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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C14orf132 Gene

protein-coding GIFtS: 32
GCID: GC14P096505

chromosome 14 open reading frame 132

(Previous name: chromosome 14 open reading frame 88 )
(Previous symbol: C14orf88)

Search for C14orf132
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 14 Open Reading Frame 132¹ ²
C14orf88¹ ²
Chromosome 14 Open Reading Frame 88¹
Putative Uncharacterized Protein C14orf132²
Uncharacterized Protein C14orf132²

External Ids:	HGNC: 20346¹	Entrez Gene: 56967²	Ensembl: ENSG00000227051⁷	UniProtKB: Q9NPU4³

ORGUL members:
	NONCODE:n344786 n406496

Export aliases for C14orf132 gene to outside databases

Previous GC identifers: GC14P090373 GC14P094546 GC14P094495 GC14P095575 GC14P076690

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C14orf132 gene promoter:
Max1 AML1a XBP-1 HNF-4alpha2 HNF-4alpha1 Egr-4 HOXA5 ZID c-Myc
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf132

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2 Ensembl cytogenetic band: 14q32.2 HGNC cytogenetic band: 14q32.2

C14orf132 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf132 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P096505: view genomic region (about GC identifiers)

Start:	96,505,661 bp from pter	End:	96,560,417 bp from pter
Size:	54,757 bases	Orientation:	plus strand

ORGUL member locations:
Legend (see complete legend)

n406496
n344786

lncRNA
Full Legend

96505661 96532936 96560211 chr14

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CN132_HUMAN, Q9NPU4 (See protein sequence)

Recommended Name: Putative uncharacterized protein C14orf132

Size: 173 amino acids; 19096 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Caution: Product of a dubious CDS prediction

Secondary accessions: B2R7K5

Explore the universe of human proteins at neXtProt for C14orf132: NX_Q9NPU4

C14orf132 Protein expression data from MOPED and PaxDb: --

REFSEQ proteins: NP_001239436.1

ENSEMBL proteins:

ENSP00000451731 ENSP00000440920

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

C14orf132 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9NPU4

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C14orf132

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Search CenterWatch for drugs/clinical trials and news about C14orf132 / CN132

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for C14orf132 gene (2 alternative transcripts):

NM_020215.2 NM_001252507.1

Unigene Clusters for C14orf132:

Chromosome 14 open reading frame 132

Hs.6434 [show with all ESTs], Hs.733033 [show with all ESTs]

Unigene Representative Sequences: NM_001252507, AK074462

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000555004(uc001yff.4) ENST00000553764 ENST00000556728 ENST00000553782

ENST00000421193

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Additional cDNA sequence:

AK025915.1 AK074462.1

6 DOTS entries:

DT.206967 DT.101971146 DT.451977 DT.95345252 DT.100811797 DT.120753382

24/174 AceView cDNA sequences (see all 174):

BF923881 BQ884086 BI791809 AF131832 AI939384 AL120236 F02149 BM988593

AA355825 CR603350 T06202 BM352639 CB153241 Z38976 BM725767 AI051641

BM893938 AK074462 BQ070454 BM972387 BM352608 BQ069257 AU119136 BM967279

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C14orf132 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGATCACTGA

About this image

C14orf132 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)

Adipose, Bone, Cartilage

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Genevestigator expression for C14orf132

SOURCE GeneReport for Unigene clusters: Hs.6434 Hs.733033

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for C14orf132 gene from 1 species (see representative species ) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	D430019H16Rik⁵	RIKEN cDNA D430019H16 gene	--		12 (55.61 cM) 105453856

ENSEMBL Gene Tree for C14orf132 (if available)
TreeFam Gene Tree for C14orf132 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs147318931^1,2		--	96503680(+)	`CTAGCA/GTATTC`	1	--	us2k¹		0	--	--	--	--
rs116815373^1,2	F,	--	96503768(+)	`AGAAAA/CCCTGG`	1	--	us2k¹		1		WA	118
rs181180405^1,2		--	96503870(+)	`ATATAC/TGTCAA`	1	--	us2k¹		0	--	--	--	--
rs186702783^1,2		--	96503883(+)	`ACACAA/GATAAT`	1	--	us2k¹		0	--	--	--	--
rs79437319^1,2	F,	--	96503967(+)	`AGGTAA/CTCTAT`	1	--	us2k¹		1		WA	118
rs7142540^1,2	C,F,A,H,	--	96504116(+)	`TTCCAC/TTTTTT`	1	--	us2k¹		15		NS EA NA WA	2212
rs139887780^1,2		--	96504121(+)	`CTTTTG/TAACCT`	1	--	us2k¹		0	--	--	--	--
rs7142730^1,2	C,F,H,	--	96504195(+)	`TATGCC/TGTGTA`	1	--	us2k¹		9		NS EA NA	1304
rs149814995^1,2		--	96504205(+)	`ACATAA/GTATTT`	1	--	us2k¹		0	--	--	--	--
rs7143235^1,2	C,F,A,H,	--	96504285(+)	`GAGGAG/AGTGGG`	1	--	us2k¹		9		NA WA CSA EA	372

HapMap Linkage Disequilibrium report for C14orf132 (96505661 - 96560417 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for C14orf132
2 CNVs: 66699 49448

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C14orf132 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C14orf132)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)¹ Oshikawa M.... Kato S. (2011)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)¹ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Large-scale concatenation cDNA sequencing. (PubMed id 9110174)¹ Yu W.... Gibbs R.A. (1997)
A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)¹ Andersson B.... Gibbs R.A. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 56967	HGNC: 20346	AceView: C14orf132	Ensembl:ENSG00000227051	euGenes: HUgn56967
ECgene: C14orf132	H-InvDB: C14orf132

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C14orf132	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C14orf132 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C14orf132 gene:
Search GeneIP for patents involving C14orf132

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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C14orf132 Gene

chromosome 14 open reading frame 132

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C14orf132 Gene

chromosome 14 open reading frame 132

Aliasesfor C14orf132 gene

Summariesfor C14orf132 gene

Genomic Viewsfor C14orf132 gene

Proteinsfor C14orf132 gene

Protein Domains /Familiesfor C14orf132 gene

Functionfor C14orf132 gene

Pathways & Interactionsfor C14orf132 gene

Drugs & Compoundsfor C14orf132 gene

Transcriptsfor C14orf132 gene

Expression for C14orf132 gene

Orthologsfor C14orf132 gene

Paralogsfor C14orf132 gene

Genomic Variantsfor C14orf132 gene

Disorders / Diseasesfor C14orf132 gene

Publicationsfor C14orf132 gene

External Searches for C14orf132 gene

Genome Databases showing C14orf132 gene

Other Databases showing C14orf132 gene

Specialized Databases showing C14orf132 gene

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Aliases
for C14orf132 gene

Summaries
for C14orf132 gene

Genomic Views
for C14orf132 gene

Proteins
for C14orf132 gene

Protein Domains /
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for C14orf132 gene

Function
for C14orf132 gene

Pathways & Interactions
for C14orf132 gene

Drugs & Compounds
for C14orf132 gene

Transcripts
for C14orf132 gene

Expression
for C14orf132 gene

Orthologs
for C14orf132 gene

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Genomic Variants
for C14orf132 gene

Disorders / Diseases
for C14orf132 gene

Publications
for C14orf132 gene

Intellectual Property
for C14orf132 gene

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