Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C12orf76 Gene

Aliases for C12orf76 Gene

  • Chromosome 12 Open Reading Frame 76 2 3

External Ids for C12orf76 Gene

Previous GeneCards Identifiers for C12orf76 Gene

  • GC12M108963
  • GC12M110478
  • GC12M107494

Summaries for C12orf76 Gene

GeneCards Summary for C12orf76 Gene

C12orf76 (Chromosome 12 Open Reading Frame 76) is a Protein Coding gene. GO annotations related to this gene include ion channel activity and purinergic nucleotide receptor activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf76 Gene

Genomics for C12orf76 Gene

Regulatory Elements for C12orf76 Gene

Genomic Location for C12orf76 Gene

Chromosome:
12
Start:
110,027,028 bp from pter
End:
110,082,224 bp from pter
Size:
55,197 bases
Orientation:
Minus strand

Genomic View for C12orf76 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C12orf76 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf76 Gene

Proteins for C12orf76 Gene

  • Protein details for C12orf76 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N812-CL076_HUMAN
    Recommended name:
    Uncharacterized protein C12orf76
    Protein Accession:
    Q8N812

    Protein attributes for C12orf76 Gene

    Size:
    135 amino acids
    Molecular mass:
    14959 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C12orf76 Gene

Proteomics data for C12orf76 Gene at MOPED

Post-translational modifications for C12orf76 Gene

No Post-translational modifications

Other Protein References for C12orf76 Gene

No data available for DME Specific Peptides for C12orf76 Gene

Domains & Families for C12orf76 Gene

Protein Domains for C12orf76 Gene

Blocks:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C12orf76: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C12orf76 Gene

Function for C12orf76 Gene

Gene Ontology (GO) - Molecular Function for C12orf76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001614 purinergic nucleotide receptor activity --
GO:0004931 extracellular ATP-gated cation channel activity --
GO:0005524 ATP binding --
genes like me logo Genes that share ontologies with C12orf76: view

Phenotypes for C12orf76 Gene

GenomeRNAi human phenotypes for C12orf76:
genes like me logo Genes that share phenotypes with C12orf76: view

Animal Model Products

CRISPR Products

miRNA for C12orf76 Gene

miRTarBase miRNAs that target C12orf76

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C12orf76

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for C12orf76 Gene

Localization for C12orf76 Gene

Gene Ontology (GO) - Cellular Components for C12orf76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005887 integral component of plasma membrane --
genes like me logo Genes that share ontologies with C12orf76: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for C12orf76 Gene

Pathways & Interactions for C12orf76 Gene

SuperPathways for C12orf76 Gene

No Data Available

Interacting Proteins for C12orf76 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000308368%0d%0a9606.ENSP00000338160%0d%0a9606.ENSP00000222005%0d%0a
Selected Interacting proteins: ENSP00000308368 for C12orf76 Gene via STRING

Gene Ontology (GO) - Biological Process for C12orf76 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0033198 response to ATP --
GO:0035590 purinergic nucleotide receptor signaling pathway --
GO:0098655 cation transmembrane transport --
genes like me logo Genes that share ontologies with C12orf76: view

No data available for Pathways by source and SIGNOR curated interactions for C12orf76 Gene

Drugs & Compounds for C12orf76 Gene

No Compound Related Data Available

Transcripts for C12orf76 Gene

Unigene Clusters for C12orf76 Gene

Chromosome 12 open reading frame 76:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C12orf76

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf76 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for C12orf76 Gene

GeneLoc Exon Structure for
C12orf76
ECgene alternative splicing isoforms for
C12orf76

Expression for C12orf76 Gene

mRNA expression in normal human tissues for C12orf76 Gene

mRNA differential expression in normal tissues according to GTEx for C12orf76 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.4).

Protein differential expression in normal tissues from HIPED for C12orf76 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C12orf76 Gene



SOURCE GeneReport for Unigene cluster for C12orf76 Gene Hs.44817

genes like me logo Genes that share expression patterns with C12orf76: view

Protein tissue co-expression partners for C12orf76 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C12orf76 Gene

Orthologs for C12orf76 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C12orf76 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf76 35
  • 99.26 (n)
  • 98.52 (a)
C12orf76 36
  • 99 (a)
OneToOne
Species with no ortholog for C12orf76:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C12orf76 Gene

ENSEMBL:
Gene Tree for C12orf76 (if available)
TreeFam:
Gene Tree for C12orf76 (if available)

Paralogs for C12orf76 Gene

Pseudogenes.org Pseudogenes for C12orf76 Gene

genes like me logo Genes that share paralogs with C12orf76: view

No data available for Paralogs for C12orf76 Gene

Variants for C12orf76 Gene

Sequence variations from dbSNP and Humsavar for C12orf76 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs11540 -- 110,041,486(+) AGCAG(C/T)ATTTT utr-variant-3-prime, intron-variant
rs1013631 -- 110,052,999(+) agatc(A/G)agacc intron-variant
rs1558796 -- 110,044,626(+) CCCCC(A/C)ACCCC intron-variant
rs1968181 -- 110,068,332(+) agaag(A/G)CGgcc upstream-variant-2KB, intron-variant
rs1968182 -- 110,068,333(+) gaagg(A/C)ggcca upstream-variant-2KB, intron-variant

Variation tolerance for C12orf76 Gene

Residual Variation Intolerance Score: 60.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.16; 3.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C12orf76 Gene

HapMap Linkage Disequilibrium report
C12orf76

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C12orf76 Gene

Disorders for C12orf76 Gene

Relevant External Links for C12orf76

Genetic Association Database (GAD)
C12orf76
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C12orf76
genes like me logo Genes that share disorders with C12orf76: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf76 Gene

Publications for C12orf76 Gene

  1. Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. (PMID: 19729612) Paterson A.D. … Bull S.B. (Arterioscler. Thromb. Vasc. Biol. 2009) 67
  2. The consensus coding sequences of human breast and colorectal cancers. (PMID: 16959974) Sjoeblom T. … Velculescu V.E. (Science 2006) 67
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for C12orf76 Gene

Sources for C12orf76 Gene

Back to Top

Content