Aliases for C12orf76 Gene
External Ids for C12orf76 Gene
- HGNC: 33790
- Entrez Gene: 400073
- Ensembl: ENSG00000174456
- UniProtKB: Q8N812
Previous GeneCards Identifiers for C12orf76 Gene
- GC12M108963
- GC12M110478
- GC12M107494
Summaries for C12orf76 Gene
GeneCards Summary for C12orf76 Gene
C12orf76 (Chromosome 12 Open Reading Frame 76) is a Protein Coding gene. GO annotations related to this gene include ion channel activity and purinergic nucleotide receptor activity.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf76 Gene
Genomics for C12orf76 Gene
Regulatory Elements for C12orf76 Gene
Enhancers for C12orf76 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C12orf76 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the C12orf76 gene promoter:
Regulatory Element Products
Genomic Location for C12orf76 Gene
- Chromosome:
- 12
- Start:
- 110,027,028 bp from pter
- End:
- 110,082,224 bp from pter
- Size:
- 55,197 bases
- Orientation:
- Minus strand
Genomic View for C12orf76 Gene
Genes around C12orf76 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q24.11 by Ensembl
- 12q24.11 by Entrez Gene
- 12q24.11 by HGNC
C12orf76 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C12orf76 Gene
Proteins for C12orf76 Gene
-
Protein details for C12orf76 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N812-CL076_HUMAN
- Recommended name:
- Uncharacterized protein C12orf76
- Protein Accession:
- Q8N812
Protein attributes for C12orf76 Gene
- Size:
- 135 amino acids
- Molecular mass:
- 14959 Da
- Quaternary structure:
- No Data Available
Protein Expression for C12orf76 Gene
Post-translational modifications for C12orf76 Gene
No Post-translational modifications
Other Protein References for C12orf76 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C12orf76
-
Abcam antibodies for C12orf76
- Invitrogen Antibodies for C12orf76
- Search GeneTex for Antibodies for C12orf76
Protein Products
-
OriGene Purified Proteins for C12orf76
- Search Origene for MassSpec and Protein Over-expression Lysates for C12orf76
- Origene Custom Protein Services for C12orf76
- Novus Biologicals proteins for C12orf76
- Search GeneTex for Proteins for C12orf76
Assay Products
No data available for DME Specific Peptides for C12orf76 Gene
Domains & Families for C12orf76 Gene
Protein Domains for C12orf76 Gene
- Blocks:
- ProtoNet:
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C12orf76 Gene
Function for C12orf76 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004931 | extracellular ATP-gated cation channel activity | IEA | -- |
| GO:0005216 | ion channel activity | IEA | -- |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for C12orf76 Gene
- GenomeRNAi human phenotypes for C12orf76:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C12orf76
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C12orf76 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf76 gene
- Search ViGene Biosciences for C12orf76
CRISPR Products
-
OriGene CRISPR knockouts for C12orf76
-
Santa Cruz Biotechnology (SCBT) CRISPR for C12orf76
- GenScript: Design CRISPR guide RNA sequences for C12orf76
miRNA for C12orf76 Gene
- miRTarBase miRNAs that target C12orf76
miRNA Products
- Search ViGene Biosciences for C12orf76
Inhibitory RNA Products
- Origene siRNA, RNAi, and shRNA products in human, mouse, rat for C12orf76
- Browse OriGene Inhibitory RNA Products For C12orf76
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf76 gene
Clone Products
-
OriGene ORF clones in human for C12orf76
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C12orf76
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf76
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C12orf76
-
ViGene Biosciences adenoviral particle packaged cDNA for C12orf76 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C12orf76 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf76 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C12orf76 Gene
Localization for C12orf76 Gene
| Compartment | Confidence |
|---|---|
| extracellular | 3 |
| nucleus | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005887 | integral component of plasma membrane | IEA | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0098794 | postsynapse | IEA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for C12orf76 Gene
Pathways & Interactions for C12orf76 Gene
No Data Available
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006811 | ion transport | IEA | -- |
| GO:0033198 | response to ATP | IEA | -- |
| GO:0035590 | purinergic nucleotide receptor signaling pathway | IEA | -- |
| GO:0060079 | excitatory postsynaptic potential | IEA | -- |
| GO:0098655 | cation transmembrane transport | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for C12orf76 Gene
Transcripts for C12orf76 Gene
mRNA/cDNA for C12orf76 Gene
- (2) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (185) Selected AceView cDNA sequences:
- (9) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C12orf76 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C12orf76
-
Santa Cruz Biotechnology (SCBT) CRISPR for C12orf76
- GenScript: Design CRISPR guide RNA sequences for C12orf76
miRNA Products
- Search ViGene Biosciences for C12orf76
Inhibitory RNA Products
- Origene siRNA, RNAi, and shRNA products in human, mouse, rat for C12orf76
- Browse OriGene Inhibitory RNA Products For C12orf76
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf76 gene
Clone Products
-
OriGene ORF clones in human for C12orf76
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C12orf76
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf76
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||
| SP4: | - |
Expression for C12orf76 Gene
mRNA differential expression in normal tissues according to GTEx for C12orf76 Gene
This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.4).
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C12orf76 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of C12orf76 Gene:
C12orf76SOURCE GeneReport for Unigene cluster for C12orf76 Gene:
Hs.44817Evidence on tissue expression from TISSUES for C12orf76 Gene
- Nervous system(3.8)
Primer Products
-
OriGene qPCR primer pairs for C12orf76
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C12orf76 Gene
Orthologs for C12orf76 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C12H12orf76 34 |
|
||
| C12orf76 35 |
|
OneToOne |
- Species where no ortholog for C12orf76 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- cow (Bos Taurus)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C12orf76 Gene
(91) SIMAP similar genes for C12orf76 Gene using alignment to 5 proteins:
- TNNT1
- ZNF85
- ARL6IP5
- VPS33A
- PPIL6
- NDC80
- CCNJL
- UTY
- SMYD4
- LSM12
- ZNF66
- ZNF28
- RPS13
- RBP7
- MRPL45
- HINFP
- EIF3K
- EEF1E1
- BIRC3
- COQ5
- ZMAT1
- SEC14L3
- ZNF799
- TP63
- SEPSECS
- GCDH
- FRG1
- DYNC2LI1
- CDK10
- C11orf80
- SLC24A1
- RHBG
- LDLRAD3
- GEMIN6
- CLTA
- ARIH1
- PFKFB3
- P2RX7
- FLJ00047
- ETFA
- EIF3G
- DCAF17
- CALCOCO2
- ADCK1
- TMEM78
- TMEM209
- SUV420H1
- NLRC5
- GALK2
- FTSJ2
- DPP9
- ASCC1
- ZNF257
- NDUFS3
- DYNC1LI1
- PUS1
- RARS
- NEK4
- MMADHC
- CCDC122
- AAMDC
- NLN
- TM2D1
- FLJ16124
- BEAN1
- ZNF554
- TBCB
- PARK2
- MUC20
- PGS1
- C14orf105
- ERMN
- C1orf143
- DOCK8
- CSPP1
- UBXN4
- RRM2B
- TUBA1C
- FBLN5
- AAR2
- TAF2
- LINC00999
- C4BPB
- MAN2C1
- FKBP11
- C3orf33
- TMX3
- NUP93
- PACRG
- ZNF415
- HDGFRP2
Pseudogenes.org Pseudogenes for C12orf76 Gene
No data available for Paralogs for C12orf76 Gene
Variants for C12orf76 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| VAR_039916 | A colorectal cancer sample | ||||
| rs1000021183 | -- | 110,065,839(+) | GGTCT(A/G)GCTCT | intron-variant | |
| rs1000111177 | -- | 110,052,907(+) | ATATT(C/T)GTTAA | intron-variant | |
| rs1000117147 | -- | 110,054,910(+) | TCAAG(A/T)GATCC | intron-variant | |
| rs1000153304 | -- | 110,043,260(+) | AAGGC(C/T)GGGGC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2761769 | CNV | loss | 21179565 |
| nsv1134262 | CNV | deletion | 24896259 |
| nsv1144647 | CNV | deletion | 24896259 |
| nsv977146 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
60.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.16;
3.56% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C12orf76 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C12orf76
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf76 Gene
Disorders for C12orf76 Gene
Relevant External Links for C12orf76
No disorders were found for C12orf76 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf76 Gene
Publications for C12orf76 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. (PMID: 19729612) Paterson A.D. … Bull S.B. (Arterioscler. Thromb. Vasc. Biol. 2009) 46 64
- The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64
Products for C12orf76 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
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- OriGene Purified Proteins for C12orf76
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C12orf76
- Browse OriGene Inhibitory RNA Products For C12orf76
- OriGene qPCR primer pairs for C12orf76
- OriGene CRISPR knockouts for C12orf76
- OriGene ORF clones in human for C12orf76
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For C12orf76
- GenScript: Next-day shipping cDNA ORF clone for C12orf76 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for C12orf76
- GenScript Custom Assay Services for C12orf76
- GenScript Custom overexpressing Cell Line Services for C12orf76
- GenScript: Design CRISPR guide RNA sequences for C12orf76
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- Browse Sino Biological cDNA Clones
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for C12orf76
- Novus Biologicals proteins for C12orf76
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for C12orf76 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C12orf76 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C12orf76 gene
- Search ViGene Biosciences for C12orf76
- Horizon Cell Lines for C12orf76
- Cyagen custom Knockout/knockin (KOKI) mouse models for C12orf76
- VectorBuilder custom plasmid, inducible vectors for C12orf76
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf76
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C12orf76 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer