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Aliases for C14orf166 Gene

Aliases for C14orf166 Gene

  • Chromosome 14 Open Reading Frame 166 2 3
  • RLL Motif Containing 1 2 3
  • CLE7 Homolog 3 4
  • CGI99 3 6
  • CLE 3 4
  • UPF0568 Protein C14orf166 3
  • LCRP369 3
  • CGI-99 3
  • RLLM1 3
  • CLE7 3

External Ids for C14orf166 Gene

Summaries for C14orf166 Gene

GeneCards Summary for C14orf166 Gene

C14orf166 (Chromosome 14 Open Reading Frame 166) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and RNA polymerase II core binding.

UniProtKB/Swiss-Prot for C14orf166 Gene

  • RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication. Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264).

Gene Wiki entry for C14orf166 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf166 Gene

Genomics for C14orf166 Gene

Genomic Location for C14orf166 Gene

Start:
51,989,475 bp from pter
End:
52,010,691 bp from pter
Size:
21,217 bases
Orientation:
Plus strand

Genomic View for C14orf166 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C14orf166 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf166 Gene

Regulatory Elements for C14orf166 Gene

Proteins for C14orf166 Gene

  • Protein details for C14orf166 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y224-CN166_HUMAN
    Recommended name:
    UPF0568 protein C14orf166
    Protein Accession:
    Q9Y224
    Secondary Accessions:

    Protein attributes for C14orf166 Gene

    Size:
    244 amino acids
    Molecular mass:
    28068 Da
    Quaternary structure:
    • Homodimer (Probable). Interacts with NIN; which may prevent phosphorylation of NIN. Interacts with POLR2A. Component of a tRNA-splicing ligase complex with FAM98B, DDX1 and RTCB. Interacts with influenza A virus RNA polymerase subunits PA, PB1 and PB2, and nucleocapsid NP. Interacts with hepatitis C virus core protein p19.

neXtProt entry for C14orf166 Gene

Proteomics data for C14orf166 Gene at MOPED

Post-translational modifications for C14orf166 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys58, Lys72, Lys98, Lys115, Lys154, Lys171, Lys176, Lys185, and Lys218

Other Protein References for C14orf166 Gene

No data available for DME Specific Peptides for C14orf166 Gene

Domains for C14orf166 Gene

Protein Domains for C14orf166 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CN166_HUMAN
Family:
  • Belongs to the UPF0568 family.:
    • Q9Y224
genes like me logo Genes that share domains with C14orf166: view

No data available for Gene Families for C14orf166 Gene

Function for C14orf166 Gene

Molecular function for C14orf166 Gene

UniProtKB/Swiss-Prot Function: RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication. Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264).

Gene Ontology (GO) - Molecular Function for C14orf166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 16950395
GO:0003723 RNA binding IDA 24608264
GO:0005515 protein binding IPI 11507205
GO:0042802 identical protein binding IPI 15147888
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with C14orf166: view
genes like me logo Genes that share phenotypes with C14orf166: view

miRNA for C14orf166 Gene

miRTarBase miRNAs that target C14orf166

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C14orf166 Gene

Localization for C14orf166 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf166 Gene

Nucleus. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May localize at the centrosome during mitosis. Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). {ECO:0000269 PubMed:24608264}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C14orf166 Gene COMPARTMENTS Subcellular localization image for C14orf166 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for C14orf166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24608264
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 24608264
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with C14orf166: view

Pathways for C14orf166 Gene

SuperPathways for C14orf166 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C14orf166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation IMP 24870230
GO:0016032 viral process IEA --
GO:0045944 positive regulation of transcription from RNA polymerase II promoter IMP 16950395
GO:0050658 RNA transport TAS 24608264
genes like me logo Genes that share ontologies with C14orf166: view

No data available for Pathways by source for C14orf166 Gene

Transcripts for C14orf166 Gene

mRNA/cDNA for C14orf166 Gene

Unigene Clusters for C14orf166 Gene

Chromosome 14 open reading frame 166:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf166 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for C14orf166 Gene

GeneLoc Exon Structure for
C14orf166
ECgene alternative splicing isoforms for
C14orf166

Expression for C14orf166 Gene

mRNA expression in normal human tissues for C14orf166 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C14orf166 Gene

SOURCE GeneReport for Unigene cluster for C14orf166 Gene Hs.534457

mRNA Expression by UniProt/SwissProt for C14orf166 Gene

Q9Y224-CN166_HUMAN
Tissue specificity: Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors.
genes like me logo Genes that share expressions with C14orf166: view

Orthologs for C14orf166 Gene

This gene was present in the common ancestor of animals.

Orthologs for C14orf166 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf166 36
  • 99.73 (n)
  • 100 (a)
C14ORF166 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C10H14orf166 36
  • 94.13 (n)
  • 98.36 (a)
C10H14ORF166 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C14orf166 37
  • 99 (a)
OneToOne
C8H14orf166 36
  • 94.54 (n)
  • 98.77 (a)
mouse
(Mus musculus)
Mammalia 2700060E02Rik 36
  • 92.35 (n)
  • 97.13 (a)
2700060E02Rik 16
2700060E02Rik 37
  • 97 (a)
OneToMany
Gm10704 37
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia C14orf166 37
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf166 37
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1304704 36
  • 89.62 (n)
  • 97.13 (a)
chicken
(Gallus gallus)
Aves C5H14ORF166 36
  • 83.68 (n)
  • 88.7 (a)
C5H14ORF166 37
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C14orf166 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.18755 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493394 36
  • 76.25 (n)
  • 86.25 (a)
Str.9974 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6642 36
zebrafish
(Danio rerio)
Actinopterygii C17H14orf166 37
  • 85 (a)
OneToOne
zgc56576 36
zgc:56576 36
  • 73.28 (n)
  • 84.3 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001816 36
  • 49.52 (n)
  • 45.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31249 36
  • 50.23 (n)
  • 41.55 (a)
CG31249 37
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E02H1.5 37
  • 23 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3718 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 52 (a)
OneToOne
Species with no ortholog for C14orf166:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C14orf166 Gene

ENSEMBL:
Gene Tree for C14orf166 (if available)
TreeFam:
Gene Tree for C14orf166 (if available)

Paralogs for C14orf166 Gene

Pseudogenes.org Pseudogenes for C14orf166 Gene

genes like me logo Genes that share paralogs with C14orf166: view

No data available for Paralogs for C14orf166 Gene

Variants for C14orf166 Gene

Sequence variations from dbSNP and Humsavar for C14orf166 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1056352 -- 52,003,510(-) ACACA(C/G)TACCC intron-variant
rs1151569 -- 51,993,777(+) CTATT(C/G)ACTGG missense, reference
rs1151570 -- 51,998,742(-) CACAT(C/T)ATAAA intron-variant
rs1151571 -- 52,000,122(+) tgaca(A/G)agcca intron-variant
rs1151572 -- 52,000,192(+) TTAGT(G/T)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf166 Gene

Variant ID Type Subtype PubMed ID
nsv901947 CNV Gain 21882294

Relevant External Links for C14orf166 Gene

HapMap Linkage Disequilibrium report
C14orf166

Disorders for C14orf166 Gene

(1) University of Copenhagen DISEASES for C14orf166 Gene

genes like me logo Genes that share disorders with C14orf166: view

No data available for UniProtKB/Swiss-Prot for C14orf166 Gene

Publications for C14orf166 Gene

  1. A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors. (PMID: 15147888) Howng S.-L. … Hong Y.-R. (FEBS Lett. 2004) 3 4 23
  2. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 3 4
  3. hCLE/C14orf166 Associates with DDX1-HSPC117-FAM98B in a Novel Transcription-Dependent Shuttling RNA-Transporting Complex. (PMID: 24608264) PAcrez-GonzA!lez A. … Nieto A. (PLoS ONE 2014) 2 3 4
  4. Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors. (PMID: 24870230) Popow J. … Martinez J. (Nature 2014) 3 4
  5. PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators. (PMID: 11507205) Huarte M. … Nieto A. (J. Virol. 2001) 3 4

Products for C14orf166 Gene

Sources for C14orf166 Gene

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