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Aliases for C14orf1 Gene

Aliases for C14orf1 Gene

  • Chromosome 14 Open Reading Frame 1 2 3 5
  • ERG28 3
  • NET51 3

External Ids for C14orf1 Gene

Previous GeneCards Identifiers for C14orf1 Gene

  • GC14M073621
  • GC14M069933
  • GC14M074106
  • GC14M075185
  • GC14M076116
  • GC14M056285

Summaries for C14orf1 Gene

GeneCards Summary for C14orf1 Gene

C14orf1 (Chromosome 14 Open Reading Frame 1) is a Protein Coding gene.

Gene Wiki entry for C14orf1 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf1 Gene

Genomics for C14orf1 Gene

Regulatory Elements for C14orf1 Gene

Enhancers for C14orf1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C14orf1 on UCSC Golden Path with GeneCards custom track

Promoters for C14orf1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C14orf1 on UCSC Golden Path with GeneCards custom track

Genomic Location for C14orf1 Gene

Chromosome:
14
Start:
75,649,791 bp from pter
End:
75,661,195 bp from pter
Size:
11,405 bases
Orientation:
Minus strand

Genomic View for C14orf1 Gene

Genes around C14orf1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf1 Gene

Proteins for C14orf1 Gene

  • Protein details for C14orf1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UKR5-ERG28_HUMAN
    Recommended name:
    Probable ergosterol biosynthetic protein 28
    Protein Accession:
    Q9UKR5
    Secondary Accessions:
    • Q9P093
    • Q9UPI2

    Protein attributes for C14orf1 Gene

    Size:
    140 amino acids
    Molecular mass:
    15864 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD51373.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAF28966.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C14orf1 Gene

Proteomics data for C14orf1 Gene at MOPED

Post-translational modifications for C14orf1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C14orf1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C14orf1 Gene

Domains & Families for C14orf1 Gene

Protein Domains for C14orf1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for C14orf1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UKR5

UniProtKB/Swiss-Prot:

ERG28_HUMAN :
  • Belongs to the ERG28 family.
Family:
  • Belongs to the ERG28 family.
genes like me logo Genes that share domains with C14orf1: view

No data available for Gene Families for C14orf1 Gene

Function for C14orf1 Gene

Molecular function for C14orf1 Gene

GENATLAS Biochemistry:
chromosome 14 open reading frame 14,expressed in testis and cancer cell lines (see TSG14B),homolog to yeast Yer044C
genes like me logo Genes that share phenotypes with C14orf1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf1 Gene

Localization for C14orf1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C14orf1 Gene COMPARTMENTS Subcellular localization image for C14orf1 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C14orf1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA,NAS 10449901
genes like me logo Genes that share ontologies with C14orf1: view

Pathways & Interactions for C14orf1 Gene

SuperPathways for C14orf1 Gene

No Data Available

Interacting Proteins for C14orf1 Gene

Gene Ontology (GO) - Biological Process for C14orf1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C14orf1: view

No data available for Pathways by source and SIGNOR curated interactions for C14orf1 Gene

Drugs & Compounds for C14orf1 Gene

No Compound Related Data Available

Transcripts for C14orf1 Gene

mRNA/cDNA for C14orf1 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(203) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C14orf1 Gene

Chromosome 14 open reading frame 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5
SP1:
SP2:
SP3: - -

Relevant External Links for C14orf1 Gene

GeneLoc Exon Structure for
C14orf1
ECgene alternative splicing isoforms for
C14orf1

Expression for C14orf1 Gene

mRNA expression in normal human tissues for C14orf1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C14orf1 Gene

This gene is overexpressed in Nasal epithelium (28.6) and Colon muscle (17.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C14orf1 Gene



SOURCE GeneReport for Unigene cluster for C14orf1 Gene Hs.15106

mRNA Expression by UniProt/SwissProt for C14orf1 Gene

Q9UKR5-ERG28_HUMAN
Tissue specificity: Ubiquitous; strongly expressed in testis and some cancer cell lines.
genes like me logo Genes that share expression patterns with C14orf1: view

Protein tissue co-expression partners for C14orf1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for C14orf1 Gene

Orthologs for C14orf1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C14orf1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C10H14orf1 35
  • 88.1 (n)
  • 88.57 (a)
C10H14ORF1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C8H14orf1 35
  • 92.62 (n)
  • 95.71 (a)
C14orf1 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 0610007P14Rik 35
  • 92.14 (n)
  • 97.86 (a)
0610007P14Rik 16
0610007P14Rik 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf1 35
  • 99.52 (n)
  • 100 (a)
C14orf1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1310769 35
  • 92.14 (n)
  • 97.86 (a)
oppossum
(Monodelphis domestica)
Mammalia C14orf1 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C14orf1 36
  • 95 (a)
OneToOne
chicken
(Gallus gallus)
Aves C14ORF1 35
  • 74.84 (n)
  • 79.25 (a)
C14orf1 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c14orf1 35
  • 72.86 (n)
  • 78.57 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC565132 35
  • 72.66 (n)
  • 77.7 (a)
C14orf1 36
  • 69 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10474 35
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ERG28 36
  • 27 (a)
OneToOne
ERG28 38
Species with no ortholog for C14orf1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C14orf1 Gene

ENSEMBL:
Gene Tree for C14orf1 (if available)
TreeFam:
Gene Tree for C14orf1 (if available)

Paralogs for C14orf1 Gene

No data available for Paralogs for C14orf1 Gene

Variants for C14orf1 Gene

Sequence variations from dbSNP and Humsavar for C14orf1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs7141947 -- 75,652,050(+) ACAAC(A/G)ATATT intron-variant
rs7142778 -- 75,652,014(+) GACAC(G/T)TGTTC intron-variant
rs3214359 -- 75,657,020(+) AATGC(-/T)TTTTT intron-variant
rs7149678 -- 75,655,321(+) GGGAA(C/T)GTTGT intron-variant
rs3783999 -- 75,653,385(-) acctc(A/G)tgatc intron-variant

Variation tolerance for C14orf1 Gene

Residual Variation Intolerance Score: 55.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C14orf1 Gene

HapMap Linkage Disequilibrium report
C14orf1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C14orf1 Gene

Disorders for C14orf1 Gene

Relevant External Links for C14orf1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C14orf1

No disorders were found for C14orf1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf1 Gene

Publications for C14orf1 Gene

  1. A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines. (PMID: 10449901) Veitia R.A. … Fellous A. (Cytogenet. Cell Genet. 1999) 2 3 4 67
  2. Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PMID: 12958361) Schirmer E.C. … Gerace L. (Science 2003) 2 3
  3. A novel gene conserved from yeast to humans is involved in sterol biosynthesis. (PMID: 11160377) Gachotte D. … Bard M. (J. Lipid Res. 2001) 2 3
  4. Identifying protein partners of CLN8, an ER-resident protein involved in neuronal ceroid lipofuscinosis. (PMID: 23142642) Passantino R. … Guarneri P. (Biochim. Biophys. Acta 2013) 3
  5. Arabidopsis ERG28 tethers the sterol C4-demethylation complex to prevent accumulation of a biosynthetic intermediate that interferes with polar auxin transport. (PMID: 24326590) Mialoundama A.S. … Bouvier F. (Plant Cell 2013) 3

Products for C14orf1 Gene

Sources for C14orf1 Gene

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