C12orf75 Gene
protein-coding GIFtS: 35
GCID: GC12P105629
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chromosome 12 open reading frame 75
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Aliases
for C12orf75 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 12 Open Reading Frame 751 2 | | Overexpressed In Colon Carcinoma 1 Protein2 | | OCC-11 2 3 | | Overexpressed In Colon Carcinoma-12 | | AGD32 3 | | Putative Overexpressed In Colon Carcinoma-1 Protein Variant C2 | | OCC12 | | |
Export aliases for C12orf75 gene to outside databasesPrevious GC identifers: GC12P104154 GC12P105724 GC12P102783 |
Summaries
for C12orf75 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C12orf75 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C12orf75 gene promoter:
AhR ISGF-3 Olf-1 Arnt Evi-1 AREB6 RORalpha1 STAT3 NF-Y CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for C12orf75
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C12orf75 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q23.3 Ensembl cytogenetic band: 12q23.3 HGNC cytogenetic band: 12q23.3C12orf75 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P105629: view genomic region
(about GC identifiers)
Start:
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105,629,068 bp from pter |
End:
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105,789,875 bp from pter |
Size:
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160,808 bases |
Orientation:
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plus strand |
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Proteins
for C12orf75 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: OCC1_HUMAN, Q8TAD7 (See
protein sequence)Recommended Name: Overexpressed in colon carcinoma 1 protein Size: 63 amino acids; 6407 Da
Caution: Was reported to be transcribed but not translated (PubMed:11890990). However, it was later shown that it isexpressed at protein level (PubMed:19531736)
Sequence caution: Sequence=AAH13920.2; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=AAH45812.1;Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=AAH61920.1; Type=Erroneous translation; Note=Wrongchoice of CDS; Sequence=AAH67897.1; Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=CAC85391.1;Type=Erroneous translation; Note=Wrong choice of CDS; Sequence=CAC85392.1; Type=Erroneous translation; Note=Wrongchoice of CDS;Explore the universe of human proteins at neXtProt for C12orf75: NX_Q8TAD7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8TAD7
C12orf75 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001138671.1
ENSEMBL proteins: ENSP00000448536 ENSP00000447440 ENSP00000449096 ENSP00000450095
Human Recombinant Protein Products:
C12orf75 Antibody Products:
Assay Products for C12orf75: |
Protein
Domains /
Families
for C12orf75 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q8TAD7 UniProtKB/Swiss-Prot: OCC1_HUMAN, Q8TAD7Similarity: Belongs to the OCC1 family |
Function
for C12orf75 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf75 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf75
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C12orf75 (NM_001145199) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C12orf75 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf75 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C12orf75 |
|
Pathways & Interactions
for C12orf75 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C12orf75
|
Drugs & Compounds
for C12orf75 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C12orf75
Search CenterWatch for drugs/clinical trials and news about C12orf75 / OCC1
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Transcripts
for C12orf75 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C12orf75 gene (2 alternative transcripts): NM_207376.1 NM_001145199.1 Unigene Cluster for C12orf75: Chromosome 12 open reading frame 75 Hs.368938 [show with all ESTs]Unigene Representative Sequence: BC0139207 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000548458 ENST00000443585(uc001tlh.4) ENST00000552457 ENST00000549893
ENST00000546866 ENST00000549934 ENST00000548336
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf75 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf75
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C12orf75 (NM_001145199) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C12orf75 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf75 |
Additional cDNA sequence: AB735446.1 AB735447.1 AJ311377.1 AJ311378.1 AK056999.1 BC013920.1 BC045812.1 BC061920.1 BC067897.1 BC126980.1 BC127012.1 BC131552.1 10 DOTS entries: DT.75199506 DT.97774903 DT.100790481 DT.100790486 DT.100790487 DT.95186456 DT.121114319 DT.430337 DT.92435275 DT.95349195 24/230 AceView cDNA sequences (see all 230): BX383669 BU674555 CB105354 BQ021766 AI432733 AA456532 AA677743 AJ311378 BC061920 AA885508 CA443286 BM847756 AI337976 BU679019 CA414737 AA906813 T19359 CA434822 CA865489 AI334585 BU528810 BM068867 AA810960 AA252121
GeneLoc Exon Structure
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Expression
for C12orf75 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C12orf75 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCAACTACA
About this image
See C12orf75 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C12orf75
SOURCE GeneReport for Unigene cluster: Hs.368938
UniProtKB/Swiss-Prot: OCC1_HUMAN, Q8TAD7Tissue specificity: High expression in placenta, skeletal muscle, kidney and pancreas tissues. Absent or very faintexpression in heart, brain, lung and liver. Expressed during adipogenic differentiation of mesenchymal stem cells (atprotein level)
SABiosciences Custom PCR Arrays for C12orf75
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C12orf75
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C12orf75 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C12orf75 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C12orf75 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C12orf75 |
Orthologs
for C12orf75 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of human and mouse.
Orthologs for C12orf75 gene from 1/3 species (see all 3) About this table
ENSEMBL Gene Tree for C12orf75 (if available)
TreeFam Gene Tree for C12orf75 (if available) |
Paralogs
for C12orf75 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C12orf75 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
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HapMap Linkage Disequilibrium report for C12orf75 (105629068 - 105789875 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C12orf75: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for C12orf75 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
C12orf75 for disorders About GeneDecksing
3  diseases for C12orf75: About MalaCardscolon carcinoma carcinoma fainting
Export disorders for C12orf75 gene to outside databases
|
Publications
for C12orf75 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C12orf75 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C12orf75) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Cloning of the mRNA of overexpression in colon carcinoma-1: a sequence overexpressed in a subset of colon carcinomas. (PubMed id 11890990)1, 2 Pibouin L.... Goubin G. (2002)
- Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation. (PubMed id 19531736)2 Kikuchi K.... Aizawa Y. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The finished DNA sequence of human chromosome 12. (PubMed id 16541075)2 Scherer S.E.... Gibbs R.A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for C12orf75 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing C12orf75 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C12orf75 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C12orf75 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C12orf75 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for C12orf75 gene:
Search GeneIP for patents involving C12orf75
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C12orf75 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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| | |  | OriGene Antibodies for C12orf75 | | OriGene shRNA RFP for C12orf75 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C12orf75 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C12orf75 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C12orf75 | | OriGene 3'-UTR Clone for C12orf75 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf75 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf75 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for C12orf75 | | OriGene Custom Protein Services for C12orf75 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C12orf75 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C12orf75 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C12orf75 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C12orf75 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C12orf75 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C12orf75 |
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 | | | C12orf75 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C12orf75 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf75 |
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