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C14orf105 Gene

protein-coding   GIFtS: 43
GCID: GC14M057936

Chromosome 14 Open Reading Frame 105

  Search for C14orf105
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 14 Open Reading Frame 1051 2
Uncharacterized Protein C14orf1052

External Ids:    HGNC: 201891   Entrez Gene: 551952   Ensembl: ENSG000001005577   UniProtKB: Q9NVL83   

Export aliases for C14orf105 gene to outside databases

Previous GC identifers: GC14M051732 GC14M055926 GC14M057006 GC14M038101


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C14orf105 Gene:
C14orf105 (chromosome 14 open reading frame 105) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C14orf105 gene promoter:
         PPAR-gamma1   PPAR-gamma2   HNF-4alpha2   HNF-4alpha1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C14orf105

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C14orf105


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.3   Ensembl cytogenetic band:  14q22.3   HGNC cytogenetic band: 14q22.2

C14orf105 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C14orf105 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M057936:  view genomic region     (about GC identifiers)

Start:
57,936,019 bp from pter      End:
57,960,585 bp from pter
Size:
24,567 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CN105_HUMAN, Q9NVL8 (See protein sequence)
Recommended Name: Uncharacterized protein C14orf105  
Size: 296 amino acids; 34690 Da
Secondary accessions: Q53G04

Explore the universe of human proteins at neXtProt for C14orf105: NX_Q9NVL8

Explore proteomics data for C14orf105 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C14orf105 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001269985.1  NP_001269986.1  NP_001269987.1  NP_001269988.1  NP_001269989.1  NP_060638.2  

    ENSEMBL proteins: 
     ENSP00000216445   ENSP00000434003   ENSP00000431919   ENSP00000392368   ENSP00000436784  
     ENSP00000436475   ENSP00000431623   ENSP00000436589   ENSP00000436517  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9NVL8


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C14orf105
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    hsa-miR-27b* hsa-miR-1304 hsa-miR-3140-3p hsa-miR-499-5p hsa-miR-508-5p hsa-miR-548b-3p
    SwitchGear 3'UTR luciferase reporter plasmidC14orf105 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C14orf105
    Interactions:

        Search GeneGlobe Interaction Network for C14orf105

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C14orf105 (CN105)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for C14orf105 gene (6 alternative transcripts): 
    NM_001283056.1  NM_001283057.1  NM_001283058.1  NM_001283059.1  NM_001283060.1  NM_018168.3  

    Unigene Cluster for C14orf105:

    Chromosome 14 open reading frame 105
    Hs.659706  [show with all ESTs]
    Unigene Representative Sequence: NM_018168
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000216445(uc001xcy.2 uc010trl.1 uc010trm.1 uc010trn.1 uc001xcz.2)
    ENST00000534126 ENST00000534528 ENST00000422976 ENST00000530417 ENST00000524996
    ENST00000526745(uc010aox.1) ENST00000529860(uc010aoy.2) ENST00000527032
    ENST00000532286 ENST00000526336
    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate C14orf105:
    hsa-miR-27b* hsa-miR-1304 hsa-miR-3140-3p hsa-miR-499-5p hsa-miR-508-5p hsa-miR-548b-3p
    SwitchGear 3'UTR luciferase reporter plasmidC14orf105 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for C14orf105
    Predesigned siRNA for gene silencing in human, mouse, rat C14orf105
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf105
    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C14orf105
      QuantiTect SYBR Green Assays in human, mouse, rat C14orf105
      QuantiFast Probe-based Assays in human, mouse, rat C14orf105

    Additional mRNA sequence: 

    AK001512.1 AK223127.1 AK307238.1 BC028060.1 BC117405.1 BC143565.1 BC143566.1 BC143567.1 
    BC143568.1 

    4 DOTS entries:

    DT.75100345  DT.95153226  DT.40126617  DT.97789624 

    Selected AceView cDNA sequences (see all 29):

    BQ102377 AI792777 CK822958 AI768490 AI590209 CK822959 BQ086291 AI674984 
    AI933899 AU129598 NM_018168 AK001512 AW295960 BX498073 BF115107 BC028060 
    AI860795 AA918869 BX951750 BI760135 BG399157 AA340456 AI733133 AI985118 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for C14orf105 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6
    SP1:                                -     -     -                                 
    SP2:                    -           -     -     -                                 
    SP3:                                -     -     -                                 
    SP4:                                                                              
    SP5:                                -     -                                       


    ECgene alternative splicing isoforms for C14orf105

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C14orf105 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTGAGACACC
    C14orf105 Expression
    About this image


    C14orf105 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Ureteric Bud Cells Ureteric Bud
             Ureteric Bud
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Liver (Hepatobiliary System)
    C14orf105 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C14orf105 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.659706
        Custom PCR Arrays for C14orf105
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf105

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for C14orf105 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1700011H14Rik1 , 5 RIKEN cDNA 1700011H14 gene1, 5 78.31(n)1
    64.04(a)1
      14 (25.46 cM)5
    670821  NM_025956.41  NP_080232.31 
     492263585 
    chicken
    (Gallus gallus)
    Aves C5H14ORF1051 chromosome 5 open reading frame, human C14orf105 53.91(n)
    42.6(a)
      423546  XM_421439.3  XP_421439.3 
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004966101 chromosome unknown open reading frame, human C14orf1 more 53.66(n)
    42.68(a)
      100496610  XM_002933727.2  XP_002933773.2 


    ENSEMBL Gene Tree for C14orf105 (if available)
    TreeFam Gene Tree for C14orf105 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for C14orf105 gene
    Selected SIMAP similar genes for C14orf105 using alignment to 8 protein entries:     CN105_HUMAN (see all proteins) (see all similar genes):
    CALCOCO2    ARL6IP5    IK    SLC24A1    DCAF17    RBP7
    KIAA1651    CSPP1    FP6651    RTBDN    TMX3    FRG1
    LDLRAD3    OK/SW-cl.41    C3orf64    RQCD1    pp12301    ZNF429

    C14orf105 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C14orf105 (see all 500)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1429876541,2
    C--57936099(+) AAGACA/GTGGTT 1 -- ds50010--------
    rs1920824841,2
    --57936129(+) CAGTTC/TATTAA 1 -- ds50010--------
    rs1461228401,2
    C--57936205(+) TTTGGC/TTCCAC 1 -- ds50010--------
    rs1118736021,2
    F--57936284(+) GTGAGG/AACACC 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1854281131,2
    --57936340(+) CTAGAA/GAGCTG 1 -- ds50010--------
    rs1902524631,2
    --57936385(+) AATATA/GCTTCT 1 -- ds50010--------
    rs761430371,2
    --57936425(+) CTCACA/GAAGAA 1 -- ds50010--------
    rs1824795981,2
    --57936484(+) AAGAAA/TCATGA 1 -- ds50010--------
    rs1857713651,2
    --57936485(+) AGAAAC/GATGAA 1 -- ds50010--------
    rs9979311,2
    C,F,A,H--57936491(-) TAAAAA/CTTCAT 1 -- ds500135Minor allele frequency- G:0.00NA EA NS WA CSA 2962

    HapMap Linkage Disequilibrium report for C14orf105 (57936019 - 57960585 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C14orf105:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832806CNV Loss17160897

    Human Gene Mutation Database (HGMD): C14orf105
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C14orf105
    DNA2.0 Custom Variant and Variant Library Synthesis for C14orf105

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    C14orf105 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: C14orf105 (1 document)

    Export disorders for C14orf105 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C14orf105 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C14orf105)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)2 Heilig R.... Weissenbach J. (Nature 2003)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55195 HGNC: 20189 AceView: C14orf105 Ensembl:ENSG00000100557 euGenes: HUgn55195
    ECgene: C14orf105 H-InvDB: C14orf105

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C14orf105 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C14orf105 gene:
    Search GeneIP for patents involving C14orf105

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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