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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C13orf35 Gene

protein-coding   GIFtS: 33
GCID: GC13P113301          (predicted)

Chromosome 13 Open Reading Frame 35

  Search for C13orf35
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 13 Open Reading Frame 351 2
Small Blood Protein 11 2
SMABLO12
Putative Uncharacterized Protein C13orf352

External Ids:    HGNC: 337931   Entrez Gene: 4001652   Ensembl: ENSG000001975957   UniProtKB: Q6ZP683   

Export aliases for C13orf35 gene to outside databases

Previous GC identifers: GC13P112350 GC13P093743


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C13orf35 Gene: 
C13orf35 (chromosome 13 open reading frame 35) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_027140.6  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C13orf35 gene promoter:
         STAT5B   GATA-3   AML1a   NRSF form 1   POU6F1 (c2)   NRSF form 2   HNF-1A   Evi-1   HNF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC13orf35 promoter sequence
   Search SABiosciences Chromatin IP Primers for C13orf35

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C13orf35


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q34   Ensembl cytogenetic band:  13q34   HGNC cytogenetic band: 13q34

C13orf35 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C13orf35 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P113301:  view genomic region     (about GC identifiers)

Start:
113,301,358 bp from pter      End:
113,338,811 bp from pter
Size:
37,454 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CM035_HUMAN, Q6ZP68 (See protein sequence)
Recommended Name: Putative uncharacterized protein C13orf35  
Size: 121 amino acids; 13416 Da

Explore the universe of human proteins at neXtProt for C13orf35: NX_Q6ZP68

Explore proteomics data for C13orf35 at MOPED 

C13orf35 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

C13orf35 Protein Expression

REFSEQ proteins: NP_997323.1  
ENSEMBL proteins: 
 ENSP00000348337  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6ZP68


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for C13orf35:
 Decreased POU5F1-GFP protein e 

Animal Models:
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C13orf35

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C13orf35 (CM035)

Search CenterWatch for drugs/clinical trials and news about C13orf35 / CM035

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C13orf35 gene: 
NM_207440.1  

Unigene Cluster for C13orf35:

Chromosome 13 open reading frame 35
Hs.591213
Unigene Representative Sequence: AK129953
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000356049(uc001vsh.1)
miRNA
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Inhib. RNA
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Additional mRNA sequence: AK129953.1 

1 DOTS entry:

DT.101957177 

2 AceView cDNA sequences:

AK129953 NM_207440 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C13orf35 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: CTTCTGTCTG
C13orf35 Expression
About this image


See C13orf35 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.591213
    SABiosciences Custom PCR Arrays for C13orf35
Primer
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and chimp.

Orthologs for C13orf35 gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia C13H13orf351 chromosome 13 open reading frame, human C13orf35 98.33(n)
95(a)
  744290  XM_001148903.2  XP_001148903.1 


ENSEMBL Gene Tree for C13orf35 (if available)
TreeFam Gene Tree for C13orf35 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1136 SNPs in C13orf35 are shown (see all 1136)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 13 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2014135511,2
C--94238258(+) GGGCCA/GGGTGC 1 -- us2k10--------
rs749987571,2
C--113299368(+) CATCTC/TTACTA 1 -- us2k10--------
rs1407754751,2
C--113299385(+) CAAAAA/CTTAGC 1 -- us2k10--------
rs1870193971,2
--113299386(+) AAAACA/TTAGCC 1 -- us2k10--------
rs1447129741,2
C--113299407(+) GCAGGC/TGCCTG 1 -- us2k10--------
rs1385194561,2
C--113299497(+) GCCACC/TGCATT 1 -- us2k10--------
rs790173901,2
C--113299522(+) AGAGCG/AAGAGT 1 -- us2k12Minor allele frequency- A:0.13CSA NA 121
rs1173358631,2
C,F--113299537(+) ATCAAA/GAAAAA 1 -- us2k11Minor allele frequency- G:0.03EA 120
rs1150068611,2
F--113299554(+) AAGGAA/CATCTG 1 -- us2k11Minor allele frequency- C:0.03WA 118
rs1914602841,2
--113299584(+) ACACAC/G/TACACA 1 -- us2k10--------

HapMap Linkage Disequilibrium report for C13orf35 (113301358 - 113338811 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/18 variations for C13orf35 (see all 18):    About this table     
Variant IDTypeSubtypePubMed ID
esv2748168CNV Deletion23290073
esv2748170CNV Deletion23290073
esv2748162CNV Deletion23290073
esv2748169CNV Deletion23290073
dgv381e199CNV Deletion23128226
esv2748167CNV Deletion23290073
dgv273e201CNV Deletion23290073
esv2220906CNV Deletion18987734
esv3166CNV Deletion18987735
esv2748166CNV Deletion23290073

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C13orf35 for disorders           About MalaCards

C13orf35 for disorders           About GeneDecksing

Genetic Association Database (GAD): C13orf35

Export disorders for C13orf35 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C13orf35 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C13orf35)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Common variants at 10 genomic loci influence hemoglob in Aa88(C) levels via glycemic and nonglycemic pathways. (PubMed id 20858683)1, 4 Soranzo N....Ricketts S.L. (2010)
  2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)2 Dunham A.... Ross M.T. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 400165 HGNC: 33793 AceView: FLJ26443 Ensembl:ENSG00000197595 euGenes: HUgn400165
ECgene: C13orf35 H-InvDB: C13orf35

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C13orf35 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C13orf35 gene:
Search GeneIP for patents involving C13orf35

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section

 
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