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Aliases for C14orf1 Gene

Aliases for C14orf1 Gene

  • Chromosome 14 Open Reading Frame 1 2 3
  • Probable Ergosterol Biosynthetic Protein 28 3
  • ERG28 3
  • NET51 3

External Ids for C14orf1 Gene

Summaries for C14orf1 Gene

GeneCards Summary for C14orf1 Gene

C14orf1 (Chromosome 14 Open Reading Frame 1) is a Protein Coding gene.

Gene Wiki entry for C14orf1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf1 Gene

Genomics for C14orf1 Gene

Genomic Location for C14orf1 Gene

Start:
75,649,791 bp from pter
End:
75,661,195 bp from pter
Size:
11,405 bases
Orientation:
Minus strand

Genomic View for C14orf1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C14orf1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf1 Gene

Regulatory Elements for C14orf1 Gene

Proteins for C14orf1 Gene

  • Protein details for C14orf1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKR5-ERG28_HUMAN
    Recommended name:
    Probable ergosterol biosynthetic protein 28
    Protein Accession:
    Q9UKR5
    Secondary Accessions:
    • Q9P093
    • Q9UPI2

    Protein attributes for C14orf1 Gene

    Size:
    140 amino acids
    Molecular mass:
    15864 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD51373.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAF28966.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C14orf1 Gene

Proteomics data for C14orf1 Gene at MOPED

Post-translational modifications for C14orf1 Gene

No Post-translational modifications

Other Protein References for C14orf1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C14orf1 Gene

Domains for C14orf1 Gene

Protein Domains for C14orf1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

ERG28_HUMAN
Family:
  • Belongs to the ERG28 family.:
    • Q9UKR5
genes like me logo Genes that share domains with C14orf1: view

No data available for Gene Families for C14orf1 Gene

Function for C14orf1 Gene

Molecular function for C14orf1 Gene

GENATLAS Biochemistry: chromosome 14 open reading frame 14,expressed in testis and cancer cell lines (see TSG14B),homolog to yeast Yer044C

Gene Ontology (GO) - Molecular Function for C14orf1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C14orf1: view

Phenotypes for C14orf1 Gene

genes like me logo Genes that share phenotypes with C14orf1: view

miRNA for C14orf1 Gene

miRTarBase miRNAs that target C14orf1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C14orf1 Gene

Localization for C14orf1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C14orf1 Gene COMPARTMENTS Subcellular localization image for C14orf1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C14orf1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane NAS 10449901
GO:0030133 transport vesicle IDA --
genes like me logo Genes that share ontologies with C14orf1: view

Pathways for C14orf1 Gene

SuperPathways for C14orf1 Gene

No Data Available

Interacting Proteins for C14orf1 Gene

Gene Ontology (GO) - Biological Process for C14orf1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016126 sterol biosynthetic process IEA --
genes like me logo Genes that share ontologies with C14orf1: view

No data available for Pathways by source for C14orf1 Gene

Transcripts for C14orf1 Gene

mRNA/cDNA for C14orf1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(203) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C14orf1 Gene

Chromosome 14 open reading frame 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5
SP1:
SP2:
SP3: - -

Relevant External Links for C14orf1 Gene

GeneLoc Exon Structure for
C14orf1
ECgene alternative splicing isoforms for
C14orf1

Expression for C14orf1 Gene

mRNA expression in normal human tissues for C14orf1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C14orf1 Gene

SOURCE GeneReport for Unigene cluster for C14orf1 Gene Hs.15106

mRNA Expression by UniProt/SwissProt for C14orf1 Gene

Q9UKR5-ERG28_HUMAN
Tissue specificity: Ubiquitous; strongly expressed in testis and some cancer cell lines
genes like me logo Genes that share expressions with C14orf1: view

Orthologs for C14orf1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C14orf1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf1 36
  • 99.52 (n)
  • 100 (a)
C14orf1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C10H14orf1 36
  • 88.1 (n)
  • 88.57 (a)
C10H14ORF1 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C14orf1 37
  • 84 (a)
OneToOne
C8H14orf1 36
  • 92.62 (n)
  • 95.71 (a)
mouse
(Mus musculus)
Mammalia 0610007P14Rik 36
  • 92.14 (n)
  • 97.86 (a)
0610007P14Rik 16
0610007P14Rik 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C14orf1 37
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf1 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1310769 36
  • 92.14 (n)
  • 97.86 (a)
chicken
(Gallus gallus)
Aves C14ORF1 36
  • 74.84 (n)
  • 79.25 (a)
C14orf1 37
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c14orf1 36
  • 72.86 (n)
  • 78.57 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10474 36
zebrafish
(Danio rerio)
Actinopterygii C14orf1 37
  • 69 (a)
OneToOne
LOC565132 36
  • 72.66 (n)
  • 77.7 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG28 37
  • 27 (a)
OneToOne
ERG28 39
Species with no ortholog for C14orf1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C14orf1 Gene

ENSEMBL:
Gene Tree for C14orf1 (if available)
TreeFam:
Gene Tree for C14orf1 (if available)

Paralogs for C14orf1 Gene

No data available for Paralogs for C14orf1 Gene

Variants for C14orf1 Gene

Sequence variations from dbSNP and Humsavar for C14orf1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2241086 -- 75,650,412(+) ACTCA(A/T)CAAAT downstream-variant-500B
rs3214359 -- 75,657,020(+) AATGC(-/T)TTTTT intron-variant
rs3783999 -- 75,653,385(-) acctc(A/G)tgatc intron-variant
rs7141947 -- 75,652,050(+) ACAAC(A/G)ATATT intron-variant
rs7142778 -- 75,652,014(+) GACAC(G/T)TGTTC intron-variant

Relevant External Links for C14orf1 Gene

HapMap Linkage Disequilibrium report
C14orf1

No data available for Structural Variations from Database of Genomic Variants (DGV) for C14orf1 Gene

Disorders for C14orf1 Gene

No disorders were found for C14orf1 Gene.

No data available for UniProtKB/Swiss-Prot for C14orf1 Gene

Publications for C14orf1 Gene

  1. A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines. (PMID: 10449901) Veitia R.A. … Fellous A. (Cytogenet. Cell Genet. 1999) 2 3 4
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. A novel gene conserved from yeast to humans is involved in sterol biosynthesis. (PMID: 11160377) Gachotte D. … Bard M. (J. Lipid Res. 2001) 2 3
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for C14orf1 Gene

Sources for C14orf1 Gene

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