Aliases for C14orf166 Gene
Aliases for C14orf166 Gene
External Ids for C14orf166 Gene
- HGNC: 23169
- Entrez Gene: 51637
- Ensembl: ENSG00000087302
- OMIM: 610858
- UniProtKB: Q9Y224
Previous GeneCards Identifiers for C14orf166 Gene
- GC14P050446
- GC14P051525
- GC14P052456
- GC14P032616
Summaries for C14orf166 Gene
GeneCards Summary for C14orf166 Gene
C14orf166 (Chromosome 14 Open Reading Frame 166) is a Protein Coding gene. Diseases associated with C14orf166 include Influenza and Leukoencephalopathy With Vanishing White Matter. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include poly(A) RNA binding and RNA binding.
UniProtKB/Swiss-Prot for C14orf166 Gene
-
RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication. Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf166 Gene
Genomics for C14orf166 Gene
Regulatory Elements for C14orf166 Gene
Regulatory Element Products
Genomic Location for C14orf166 Gene
- Chromosome:
- 14
- Start:
- 51,989,475 bp from pter
- End:
- 52,010,691 bp from pter
- Size:
- 21,217 bases
- Orientation:
- Plus strand
Genomic View for C14orf166 Gene
- Cytogenetic band:
-
- 14q22.1 by Ensembl
- 14q22.1 by Entrez Gene
- 14q22.1 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C14orf166 Gene
Proteins for C14orf166 Gene
-
Protein details for C14orf166 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y224-CN166_HUMAN
- Recommended name:
- UPF0568 protein C14orf166
- Protein Accession:
- Q9Y224
Protein attributes for C14orf166 Gene
- Size:
- 244 amino acids
- Molecular mass:
- 28068 Da
- Quaternary structure:
-
- Homodimer (Probable). Interacts with NIN; which may prevent phosphorylation of NIN. Interacts with POLR2A. Component of a tRNA-splicing ligase complex with FAM98B, DDX1 and RTCB. Interacts with influenza A virus RNA polymerase subunits PA, PB1 and PB2, and nucleocapsid NP. Interacts with hepatitis C virus core protein p19.
Protein Expression for C14orf166 Gene
Post-translational modifications for C14orf166 Gene
Other Protein References for C14orf166 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for C14orf166
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-
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Protein Products
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-
Abcam proteins for C14orf166
Assay Products
No data available for DME Specific Peptides for C14orf166 Gene
Domains & Families for C14orf166 Gene
Suggested Antigen Peptide Sequences for C14orf166 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9Y224- Family:
-
- Belongs to the UPF0568 family.
No data available for Gene Families for C14orf166 Gene
Function for C14orf166 Gene
Molecular function for C14orf166 Gene
- UniProtKB/Swiss-Prot Function:
- RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication. Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264).
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000993 | RNA polymerase II core binding | IDA | 16950395 |
| GO:0003723 | RNA binding | IDA,IEA | 22658674 |
| GO:0005515 | protein binding | IPI | 11507205 |
| GO:0042802 | identical protein binding | IPI | 15147888 |
Phenotypes for C14orf166 Gene
- MGI mutant phenotypes for C14orf166:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for C14orf166:
-
- Increased vaccinia virus (VACV) infection
- Increased gamma-H2AX phosphorylation
- Decreased viability in esophageal squamous lineage
- Decreased shRNA abundance (Z-score < -2)
- Downregulation of NF-kappaB pathway after LMP1 stimulation
- Increased shRNA abundance (Z-score > 2)
- Decreased homologous recombination repair frequency
- Decreased viability
- Downregulation of NF-kappaB pathway after TNFalpha stimulation
Animal Models for C14orf166 Gene
- MGI Knock Outs for C14orf166:
-
- 2700060E02Rik tm1b(EUCOMM)Hmgu
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
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-
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CRISPR Products
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miRNA for C14orf166 Gene
- miRTarBase miRNAs that target C14orf166
miRNA Products
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Inhibitory RNA Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
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Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C14orf166 Gene
Localization for C14orf166 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C14orf166 Gene
- Nucleus. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May localize at the centrosome during mitosis. Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). {ECO:0000269 PubMed:24608264}.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IDA | 24608264 |
| GO:0005654 | nucleoplasm | IDA,TAS | -- |
| GO:0005737 | cytoplasm | IEA,IDA | 24608264 |
| GO:0005815 | microtubule organizing center | IEA | -- |
| GO:0005829 | cytosol | IEA | -- |
Pathways & Interactions for C14orf166 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | tRNA processing |
.55
|
|
| 2 | Gene Expression |
.48
|
|
Pathways by source for C14orf166 Gene
3 Reactome pathways for C14orf166 Gene
Interacting Proteins for C14orf166 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006388 | tRNA splicing, via endonucleolytic cleavage and ligation | TAS | -- |
| GO:0016032 | viral process | IEA | -- |
| GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | IMP | 16950395 |
No data available for SIGNOR curated interactions for C14orf166 Gene
Transcripts for C14orf166 Gene
mRNA/cDNA for C14orf166 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (458) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C14orf166 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C14orf166
-
Santa Cruz Biotechnology (SCBT) CRISPR for C14orf166
- GenScript: Design CRISPR guide RNA sequences for C14orf166
miRNA Products
- Search ViGene Biosciences for C14orf166
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C14orf166
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Clone Products
-
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- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C14orf166
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf166
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||
| SP6: |
Expression for C14orf166 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Head Mesenchyme (Muscoskeletal System)
- Dental Mesenchymal Cells Branchial Arch 1
-
Tooth
- Dental Mesenchymal Cells Branchial Arch 1
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Placenta (Extraembryonic Tissues)
-
Spleen (Hematopoietic System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Kidney (Urinary System)
-
Testis (Reproductive System)
-
Adrenal Gland (Endocrine System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Liver (Hepatobiliary System)
-
Pancreas (Endocrine System)
-
Ovary (Reproductive System)
-
Adipose (Muscoskeletal System)
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for C14orf166 Gene
NURSA nuclear receptor signaling pathways regulating expression of C14orf166 Gene:
C14orf166SOURCE GeneReport for Unigene cluster for C14orf166 Gene:
Hs.534457mRNA Expression by UniProt/SwissProt for C14orf166 Gene:
Q9Y224-CN166_HUMANEvidence on tissue expression from TISSUES for C14orf166 Gene
- Nervous system(4.6)
- Liver(4.5)
- Muscle(4.5)
- Lung(3.1)
- Pancreas(2.7)
- Heart(2.6)
- Lymph node(2.5)
- Spleen(2.3)
- Kidney(2.2)
- Intestine(2)
Primer Products
-
OriGene qPCR primer pairs and template standards for C14orf166
-
OriGene qPCR primer pairs for C14orf166
No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf166 Gene
Orthologs for C14orf166 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C14ORF166 35 |
|
OneToOne | |
| C14H14orf166 34 |
|
||||
| dog (Canis familiaris) |
Mammalia | C14orf166 35 |
|
OneToOne | |
| C8H14orf166 34 |
|
||||
| cow (Bos Taurus) |
Mammalia | C10H14ORF166 35 |
|
OneToOne | |
| C10H14orf166 34 |
|
||||
| oppossum (Monodelphis domestica) |
Mammalia | C14orf166 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Gm10704 35 |
|
OneToMany | |
| 2700060E02Rik 34 16 35 |
|
||||
| rat (Rattus norvegicus) |
Mammalia | RGD1304704 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | C14orf166 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | C5H14ORF166 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | C14orf166 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100493394 34 |
|
||
| Str.9974 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.18755 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | C17H14orf166 35 |
|
OneToOne | |
| zgc:56576 34 |
|
||||
| zgc56576 34 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6642 34 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | CG31249 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP001816 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | E02H1.5 35 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 35 |
|
OneToOne | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.3718 34 |
|
- Species where no ortholog for C14orf166 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for C14orf166 Gene
Pseudogenes.org Pseudogenes for C14orf166 Gene
No data available for Paralogs for C14orf166 Gene
Variants for C14orf166 Gene
| SNP ID | Clin | Chr 14 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000041219 | -- | 51,990,812(+) | TTTAC(-/TTA)TTATT | intron-variant | |
| rs1000056572 | -- | 51,992,827(+) | GGGGT(C/T)CGAGA | intron-variant | |
| rs1000173336 | -- | 52,005,175(+) | AATTC(G/T)TAGTT | intron-variant, utr-variant-3-prime | |
| rs1000213083 | -- | 52,004,845(+) | GAAAA(C/T)TTTAA | intron-variant, utr-variant-3-prime | |
| rs1000237193 | -- | 51,996,727(+) | AACCA(A/C)AGTAC | intron-variant |
Relevant External Links for C14orf166 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C14orf166
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf166 Gene
Disorders for C14orf166 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| influenza |
|
|
| leukoencephalopathy with vanishing white matter |
|
|
Relevant External Links for C14orf166
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- C14orf166
No data available for UniProtKB/Swiss-Prot and Genatlas for C14orf166 Gene
Publications for C14orf166 Gene
- hCLE/C14orf166 Associates with DDX1-HSPC117-FAM98B in a Novel Transcription-Dependent Shuttling RNA-Transporting Complex. (PMID: 24608264) PAcrez-GonzA!lez A. … Nieto A. (PLoS ONE 2014) 2 3 4 64
- A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors. (PMID: 15147888) Howng S.-L. … Hong Y.-R. (FEBS Lett. 2004) 3 4 22 64
- PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators. (PMID: 11507205) Huarte M. … Nieto A. (J. Virol. 2001) 2 3 4 64
- Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors. (PMID: 24870230) Popow J. … Martinez J. (Nature 2014) 3 4 64
- HSPC117 is the essential subunit of a human tRNA splicing ligase complex. (PMID: 21311021) Popow J. … Martinez J. (Science 2011) 3 4 64
Products for C14orf166 Gene
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- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C14orf166
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C14orf166 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
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- (153) dbSUPER
- (154) TISSUES
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