Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



C14orf166 Gene

protein-coding   GIFtS: 51
GCID: GC14P052456

Chromosome 14 Open Reading Frame 166

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Chromosome 14 Open Reading Frame 1661 2     CLE72
RLL Motif Containing 11 2     LCRP3692
CLE2 3     RLLM12
CLE7 Homolog2 3     UPF0568 Protein C14orf1662
CGI992 5     

External Ids:    HGNC: 231691   Entrez Gene: 516372   Ensembl: ENSG000000873027   OMIM: 6108585   UniProtKB: Q9Y2243   

Export aliases for C14orf166 gene to outside databases

Previous GC identifers: GC14P050446 GC14P051525 GC14P032616


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for C14orf166 Gene:
C14orf166 (chromosome 14 open reading frame 166) is a protein-coding gene. Diseases associated with C14orf166 include endocarditis, and barrett's esophagus. GO annotations related to this gene include RNA polymerase II core binding and identical protein binding.

UniProtKB/Swiss-Prot: CN166_HUMAN, Q9Y224
Function: Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus
A, is involved in viral replication

Gene Wiki entry for C14orf166 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the C14orf166 gene promoter:
         FOXO3   IRF-1   CUTL1   FOXO3b   Meis-1b   Arnt   AREB6   FOXO3a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC14orf166 promoter sequence
   Search Chromatin IP Primers for C14orf166

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C14orf166


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q22.1

C14orf166 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf166 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P052456:  view genomic region     (about GC identifiers)

Start:
52,456,193 bp from pter      End:
52,471,420 bp from pter
Size:
15,228 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CN166_HUMAN, Q9Y224 (See protein sequence)
Recommended Name: UPF0568 protein C14orf166  
Size: 244 amino acids; 28068 Da
Subunit: Homodimer (Probable). Interacts with NIN; which may prevent phosphorylation of NIN. Interacts with
POLR2A. Component of a tRNA-splicing ligase complex. Interacts with influenza A virus RNA polymerase subunits PA,
PB1 and PB2, and nucleocapsid NP. Interacts with hepatitis C virus core protein p19

Explore the universe of human proteins at neXtProt for C14orf166: NX_Q9Y224

Explore proteomics data for C14orf166 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys58, Lys72, Lys98, Lys115, Lys154, Lys171, Lys176, Lys185, Lys218
  • Modification sites at PhosphoSitePlus

  • See C14orf166 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057123.1  
    ENSEMBL proteins: 
     ENSP00000261700   ENSP00000451751   ENSP00000451715   ENSP00000451153  

    C14orf166 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for C14orf166
    OriGene Protein Over-expression Lysate for C14orf166
    OriGene MassSpec for C14orf166
    OriGene Custom Protein Services for C14orf166
    GenScript Custom Purified and Recombinant Proteins Services for C14orf166
    Novus Biologicals C14orf166 Protein
    Novus Biologicals C14orf166 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

    C14orf166 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for C14orf166
    OriGene Custom Antibody Services for C14orf166
    Novus Biologicals C14orf166 Antibodies
    Abcam antibodies for C14orf166
    Browse Antibodies at Cloud-Clone Corp.
    Search ThermoFisher Antibodies for C14orf166
    LSBio Antibodies in human, mouse, rat for C14orf166

    C14orf166 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for C14orf166
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for C14orf166
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR019265 UPF0568

    Graphical View of Domain Structure for InterPro Entry Q9Y224

    ProtoNet protein and cluster: Q9Y224

    UniProtKB/Swiss-Prot: CN166_HUMAN, Q9Y224
    Similarity: Belongs to the UPF0568 family


    C14orf166 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CN166_HUMAN, Q9Y224
    Function: Involved in modulation of mRNA transcription by Polymerase II. In case of infection by influenza virus
    A, is involved in viral replication

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000993RNA polymerase II core binding IDA16950395
    GO:0005515protein binding IPI11507205
    GO:0042802identical protein binding IPI15147888
    GO:0044822poly(A) RNA binding IDA--
         
    C14orf166 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for C14orf166:
     Decreased viability  Downregulation of NF-kappaB pa  Downregulation of NF-kappaB pa  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C14orf166
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C14orf166

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C14orf166
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C14orf166

    miRNA
    Products:
        
    miRTarBase miRNAs that target C14orf166:
    hsa-mir-331-3p (MIRT043459), hsa-mir-484 (MIRT041637)

    Block miRNA regulation of human, mouse, rat C14orf166 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate C14orf166:
    hsa-miR-186 hsa-miR-3133
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for C14orf166
    Predesigned siRNA for gene silencing in human, mouse, rat C14orf166

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for C14orf166

    Clone
    Products:
         
    OriGene clones in human, mouse for C14orf166 (see all 6)
    OriGene ORF clones in mouse, rat for C14orf166
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C14orf166 (NM_016039)
    Sino Biological Human cDNA Clone for C14orf166
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C14orf166
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf166

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for C14orf166
    Browse ESI BIO Cell Lines and PureStem Progenitors for C14orf166 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf166


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CN166_HUMAN, Q9Y224: Nucleus. Cytoplasm, perinuclear region. Cytoplasm, cytoskeleton, microtubule organizing
    center, centrosome. Note=May localize at the centrosome during mitosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3
    plasma membrane2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0015629actin cytoskeleton IDA--

    C14orf166 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus




        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C14orf166
    Interactions:

        Search GeneGlobe Interaction Network for C14orf166

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for C14orf166 (Q9Y2241, 2, 3 ENSP000002617004) via UniProtKB, MINT, STRING, and/or I2D (see all 42)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NINQ8N4C61, 3, ENSP000002454414EBI-1104547,EBI-1164022 I2D: score=3 STRING: ENSP00000245441
    YWHAZP631042, 3, ENSP000003095034MINT-3307487 I2D: score=1 STRING: ENSP00000309503
    DISC1Q9NRI53, ENSP000003555964I2D: score=2 STRING: ENSP00000355596
    MEPCEQ7L2J03, ENSP000003085464I2D: score=1 STRING: ENSP00000308546
    MAP3K3Q997593I2D: score=2 
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0016032viral process IEA--
    GO:0019048modulation by virus of host morphology or physiology ----
    GO:0045944positive regulation of transcription from RNA polymerase II promoter IMP16950395

    C14orf166 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C14orf166 (CN166)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for C14orf166 gene: 
    NM_016039.2  

    Unigene Cluster for C14orf166:

    Chromosome 14 open reading frame 166
    Hs.534457  [show with all ESTs]
    Unigene Representative Sequence: AK129516
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000261700(uc010aod.3) ENST00000557553 ENST00000556760 ENST00000553362
    ENST00000553707 ENST00000555319 ENST00000553479
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat C14orf166 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate C14orf166:
    hsa-miR-186 hsa-miR-3133
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for C14orf166
    Predesigned siRNA for gene silencing in human, mouse, rat C14orf166
    Clone
    Products:
         
    OriGene clones in human, mouse for C14orf166 (see all 6)
    OriGene ORF clones in mouse, rat for C14orf166
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C14orf166 (NM_016039)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C14orf166
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf166
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for C14orf166
    OriGene qSTAR qPCR primer pairs in human, mouse for C14orf166
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat C14orf166
      QuantiTect SYBR Green Assays in human, mouse, rat C14orf166
      QuantiFast Probe-based Assays in human, mouse, rat C14orf166

    Additional mRNA sequence: 

    AF087877.1 AF100755.1 AF151857.1 AK129516.1 AK312004.1 AY817175.1 BC001722.1 DQ525179.1 

    15 DOTS entries:

    DT.100874513  DT.454678  DT.87017563  DT.100667260  DT.92424619  DT.99966737  DT.120978501  DT.95175083 
    DT.65285945  DT.100667252  DT.100667254  DT.75153399  DT.92456733  DT.95175089  DT.102834399 

    Selected AceView cDNA sequences (see all 458):

    BG677823 BM510541 AW026250 BU860026 CB242523 AI832171 CA843719 CR623591 
    BQ926251 AI739318 BE501384 CA310597 AA186586 BF795122 AI754520 AA181851 
    CA867150 CD676772 CA942012 BG941895 BQ671180 CK724872 AA714543 BM711415 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for C14orf166 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b ^ 7 ^ 8
    SP1:                                -                             -               
    SP2:                                -                 -           -               
    SP3:                    -           -                                             
    SP4:                                -                             -     -         
    SP5:                                                  -           -               


    ECgene alternative splicing isoforms for C14orf166

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    C14orf166 expression in normal human tissues (normalized intensities)      C14orf166 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTGGAAATC
    C14orf166 Expression
    About this image


    C14orf166 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Colon (Gastrointestinal Tract)
     
     Uterus (Reproductive System)
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    C14orf166 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C14orf166 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.534457

    UniProtKB/Swiss-Prot: CN166_HUMAN, Q9Y224
    Tissue specificity: Widely expressed. Expressed at high level in heart and skeletal muscle. Expressed at
    intermediate level in liver, pancreas, fetal brain and fetal lung. Weakly expressed in adult brain, adult lung,
    placenta, fetal liver and fetal kidney. Overexpressed in many brain tumors

        Custom PCR Arrays for C14orf166
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for C14orf166
    OriGene qSTAR qPCR primer pairs in human, mouse for C14orf166
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat C14orf166
    QuantiTect SYBR Green Assays in human, mouse, rat C14orf166
    QuantiFast Probe-based Assays in human, mouse, rat C14orf166
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf166

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for C14orf166 gene from Selected species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2700060E02Rik1 , 5 RIKEN cDNA 2700060E02 gene1, 5 92.35(n)1
    97.13(a)1
      14 (10.95 cM)5
    680451  NM_026528.31  NP_080804.11 
     198114025 
    chicken
    (Gallus gallus)
    Aves C5H14ORF1661 chromosome 5 open reading frame, human C14orf166 83.68(n)
    88.7(a)
      396326  NM_205369.1  NP_990700.1 
    lizard
    (Anolis carolinensis)
    Reptilia C14orf1666
    chromosome 14 open reading frame 166
    74(a)
    1 ↔ 1
    GL343501.1(461184-477252)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.187552 Xenopus laevis transcribed sequence with moderate similarity more 77.43(n)    BX850709.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc565762 hypothetical protein MGC56576 76.97(n)   393240  BC049049.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG312491 CG31249 50.23(n)
    41.55(a)
      42129  NM_169774.3  NP_732262.1 
    worm
    (Caenorhabditis elegans)
    Secernentea E02H1.56
    Protein E02H1.5 (E02H1.5) mRNA, complete cds
    23(a)
    1 ↔ 1
    II(9595224-9596599) WBGene00008457


    ENSEMBL Gene Tree for C14orf166 (if available)
    TreeFam Gene Tree for C14orf166 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for C14orf166 gene

    C14orf166 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for C14orf166
    PGOHUM00000240258 PGOHUM00000235699


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for C14orf166 (see all 405)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1436953271,2
    C--52454232(+) CCTTA-/TTTTTT 1 -- us2k10--------
    rs360624791,2
    C--52454239(+) TTTTT-/TAAAGA 1 -- us2k10--------
    rs360161971,2
    C,F--52454378(+) CTAGCA/CTGCAC 1 -- us2k16Minor allele frequency- C:0.23NA EA 248
    rs747452131,2
    C,F--52454459(+) CTTGAT/CTCACT 1 -- us2k12Minor allele frequency- C:0.03CSA EA 122
    rs754372031,2
    F--52454553(+) TTTTAT/ATATTA 1 -- us2k11Minor allele frequency- A:0.50NA 4
    rs37596511,2
    C--52454627(-) ctgcaA/Gggttg 1 -- us2k10--------
    rs341948471,2
    C,F--52454636(+) AGGCTC/GAAGTG 1 -- us2k11Minor allele frequency- G:0.08NA 120
    rs2010187971,2
    C--52454717(+) TTCTTC/TTTTTT 1 -- us2k10--------
    rs1912962381,2
    --52454891(+) TTTCTC/TGTAAT 1 -- us2k10--------
    rs1837998091,2
    --52454934(+) ATTTAG/TTTACA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C14orf166 (52456193 - 52471420 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C14orf166:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv901947CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing C14orf166
    DNA2.0 Custom Variant and Variant Library Synthesis for C14orf166

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 610858    OMIM disorders: --

    11 diseases for C14orf166:    About MalaCards
    endocarditis    barrett's esophagus    hepatitis c virus    influenza
    hepatitis c    schizophrenia    pancreatic cancer    pancreatitis
    hepatitis    hiv-1    malaria

    1 disease from the University of Copenhagen DISEASES database for C14orf166:
    Barrett's esophagus

    C14orf166 for disorders           About GeneDecksing


    Export disorders for C14orf166 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for C14orf166 gene, integrated from 10 sources (see all 39):
    (articles sorted by number of sources associating them with C14orf166)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. (PubMed id 10810093)1, 2, 3 Lai C.-H.... Lin W.-C. (Genome Res. 2000)
    2. A novel ninein-interaction protein, CGI-99, blocks ninein phosphorylation by GSK3beta and is highly expressed in brain tumors. (PubMed id 15147888)1, 2, 9 Howng S.-L....Hong Y.-R. (FEBS Lett. 2004)
    3. hCLE/C14orf166 Associates with DDX1-HSPC117-FAM98B in a Novel Transcription-Dependent Shuttling RNA-Transporting Complex. (PubMed id 24608264)1, 3 PAcrez-GonzA!lez A....Nieto A. (PLoS ONE 2014)
    4. Identification of hnRNPH1, NF45, and C14orf166 as novel host interacting partners of the mature hepatitis C virus core protein. (PubMed id 21823664)1, 2 Lee J.W.... Wang S.W. (J. Proteome Res. 2011)
    5. Cellular human CLE/C14orf166 protein interacts with influenza virus polymerase and is required for viral replication. (PubMed id 21900157)1, 2 Rodriguez A.... Nieto A. (J. Virol. 2011)
    6. hCLE/CGI-99, a human protein that interacts with the influenza virus polymerase, is a mRNA transcription modulator. (PubMed id 16950395)1, 2 Perez-Gonzalez A.... Nieto A. (J. Mol. Biol. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. PA subunit from influenza virus polymerase complex interacts with a cellular protein with homology to a family of transcriptional activators. (PubMed id 11507205)1, 2 Huarte M.... Nieto A. (J. Virol. 2001)
    9. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    10. The identification of novel proteins that interact with the GLP-1 receptor and restrain its activity. (PubMed id 23864651)1 Huang X....Wheeler M.B. (Mol. Endocrinol. 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51637 HGNC: 23169 AceView: C14orf166 Ensembl:ENSG00000087302 euGenes: HUgn51637
    ECgene: C14orf166 H-InvDB: C14orf166

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for C14orf166 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for C14orf166 gene:
    Search GeneIP for patents involving C14orf166

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for C14orf166   OriGene RNAi products in human, mouse, rat for C14orf166  
     OriGene qPCR primer pairs and template standards for C14orf166   OriGene Protein Over-expression Lysate for C14orf166  
     OriGene MassSpec something-or-other for C14orf166   OriGene clones in human, mouse for C14orf166  
     OriGene qSTAR qPCR primer pairs in human, mouse for C14orf166   OriGene Purified Protein for C14orf166  
     OriGene ORF clones in mouse, rat for C14orf166   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for C14orf166   OriGene Custom Protein Services for C14orf166  

     
     
     Block miRNA regulation of human, mouse, rat C14orf166 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing C14orf166
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C14orf166 Predesigned siRNA for gene silencing in human, mouse, rat C14orf166
     QuantiFast Probe-based Assays in human, mouse, rat C14orf166 QuantiTect SYBR Green Assays in human, mouse, rat C14orf166
     Custom PCR Arrays for C14orf166 Search Chromatin IP Primers for C14orf166
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat C14orf166  Search GeneGlobe Interaction Network for C14orf166
     Regulatory tfbs in C14orf166 promoter
     GenScript Custom Purified and Recombinant Proteins Services for C14orf166 GenScript cDNA clones with any tag delivered in your preferred vector for C14orf166
     GenScript Custom Assay Services for C14orf166 GenScript Custom overexpressing Cell Line Services for C14orf166
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for C14orf166 (CN166)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for C14orf166
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     C14orf166 antibodies
     C14orf166 proteins
     C14orf166 lysates
     Antibodies for C14orf166
     See all of Abcam's Antibodies, Kits and Proteins for C14orf166
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for C14orf166
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf166
     Browse SwitchGear 3'UTR luciferase reporter plasmids for C14orf166
     SwitchGear Promoter luciferase reporter plasmids for C14orf166
     Search ThermoFisher Antibodies for C14orf166
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf166
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C14orf166
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C14orf166
     LSBio Antibodies in human, mouse, rat for C14orf166
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      C14orf166 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4