Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C12orf76 Gene

Aliases for C12orf76 Gene

  • Chromosome 12 Open Reading Frame 76 2 3 5

External Ids for C12orf76 Gene

Previous GeneCards Identifiers for C12orf76 Gene

  • GC12M108963
  • GC12M110478
  • GC12M107494

Summaries for C12orf76 Gene

GeneCards Summary for C12orf76 Gene

C12orf76 (Chromosome 12 Open Reading Frame 76) is a Protein Coding gene. GO annotations related to this gene include ion channel activity and purinergic nucleotide receptor activity.

Additional gene information for C12orf76 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf76 Gene

Genomics for C12orf76 Gene

Regulatory Elements for C12orf76 Gene

Enhancers for C12orf76 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H110046 1.4 ENCODE dbSUPER 18.3 +33.8 33831 3.1 MLX DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A MEF2D ZNF610 C12orf76 ANKRD13A GIT2 TRPV4 GLTP GC12P110049 PIR31988
GH12H110928 1.5 VISTA ENCODE dbSUPER 13.2 -848.3 -848343 3.7 BCOR HDGF CTCF ZNF777 SUZ12 ZSCAN4 TSC22D4 ZMYM3 CDC5L GATA3 MAPKAPK5 IFT81 LINC01405 C12orf76 ATXN2 MYL2
GH12H110036 1.6 Ensembl ENCODE dbSUPER 12.3 +41.7 41720 7.5 HDGF FOXA2 ARID4B SIN3A FEZF1 YY1 SLC30A9 ZNF143 FOS PAF1 TRPV4 ALKBH2 GIT2 ANKRD13A C12orf76 RNU4-32P GLTP PIR31988 GC12P110049
GH12H110266 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.7 -185.0 -184957 2.2 FEZF1 TCF12 ZNF121 GLIS2 GATA2 ATF7 CAVIN1 REST ZNF592 SMARCA4 GPN3 RNU4-32P IFT81 C12orf76 UBE3B ATP2A2 PPTC7 GC12P110274 GC12P110258
GH12H110054 1.5 Ensembl ENCODE dbSUPER 12.5 +26.4 26395 1.9 PKNOX1 ATF1 TCF12 GTF3C2 ZNF766 GATA2 ELK1 FOS ATF7 NCOA1 RNU4-32P C12orf76 UBE3B GIT2 ANKRD13A GLTP ENSG00000279360 GC12P110049
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C12orf76 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C12orf76 Gene

Genomic Locations for C12orf76 Gene
55,197 bases
Minus strand

Genomic View for C12orf76 Gene

Genes around C12orf76 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C12orf76 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C12orf76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf76 Gene

Proteins for C12orf76 Gene

  • Protein details for C12orf76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C12orf76
    Protein Accession:

    Protein attributes for C12orf76 Gene

    135 amino acids
    Molecular mass:
    14959 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C12orf76 Gene

Post-translational modifications for C12orf76 Gene

No Post-translational modifications

No data available for DME Specific Peptides for C12orf76 Gene

Domains & Families for C12orf76 Gene

Gene Families for C12orf76 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for C12orf76 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C12orf76: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C12orf76 Gene

Function for C12orf76 Gene

Phenotypes From GWAS Catalog for C12orf76 Gene

Gene Ontology (GO) - Molecular Function for C12orf76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004931 extracellular ATP-gated cation channel activity IEA --
GO:0005216 ion channel activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with C12orf76: view

Phenotypes for C12orf76 Gene

GenomeRNAi human phenotypes for C12orf76:
genes like me logo Genes that share phenotypes with C12orf76: view

miRNA for C12orf76 Gene

miRTarBase miRNAs that target C12orf76

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C12orf76 Gene

Localization for C12orf76 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C12orf76 gene
Compartment Confidence
extracellular 3
nucleus 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Actin filaments (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C12orf76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0098794 postsynapse IEA --
genes like me logo Genes that share ontologies with C12orf76: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C12orf76 Gene

Pathways & Interactions for C12orf76 Gene

SuperPathways for C12orf76 Gene

No Data Available

Interacting Proteins for C12orf76 Gene

Selected Interacting proteins: Q8N812-CL076_HUMAN for C12orf76 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C12orf76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006811 ion transport IEA --
GO:0033198 response to ATP IEA --
GO:0035590 purinergic nucleotide receptor signaling pathway IEA --
GO:0060079 excitatory postsynaptic potential IEA --
GO:0098655 cation transmembrane transport IEA --
genes like me logo Genes that share ontologies with C12orf76: view

No data available for Pathways by source and SIGNOR curated interactions for C12orf76 Gene

Drugs & Compounds for C12orf76 Gene

No Compound Related Data Available

Transcripts for C12orf76 Gene

Unigene Clusters for C12orf76 Gene

Chromosome 12 open reading frame 76:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf76 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for C12orf76 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C12orf76 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C12orf76 Gene

mRNA differential expression in normal tissues according to GTEx for C12orf76 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.4).

Protein differential expression in normal tissues from HIPED for C12orf76 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C12orf76 Gene

Protein tissue co-expression partners for C12orf76 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C12orf76 Gene:


SOURCE GeneReport for Unigene cluster for C12orf76 Gene:


Evidence on tissue expression from TISSUES for C12orf76 Gene

  • Nervous system(3.8)
genes like me logo Genes that share expression patterns with C12orf76: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C12orf76 Gene

Orthologs for C12orf76 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C12orf76 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C12H12orf76 33
  • 99.26 (n)
C12orf76 34
  • 99 (a)
Species where no ortholog for C12orf76 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C12orf76 Gene

Gene Tree for C12orf76 (if available)
Gene Tree for C12orf76 (if available)

Paralogs for C12orf76 Gene Pseudogenes for C12orf76 Gene

genes like me logo Genes that share paralogs with C12orf76: view

No data available for Paralogs for C12orf76 Gene

Variants for C12orf76 Gene

Sequence variations from dbSNP and Humsavar for C12orf76 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_039916 A colorectal cancer sample
rs1000021183 -- 110,065,839(+) GGTCT(A/G)GCTCT intron-variant
rs1000111177 -- 110,052,907(+) ATATT(C/T)GTTAA intron-variant
rs1000117147 -- 110,054,910(+) TCAAG(A/T)GATCC intron-variant
rs1000153304 -- 110,043,260(+) AAGGC(C/T)GGGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C12orf76 Gene

Variant ID Type Subtype PubMed ID
esv2761769 CNV loss 21179565
nsv1134262 CNV deletion 24896259
nsv1144647 CNV deletion 24896259
nsv977146 CNV duplication 23825009

Variation tolerance for C12orf76 Gene

Residual Variation Intolerance Score: 60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C12orf76 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf76 Gene

Disorders for C12orf76 Gene

Relevant External Links for C12orf76

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C12orf76 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf76 Gene

Publications for C12orf76 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. (PMID: 19729612) Paterson AD … Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research Group (Arteriosclerosis, thrombosis, and vascular biology 2009) 45 60
  3. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjöblom T … Velculescu VE (Science (New York, N.Y.) 2006) 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for C12orf76 Gene

Sources for C12orf76 Gene

Loading form....