Aliases for C12orf75 Gene
Aliases for C12orf75 Gene
External Ids for C12orf75 Gene
- HGNC: 35164
- Entrez Gene: 387882
- Ensembl: ENSG00000235162
- UniProtKB: Q8TAD7
Previous GeneCards Identifiers for C12orf75 Gene
- GC12P104154
- GC12P105724
- GC12P102783
- GC12P105629
Summaries for C12orf75 Gene
GeneCards Summary for C12orf75 Gene
C12orf75 (Chromosome 12 Open Reading Frame 75) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf75 Gene
Genomics for C12orf75 Gene
Regulatory Elements for C12orf75 Gene
Enhancers for C12orf75 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G105326 | 1.3 | Ensembl ENCODE | 46 | +96.7 | 96734 | 11.8 | HDGF PKNOX1 WRNIP1 SIN3A FEZF1 GLIS2 ZNF143 KLF7 FOS ZNF263 | C12orf75 APPL2 KCCAT198 LOC105369957 |
| GH12G105091 | 1.3 | FANTOM5 Ensembl ENCODE | 22.9 | -143.0 | -142994 | 1.8 | CTCF PKNOX1 TAL1 CHD1 CHD7 RAD21 NR2F2 GATA2 POLR2A SCRT2 | WASHC4 APPL2 C12orf75 ALDH1L2 |
| GH12G105253 | 1 | Ensembl ENCODE | 27.2 | +20.5 | 20537 | 5.1 | CTCF TAL1 ETV1 JUN FOSL1 TCF12 NFE2 FOS CHD2 SMARCC1 | C12orf75 APPL2 WASHC4 KCCAT198 |
| GH12G105225 | 1.9 | FANTOM5 Ensembl ENCODE dbSUPER | 13.1 | -4.0 | -3963 | 11.5 | PKNOX1 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF766 FOS SP3 MXD4 | WASHC4 APPL2 C12orf75 PIR46520 |
| GH12G105315 | 1.3 | FANTOM5 Ensembl ENCODE | 18.2 | +82.3 | 82303 | 4.8 | SOX13 CTCF ESRRA FOXA2 ARID4B SIN3A RAD21 ZNF366 NCOR1 SCRT2 | C12orf75 KCCAT198 APPL2 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C12orf75 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for C12orf75 Gene
- Chromosome:
- 12
- Start:
- 105,235,290 bp from pter
- End:
- 105,396,097 bp from pter
- Size:
- 160,808 bases
- Orientation:
- Plus strand
Genomic View for C12orf75 Gene
Genes around C12orf75 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q23.3 by Ensembl
- 12q23.3 by Entrez Gene
- 12q23.3 by HGNC
C12orf75 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C12orf75 Gene
Proteins for C12orf75 Gene
-
Protein details for C12orf75 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8TAD7-OCC1_HUMAN
- Recommended name:
- Overexpressed in colon carcinoma 1 protein
- Protein Accession:
- Q8TAD7
Protein attributes for C12orf75 Gene
- Size:
- 63 amino acids
- Molecular mass:
- 6407 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH13920.2; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH45812.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH61920.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=AAH67897.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAC85391.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305}; Sequence=CAC85392.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};
Protein Expression for C12orf75 Gene
Post-translational modifications for C12orf75 Gene
Other Protein References for C12orf75 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C12orf75
-
Abcam antibodies for C12orf75
- GeneTex C12orf75 antibody for C12orf75
-
Custom Antibody ServicesProSci Antibodies for C12orf75
Protein Products
-
OriGene Purified Proteins for C12orf75
- Search Origene for MassSpec and Protein Over-expression Lysates for C12orf75
- Origene Custom Protein Services for C12orf75
- Novus Biologicals proteins for C12orf75
- Search GeneTex for Proteins for C12orf75
Assay Products
No data available for DME Specific Peptides for C12orf75 Gene
Domains & Families for C12orf75 Gene
Graphical View of Domain Structure for InterPro Entry
Q8TAD7- Family:
-
- Belongs to the OCC1 family.
No data available for Gene Families and Suggested Antigen Peptide Sequences for C12orf75 Gene
Function for C12orf75 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C12orf75
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C12orf75 gene
- Search ViGene Biosciences for C12orf75
CRISPR Products
-
OriGene CRISPR knockouts for C12orf75
-
Santa Cruz Biotechnology (SCBT) CRISPR for C12orf75
- GenScript: Design CRISPR guide RNA sequences for C12orf75
miRNA Products
- Search ViGene Biosciences for C12orf75
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C12orf75
- Browse OriGene Inhibitory RNA Products For C12orf75
- Search ViGene Biosciences for C12orf75
Clone Products
-
OriGene ORF clones in human for C12orf75
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C12orf75
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf75
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C12orf75
-
ViGene Biosciences adenoviral particle packaged cDNA for C12orf75 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C12orf75 gene
- Search ViGene Biosciences for C12orf75
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C12orf75 Gene
Localization for C12orf75 Gene
No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C12orf75 Gene
Pathways & Interactions for C12orf75 Gene
No Data Available
Interacting Proteins for C12orf75 Gene
No data available for Pathways by source and SIGNOR curated interactions for C12orf75 Gene
Transcripts for C12orf75 Gene
mRNA/cDNA for C12orf75 Gene
- (2) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (230) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C12orf75 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C12orf75
-
Santa Cruz Biotechnology (SCBT) CRISPR for C12orf75
- GenScript: Design CRISPR guide RNA sequences for C12orf75
miRNA Products
- Search ViGene Biosciences for C12orf75
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C12orf75
- Browse OriGene Inhibitory RNA Products For C12orf75
- Search ViGene Biosciences for C12orf75
Clone Products
-
OriGene ORF clones in human for C12orf75
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C12orf75
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf75
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for C12orf75 Gene
mRNA differential expression in normal tissues according to GTEx for C12orf75 Gene
This gene is overexpressed in Artery - Tibial (x6.3) and Artery - Aorta (x4.9).
This gene is overexpressed in Adrenal (18.0), Amniocyte (16.1), Peripheral blood mononuclear cells (10.6), and Pancreas (7.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C12orf75 Gene
NURSA nuclear receptor signaling pathways regulating expression of C12orf75 Gene:
C12orf75SOURCE GeneReport for Unigene cluster for C12orf75 Gene:
Hs.368938mRNA Expression by UniProt/SwissProt for C12orf75 Gene:
Q8TAD7-OCC1_HUMAN
Tissue specificity:
High expression in placenta, skeletal muscle, kidney and pancreas tissues. Absent or very faint expression in heart, brain, lung and liver. Expressed during adipogenic differentiation of mesenchymal stem cells (at protein level).
Primer Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C12orf75 Gene
Orthologs for C12orf75 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C12H12orf75 34 |
|
||
| C12orf75 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C12orf75 35 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | 1500009L16Rik 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | OCC-1 35 |
|
OneToOne |
- Species where no ortholog for C12orf75 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- dog (Canis familiaris)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C12orf75 Gene
(2) SIMAP similar genes for C12orf75 Gene using alignment to 3 proteins:
No data available for Paralogs for C12orf75 Gene
Variants for C12orf75 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000020684 | -- | 105,371,246(+) | AATTT(G/T)CATGC | upstream-variant-2KB, utr-variant-3-prime | |
| rs1000021302 | -- | 105,330,149(+) | TCTCA(C/T)TTATC | upstream-variant-2KB | |
| rs1000061532 | -- | 105,336,151(+) | TTGGC(A/G)CATTT | intron-variant | |
| rs1000078290 | -- | 105,339,567(+) | ATGGT(G/T)GTCAT | intron-variant | |
| rs1000202382 | -- | 105,330,649(+) | CCGGC(G/T)GGTCC | utr-variant-5-prime |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2746323 | CNV | deletion | 23290073 |
| nsv1118245 | CNV | deletion | 24896259 |
| nsv510316 | OTHER | sequence alteration | 20534489 |
| nsv510589 | CNV | deletion | 20534489 |
Gene Damage Index Score:
0.21;
4.64% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C12orf75 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C12orf75
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf75 Gene
Disorders for C12orf75 Gene
Relevant External Links for C12orf75
No disorders were found for C12orf75 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf75 Gene
Publications for C12orf75 Gene
- Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation. (PMID: 19531736) Kikuchi K. … Aizawa Y. (Nucleic Acids Res. 2009) 2 3 4 64
- Cloning of the mRNA of overexpression in colon carcinoma-1: a sequence overexpressed in a subset of colon carcinomas. (PMID: 11890990) Pibouin L. … Goubin G. (Cancer Genet. Cytogenet. 2002) 2 3 4 64
- A novel transcript is up-regulated by fasting in the hypothalamus and enhances insulin signalling. (PMID: 22935015) Chai B. … Mulholland M.W. (J. Neuroendocrinol. 2013) 2 3 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
Products for C12orf75 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
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- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Immunoprecipitation Assays
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- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for C12orf75
- Search Origene for MassSpec and Protein Over-expression Lysates for C12orf75
- Origene Custom Protein Services for C12orf75
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C12orf75
- Browse OriGene Inhibitory RNA Products For C12orf75
- Browse OriGene qPCR primer pairs and template standards
- OriGene CRISPR knockouts for C12orf75
- OriGene ORF clones in human for C12orf75
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For C12orf75
- GenScript: Next-day shipping cDNA ORF clone for C12orf75 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for C12orf75
- GenScript Custom Assay Services for C12orf75
- GenScript Custom overexpressing Cell Line Services for C12orf75
- GenScript: Design CRISPR guide RNA sequences for C12orf75
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- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for C12orf75
- Novus Biologicals proteins for C12orf75
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ViGene Biosciences adenoviral particle packaged cDNA for C12orf75 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C12orf75 gene
- Search ViGene Biosciences for C12orf75
- Custom Antibody ServicesProSci Antibodies for C12orf75
- Search for C12orf75 Proteins at ProSci
- Horizon Cell Lines for C12orf75
- Cyagen custom Knockout/knockin (KOKI) mouse models for C12orf75
- VectorBuilder custom plasmid, inducible vectors for C12orf75
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf75
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C12orf75 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer