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Aliases for C12orf73 Gene

Aliases for C12orf73 Gene

  • Chromosome 12 Open Reading Frame 73 2 3 5

External Ids for C12orf73 Gene

Previous GeneCards Identifiers for C12orf73 Gene

  • GC12M102870
  • GC12M104343
  • GC12M101403

Summaries for C12orf73 Gene

GeneCards Summary for C12orf73 Gene

C12orf73 (Chromosome 12 Open Reading Frame 73) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf73 Gene

Genomics for C12orf73 Gene

Regulatory Elements for C12orf73 Gene

Enhancers for C12orf73 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F103960 0.6 ENCODE 14.2 +4.6 4621 1.7 HDAC1 ATF1 PKNOX1 SCRT2 CREM SMARCA5 ZNF623 SSRP1 SMARCA4 IKZF1 TTC41P C12orf73 HSP90B1 MIR3652 NT5DC3 GC12P103942
GH12F103964 0.5 ENCODE 13.5 -0.2 -244 3.1 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 C12orf73 NFYB TTC41P HSP90B1 MIR3652 GLT8D2 TDG GC12P104022
GH12F103955 1.2 ENCODE 13.5 +8.8 8762 2.6 HDGF ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 GLT8D2 C12orf73 HSP90B1 MIR3652 TTC41P HCFC2 TDG GC12P103942
GH12F103968 0.5 ENCODE 13.2 -3.8 -3794 1.3 GATA3 JUND PKNOX1 CTBP1 FOS KDM1A C12orf73 TTC41P HSP90B1 MIR3652 TDG GC12P104022
GH12F103986 0.4 ENCODE 11.7 -21.3 -21290 1.1 C12orf73 TDG GC12P104022
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around C12orf73 on UCSC Golden Path with GeneCards custom track

Promoters for C12orf73 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000090578 -292 2801 HDGF PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for C12orf73 Gene

Chromosome:
12
Start:
103,950,202 bp from pter
End:
103,965,708 bp from pter
Size:
15,507 bases
Orientation:
Minus strand

Genomic View for C12orf73 Gene

Genes around C12orf73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C12orf73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C12orf73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf73 Gene

Proteins for C12orf73 Gene

  • Protein details for C12orf73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YU5-CL073_HUMAN
    Recommended name:
    Uncharacterized protein C12orf73
    Protein Accession:
    Q69YU5

    Protein attributes for C12orf73 Gene

    Size:
    71 amino acids
    Molecular mass:
    8023 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C12orf73 Gene

Post-translational modifications for C12orf73 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C12orf73 Gene

Domains & Families for C12orf73 Gene

Protein Domains for C12orf73 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C12orf73: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C12orf73 Gene

Function for C12orf73 Gene

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C12orf73 Gene

Localization for C12orf73 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C12orf73 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C12orf73 Gene COMPARTMENTS Subcellular localization image for C12orf73 gene
Compartment Confidence
extracellular 4
cytoskeleton 2
mitochondrion 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for C12orf73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C12orf73: view

Pathways & Interactions for C12orf73 Gene

SuperPathways for C12orf73 Gene

No Data Available

Interacting Proteins for C12orf73 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000367330%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000367330 for C12orf73 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for C12orf73 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C12orf73 Gene

Transcripts for C12orf73 Gene

mRNA/cDNA for C12orf73 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C12orf73 Gene

Chromosome 12 open reading frame 73:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf73 Gene

No ASD Table

Relevant External Links for C12orf73 Gene

GeneLoc Exon Structure for
C12orf73
ECgene alternative splicing isoforms for
C12orf73

Expression for C12orf73 Gene

mRNA expression in normal human tissues for C12orf73 Gene

Protein differential expression in normal tissues from HIPED for C12orf73 Gene

This gene is overexpressed in Heart (36.4) and Frontal cortex (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C12orf73 Gene



NURSA nuclear receptor signaling pathways regulating expression of C12orf73 Gene:

C12orf73

SOURCE GeneReport for Unigene cluster for C12orf73 Gene:

Hs.42547
genes like me logo Genes that share expression patterns with C12orf73: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C12orf73 Gene

Orthologs for C12orf73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C12orf73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12orf73 35
  • 100 (a)
OneToOne
C12H12orf73 34
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia C15H12orf73 34
  • 88.06 (n)
C12orf73 35
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C5H12orf73 34
  • 85.13 (n)
C12orf73 35
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1190007I07Rik 34 16 35
  • 85.07 (n)
rat
(Rattus norvegicus)
Mammalia LOC691921 34
  • 82.59 (n)
oppossum
(Monodelphis domestica)
Mammalia C12orf73 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H12ORF73 34 35
  • 75.62 (n)
lizard
(Anolis carolinensis)
Reptilia C12orf73 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c12orf73 34
  • 68.85 (n)
zebrafish
(Danio rerio)
Actinopterygii C25H12orf73 35
  • 71 (a)
OneToOne
si:ch211-68a17.7 34
  • 68.78 (n)
Species where no ortholog for C12orf73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C12orf73 Gene

ENSEMBL:
Gene Tree for C12orf73 (if available)
TreeFam:
Gene Tree for C12orf73 (if available)

Paralogs for C12orf73 Gene

Pseudogenes.org Pseudogenes for C12orf73 Gene

genes like me logo Genes that share paralogs with C12orf73: view

No data available for Paralogs for C12orf73 Gene

Variants for C12orf73 Gene

Sequence variations from dbSNP and Humsavar for C12orf73 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs10047614 -- 103,959,928(+) CACCA(C/T)GCCCA intron-variant
rs10247 -- 103,951,405(+) ATCCA(C/T)TGAGC utr-variant-3-prime
rs1047490 -- 103,951,278(-) TATAA(C/T)GCGAA utr-variant-3-prime
rs10507173 -- 103,950,058(+) CAGGA(A/G)AGCAT downstream-variant-500B
rs10669608 -- 103,950,188(+) AAAAA(-/CGT)CATTA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for C12orf73 Gene

Variant ID Type Subtype PubMed ID
nsv560039 CNV gain 21841781

Variation tolerance for C12orf73 Gene

Gene Damage Index Score: 5.49; 71.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C12orf73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C12orf73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf73 Gene

Disorders for C12orf73 Gene

Relevant External Links for C12orf73

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C12orf73

No disorders were found for C12orf73 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf73 Gene

Publications for C12orf73 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for C12orf73 Gene

Sources for C12orf73 Gene

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