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Aliases for C12orf75 Gene

Aliases for C12orf75 Gene

  • Chromosome 12 Open Reading Frame 75 2 3 5
  • Adipogenesis Down-Regulated 3 2 3
  • OCC-1 3 4
  • OCC1 3 4
  • AGD3 3 4
  • Putative Overexpressed In Colon Carcinoma-1 Protein Variant C 3
  • Overexpressed In Colon Carcinoma 1 Protein 3
  • Overexpressed In Colon Carcinoma 1 2
  • Overexpressed In Colon Carcinoma-1 3

External Ids for C12orf75 Gene

Previous GeneCards Identifiers for C12orf75 Gene

  • GC12P104154
  • GC12P105724
  • GC12P102783
  • GC12P105629

Summaries for C12orf75 Gene

GeneCards Summary for C12orf75 Gene

C12orf75 (Chromosome 12 Open Reading Frame 75) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf75 Gene

Genomics for C12orf75 Gene

Regulatory Elements for C12orf75 Gene

Enhancers for C12orf75 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G105326 1.3 Ensembl ENCODE 46 +96.7 96734 11.8 HDGF PKNOX1 WRNIP1 SIN3A FEZF1 GLIS2 ZNF143 KLF7 FOS ZNF263 C12orf75 APPL2 KCCAT198 LOC105369957
GH12G105091 1.3 FANTOM5 Ensembl ENCODE 22.9 -143.0 -142994 1.8 CTCF PKNOX1 TAL1 CHD1 CHD7 RAD21 NR2F2 GATA2 POLR2A SCRT2 WASHC4 APPL2 C12orf75 ALDH1L2
GH12G105253 1 Ensembl ENCODE 27.2 +20.5 20537 5.1 CTCF TAL1 ETV1 JUN FOSL1 TCF12 NFE2 FOS CHD2 SMARCC1 C12orf75 APPL2 WASHC4 KCCAT198
GH12G105225 1.9 FANTOM5 Ensembl ENCODE dbSUPER 13.1 -4.0 -3963 11.5 PKNOX1 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF766 FOS SP3 MXD4 WASHC4 APPL2 C12orf75 PIR46520
GH12G105315 1.3 FANTOM5 Ensembl ENCODE 18.2 +82.3 82303 4.8 SOX13 CTCF ESRRA FOXA2 ARID4B SIN3A RAD21 ZNF366 NCOR1 SCRT2 C12orf75 KCCAT198 APPL2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C12orf75 on UCSC Golden Path with GeneCards custom track

Promoters for C12orf75 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000056679 410 2201 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF766 SP3 MXD4 ZNF592 KAT8

Genomic Location for C12orf75 Gene

Chromosome:
12
Start:
105,235,290 bp from pter
End:
105,396,097 bp from pter
Size:
160,808 bases
Orientation:
Plus strand

Genomic View for C12orf75 Gene

Genes around C12orf75 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C12orf75 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C12orf75 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf75 Gene

Proteins for C12orf75 Gene

  • Protein details for C12orf75 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TAD7-OCC1_HUMAN
    Recommended name:
    Overexpressed in colon carcinoma 1 protein
    Protein Accession:
    Q8TAD7

    Protein attributes for C12orf75 Gene

    Size:
    63 amino acids
    Molecular mass:
    6407 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH13920.2; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH45812.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH61920.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH67897.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAC85391.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAC85392.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

neXtProt entry for C12orf75 Gene

Post-translational modifications for C12orf75 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C12orf75 Gene

No data available for DME Specific Peptides for C12orf75 Gene

Domains & Families for C12orf75 Gene

Protein Domains for C12orf75 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8TAD7

UniProtKB/Swiss-Prot:

OCC1_HUMAN :
  • Belongs to the OCC1 family.
Family:
  • Belongs to the OCC1 family.
genes like me logo Genes that share domains with C12orf75: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for C12orf75 Gene

Function for C12orf75 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C12orf75 Gene

Localization for C12orf75 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C12orf75 Gene

Pathways & Interactions for C12orf75 Gene

SuperPathways for C12orf75 Gene

No Data Available

Interacting Proteins for C12orf75 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000448536%0d%0a9606.ENSP00000337040%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000448536 Q8TAD7-OCC1_HUMAN for C12orf75 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C12orf75 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C12orf75 Gene

Transcripts for C12orf75 Gene

Unigene Clusters for C12orf75 Gene

Chromosome 12 open reading frame 75:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf75 Gene

No ASD Table

Relevant External Links for C12orf75 Gene

GeneLoc Exon Structure for
C12orf75
ECgene alternative splicing isoforms for
C12orf75

Expression for C12orf75 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C12orf75 Gene

mRNA differential expression in normal tissues according to GTEx for C12orf75 Gene

This gene is overexpressed in Artery - Tibial (x6.3) and Artery - Aorta (x4.9).

Protein differential expression in normal tissues from HIPED for C12orf75 Gene

This gene is overexpressed in Adrenal (18.0), Amniocyte (16.1), Peripheral blood mononuclear cells (10.6), and Pancreas (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C12orf75 Gene



NURSA nuclear receptor signaling pathways regulating expression of C12orf75 Gene:

C12orf75

SOURCE GeneReport for Unigene cluster for C12orf75 Gene:

Hs.368938

mRNA Expression by UniProt/SwissProt for C12orf75 Gene:

Q8TAD7-OCC1_HUMAN
Tissue specificity: High expression in placenta, skeletal muscle, kidney and pancreas tissues. Absent or very faint expression in heart, brain, lung and liver. Expressed during adipogenic differentiation of mesenchymal stem cells (at protein level).
genes like me logo Genes that share expression patterns with C12orf75: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C12orf75 Gene

Orthologs for C12orf75 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C12orf75 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf75 34
  • 98.94 (n)
C12orf75 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C12orf75 35
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1500009L16Rik 35
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves OCC-1 35
  • 66 (a)
OneToOne
Species where no ortholog for C12orf75 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C12orf75 Gene

ENSEMBL:
Gene Tree for C12orf75 (if available)
TreeFam:
Gene Tree for C12orf75 (if available)

Paralogs for C12orf75 Gene

(2) SIMAP similar genes for C12orf75 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with C12orf75: view

No data available for Paralogs for C12orf75 Gene

Variants for C12orf75 Gene

Sequence variations from dbSNP and Humsavar for C12orf75 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000020684 -- 105,371,246(+) AATTT(G/T)CATGC upstream-variant-2KB, utr-variant-3-prime
rs1000021302 -- 105,330,149(+) TCTCA(C/T)TTATC upstream-variant-2KB
rs1000061532 -- 105,336,151(+) TTGGC(A/G)CATTT intron-variant
rs1000078290 -- 105,339,567(+) ATGGT(G/T)GTCAT intron-variant
rs1000202382 -- 105,330,649(+) CCGGC(G/T)GGTCC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C12orf75 Gene

Variant ID Type Subtype PubMed ID
esv2746323 CNV deletion 23290073
nsv1118245 CNV deletion 24896259
nsv510316 OTHER sequence alteration 20534489
nsv510589 CNV deletion 20534489

Variation tolerance for C12orf75 Gene

Gene Damage Index Score: 0.21; 4.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C12orf75 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C12orf75

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf75 Gene

Disorders for C12orf75 Gene

Relevant External Links for C12orf75

Genetic Association Database (GAD)
C12orf75
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C12orf75

No disorders were found for C12orf75 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf75 Gene

Publications for C12orf75 Gene

  1. Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation. (PMID: 19531736) Kikuchi K. … Aizawa Y. (Nucleic Acids Res. 2009) 2 3 4 64
  2. Cloning of the mRNA of overexpression in colon carcinoma-1: a sequence overexpressed in a subset of colon carcinomas. (PMID: 11890990) Pibouin L. … Goubin G. (Cancer Genet. Cytogenet. 2002) 2 3 4 64
  3. A novel transcript is up-regulated by fasting in the hypothalamus and enhances insulin signalling. (PMID: 22935015) Chai B. … Mulholland M.W. (J. Neuroendocrinol. 2013) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for C12orf75 Gene

Sources for C12orf75 Gene

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