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Aliases for C14orf1 Gene

Aliases for C14orf1 Gene

  • Chromosome 14 Open Reading Frame 1 2 3
  • Probable Ergosterol Biosynthetic Protein 28 3
  • ERG28 3
  • NET51 3

External Ids for C14orf1 Gene

Previous GeneCards Identifiers for C14orf1 Gene

  • GC14M073621
  • GC14M069933
  • GC14M074106
  • GC14M075185
  • GC14M076116
  • GC14M056285

Summaries for C14orf1 Gene

GeneCards Summary for C14orf1 Gene

C14orf1 (Chromosome 14 Open Reading Frame 1) is a Protein Coding gene.

Gene Wiki entry for C14orf1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf1 Gene

Genomics for C14orf1 Gene

Regulatory Elements for C14orf1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C14orf1 Gene

75,649,791 bp from pter
75,661,195 bp from pter
11,405 bases
Minus strand

Genomic View for C14orf1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C14orf1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf1 Gene

Proteins for C14orf1 Gene

  • Protein details for C14orf1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable ergosterol biosynthetic protein 28
    Protein Accession:
    Secondary Accessions:
    • Q9P093
    • Q9UPI2

    Protein attributes for C14orf1 Gene

    140 amino acids
    Molecular mass:
    15864 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD51373.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAF28966.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C14orf1 Gene

Proteomics data for C14orf1 Gene at MOPED

Post-translational modifications for C14orf1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C14orf1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for C14orf1 Gene

Domains for C14orf1 Gene

Protein Domains for C14orf1 Gene


Suggested Antigen Peptide Sequences for C14orf1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UKR5
  • Belongs to the ERG28 family.
genes like me logo Genes that share domains with C14orf1: view

No data available for Gene Families for C14orf1 Gene

Function for C14orf1 Gene

Molecular function for C14orf1 Gene

GENATLAS Biochemistry:
chromosome 14 open reading frame 14,expressed in testis and cancer cell lines (see TSG14B),homolog to yeast Yer044C

Gene Ontology (GO) - Molecular Function for C14orf1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with C14orf1: view

Phenotypes for C14orf1 Gene

genes like me logo Genes that share phenotypes with C14orf1: view

Animal Model Products

CRISPR Products

miRNA for C14orf1 Gene

miRTarBase miRNAs that target C14orf1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C14orf1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C14orf1 Gene

Localization for C14orf1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for C14orf1 Gene COMPARTMENTS Subcellular localization image for C14orf1 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C14orf1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane NAS 10449901
GO:0030133 transport vesicle IDA --
genes like me logo Genes that share ontologies with C14orf1: view

Pathways for C14orf1 Gene

SuperPathways for C14orf1 Gene

No Data Available

Interacting Proteins for C14orf1 Gene

Gene Ontology (GO) - Biological Process for C14orf1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0016126 sterol biosynthetic process IEA --
genes like me logo Genes that share ontologies with C14orf1: view

No data available for Pathways by source for C14orf1 Gene

Transcripts for C14orf1 Gene

mRNA/cDNA for C14orf1 Gene

(203) Selected AceView cDNA sequences:
(8) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C14orf1 Gene

Chromosome 14 open reading frame 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C14orf1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5
SP3: - -

Relevant External Links for C14orf1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C14orf1 Gene

mRNA expression in normal human tissues for C14orf1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for C14orf1 Gene

This gene is overexpressed in Nasal epithelium (28.6) and Colon muscle (17.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C14orf1 Gene

SOURCE GeneReport for Unigene cluster for C14orf1 Gene Hs.15106

mRNA Expression by UniProt/SwissProt for C14orf1 Gene

Tissue specificity: Ubiquitous; strongly expressed in testis and some cancer cell lines
genes like me logo Genes that share expressions with C14orf1: view

Expression partners for C14orf1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for C14orf1 Gene

Orthologs for C14orf1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C14orf1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C10H14orf1 35
  • 88.1 (n)
  • 88.57 (a)
C10H14ORF1 36
  • 89 (a)
(Canis familiaris)
Mammalia C8H14orf1 35
  • 92.62 (n)
  • 95.71 (a)
C14orf1 36
  • 84 (a)
(Mus musculus)
Mammalia 0610007P14Rik 35
  • 92.14 (n)
  • 97.86 (a)
0610007P14Rik 16
0610007P14Rik 36
  • 98 (a)
(Pan troglodytes)
Mammalia C14H14orf1 35
  • 99.52 (n)
  • 100 (a)
C14orf1 36
  • 100 (a)
(Rattus norvegicus)
Mammalia RGD1310769 35
  • 92.14 (n)
  • 97.86 (a)
(Monodelphis domestica)
Mammalia C14orf1 36
  • 87 (a)
(Ornithorhynchus anatinus)
Mammalia C14orf1 36
  • 95 (a)
(Gallus gallus)
Aves C14ORF1 35
  • 74.84 (n)
  • 79.25 (a)
C14orf1 36
  • 79 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c14orf1 35
  • 72.86 (n)
  • 78.57 (a)
(Danio rerio)
Actinopterygii LOC565132 35
  • 72.66 (n)
  • 77.7 (a)
C14orf1 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10474 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG28 36
  • 27 (a)
ERG28 38
Species with no ortholog for C14orf1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C14orf1 Gene

Gene Tree for C14orf1 (if available)
Gene Tree for C14orf1 (if available)

Paralogs for C14orf1 Gene

No data available for Paralogs for C14orf1 Gene

Variants for C14orf1 Gene

Sequence variations from dbSNP and Humsavar for C14orf1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs2241086 -- 75,650,412(+) ACTCA(A/T)CAAAT downstream-variant-500B
rs3214359 -- 75,657,020(+) AATGC(-/T)TTTTT intron-variant
rs3783999 -- 75,653,385(-) acctc(A/G)tgatc intron-variant
rs7141947 -- 75,652,050(+) ACAAC(A/G)ATATT intron-variant
rs7142778 -- 75,652,014(+) GACAC(G/T)TGTTC intron-variant

Relevant External Links for C14orf1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C14orf1 Gene

Disorders for C14orf1 Gene

No disorders were found for C14orf1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for C14orf1 Gene

Publications for C14orf1 Gene

  1. A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines. (PMID: 10449901) Veitia R.A. … Fellous A. (Cytogenet. Cell Genet. 1999) 2 3 4
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. A novel gene conserved from yeast to humans is involved in sterol biosynthesis. (PMID: 11160377) Gachotte D. … Bard M. (J. Lipid Res. 2001) 2 3
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 3 4

Products for C14orf1 Gene

Sources for C14orf1 Gene

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