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Aliases for C12orf74 Gene

Aliases for C12orf74 Gene

  • Chromosome 12 Open Reading Frame 74 2 3 5

External Ids for C12orf74 Gene

Previous GeneCards Identifiers for C12orf74 Gene

  • GC12P091620
  • GC12P093096
  • GC12P090164

Summaries for C12orf74 Gene

GeneCards Summary for C12orf74 Gene

C12orf74 (Chromosome 12 Open Reading Frame 74) is a Protein Coding gene.

Additional gene information for C12orf74 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf74 Gene

Genomics for C12orf74 Gene

Regulatory Elements for C12orf74 Gene

Enhancers for C12orf74 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H092592 1.9 FANTOM5 Ensembl ENCODE dbSUPER 10.2 -107.1 -107107 6 HDGF PKNOX1 FOXA2 TBL1XR1 SIN3A ZBTB40 BATF RARA FOS ATF7 C12orf74 BTG1 UBE2N LOC100287544 EEA1 LOC105369905
GH12H092436 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.5 -264.5 -264518 3 RB1 JUN EBF1 RELA RFX5 RCOR1 FOS ATF7 IKZF2 JUNB C12orf74 BTG1 LINC02397 CLLU1OS
GH12H092987 1.6 FANTOM5 Ensembl ENCODE 9.9 +286.0 285985 3 HDGF PKNOX1 FOXA2 MLX ARID4B ZNF2 YY1 ZNF143 ZNF207 ATF7 EEA1 UBE2N ENSG00000271382 C12orf74 LINC02413 RNU6-1329P
GH12H092442 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.1 -257.3 -257339 5 PKNOX1 TBL1XR1 BATF ZNF143 ATF7 ETV6 RUNX3 CREM IKZF2 SMAD5 LINC02397 CLLU1 C12orf74 BTG1 ENSG00000257252 EEA1 CLLU1OS
GH12H092734 1.1 Ensembl ENCODE 10.7 +32.3 32336 1 ZSCAN4 INSM2 FEZF1 ZNF2 ZNF366 ZSCAN5C SCRT2 CEBPB TSHZ1 ZEB2 C12orf74 RN7SL737P UBE2N PLEKHG7 GC12M092788
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C12orf74 on UCSC Golden Path with GeneCards custom track

Genomic Location for C12orf74 Gene

92,702,843 bp from pter
92,708,549 bp from pter
5,707 bases
Plus strand

Genomic View for C12orf74 Gene

Genes around C12orf74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C12orf74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C12orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf74 Gene

Proteins for C12orf74 Gene

  • Protein details for C12orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C12orf74
    Protein Accession:
    Secondary Accessions:
    • F5H4P0

    Protein attributes for C12orf74 Gene

    190 amino acids
    Molecular mass:
    21196 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C12orf74 Gene


neXtProt entry for C12orf74 Gene

Post-translational modifications for C12orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C12orf74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C12orf74 Gene

Domains & Families for C12orf74 Gene

Gene Families for C12orf74 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C12orf74 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C12orf74: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C12orf74 Gene

Function for C12orf74 Gene

Phenotypes From GWAS Catalog for C12orf74 Gene

genes like me logo Genes that share phenotypes with C12orf74: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C12orf74
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C12orf74 Gene

Localization for C12orf74 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C12orf74 gene
Compartment Confidence
nucleus 2
cytosol 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C12orf74 Gene

Pathways & Interactions for C12orf74 Gene

SuperPathways for C12orf74 Gene

No Data Available

Interacting Proteins for C12orf74 Gene

Gene Ontology (GO) - Biological Process for C12orf74 Gene


No data available for Pathways by source and SIGNOR curated interactions for C12orf74 Gene

Drugs & Compounds for C12orf74 Gene

No Compound Related Data Available

Transcripts for C12orf74 Gene

mRNA/cDNA for C12orf74 Gene

(2) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C12orf74 Gene

Chromosome 12 open reading frame 74:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C12orf74
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf74 Gene

No ASD Table

Relevant External Links for C12orf74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C12orf74 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C12orf74 Gene

mRNA differential expression in normal tissues according to GTEx for C12orf74 Gene

This gene is overexpressed in Cervix - Endocervix (x5.9).

NURSA nuclear receptor signaling pathways regulating expression of C12orf74 Gene:


SOURCE GeneReport for Unigene cluster for C12orf74 Gene:

genes like me logo Genes that share expression patterns with C12orf74: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C12orf74 Gene

Orthologs for C12orf74 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C12orf74 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C12H12orf74 33
  • 99.3 (n)
C12orf74 34
  • 98 (a)
(Bos Taurus)
Mammalia C12orf74 34
  • 48 (a)
Species where no ortholog for C12orf74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C12orf74 Gene

Gene Tree for C12orf74 (if available)
Gene Tree for C12orf74 (if available)

Paralogs for C12orf74 Gene

No data available for Paralogs for C12orf74 Gene

Variants for C12orf74 Gene

Sequence variations from dbSNP and Humsavar for C12orf74 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000174517 -- 92,703,402(+) AACAT(-/AAAG)AAGAG intron-variant
rs1000258420 -- 92,701,177(+) GCGAG(C/T)TGCTC upstream-variant-2KB
rs1000866377 -- 92,706,324(+) AATTA(C/T)CTTCT intron-variant
rs1001082815 -- 92,708,561(+) TATTG(A/T)TTCTT downstream-variant-500B
rs1001267297 -- 92,701,902(+) TAAAC(A/G)CAGAC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C12orf74 Gene

Variant ID Type Subtype PubMed ID
esv2761762 CNV loss 21179565
nsv7234 OTHER inversion 18451855

Variation tolerance for C12orf74 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.80; 47.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C12orf74 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf74 Gene

Disorders for C12orf74 Gene

Relevant External Links for C12orf74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C12orf74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf74 Gene

Publications for C12orf74 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. Genome-wide association study of chronic periodontitis in a general German population. (PMID: 24024966) Teumer A … Kocher T (Journal of clinical periodontology 2013) 3 60
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  5. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer SE … Baylor College of Medicine Human Genome Sequencing Center Sequence Production Team (Nature 2006) 4 60

Products for C12orf74 Gene

Sources for C12orf74 Gene

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