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Aliases for C14orf105 Gene

Aliases for C14orf105 Gene

  • Chromosome 14 Open Reading Frame 105 2 3 5

External Ids for C14orf105 Gene

Previous GeneCards Identifiers for C14orf105 Gene

  • GC14M051732
  • GC14M055926
  • GC14M057006
  • GC14M057936
  • GC14M038101

Summaries for C14orf105 Gene

GeneCards Summary for C14orf105 Gene

C14orf105 (Chromosome 14 Open Reading Frame 105) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf105 Gene

Genomics for C14orf105 Gene

Regulatory Elements for C14orf105 Gene

Enhancers for C14orf105 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G057461 0.4 ENCODE 11.3 +31.7 31705 1.4 FOS C14orf105 GC14P057427
GH14G057463 0.4 ENCODE 11.1 +29.8 29764 0.9 HNF1A C14orf105 GC14P057427
GH14G057486 0.6 FANTOM5 5.8 +6.9 6938 0.4 CTCF ZNF654 SCRT2 TRIM22 SMC3 RAD21 MIXL1 NAA30 C14orf105 GC14P057427
GH14G057491 1.2 Ensembl ENCODE 0.7 +0.2 208 4.3 PKNOX1 FOXA2 FEZF1 YY1 FOS TSHZ1 ZNF518A RFX3 HNF4A WT1 C14orf105 GC14P057427
GH14G057478 0.4 ENCODE 0.4 +15.7 15654 0.2 ZNF366 ZNF512 C14orf105 GC14P057427
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C14orf105 on UCSC Golden Path with GeneCards custom track

Genomic Location for C14orf105 Gene

57,469,300 bp from pter
57,493,891 bp from pter
24,592 bases
Minus strand

Genomic View for C14orf105 Gene

Genes around C14orf105 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf105 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf105 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf105 Gene

Proteins for C14orf105 Gene

  • Protein details for C14orf105 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C14orf105
    Protein Accession:
    Secondary Accessions:
    • Q53G04

    Protein attributes for C14orf105 Gene

    296 amino acids
    Molecular mass:
    34690 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C14orf105 Gene

Post-translational modifications for C14orf105 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C14orf105 Gene

Domains & Families for C14orf105 Gene

Protein Domains for C14orf105 Gene


Suggested Antigen Peptide Sequences for C14orf105 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf105: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C14orf105 Gene

Function for C14orf105 Gene

genes like me logo Genes that share phenotypes with C14orf105: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf105 Gene

Localization for C14orf105 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf105 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C14orf105 Gene

Pathways & Interactions for C14orf105 Gene

SuperPathways for C14orf105 Gene

No Data Available

Interacting Proteins for C14orf105 Gene

Gene Ontology (GO) - Biological Process for C14orf105 Gene


No data available for Pathways by source and SIGNOR curated interactions for C14orf105 Gene

Drugs & Compounds for C14orf105 Gene

No Compound Related Data Available

Transcripts for C14orf105 Gene

Unigene Clusters for C14orf105 Gene

Chromosome 14 open reading frame 105:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf105 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6
SP1: - - -
SP2: - - - -
SP3: - - -
SP5: - -

Relevant External Links for C14orf105 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C14orf105 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C14orf105 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C14orf105 Gene

This gene is overexpressed in Kidney - Cortex (x22.4), Liver (x11.9), and Pancreas (x10.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C14orf105 Gene

Protein tissue co-expression partners for C14orf105 Gene

NURSA nuclear receptor signaling pathways regulating expression of C14orf105 Gene:


SOURCE GeneReport for Unigene cluster for C14orf105 Gene:


Evidence on tissue expression from TISSUES for C14orf105 Gene

  • Liver(5)
  • Kidney(2)
genes like me logo Genes that share expression patterns with C14orf105: view

Primer Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf105 Gene

Orthologs for C14orf105 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C14orf105 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C14H14orf105 34
  • 99.32 (n)
C14orf105 35
  • 99 (a)
(Canis familiaris)
Mammalia C8H14orf105 34
  • 86.23 (n)
C14orf105 35
  • 69 (a)
(Bos Taurus)
Mammalia C10H14orf105 34
  • 85.94 (n)
C14orf105 35
  • 67 (a)
(Mus musculus)
Mammalia 1700011H14Rik 34 16 35
  • 78.31 (n)
(Rattus norvegicus)
Mammalia LOC102556129 34
  • 78.22 (n)
(Monodelphis domestica)
Mammalia C14orf105 35
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia C14orf105 35
  • 38 (a)
(Gallus gallus)
Aves C5H14ORF105 34
  • 53.91 (n)
C14orf105 35
  • 32 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100496610 34
  • 53.66 (n)
Species where no ortholog for C14orf105 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf105 Gene

Gene Tree for C14orf105 (if available)
Gene Tree for C14orf105 (if available)

Paralogs for C14orf105 Gene

No data available for Paralogs for C14orf105 Gene

Variants for C14orf105 Gene

Sequence variations from dbSNP and Humsavar for C14orf105 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs34960436 Benign 57,480,703(+) ACTTT(A/G)CTTAT nc-transcript-variant, reference, stop-gained
rs1000117454 -- 57,484,989(+) TTCAT(C/T)ATGGT intron-variant
rs1000299211 -- 57,488,577(+) TAAGA(C/G)ATAGT intron-variant
rs1000341873 -- 57,471,595(+) CCTAC(-/A)AAAAA intron-variant
rs1000500759 -- 57,476,982(+) GAGTC(A/G)GGTGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf105 Gene

Variant ID Type Subtype PubMed ID
nsv1046422 CNV gain 25217958
nsv1053638 CNV loss 25217958
nsv832806 CNV loss 17160897

Variation tolerance for C14orf105 Gene

Residual Variation Intolerance Score: 89.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.32; 53.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C14orf105 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf105 Gene

Disorders for C14orf105 Gene

Relevant External Links for C14orf105

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C14orf105 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf105 Gene

Publications for C14orf105 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 4 64

Products for C14orf105 Gene

Sources for C14orf105 Gene

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