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C14orf142 Gene

protein-coding   GIFtS: 39
GCID: GC14M093669

Chromosome 14 Open Reading Frame 142

  Search for C14orf142
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 14 Open Reading Frame 1421 2
PNAS-1272
Uncharacterized Protein C14orf1422

External Ids:    HGNC: 203561   Entrez Gene: 845202   Ensembl: ENSG000001702707   UniProtKB: Q9BXV93   

Export aliases for C14orf142 gene to outside databases

Previous GC identifers: GC14M087485 GC14M091659 GC14M092738 GC14M073849


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C14orf142 Gene:
C14orf142 (chromosome 14 open reading frame 142) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  NT_187601.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the C14orf142 gene promoter:
         HOXA9B   HOXA9   Pax-5   Nkx2-5   AREB6   Pax-3   FOXO4   c-Myb   RSRFC4   Meis-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C14orf142

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C14orf142


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.12   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q32.12

C14orf142 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf142 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M093669:  view genomic region     (about GC identifiers)

Start:
93,669,237 bp from pter      End:
93,673,459 bp from pter
Size:
4,223 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CN142_HUMAN, Q9BXV9 (See protein sequence)
Recommended Name: Uncharacterized protein C14orf142  
Size: 100 amino acids; 10859 Da
Sequence caution: Sequence=AAK07544.1; Type=Erroneous translation; Note=Wrong choice of frame;
Secondary accessions: Q0D2N1 Q0P6C4 Q3B7W5

Explore the universe of human proteins at neXtProt for C14orf142: NX_Q9BXV9

Explore proteomics data for C14orf142 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C14orf142 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115879.2  
    ENSEMBL proteins: 
     ENSP00000306320   ENSP00000451114  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR027893 DUF4611

    Graphical View of Domain Structure for InterPro Entry Q9BXV9

    ProtoNet protein and cluster: Q9BXV9


    C14orf142 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C14orf142
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    SwitchGear 3'UTR luciferase reporter plasmidC14orf142 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol2
    nucleus2
    extracellular1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C14orf142
    Interactions:

        Search GeneGlobe Interaction Network for C14orf142

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C14orf142 (CN142)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for C14orf142 gene: 
    NM_032490.4  

    Unigene Cluster for C14orf142:

    Chromosome 14 open reading frame 142
    Hs.20142  [show with all ESTs]
    Unigene Representative Sequence: NM_032490
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306954(uc001ybl.1) ENST00000556566
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidC14orf142 3' UTR sequence
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    Additional mRNA sequence: 

    AF277185.1 BC021733.2 BC065216.1 BC107429.1 BC109390.1 

    6 DOTS entries:

    DT.100719724  DT.100837020  DT.454784  DT.100823685  DT.97789449  DT.100774072 

    Selected AceView cDNA sequences (see all 179):

    BU679201 CB242343 AA101821 AI279088 AI376802 AA846823 BX337878 AI672495 
    AI739358 CB120578 BX383621 BI324853 BG285099 AA961471 BU607275 BC065216 
    BE048492 AI522167 AI378175 BM458063 AA098977 BI439813 CB854874 BC021733 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for C14orf142    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b
    SP1:                              
    SP2:              -               


    ECgene alternative splicing isoforms for C14orf142

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C14orf142 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCTTAAGA
    C14orf142 Expression
    About this image

    C14orf142 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C14orf142 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.20142
        Custom PCR Arrays for C14orf142
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf142

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for C14orf142 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia AK0108781 , 5 cDNA sequence AK0108781, 5 77.89(n)1
    65.31(a)1
      12 (52.14 cM)5
    1002331751  NM_001142938.11  NP_001136410.11 
     1027532755 


    ENSEMBL Gene Tree for C14orf142 (if available)
    TreeFam Gene Tree for C14orf142 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C14orf142 (see all 39)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1906105351,2
    --93668936(+) AAAAAA/TGTTGA 1 -- int10--------
    rs1836611741,2
    --93668977(+) AATCTA/GAAGGC 1 -- int10--------
    rs1177154591,2
    C,F--93669156(+) TTGAAG/ACTATC 1 -- int11Minor allele frequency- A:0.02EA 120
    rs1873935801,2
    C--93669312(+) AGGAGG/TAGAGG 1 -- ut310--------
    rs154181,2
    C--93669344(+) TGCAGA/GTTGTT 1 -- ut312Minor allele frequency- G:0.00MN NA 186
    rs1176508231,2
    C,F--93669466(+) AAGTGG/CCATCA 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs1379019401,2
    C--93669469(+) TGGCAC/TCATCT 1 -- ut310--------
    rs1921334881,2
    --93669704(+) AGTTAA/GAAGAT 1 -- ut310--------
    rs1426536341,2
    C--93669745(+) AAAAAC/TAGAAA 1 -- ut310--------
    rs1460443771,2
    C--93669934(+) CAACAA/CAAATG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for C14orf142 (93669237 - 93673459 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C14orf142:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv902205CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing C14orf142
    DNA2.0 Custom Variant and Variant Library Synthesis for C14orf142

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C14orf142 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C14orf142)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS. (PubMed id 23455922)1 Varjosalo M....Superti-Furga G. (Nat. Methods 2013)
    3. The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME. (PubMed id 22912744)1 Costessi A....Stunnenberg H.G. (PLoS ONE 2012)
    4. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    5. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84520 HGNC: 20356 AceView: C14orf142 Ensembl:ENSG00000170270 euGenes: HUgn84520
    ECgene: C14orf142 H-InvDB: C14orf142

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C14orf142 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C14orf142 gene:
    Search GeneIP for patents involving C14orf142

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     SwitchGear 3'UTR luciferase reporter plasmids for C14orf142
     Browse SwitchGear Promoter luciferase reporter plasmids for C14orf142
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf142
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C14orf142
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     LSBio Antibodies in human, mouse, rat for C14orf142
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