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Aliases for C14orf159 Gene

Aliases for C14orf159 Gene

  • Chromosome 14 Open Reading Frame 159 2 3 5

External Ids for C14orf159 Gene

Previous GeneCards Identifiers for C14orf159 Gene

  • GC14P089570
  • GC14P089571
  • GC14P090650
  • GC14P091580
  • GC14P071755
  • GC14P091526

Summaries for C14orf159 Gene

GeneCards Summary for C14orf159 Gene

C14orf159 (Chromosome 14 Open Reading Frame 159) is a Protein Coding gene.

Gene Wiki entry for C14orf159 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf159 Gene

Genomics for C14orf159 Gene

Regulatory Elements for C14orf159 Gene

Enhancers for C14orf159 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F091112 1.3 Ensembl ENCODE 27.6 +56.8 56798 8.4 HDGF PKNOX1 CREB3L1 MLX WRNIP1 SIN3A ARID4B DMAP1 ZNF48 ZNF2 C14orf159 RNU7-30P RPS6KA5 GC14P091127 GC14P091092
GH14F091107 1.5 FANTOM5 Ensembl ENCODE 21.1 +48.9 48890 3.1 PKNOX1 SIN3A GLI4 ZNF2 ZNF121 GLIS2 ZNF207 ZNF263 SP3 JUNB C14orf159 RPS6KA5 TRIP11 RPS18P2 CCDC88C PPP4R3A GPR68 GC14P091092 GC14P091127
GH14F091154 1.2 Ensembl ENCODE 18.4 +94.9 94906 1.2 INSM2 ZNF76 FEZF1 RAD21 ZNF121 GLIS2 ZNF366 EGR2 CEBPB TSHZ1 C14orf159 SNORA11B RPS6KA5 GC14P091148 GC14P091227
GH14F091148 1.3 Ensembl ENCODE 13 +89.2 89156 1.5 ARID4B FEZF1 ZNF2 YY1 ZNF121 KLF7 FOS TSHZ1 ZNF488 MBD2 SNORA11B C14orf159 GC14P091148 GC14P091227
GH14F091201 1.5 FANTOM5 Ensembl ENCODE 10.7 +142.0 141991 1.3 HDAC1 PKNOX1 ARNT TBL1XR1 CREB3L1 ZBTB40 CBX5 ELK1 ETV6 CREM GPR68 C14orf159 PPP4R3A GC14P091227 GC14P091148
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C14orf159 on UCSC Golden Path with GeneCards custom track

Promoters for C14orf159 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000422529 67 2801 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF143 ZNF207

Genomic Location for C14orf159 Gene

Chromosome:
14
Start:
91,060,333 bp from pter
End:
91,225,632 bp from pter
Size:
165,300 bases
Orientation:
Plus strand

Genomic View for C14orf159 Gene

Genes around C14orf159 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf159 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf159 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf159 Gene

Proteins for C14orf159 Gene

  • Protein details for C14orf159 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z3D6-CN159_HUMAN
    Recommended name:
    UPF0317 protein C14orf159, mitochondrial
    Protein Accession:
    Q7Z3D6
    Secondary Accessions:
    • B3KUI7
    • Q86SW3
    • Q86SX8
    • Q86SX9
    • Q86T08
    • Q86TV5
    • Q96GW5
    • Q9H7G0
    • Q9H8Y9
    • Q9H9W6

    Protein attributes for C14orf159 Gene

    Size:
    616 amino acids
    Molecular mass:
    66437 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14932.1; Type=Frameshift; Positions=436, 582; Evidence={ECO:0000305};

    Alternative splice isoforms for C14orf159 Gene

neXtProt entry for C14orf159 Gene

Post-translational modifications for C14orf159 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C14orf159 Gene

Domains & Families for C14orf159 Gene

Protein Domains for C14orf159 Gene

Suggested Antigen Peptide Sequences for C14orf159 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z3D6

UniProtKB/Swiss-Prot:

CN159_HUMAN :
  • Belongs to the UPF0317 family.
Family:
  • Belongs to the UPF0317 family.
genes like me logo Genes that share domains with C14orf159: view

No data available for Gene Families for C14orf159 Gene

Function for C14orf159 Gene

Gene Ontology (GO) - Molecular Function for C14orf159 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C14orf159: view
genes like me logo Genes that share phenotypes with C14orf159: view

Animal Model Products

miRNA for C14orf159 Gene

miRTarBase miRNAs that target C14orf159

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf159 Gene

Localization for C14orf159 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf159 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf159 gene
Compartment Confidence
mitochondrion 5
cytosol 4
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for C14orf159 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with C14orf159: view

Pathways & Interactions for C14orf159 Gene

SuperPathways for C14orf159 Gene

No Data Available

Interacting Proteins for C14orf159 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000256324%0d%0a9606.ENSP00000216455%0d%0a
Selected Interacting proteins: Q7Z3D6-CN159_HUMAN ENSP00000256324 for C14orf159 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for C14orf159 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C14orf159: view

No data available for Pathways by source and SIGNOR curated interactions for C14orf159 Gene

Transcripts for C14orf159 Gene

Unigene Clusters for C14orf159 Gene

Chromosome 14 open reading frame 159:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf159 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c · 3d · 3e ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c ·
SP1: - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - -
SP5: - - - - - - - - - - - - - -
SP6: - - - - - - - - - - -
SP7: - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - - - - - - - - - - - -
SP10: - - - - - - - - - -
SP11: - - - - - - - - - -
SP12: - - - - - - - - - - - - - - -
SP13: - - - - - - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - -
SP16:
SP17:
SP18:
SP19:
SP20: -

ExUns: 11d · 11e ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b · 23c
SP1: - - -
SP2: - - - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - - -
SP6: - - - - -
SP7: - - - - -
SP8:
SP9: - - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17: - -
SP18: -
SP19:
SP20:

Relevant External Links for C14orf159 Gene

GeneLoc Exon Structure for
C14orf159
ECgene alternative splicing isoforms for
C14orf159

Expression for C14orf159 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C14orf159 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C14orf159 Gene

This gene is overexpressed in Heart (15.3) and Uterus (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C14orf159 Gene



Protein tissue co-expression partners for C14orf159 Gene

NURSA nuclear receptor signaling pathways regulating expression of C14orf159 Gene:

C14orf159

SOURCE GeneReport for Unigene cluster for C14orf159 Gene:

Hs.309849
genes like me logo Genes that share expression patterns with C14orf159: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C14orf159 Gene

Orthologs for C14orf159 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C14orf159 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf159 34
  • 99.03 (n)
C14orf159 35
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1311756 34
  • 79.53 (n)
mouse
(Mus musculus)
Mammalia 9030617O03Rik 34 16 35
  • 78.93 (n)
oppossum
(Monodelphis domestica)
Mammalia C14orf159 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf159 35
  • 62 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C14orf159 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves C5H14ORF159 34
  • 62.85 (n)
C14orf159 35
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C14orf159 35
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c14orf159 34
  • 59.72 (n)
Str.20422 34
zebrafish
(Danio rerio)
Actinopterygii c14orf159 34
  • 59.74 (n)
C17H14orf159 35
  • 51 (a)
OneToOne
wufj56e06 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6256 34
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C19041g 34
  • 41.04 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC5H10.01 34
  • 42.68 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 33 (a)
OneToMany
-- 35
  • 29 (a)
OneToMany
-- 35
  • 28 (a)
OneToMany
Species where no ortholog for C14orf159 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C14orf159 Gene

ENSEMBL:
Gene Tree for C14orf159 (if available)
TreeFam:
Gene Tree for C14orf159 (if available)

Paralogs for C14orf159 Gene

No data available for Paralogs for C14orf159 Gene

Variants for C14orf159 Gene

Sequence variations from dbSNP and Humsavar for C14orf159 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10083403 -- 91,206,231(+) cgtaa(C/G)gggga intron-variant
rs10129644 -- 91,214,388(+) CTGGG(A/G)AATAA intron-variant
rs10130134 -- 91,211,284(+) atagt(C/T)ccagt intron-variant
rs10130721 -- 91,121,418(+) gcgca(A/G)tggct intron-variant
rs10132170 -- 91,177,777(+) AGGCG(C/T)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf159 Gene

Variant ID Type Subtype PubMed ID
nsv832857 CNV loss 17160897
nsv819108 CNV loss 19587683
nsv1394 CNV insertion 18451855
nsv1053543 CNV gain 25217958
nsv1046924 CNV gain 25217958
esv3584776 CNV gain 24956385
esv1001290 CNV deletion 20482838
dgv141n21 CNV gain 19592680

Variation tolerance for C14orf159 Gene

Residual Variation Intolerance Score: 90.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.03; 87.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C14orf159 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C14orf159

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf159 Gene

Disorders for C14orf159 Gene

Relevant External Links for C14orf159

Human Genome Epidemiology (HuGE) Navigator
C14orf159
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C14orf159

No disorders were found for C14orf159 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf159 Gene

Publications for C14orf159 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for C14orf159 Gene

Sources for C14orf159 Gene

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