642 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for C14orf166 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8
    SP1:                                -                             -               
    SP2:                                -                 -           -               
    SP3:                    -           -                                             
    SP4:                                -                             -     -         
    SP5:                                                  -           -               


    ECgene alternative splicing isoforms for C14orf166

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    C14orf166 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGGAAATC
    C14orf166 Expression
    About this image


    See C14orf166 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C14orf166

    SOURCE GeneReport for Unigene cluster: Hs.534457

    UniProtKB/Swiss-Prot: CN166_HUMAN, Q9Y224
    Tissue specificity: Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at
    intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung,
    placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for C14orf166 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2700060E02Rik1 , 5 RIKEN cDNA 2700060E02 gene1, 5 92.35(n)1
    97.13(a)1
      14 (10.95 cM)5
    680451  NM_026528.31  NP_080804.11 
     198114025 
    chicken
    (Gallus gallus)
    Aves C5H14orf1661 chromosome 5 open reading frame, human C14orf166 83.68(n)
    88.7(a)
      396326  NM_205369.1  NP_990700.1 
    lizard
    (Anolis carolinensis)
    Reptilia C14ORF1666
    Uncharacterized protein
    73(a)
    1 ↔ 1
    GL343501.1(461184-477252)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.187552 Xenopus laevis transcribed sequence with moderate similarity more 77.43(n)    BX850709.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565762 hypothetical protein MGC56576 76.97(n)   393240  BC049049.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG312491 CG31249 50.23(n)
    41.55(a)
      42129  NM_169774.2  NP_732262.1 
    worm
    (Caenorhabditis elegans)
    Secernentea E02H1.56
    Uncharacterized protein E02H1.5
    25(a)
    1 ↔ 1
    II(9595222-9596599)


    ENSEMBL Gene Tree for C14orf166 (if available)
    TreeFam Gene Tree for C14orf166 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C14orf166 gene

    C14orf166 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for C14orf166
    PGOHUM00000240258 PGOHUM00000235699


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/405 SNPs in C14orf166 are shown (see all 405)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436953271,2
    C--52454232(+) CCTTA-/TTTTTT 1 -- us2k10--------
    rs360624791,2
    C--52454239(+) TTTTT-/TAAAGA 1 -- us2k10--------
    rs360161971,2
    C,F--52454378(+) CTAGCA/CTGCAC 1 -- us2k16Minor allele frequency- C:0.23NA EA 248
    rs747452131,2
    C,F--52454459(+) CTTGAT/CTCACT 1 -- us2k12Minor allele frequency- C:0.03CSA EA 122
    rs754372031,2
    F--52454553(+) TTTTAT/ATATTA 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs37596511,2
    C--52454627(-) ctgcaA/Gggttg 1 -- us2k10--------
    rs341948471,2
    C,F--52454636(+) AGGCTC/GAAGTG 1 -- us2k11Minor allele frequency- G:0.08NA 120
    rs2010187971,2
    C--52454717(+) TTCTTC/TTTTTT 1 -- us2k10--------
    rs1912962381,2
    --52454891(+) TTTCTC/TGTAAT 1 -- us2k10--------
    rs1837998091,2
    --52454934(+) ATTTAG/TTTACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C14orf166 (52456193 - 52471420 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C14orf166:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv901947CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610858    OMIM disorders: --

    7 diseases for C14orf166:    About MalaCards
    endocarditis    influenza    hepatitis c    schizophrenia
    pancreatic cancer    pancreatitis    hepatitis

    1 disease from the University of Copenhagen DISEASES database for C14orf166:
    Barrett's esophagus

    C14orf166 for disorders           About GeneDecksing


    Export disorders for C14orf166 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C14orf166 gene, integrated from 9 sources (see all 38):
    (articles sorted by number of sources associating them with C14orf166)
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    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
    2. A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors. (PubMed id 15147888)1, 2, 9 Howng S.-L....Hong Y.-R. (2004)
    3. Identification of hnRNPH1, NF45, and C14orf166 as nov el host interacting partners of the mature hepatitis C virus core protein. (PubMed id 21823664)1, 2 Lee J.W....Wang S.W. (2011)
    4. Cellular human CLE/C14orf166 protein interacts with i nfluenza virus polymerase and is required for viral replication. (PubMed id 21900157)1, 2 Rodriguez A....Nieto A. (2011)
    5. hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator. (PubMed id 16950395)1, 2 Perez-Gonzalez A....Nieto A. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators. (PubMed id 11507205)1, 2 Huarte M.... Nieto A. (2001)
    8. Interlaboratory reproducibility of large-scale human p rotein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (2013)
    9. The Identification of Novel Proteins That Interact Wit h the GLP-1 Receptor and Restrain its Activity. (PubMed id 23864651)1 Huang X....Wheeler M.B. (2013)
    10. Bcl2-associated Athanogene 3 Interactome Analysis Reve als a New Role in Modulating Proteasome Activity. (PubMed id 23824909)1 Chen Y....Ge F. (2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51637 HGNC: 23169 AceView: C14orf166 Ensembl:ENSG00000087302 euGenes: HUgn51637
    ECgene: C14orf166 H-InvDB: C14orf166

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C14orf166 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C14orf166 gene:
    Search GeneIP for patents involving C14orf166

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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