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Aliases for C14orf166 Gene

Aliases for C14orf166 Gene

  • Chromosome 14 Open Reading Frame 166 2 3
  • RLL Motif Containing 1 2 3
  • CLE7 Homolog 3 4
  • CLE 3 4
  • LCRP369 3
  • CGI-99 3
  • CGI99 3
  • RLLM1 3
  • CLE7 3

External Ids for C14orf166 Gene

Previous GeneCards Identifiers for C14orf166 Gene

  • GC14P050446
  • GC14P051525
  • GC14P052456
  • GC14P032616

Summaries for C14orf166 Gene

GeneCards Summary for C14orf166 Gene

C14orf166 (Chromosome 14 Open Reading Frame 166) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA modification in the nucleus and cytosol. GO annotations related to this gene include poly(A) RNA binding and RNA binding.

UniProtKB/Swiss-Prot for C14orf166 Gene

  • RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication. Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264).

Gene Wiki entry for C14orf166 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf166 Gene

Genomics for C14orf166 Gene

Regulatory Elements for C14orf166 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C14orf166 Gene

Chromosome:
14
Start:
51,989,475 bp from pter
End:
52,010,691 bp from pter
Size:
21,217 bases
Orientation:
Plus strand

Genomic View for C14orf166 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for C14orf166 Gene

Proteins for C14orf166 Gene

  • Protein details for C14orf166 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y224-CN166_HUMAN
    Recommended name:
    UPF0568 protein C14orf166
    Protein Accession:
    Q9Y224

    Protein attributes for C14orf166 Gene

    Size:
    244 amino acids
    Molecular mass:
    28068 Da
    Quaternary structure:
    • Homodimer (Probable). Interacts with NIN; which may prevent phosphorylation of NIN. Interacts with POLR2A. Component of a tRNA-splicing ligase complex with FAM98B, DDX1 and RTCB. Interacts with influenza A virus RNA polymerase subunits PA, PB1 and PB2, and nucleocapsid NP. Interacts with hepatitis C virus core protein p19.

neXtProt entry for C14orf166 Gene

Proteomics data for C14orf166 Gene at MOPED

Post-translational modifications for C14orf166 Gene

  • Ubiquitination at Lys 72, Lys 98, Lys 115, Lys 154, Lys 171, Lys 185, and Lys 218
  • Modification sites at PhosphoSitePlus

Other Protein References for C14orf166 Gene

No data available for DME Specific Peptides for C14orf166 Gene

Domains & Families for C14orf166 Gene

Protein Domains for C14orf166 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C14orf166 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y224

UniProtKB/Swiss-Prot:

CN166_HUMAN :
  • Belongs to the UPF0568 family.
Family:
  • Belongs to the UPF0568 family.
genes like me logo Genes that share domains with C14orf166: view

No data available for Gene Families for C14orf166 Gene

Function for C14orf166 Gene

Molecular function for C14orf166 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus A, is involved in viral replication. Component of the tRNA-splicing ligase complex and is required for tRNA ligation (PubMed:24870230). May be required for RNA transport (PubMed:24608264).

Gene Ontology (GO) - Molecular Function for C14orf166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000993 RNA polymerase II core binding IDA 16950395
GO:0003723 RNA binding IDA 24608264
GO:0005515 protein binding IPI 11507205
GO:0042802 identical protein binding IPI 15147888
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with C14orf166: view
genes like me logo Genes that share phenotypes with C14orf166: view

Animal Model Products

CRISPR Products

miRNA for C14orf166 Gene

miRTarBase miRNAs that target C14orf166

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C14orf166

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf166 Gene

Localization for C14orf166 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf166 Gene

Nucleus. Cytoplasm, cytosol. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=May localize at the centrosome during mitosis. Shuttles between the cytosol and the nucleus: enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low (PubMed:24608264). {ECO:0000269 PubMed:24608264}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C14orf166 Gene COMPARTMENTS Subcellular localization image for C14orf166 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for C14orf166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 24608264
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 24608264
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with C14orf166: view

Pathways & Interactions for C14orf166 Gene

genes like me logo Genes that share pathways with C14orf166: view

Pathways by source for C14orf166 Gene

3 Reactome pathways for C14orf166 Gene

Gene Ontology (GO) - Biological Process for C14orf166 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation IMP 24870230
GO:0008033 tRNA processing TAS --
GO:0010467 gene expression TAS --
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with C14orf166: view

No data available for SIGNOR curated interactions for C14orf166 Gene

Drugs & Compounds for C14orf166 Gene

No Compound Related Data Available

Transcripts for C14orf166 Gene

Unigene Clusters for C14orf166 Gene

Chromosome 14 open reading frame 166:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C14orf166

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf166 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8
SP1: - -
SP2: - - -
SP3: - -
SP4: - - -
SP5: - -
SP6:

Relevant External Links for C14orf166 Gene

GeneLoc Exon Structure for
C14orf166
ECgene alternative splicing isoforms for
C14orf166

Expression for C14orf166 Gene

mRNA expression in normal human tissues for C14orf166 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C14orf166 Gene



SOURCE GeneReport for Unigene cluster for C14orf166 Gene Hs.534457

mRNA Expression by UniProt/SwissProt for C14orf166 Gene

Q9Y224-CN166_HUMAN
Tissue specificity: Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung, placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors.
genes like me logo Genes that share expression patterns with C14orf166: view

Protein tissue co-expression partners for C14orf166 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and Protein differential expression in normal tissues for C14orf166 Gene

Orthologs for C14orf166 Gene

This gene was present in the common ancestor of animals.

Orthologs for C14orf166 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C10H14orf166 35
  • 94.13 (n)
  • 98.36 (a)
C10H14ORF166 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C8H14orf166 35
  • 94.54 (n)
  • 98.77 (a)
C14orf166 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2700060E02Rik 35
  • 92.35 (n)
  • 97.13 (a)
2700060E02Rik 16
2700060E02Rik 36
  • 97 (a)
OneToMany
Gm10704 36
  • 95 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf166 35
  • 99.73 (n)
  • 100 (a)
C14ORF166 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1304704 35
  • 89.62 (n)
  • 97.13 (a)
oppossum
(Monodelphis domestica)
Mammalia C14orf166 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf166 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5H14ORF166 35
  • 83.68 (n)
  • 88.7 (a)
C5H14ORF166 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C14orf166 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100493394 35
  • 76.25 (n)
  • 86.25 (a)
Str.9974 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.18755 35
zebrafish
(Danio rerio)
Actinopterygii zgc56576 35
zgc:56576 35
  • 73.28 (n)
  • 84.3 (a)
C17H14orf166 36
  • 85 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6642 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001816 35
  • 49.52 (n)
  • 45.23 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31249 35
  • 50.23 (n)
  • 41.55 (a)
CG31249 36
  • 38 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea E02H1.5 36
  • 23 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3718 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToOne
Species with no ortholog for C14orf166:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C14orf166 Gene

ENSEMBL:
Gene Tree for C14orf166 (if available)
TreeFam:
Gene Tree for C14orf166 (if available)

Paralogs for C14orf166 Gene

Pseudogenes.org Pseudogenes for C14orf166 Gene

genes like me logo Genes that share paralogs with C14orf166: view

No data available for Paralogs for C14orf166 Gene

Variants for C14orf166 Gene

Sequence variations from dbSNP and Humsavar for C14orf166 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1056352 -- 52,003,510(-) ACACA(C/G)TACCC intron-variant
rs1151569 -- 51,993,777(+) CTATT(C/G)ACTGG missense, reference
rs1151570 -- 51,998,742(-) CACAT(C/T)ATAAA intron-variant
rs1151571 -- 52,000,122(+) tgaca(A/G)agcca intron-variant
rs1151572 -- 52,000,192(+) TTAGT(G/T)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf166 Gene

Variant ID Type Subtype PubMed ID
nsv901947 CNV Gain 21882294

Variation tolerance for C14orf166 Gene

Residual Variation Intolerance Score: 48.79% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.76; 15.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C14orf166 Gene

HapMap Linkage Disequilibrium report
C14orf166

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf166 Gene

Disorders for C14orf166 Gene

Relevant External Links for C14orf166

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C14orf166
genes like me logo Genes that share disorders with C14orf166: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf166 Gene

Publications for C14orf166 Gene

  1. hCLE/C14orf166 Associates with DDX1-HSPC117-FAM98B in a Novel Transcription-Dependent Shuttling RNA-Transporting Complex. (PMID: 24608264) PAcrez-GonzA!lez A. … Nieto A. (PLoS ONE 2014) 2 67
  2. A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors. (PMID: 15147888) Howng S.-L. … Hong Y.-R. (FEBS Lett. 2004) 23 67
  3. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PMID: 10810093) Lai C.-H. … Lin W.-C. (Genome Res. 2000) 2 67
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  5. Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy. (PMID: 25852190) So J. … Colwill K. (Sci Signal 2015) 67

Products for C14orf166 Gene

Sources for C14orf166 Gene

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