C14orf1 Gene
protein-coding GIFtS: 50
GCID: GC14M076116
|
|
chromosome 14 open reading frame 1
| |
Aliases
for C14orf1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 14 Open Reading Frame 11 2 | | ERG281 2 | | NET511 2 | | Probable Ergosterol Biosynthetic Protein 282 |
Export aliases for C14orf1 gene to outside databasesPrevious GC identifers: GC14M073621 GC14M069933 GC14M074106 GC14M075185 GC14M056285 |
Summaries
for C14orf1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for C14orf1
|
Genomic Views
for C14orf1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C14orf1 gene promoter:
c-Fos Sox5 AP-1 FosB POU3F2 (N-Oct-5b) POU3F2 (N-Oct-5a) POU3F2 CREB deltaCREB c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for C14orf1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.3C14orf1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M076116: view genomic region
(about GC identifiers)
Start:
|
76,116,134 bp from pter |
End:
|
76,127,538 bp from pter |
Size:
|
11,405 bases |
Orientation:
|
minus strand |
|
Proteins
for C14orf1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: ERG28_HUMAN, Q9UKR5 (See
protein sequence)Recommended Name: Probable ergosterol biosynthetic protein 28 Size: 140 amino acids; 15864 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAD51373.1; Type=Erroneous gene model prediction; Sequence=AAF28966.1; Type=Erroneousinitiation;
Secondary accessions: Q9P093 Q9UPI2Explore the universe of human proteins at neXtProt for C14orf1: NX_Q9UKR5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UKR5
C14orf1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_009107.1
ENSEMBL proteins: ENSP00000256319
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
C14orf1 for ontologies About GeneDecksing
C14orf1 Antibody Products:
Assay Products for C14orf1: |
Protein
Domains /
Families
for C14orf1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C14orf1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UKR5ProtoNet protein and cluster: Q9UKR5 1 Blocks protein family: IPB005352 Protein of unknown function UPF0143
UniProtKB/Swiss-Prot: ERG28_HUMAN, Q9UKR5Similarity: Belongs to the ERG28 family |
Function
for C14orf1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
Genatlas biochemistry entry for C14orf1:chromosome 14 open reading frame 14,expressed in testis and cancer cell lines (see TSG14B),homolog to yeast Yer044C
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf1 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
C14orf1 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for C14orf1:
|
Pathways & Interactions
for C14orf1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C14orf1
STRING Interaction
Network Preview (showing 5 interactants - click image to see 16)
5/98 Interacting proteins for C14orf1 (Q9UKR52, 3 ENSP000002563194) via UniProtKB, MINT, STRING, and/or I2D (see all 98)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- | | GO:0016126 | sterol biosynthetic process |
IEA | -- |
C14orf1 for ontologies About GeneDecksing
|
Drugs & Compounds
for C14orf1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C14orf1
Search CenterWatch for drugs/clinical trials and news about C14orf1 / ERG28
|
Transcripts
for C14orf1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C14orf1 gene: NM_007176.3 Unigene Cluster for C14orf1: Chromosome 14 open reading frame 1 Hs.15106 [show with all ESTs]Unigene Representative Sequence: AF1341591 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000256319(uc001xrt.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf1
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C14orf1 (NM_007176) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C14orf1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C14orf1 |
Additional cDNA sequence: AF134159.2 AF136971.1 AF161406.1 AK311764.1 AL136658.1 BC002444.2 BX248022.1 CR533443.1 14 DOTS entries: DT.443528 DT.100790260 DT.95125061 DT.100843012 DT.120752700 DT.95271085 DT.120752712 DT.120752873 DT.92435474 DT.95184866 DT.95271084 DT.120752772 DT.92017387 DT.92435467 24/203 AceView cDNA sequences (see all 203): CB215328 CK906276 CR604759 AA642233 AI863431 AA053917 CR597566 CK906277 AA583250 AL557050 BM986961 AI913778 BQ614118 BG028203 AI971022 CB156946 CA950792 AI538920 BM551326 AV711602 BX374458 BC002444 T32338 AI469642
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for C14orf1 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for C14orf1
|
Expression
for C14orf1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C14orf1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGTTGGAA
About this image
See C14orf1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C14orf1
SOURCE GeneReport for Unigene cluster: Hs.15106
UniProtKB/Swiss-Prot: ERG28_HUMAN, Q9UKR5Tissue specificity: Ubiquitous; strongly expressed in testis and some cancer cell lines
SABiosciences Custom PCR Arrays for C14orf1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C14orf1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C14orf1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C14orf1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C14orf1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf1 |
Orthologs
for C14orf1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for C14orf1 gene from 5/17 species (see all 17) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
0610007P14Rik1 , 5 |
RIKEN cDNA 0610007P14 gene1, 5 |
92.14(n)1
97.86(a)1 |
|
12 (39.81 cM)5
585201 NM_021446.21 NP_067421.11
858154485 |
chicken
(Gallus gallus) |
Aves |
C5H14orf11 |
chromosome 5 open reading frame, human C14orf1 |
74.84(n)
79.25(a) |
|
423366 XM_421281.3 XP_421281.3 |
zebrafish
(Danio rerio) |
Actinopterygii |
LOC5651321 |
probable ergosterol biosynthetic protein 28-like |
72.66(n)
77.7(a) |
|
565132 XM_688430.3 XP_693522.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
ERG286 |
Ergosterol biosynthetic protein 28 |
32(a) |
1 ↔ 1 |
1(3273825-3275837) |
rice
(Oryza sativa) |
Liliopsida |
-- |
ergosterol biosynthetic protein 28, putative, expr... |
29(a) |
1 ↔ 1 |
12(27098644-27101176) |
ENSEMBL Gene Tree for C14orf1 (if available)
TreeFam Gene Tree for C14orf1 (if available) |
Paralogs
for C14orf1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C14orf1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C14orf1 (76116134 - 76127538 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C14orf1: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C14orf1 |
|
Disorders
/ Diseases
for C14orf1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C14orf1 for disorders About MalaCards
C14orf1 for disorders About GeneDecksing
OMIM gene information: 604576
OMIM disorders: --
Export disorders for C14orf1 gene to outside databases
|
Publications
for C14orf1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C14orf1 gene, integrated from 9 sources (see all 22):
(articles sorted by number of sources associating them with C14orf1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A novel human gene, encoding a potential membrane protein conserved from yeast to man, is strongly expressed in testis and cancer cell lines. (PubMed id 10449901)1, 2, 3 Veitia R.A.... Fellous A. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Nuclear membrane proteins with potential disease links found by subtractive proteomics. (PubMed id 12958361)1, 3 Schirmer E.C....Gerace L. (2003)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2 Wiemann S.... Poustka A. (2001)
- A novel gene conserved from yeast to humans is involved in sterol biosynthesis. (PubMed id 11160377)1, 3 Gachotte D....Bard M. (2001)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Identifying protein partners of CLN8, an ER-resident p rotein involved in neuronal ceroid lipofuscinosis. (PubMed id 23142642)1 Passantino R....Guarneri P. (2013)
- RNA interference characterization of proteins discover ed by proteomic analysis of pancreatic cancer reveals function in cell growth an d survival. (PubMed id 21934552)1 Lee C.N....Moore P.A. (2012)
|
External Searches for C14orf1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C14orf1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C14orf1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C14orf1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C14orf1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C14orf1 gene:
Search GeneIP for patents involving C14orf1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C14orf1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C14orf1 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C14orf1 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C14orf1 | | | OriGene Protein Over-expression Lysate for C14orf1 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C14orf1 | | OriGene 3'-UTR Clone for C14orf1 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf1 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C14orf1 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C14orf1 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C14orf1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C14orf1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C14orf1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C14orf1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C14orf1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C14orf1 |
| |
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| |  |  |  |  | | | | |
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 | | | C14orf1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C14orf1 |
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