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C12orf73 Gene

protein-coding   GIFtS: 34
GCID: GC12M104343

Chromosome 12 Open Reading Frame 73

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 12 Open Reading Frame 731 2
Uncharacterized Protein C12orf732

External Ids:    HGNC: 344501   Entrez Gene: 7285682   Ensembl: ENSG000002049547   UniProtKB: Q69YU53   
ORGUL members:         

Export aliases for C12orf73 gene to outside databases

Previous GC identifers: GC12M102870 GC12M101403


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C12orf73 Gene:
C12orf73 (chromosome 12 open reading frame 73) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000012.11  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the C12orf73 gene promoter:
         Pax-5   p300   Pax-2   Pax-2a   Evi-1   RORalpha1   FAC1   FOXO1a   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C12orf73

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C12orf73


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

C12orf73 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C12orf73 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M104343:  view genomic region     (about GC identifiers)

Start:
104,343,980 bp from pter      End:
104,359,486 bp from pter
Size:
15,507 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CL073_HUMAN, Q69YU5 (See protein sequence)
Recommended Name: Uncharacterized protein C12orf73 precursor  
Size: 71 amino acids; 8023 Da

Explore the universe of human proteins at neXtProt for C12orf73: NX_Q69YU5

Explore proteomics data for C12orf73 at MOPED


See C12orf73 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001129042.1  
ENSEMBL proteins: 
 ENSP00000367330   ENSP00000447452   ENSP00000448771   ENSP00000446981   ENSP00000449951  
 ENSP00000449839   ENSP00000450253   ENSP00000448863   ENSP00000447403   ENSP00000447827  

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antibodies-online kits for C12orf73 (2 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR027858 DUF4516

Graphical View of Domain Structure for InterPro Entry Q69YU5

ProtoNet protein and cluster: Q69YU5


Find genes that share domains with C12orf73           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for C12orf73

miRNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
CL073_HUMAN, Q69YU5: Secreted (Potential)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
cytoskeleton1
mitochondrion1
plasma membrane1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

Find genes that share ontologies with C12orf73           About GenesLikeMe


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C12orf73
Interactions:

    Search GeneGlobe Interaction Network for C12orf73

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for C12orf73 (CL073)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for C12orf73 gene: 
NM_001135570.1  

Unigene Cluster for C12orf73:

Chromosome 12 open reading frame 73
Hs.42547  [show with all ESTs]
Unigene Representative Sequence: AL359596
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000543740(uc001tkf.3) ENST00000378090(uc009zuj.2) ENST00000547975
ENST00000549478 ENST00000553183 ENST00000549960 ENST00000547945 ENST00000552460
ENST00000552940 ENST00000546819 ENST00000546540
miRNA
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7 qRT-PCR Assays for microRNAs that regulate C12orf73:
hsa-miR-498 hsa-miR-224 hsa-miR-4328 hsa-miR-513a-5p hsa-miR-27a hsa-miR-3682-3p hsa-miR-27b
Browse SwitchGear 3'UTR luciferase reporter plasmids
Inhib. RNA
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Additional mRNA sequence: 

AK024037.1 AL359596.1 BC039467.1 BC044618.2 BC063467.1 BC073939.1 

15 DOTS entries:

DT.121182920  DT.100779536  DT.92423699  DT.436199  DT.100779535  DT.455637  DT.86852106  DT.95330957 
DT.100644602  DT.92423697  DT.102839013  DT.121182905  DT.121182973  DT.121182998  DT.95269922 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

C12orf73 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

C12orf73 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.42547
    Custom PCR Arrays for C12orf73
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for C12orf73 gene from Selected species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia 1190007I07Rik1 , 5 RIKEN cDNA 1190007I07 gene1, 5 85.07(n)1
82.09(a)1
  10 (39.72 cM)5
5447171  NM_001135567.11  NP_001129039.11 
 826198515 
chicken
(Gallus gallus)
Aves C1H12ORF731 chromosome 1 open reading frame, human C12orf73 75.62(n)
76.12(a)
  772057  NM_001135572.1  NP_001129044.1 
lizard
(Anolis carolinensis)
Reptilia C12orf736
chromosome 12 open reading frame 73
75(a)
1 ↔ 1
5(18178248-18186547)
tropical clawed frog
(Xenopus tropicalis)
Amphibia c12orf731 chromosome 12 open reading frame 73 68.85(n)
70.49(a)
  100380143  XM_004912900.1  XP_004912957.1 
zebrafish
(Danio rerio)
Actinopterygii si:ch211-68a17.71 si:ch211-68a17.7 68.78(n)
73.02(a)
  100190888  NM_001135573.1  NP_001129045.1 


ENSEMBL Gene Tree for C12orf73 (if available)
TreeFam Gene Tree for C12orf73 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for C12orf73 gene

Find genes that share paralogs with C12orf73           About GenesLikeMe


2 Pseudogenes.org Pseudogenes for C12orf73
PGOHUM00000233096 PGOHUM00000242023


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for C12orf73 (see all 214)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 12 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs71365501,2
C,F,A,H--104343515(+) AGTTTG/CCAATA 1 -- int116Minor allele frequency- C:0.20NS EA NA WA 1226
rs1166420411,2
F--104343755(+) CATCAG/TATCAC 1 -- int11Minor allele frequency- T:0.02WA 118
rs1511432311,2
C--104343826(+) CTGTT-/CCTAGC 1 -- int10--------
rs105071731,2
C,F,H--104343836(+) CAGGAA/GAGCAT 1 -- int1108Minor allele frequency- G:0.12NS EA NA PA EU CA WA CSA 6820
rs1916635421,2
C--104343879(+) TCATAA/C/TCTGTC 1 -- int10--------
rs1439304021,2
C--104343965(+) AAAAA-/CG/GTC
        
ACATT
2 -- int1 cds10--------
rs106696081,2
C--104343966(+) AAAAA-/CG    
   T
/GTC
CATTA
2 -- cds11CSA 2
rs341722721,2
C--104343967(+) AAAAC-/CG    
   T
/GTC
ATTAT
2 -- cds10--------
rs1829799331,2
--104344074(+) ATGAAA/GGCACA 1 -- ut310--------
rs343346661,2
C--104344095(+) AACACCTGAGAAAG
GAAACAG
/-
GACTG
1 -- ut311Minor allele frequency- -:0.50CSA 2

HapMap Linkage Disequilibrium report for C12orf73 (104343980 - 104359486 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for C12orf73: --
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing C12orf73
DNA2.0 Custom Variant and Variant Library Synthesis for C12orf73

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for C12orf73 gene integrated from 10 sources:
(articles sorted by number of sources associating them with C12orf73)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 728568 HGNC: 34450 Ensembl:ENSG00000204954 euGenes: HUgn728568 ECgene: C12orf73
H-InvDB: C12orf73

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for C12orf73 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C12orf73 gene:
Search GeneIP for patents involving C12orf73

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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 Search Addgene for plasmids for C12orf73
  Search eBioscience for proteins for C12orf73
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  eBioscience FlowRNA Probe Sets
 genOway: Develop your customized and physiologically relevant rodent model for C12orf73
  Search antibodies-online for antibodies for C12orf73
 antibodies-online kits for C12orf73 (2 products)
  Search antibodies-online for peptides for C12orf73
 antibodies-online proteins for C12orf73
       
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