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C14orf132 Gene

protein-coding   GIFtS: 32
GCID: GC14P096505

Chromosome 14 Open Reading Frame 132

(Previous name: chromosome 14 open reading frame 88)
(Previous symbol: C14orf88)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 14 Open Reading Frame 1321 2
C14orf881 2
Chromosome 14 Open Reading Frame 881
Putative Uncharacterized Protein C14orf1322

External Ids:    HGNC: 203461   Entrez Gene: 569672   Ensembl: ENSG000002270517   UniProtKB: Q9NPU43   

Export aliases for C14orf132 gene to outside databases

Previous GC identifers: GC14P090373 GC14P094546 GC14P094495 GC14P095575 GC14P076690


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C14orf132 Gene:
C14orf132 (chromosome 14 open reading frame 132) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the C14orf132 gene promoter:
         Max1   AML1a   XBP-1   HNF-4alpha2   HNF-4alpha1   Egr-4   HOXA5   ZID   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
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Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C14orf132


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

C14orf132 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf132 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P096505:  view genomic region     (about GC identifiers)

Start:
96,505,661 bp from pter      End:
96,560,417 bp from pter
Size:
54,757 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for C14orf132

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CN132_HUMAN, Q9NPU4 (See protein sequence)
Recommended Name: Putative uncharacterized protein C14orf132  
Size: 173 amino acids; 19096 Da
Caution: Product of a dubious CDS prediction
Secondary accessions: B2R7K5

Explore the universe of human proteins at neXtProt for C14orf132: NX_Q9NPU4

REFSEQ proteins (4 alternative transcripts): 
NP_001239436.1  NP_001269392.1  NP_001269393.1  NP_001276068.1  

ENSEMBL proteins: 
 ENSP00000451731   ENSP00000440920  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: Q9NPU4


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for C14orf132

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CN132_HUMAN, Q9NPU4: Membrane; Single-pass membrane protein (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
plasma membrane3
cytosol1
endoplasmic reticulum1
golgi apparatus1
mitochondrion1
nucleus1
peroxisome1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral component of membrane IEA--

Find genes that share ontologies with C14orf132           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C14orf132
Interactions:

    Search GeneGlobe Interaction Network for C14orf132

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C14orf132 (CN132)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C14orf132 gene (5 alternative transcripts): 
NM_020215.2  NM_001252507.2  NM_001282463.1  NM_001282464.1  NM_001289139.1  

Unigene Cluster for C14orf132:

Chromosome 14 open reading frame 132
Hs.6434  [show with all ESTs]
Unigene Representative Sequence: NM_001252507
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000555004(uc001yff.4) ENST00000553764 ENST00000556728 ENST00000553782
ENST00000421193
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Additional mRNA sequence: 

AB621830.1 AF131832.1 AK001590.1 AK022021.1 AK313017.1 AL390130.1 BC042922.1 BC043593.1 
BC067267.1 

5 DOTS entries:

DT.206967  DT.101971146  DT.451977  DT.95345252  DT.120753382 

Selected AceView cDNA sequences (see all 174):

AU119136 AI939384 CB153241 BM972387 BM352639 AI423095 AK074462 BM893938 
BQ070454 Z38976 BM725767 AI051641 T06202 BM967279 F02149 AL120236 
AI202109 AI382975 AI362756 BQ069257 BM352608 BM988593 BF923881 BI791809 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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C14orf132 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CGATCACTGA
C14orf132 Expression
About this image


C14orf132 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 5) fully expand
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Endothelial Cells Blood Brain Barrier
         Amygdala
 
 Peripheral Nervous System (Nervous System)
         Schwann Precursor Cells Peripheral Nerve Domain
 
 Adipose (Muscoskeletal System)
         Visceral White Adipose
 
 Endothelium (Cardiovascular System)
         Endothelial Cells Blood Brain Barrier
 
 Spinal Cord (Nervous System)
C14orf132 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

SOURCE GeneReport for Unigene cluster: Hs.6434
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for C14orf132 gene from Selected species (see all 2)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia D430019H16Rik5 RIKEN cDNA D430019H16 gene   --   12 (55.61 cM) 105453856 


ENSEMBL Gene Tree for C14orf132 (if available)
TreeFam Gene Tree for C14orf132 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C14orf132 (see all 1297)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1473189311,2
--96503680(+) CTAGCA/GTATTC 1 -- us2k10--------
rs1168153731,2
F--96503768(+) AGAAAA/CCCTGG 1 -- us2k11Minor allele frequency- C:0.02WA 118
rs1811804051,2
--96503870(+) ATATAC/TGTCAA 1 -- us2k10--------
rs1867027831,2
--96503883(+) ACACAA/GATAAT 1 -- us2k10--------
rs794373191,2
C,F--96503967(+) AGGTAA/CTCTAT 1 -- us2k11Minor allele frequency- C:0.06WA 118
rs71425401,2
C,F,A,H--96504116(+) TTCCAC/TTTTTT 1 -- us2k115Minor allele frequency- T:0.04NS EA NA WA 2212
rs1398877801,2
--96504121(+) CTTTTG/TAACCT 1 -- us2k10--------
rs71427301,2
C,F,H--96504195(+) TATGCC/TGTGTA 1 -- us2k19Minor allele frequency- T:0.03NS EA NA 1304
rs1498149951,2
--96504205(+) ACATAA/GTATTT 1 -- us2k10--------
rs71432351,2
C,F,A,H--96504285(+) GAGGAG/AGTGGG 1 -- us2k19Minor allele frequency- A:0.49NA WA CSA EA 372

HapMap Linkage Disequilibrium report for C14orf132 (96505661 - 96560417 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for C14orf132:    About this table    
Variant IDTypeSubtypePubMed ID
esv2657868CNV Deletion23128226
nsv1415CNV Insertion18451855
nsv520884CNV Loss19592680
esv24297CNV Loss19812545
nsv832866CNV Gain17160897

Site Specific Mutation Identification with PCR Assays
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DNA2.0 Custom Variant and Variant Library Synthesis for C14orf132

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C14orf132 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C14orf132)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (Invest. Ophthalmol. Vis. Sci. 2011)
  3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S.... Malek J. (Genome Res. 2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  7. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (Genome Res. 1997)
  8. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (Anal. Biochem. 1996)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 56967 HGNC: 20346 AceView: C14orf132 Ensembl:ENSG00000227051 euGenes: HUgn56967
ECgene: C14orf132 H-InvDB: C14orf132

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C14orf132 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C14orf132 gene:
Search GeneIP for patents involving C14orf132

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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