C14orf166 Gene
protein-coding GIFtS: 47
GCID: GC14P052456
|
|
chromosome 14 open reading frame 166
| |
Aliases
for C14orf166 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 14 Open Reading Frame 1661 2 | | CLE7 Homolog2 3 | | CLE1 2 3 | | CGI992 5 | | CLE71 2 | | CGI-991 | | LCRP3691 2 | | RLL Motif Containing 12 | | RLLM11 2 | | UPF0568 Protein C14orf1662 |
Export aliases for C14orf166 gene to outside databasesPrevious GC identifers: GC14P050446 GC14P051525 GC14P032616 |
Summaries
for C14orf166 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: CN166_HUMAN, Q9Y224Function: Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, isinvolved in viral replication
Gene Wiki entry for C14orf166
|
Genomic Views
for C14orf166 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C14orf166 gene promoter:
FOXO3 IRF-1 CUTL1 FOXO3b Meis-1b Arnt AREB6 FOXO3a Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C14orf166
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf166 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q22.1 Ensembl cytogenetic band: 14q22.1 HGNC cytogenetic band: 14q22.1C14orf166 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14P052456: view genomic region
(about GC identifiers)
Start:
|
52,456,193 bp from pter |
End:
|
52,471,420 bp from pter |
Size:
|
15,228 bases |
Orientation:
|
plus strand |
|
Proteins
for C14orf166 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CN166_HUMAN, Q9Y224 (See
protein sequence)Recommended Name: UPF0568 protein C14orf166 Size: 244 amino acids; 28068 Da
Subunit: Homodimer (Probable). Interacts with NIN; which may prevent phosphorylation of NIN. Interacts with POLR2A.Component of a tRNA-splicing ligase complex. Interacts with influenza A virus RNA polymerase subunits PA, PB1 and PB2,and nucleocapsid NP. Interacts with hepatitis C virus core protein p19
Subcellular location: Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, centrosome. Note=May localize atthe centrosome during mitosisExplore the universe of human proteins at neXtProt for C14orf166: NX_Q9Y224
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9Y224
C14orf166 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_057123.1
ENSEMBL proteins: ENSP00000261700 ENSP00000451751 ENSP00000451715 ENSP00000451153
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
C14orf166 for ontologies About GeneDecksing
C14orf166 Antibody Products:
Assay Products for C14orf166: |
Protein
Domains /
Families
for C14orf166 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C14orf166 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9Y224ProtoNet protein and cluster: Q9Y224 UniProtKB/Swiss-Prot: CN166_HUMAN, Q9Y224Similarity: Belongs to the UPF0568 family |
Function
for C14orf166 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CN166_HUMAN, Q9Y224Function: Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, isinvolved in viral replication
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf166 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf166
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf166 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
C14orf166 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for C14orf166:
|
Pathways & Interactions
for C14orf166 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C14orf166
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/32 Interacting proteins for C14orf166 (Q9Y2241, 2, 3 ENSP000002617004) via UniProtKB, MINT, STRING, and/or I2D (see all 32)About this table
Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006351 | transcription, DNA-dependent |
IEA | -- | | GO:0019048 | virus-host interaction |
IEA | -- | | GO:0044419 | interspecies interaction between organisms |
-- | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IMP | 16950395 |
C14orf166 for ontologies About GeneDecksing
|
Drugs & Compounds
for C14orf166 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C14orf166
Search CenterWatch for drugs/clinical trials and news about C14orf166 / CN166
|
Transcripts
for C14orf166 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C14orf166 gene: NM_016039.2 Unigene Cluster for C14orf166: Chromosome 14 open reading frame 166 Hs.534457 [show with all ESTs]Unigene Representative Sequence: AK1295167 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000261700(uc010aod.3) ENST00000557553 ENST00000556760 ENST00000553362
ENST00000553707 ENST00000555319 ENST00000553479
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf166 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf166
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
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Additional cDNA sequence: AF087877.1 AF100755.1 AF151857.1 AK129516.1 AK312004.1 AY817175.1 BC001722.1 DQ525179.1 15 DOTS entries: DT.100874513 DT.454678 DT.87017563 DT.100667260 DT.92424619 DT.99966737 DT.120978501 DT.95175083 DT.65285945 DT.100667252 DT.100667254 DT.75153399 DT.92456733 DT.95175089 DT.102834399 24/458 AceView cDNA sequences (see all 458): AA181851 CR605881 CR599997 BQ267844 AI023628 BM669398 BM711415 CR606481 BI908386 BC001722 CD676772 CR606480 CA392822 CA413101 AI420133 BQ061428 AJ708782 BQ672887 BM793590 CN485150 BU860026 CN479398 BQ671180 AK129516
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for C14orf166 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | - | | | | - | | | | | | |
| SP3: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | | | | | | | | | - | | - | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | - | | | | | |
ECgene alternative splicing isoforms for C14orf166
|
Expression
for C14orf166 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C14orf166 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTGGAAATC
About this image
See C14orf166 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C14orf166
SOURCE GeneReport for Unigene cluster: Hs.534457
UniProtKB/Swiss-Prot: CN166_HUMAN, Q9Y224Tissue specificity: Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediatelevel in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetalliver and fetal kidney. Overexpressed in many brain tumors
SABiosciences Custom PCR Arrays for C14orf166
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C14orf166
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf166 |
Orthologs
for C14orf166 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C14orf166 gene from 7/26 species (see all 26) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
2700060E02Rik1 , 5 |
RIKEN cDNA 2700060E02 gene1, 5 |
92.35(n)1
97.13(a)1 |
|
14 (10.95 cM)5
680451 NM_026528.31 NP_080804.11
198114025 |
chicken
(Gallus gallus) |
Aves |
C5H14orf1661 |
chromosome 5 open reading frame, human C14orf166 |
83.68(n)
88.7(a) |
|
396326 NM_205369.1 NP_990700.1 |
lizard
(Anolis carolinensis) |
Reptilia |
C14orf1666 |
-- |
90(a) |
1 ↔ 1 |
GL343501.1(461408-475739) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.187552 |
Xenopus laevis transcribed sequence with moderate similarity more |
77.43(n) |
|
BX850709.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc565762 |
hypothetical protein MGC56576 |
76.97(n) |
|
393240 BC049049.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG312491 |
CG31249 |
50.23(n)
41.55(a) |
|
42129 NM_169774.2 NP_732262.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
E02H1.56 |
Uncharacterized protein E02H1.5 |
24(a) |
1 ↔ 1 |
II(9595162-9596539) |
ENSEMBL Gene Tree for C14orf166 (if available)
TreeFam Gene Tree for C14orf166 (if available) |
Paralogs
for C14orf166 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C14orf166 gene
C14orf166 for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for C14orf166
PGOHUM00000240258 PGOHUM00000235699
|
Genomic Variants
for C14orf166 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C14orf166 (52456193 - 52471420 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C14orf166: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for C14orf166 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C14orf166 for disorders About GeneDecksing
OMIM gene information: 610858
OMIM disorders: --
7  diseases for C14orf166: About MalaCardshepatitis c endocarditis influenza pancreatic cancer
pancreatitis hepatitis schizophrenia
Export disorders for C14orf166 gene to outside databases
|
Publications
for C14orf166 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C14orf166 gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with C14orf166) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.H....Lin W. (2000)
- A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors. (PubMed id 15147888)1, 2, 9 Howng S.-L....Hong Y.-R. (2004)
- Identification of hnRNPH1, NF45, and C14orf166 as nov el host interacting partners of the mature hepatitis C virus core protein. (PubMed id 21823664)1, 2 Lee J.W....Wang S.W. (2011)
- Cellular human CLE/C14orf166 protein interacts with i nfluenza virus polymerase and is required for viral replication. (PubMed id 21900157)1, 2 Rodriguez A....Nieto A. (2011)
- hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator. (PubMed id 16950395)1, 2 Perez-Gonzalez A....Nieto A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators. (PubMed id 11507205)1, 2 Huarte M.... Nieto A. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
|
External Searches for C14orf166 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C14orf166 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C14orf166 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C14orf166 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C14orf166 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C14orf166 gene:
Search GeneIP for patents involving C14orf166
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C14orf166 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| |
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 |
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| |
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| | | |  |  |  |  | | | | |
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 |
 |
 | | | C14orf166 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf166 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf166 |
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