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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C14orf132 Gene

protein-coding   GIFtS: 31
GCID: GC14P096505

Chromosome 14 Open Reading Frame 132

(Previous name: chromosome 14 open reading frame 88)
(Previous symbol: C14orf88)
  Search for C14orf132
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 14 Open Reading Frame 1321 2
C14orf881 2
Chromosome 14 Open Reading Frame 881
Putative Uncharacterized Protein C14orf1322
Uncharacterized Protein C14orf1322

External Ids:    HGNC: 203461   Entrez Gene: 569672   Ensembl: ENSG000002270517   UniProtKB: Q9NPU43   
ORGUL members:         
NONCODE14:n344786 n406496      

Export aliases for C14orf132 gene to outside databases

Previous GC identifers: GC14P090373 GC14P094546 GC14P094495 GC14P095575 GC14P076690


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C14orf132 Gene: 
C14orf132 (chromosome 14 open reading frame 132) is a protein-coding gene, and is affiliated with the lncRNA class.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C14orf132 gene promoter:
         Max1   AML1a   XBP-1   HNF-4alpha2   HNF-4alpha1   Egr-4   HOXA5   ZID   c-Myc   
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf132


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.2   Ensembl cytogenetic band:  14q32.2   HGNC cytogenetic band: 14q32.2

C14orf132 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf132 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P096505:  view genomic region     (about GC identifiers)

Start:
96,505,661 bp from pter      End:
96,560,417 bp from pter
Size:
54,757 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for C14orf132

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CN132_HUMAN, Q9NPU4 (See protein sequence)
Recommended Name: Putative uncharacterized protein C14orf132  
Size: 173 amino acids; 19096 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Caution: Product of a dubious CDS prediction
Secondary accessions: B2R7K5

Explore the universe of human proteins at neXtProt for C14orf132: NX_Q9NPU4

C14orf132 Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001239436.1  
ENSEMBL proteins: 
 ENSP00000451731   ENSP00000440920  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

C14orf132 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9NPU4


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C14orf132

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C14orf132 (CN132)

Search CenterWatch for drugs/clinical trials and news about C14orf132 / CN132

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C14orf132 gene (2 alternative transcripts): 
NM_020215.2  NM_001252507.1  

Unigene Clusters for C14orf132:

Chromosome 14 open reading frame 132
Hs.6434  [show with all ESTs], Hs.733033  [show with all ESTs]
Unigene Representative Sequences: NM_001252507, AK074462
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000555004(uc001yff.4) ENST00000553764 ENST00000556728 ENST00000553782
ENST00000421193
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Additional mRNA sequence: 

AK025915.1 AK074462.1 

6 DOTS entries:

DT.206967  DT.101971146  DT.451977  DT.95345252  DT.100811797  DT.120753382 

24/174 AceView cDNA sequences (see all 174):

BM988593 AI939384 AI362756 AI202109 CB153241 BM967279 BM352608 BQ070454 
BQ069257 BF923881 AU132633 BI791809 F02149 BM972387 BM725767 Z38976 
T06202 CR603350 AA355825 AI382975 AF131832 AI051641 AL120236 BM893938 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C14orf132 expression in normal human tissues (normalized intensities)      C14orf132 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CGATCACTGA
C14orf132 Expression
About this image


C14orf132 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/8 selected tissues (see all 8) fully expand
 
 Brain (Nervous System)    fully expand to see all 9 entries
         Endothelial Cells Blood Brain Barrier
         Cerebellum
         Subthalamic Nucleus   
 
 Blood Brain Barrier (Nervous System)
         Endothelial Cells Blood Brain Barrier
 
 Peripheral Nervous System (Nervous System)
         Schwann Precursor Cells Peripheral Nerve Domain
 
 Eye (Sensory Organs)
         Human Trabecular Meshwork Cells (HTMC)   
 
 Fibroblast (Uncategorized)
         Human Conjunctival Fibroblasts (HConF)   

Genevestigator expression for C14orf132

SOURCE GeneReport for Unigene clusters: Hs.6434 Hs.733033
    SABiosciences Custom PCR Arrays for C14orf132
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for C14orf132 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia D430019H16Rik5 RIKEN cDNA D430019H16 gene   --   12 (55.61 cM) 105453856 


ENSEMBL Gene Tree for C14orf132 (if available)
TreeFam Gene Tree for C14orf132 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1297 SNPs in C14orf132 are shown (see all 1297)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 14 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1473189311,2
--96503680(+) CTAGCA/GTATTC 1 -- us2k10--------
rs1168153731,2
F--96503768(+) AGAAAA/CCCTGG 1 -- us2k11Minor allele frequency- C:0.02WA 118
rs1811804051,2
--96503870(+) ATATAC/TGTCAA 1 -- us2k10--------
rs1867027831,2
--96503883(+) ACACAA/GATAAT 1 -- us2k10--------
rs794373191,2
C,F--96503967(+) AGGTAA/CTCTAT 1 -- us2k11Minor allele frequency- C:0.06WA 118
rs71425401,2
C,F,A,H--96504116(+) TTCCAC/TTTTTT 1 -- us2k115Minor allele frequency- T:0.04NS EA NA WA 2212
rs1398877801,2
--96504121(+) CTTTTG/TAACCT 1 -- us2k10--------
rs71427301,2
C,F,H--96504195(+) TATGCC/TGTGTA 1 -- us2k19Minor allele frequency- T:0.03NS EA NA 1304
rs1498149951,2
--96504205(+) ACATAA/GTATTT 1 -- us2k10--------
rs71432351,2
C,F,A,H--96504285(+) GAGGAG/AGTGGG 1 -- us2k19Minor allele frequency- A:0.49NA WA CSA EA 372

HapMap Linkage Disequilibrium report for C14orf132 (96505661 - 96560417 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for C14orf132:    About this table     
Variant IDTypeSubtypePubMed ID
esv2657868CNV Deletion23128226
nsv1415CNV Insertion18451855
nsv520884CNV Loss19592680
esv24297CNV Loss19812545
nsv832866CNV Gain17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C14orf132 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C14orf132)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  2. Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. (PubMed id 21697133)1 Oshikawa M.... Kato S. (2011)
  3. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1 Gerhard D.S....Malek J. (2004)
  6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  7. Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
  8. A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1 Andersson B.... Gibbs R.A. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 56967 HGNC: 20346 AceView: C14orf132 Ensembl:ENSG00000227051 euGenes: HUgn56967
ECgene: C14orf132 H-InvDB: C14orf132

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C14orf132 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C14orf132 gene:
Search GeneIP for patents involving C14orf132

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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 Codon Optimization
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 Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf132
 Browse SwitchGear 3'UTR luciferase reporter plasmids for C14orf132
 Browse SwitchGear Promoter luciferase reporter plasmids for C14orf132
 Search ThermoFisher Antibodies for C14orf132
 Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C14orf132
 inGenious Targeting Laboratory - Custom generated mouse model solutions for C14orf132
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for C14orf132
Customized:
 lentivirus for stable overexpression of C14orf132
 lentivirus expression plasmids for stable overexpression of C14orf132
 adenovirus for overexpression of C14orf132
 Search LSBio for Antibodies for C14orf132
Customized transgenic rodents for:
 Humanization
 Biomarker expression
 Off-target effect monitoring
 Translational medicine
 Tissue-specific gene expresssion
 Time-controlled gene expresssion
       
GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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