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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C12orf73 Gene

protein-coding   GIFtS: 34
GCID: GC12M104343

Chromosome 12 Open Reading Frame 73

  Search for C12orf73
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 12 Open Reading Frame 731 2
Uncharacterized Protein C12orf732

External Ids:    HGNC: 344501   Entrez Gene: 7285682   Ensembl: ENSG000002049547   UniProtKB: Q69YU53   
ORGUL members:         
NONCODE14:n342902      

Export aliases for C12orf73 gene to outside databases

Previous GC identifers: GC12M102870 GC12M101403


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C12orf73 Gene: 
C12orf73 (chromosome 12 open reading frame 73) is a protein-coding gene, and is affiliated with the lncRNA class.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C12orf73 gene promoter:
         Pax-5   p300   Pax-2   Pax-2a   Evi-1   RORalpha1   FAC1   FOXO1a   FOXO1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C12orf73

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C12orf73


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23.3   Ensembl cytogenetic band:  12q23.3   HGNC cytogenetic band: 12q23.3

C12orf73 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C12orf73 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M104343:  view genomic region     (about GC identifiers)

Start:
104,343,980 bp from pter      End:
104,359,486 bp from pter
Size:
15,507 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CL073_HUMAN, Q69YU5 (See protein sequence)
Recommended Name: Uncharacterized protein C12orf73 precursor  
Size: 71 amino acids; 8023 Da
Subcellular location: Secreted (Potential)

Explore the universe of human proteins at neXtProt for C12orf73: NX_Q69YU5

Explore proteomics data for C12orf73 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q69YU5

  • C12orf73 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    C12orf73 Protein Expression
    REFSEQ proteins: NP_001129042.1  
    ENSEMBL proteins: 
     ENSP00000367330   ENSP00000447452   ENSP00000448771   ENSP00000446981   ENSP00000449951  
     ENSP00000449839   ENSP00000450253   ENSP00000448863   ENSP00000447403   ENSP00000447827  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    C12orf73 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q69YU5


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C12orf73

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for C12orf73 (CL073)

    Search CenterWatch for drugs/clinical trials and news about C12orf73 / CL073

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for C12orf73 gene: 
    NM_001135570.1  

    Unigene Cluster for C12orf73:

    Chromosome 12 open reading frame 73
    Hs.42547  [show with all ESTs]
    Unigene Representative Sequence: AL359596
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000543740(uc001tkf.3) ENST00000378090(uc009zuj.2) ENST00000547975
    ENST00000549478 ENST00000553183 ENST00000549960 ENST00000547945 ENST00000552460
    ENST00000552940 ENST00000546819 ENST00000546540
    miRNA
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    Additional mRNA sequence: 

    AK024037.1 AL359596.1 BC039467.1 BC044618.2 BC063467.1 BC073939.1 

    15 DOTS entries:

    DT.121182920  DT.100779536  DT.92423699  DT.436199  DT.100779535  DT.455637  DT.86852106  DT.95330957 
    DT.100644602  DT.92423697  DT.102839013  DT.121182905  DT.121182973  DT.121182998  DT.95269922 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section
    See probesets specificity/sensitivity at GeneAnnot
    CGAP TAG: --


    See C12orf73 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for C12orf73

    SOURCE GeneReport for Unigene cluster: Hs.42547
        SABiosciences Custom PCR Arrays for C12orf73
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C12orf73

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for C12orf73 gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 1190007I07Rik1 , 5 RIKEN cDNA 1190007I07 gene1, 5 85.07(n)1
    82.09(a)1
      10 (39.72 cM)5
    5447171  NM_001135567.11  NP_001129039.11 
     826198515 
    chicken
    (Gallus gallus)
    Aves C1H12orf731 chromosome 1 open reading frame, human C12orf73 75.76(n)
    77.27(a)
      772057  NM_001135572.1  NP_001129044.1 
    lizard
    (Anolis carolinensis)
    Reptilia C12ORF736
    Uncharacterized protein
    75(a)
    1 ↔ 1
    5(18178248-18186547)
    zebrafish
    (Danio rerio)
    Actinopterygii gb:cn8332181 expressed sequence CN833218 68.78(n)
    73.02(a)
      100190888  NM_001135573.1  NP_001129045.1 


    ENSEMBL Gene Tree for C12orf73 (if available)
    TreeFam Gene Tree for C12orf73 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for C12orf73 gene

    C12orf73 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for C12orf73
    PGOHUM00000233096 PGOHUM00000242023


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/214 SNPs in C12orf73 are shown (see all 214)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs71365501,2
    C,F,A,H--104343515(+) AGTTTG/CCAATA 1 -- int116Minor allele frequency- C:0.20NS EA NA WA 1226
    rs1166420411,2
    F--104343755(+) CATCAG/TATCAC 1 -- int11Minor allele frequency- T:0.02WA 118
    rs1511432311,2
    C--104343826(+) CTGTT-/CCTAGC 1 -- int10--------
    rs105071731,2
    C,F,H--104343836(+) CAGGAA/GAGCAT 1 -- int1108Minor allele frequency- G:0.12NS EA NA PA EU CA WA CSA 6820
    rs1916635421,2
    C--104343879(+) TCATAA/C/TCTGTC 1 -- int10--------
    rs1439304021,2
    C--104343965(+) AAAAA-/CG/GTC
            
    ACATT
    2 -- int1 cds10--------
    rs106696081,2
    C--104343966(+) AAAAA-/CG    
       T
    /GTC
    CATTA
    2 -- cds11CSA 2
    rs341722721,2
    C--104343967(+) AAAAC-/CG    
       T
    /GTC
    ATTAT
    2 -- cds10--------
    rs1829799331,2
    --104344074(+) ATGAAA/GGCACA 1 -- ut310--------
    rs343346661,2
    C--104344095(+) AACACCTGAGAAAG
    GAAACAG
    /-
    GACTG
    1 -- ut311Minor allele frequency- -:0.50CSA 2

    HapMap Linkage Disequilibrium report for C12orf73 (104343980 - 104359486 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for C12orf73: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing C12orf73
    DNA2.0 Custom Variant and Variant Library Synthesis for C12orf73

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for C12orf73 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with C12orf73)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 728568 HGNC: 34450 Ensembl:ENSG00000204954 euGenes: HUgn728568 ECgene: C12orf73
    H-InvDB: C12orf73

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for C12orf73 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for C12orf73 gene:
    Search GeneIP for patents involving C12orf73

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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