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Aliases for C12orf73 Gene

Aliases for C12orf73 Gene

  • Chromosome 12 Open Reading Frame 73 2 3 5

External Ids for C12orf73 Gene

Previous GeneCards Identifiers for C12orf73 Gene

  • GC12M102870
  • GC12M104343
  • GC12M101403

Summaries for C12orf73 Gene

GeneCards Summary for C12orf73 Gene

C12orf73 (Chromosome 12 Open Reading Frame 73) is a Protein Coding gene.

Additional gene information for C12orf73 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf73 Gene

Genomics for C12orf73 Gene

Regulatory Elements for C12orf73 Gene

Enhancers for C12orf73 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12H103858 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.4 +106.1 106065 2 ATF1 FOXA2 ZNF766 ELK1 KLF7 ATF7 FOS CAVIN1 ZNF592 SREBF1 TDG TTC41P C12orf73 NT5DC3 ENSG00000257327 HSP90B1
GH12H103955 1.2 ENCODE 13.5 +8.8 8762 2 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A MEF2D TDG C12orf73 TTC41P HSP90B1 GC12P103942
GH12H103964 1.2 ENCODE 13.4 -0.2 -244 3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 TDG C12orf73 NFYB HSP90B1 TTC41P GC12P104022
GH12H103927 1.4 ENCODE dbSUPER 10.1 +35.4 35361 6 HDGF PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 TTC41P C12orf73 NT5DC3 ENSG00000257681 GC12P103934 GC12P103932
GH12H104456 1.3 ENCODE dbSUPER 9.7 -493.3 -493283 5 ARNT SIN3A FEZF1 ZNF2 ZNF766 ZNF143 ZNF207 SP3 REST ZNF610 CHST11 C12orf73 GC12P104468
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C12orf73 on UCSC Golden Path with GeneCards custom track

Promoters for C12orf73 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000056482 -292 2401 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for C12orf73 Gene

Chromosome:
12
Start:
103,950,202 bp from pter
End:
103,965,708 bp from pter
Size:
15,507 bases
Orientation:
Minus strand

Genomic View for C12orf73 Gene

Genes around C12orf73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C12orf73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C12orf73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf73 Gene

Proteins for C12orf73 Gene

  • Protein details for C12orf73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YU5-CL073_HUMAN
    Recommended name:
    Uncharacterized protein C12orf73
    Protein Accession:
    Q69YU5

    Protein attributes for C12orf73 Gene

    Size:
    71 amino acids
    Molecular mass:
    8023 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C12orf73 Gene

Post-translational modifications for C12orf73 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C12orf73 Gene

Domains & Families for C12orf73 Gene

Gene Families for C12orf73 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C12orf73 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C12orf73: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C12orf73 Gene

Function for C12orf73 Gene

Phenotypes From GWAS Catalog for C12orf73 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C12orf73
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C12orf73 Gene

Localization for C12orf73 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C12orf73 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C12orf73 gene
Compartment Confidence
extracellular 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Mitochondria (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C12orf73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C12orf73: view

Pathways & Interactions for C12orf73 Gene

SuperPathways for C12orf73 Gene

No Data Available

Interacting Proteins for C12orf73 Gene

Gene Ontology (GO) - Biological Process for C12orf73 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C12orf73 Gene

Drugs & Compounds for C12orf73 Gene

No Compound Related Data Available

Transcripts for C12orf73 Gene

mRNA/cDNA for C12orf73 Gene

(4) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C12orf73 Gene

Chromosome 12 open reading frame 73:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for C12orf73
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf73 Gene

No ASD Table

Relevant External Links for C12orf73 Gene

GeneLoc Exon Structure for
C12orf73
ECgene alternative splicing isoforms for
C12orf73

Expression for C12orf73 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C12orf73 Gene

Protein differential expression in normal tissues from HIPED for C12orf73 Gene

This gene is overexpressed in Heart (36.4) and Frontal cortex (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C12orf73 Gene



NURSA nuclear receptor signaling pathways regulating expression of C12orf73 Gene:

C12orf73

SOURCE GeneReport for Unigene cluster for C12orf73 Gene:

Hs.42547

Evidence on tissue expression from TISSUES for C12orf73 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with C12orf73: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C12orf73 Gene

Orthologs for C12orf73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C12orf73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12orf73 34
  • 100 (a)
OneToOne
C12H12orf73 33
  • 99.53 (n)
dog
(Canis familiaris)
Mammalia C15H12orf73 33
  • 88.06 (n)
C12orf73 34
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C5H12orf73 33
  • 85.13 (n)
C12orf73 34
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1190007I07Rik 33 16 34
  • 85.07 (n)
rat
(Rattus norvegicus)
Mammalia LOC691921 33
  • 82.59 (n)
oppossum
(Monodelphis domestica)
Mammalia C12orf73 34
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H12ORF73 33 34
  • 75.62 (n)
lizard
(Anolis carolinensis)
Reptilia C12orf73 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c12orf73 33
  • 68.85 (n)
zebrafish
(Danio rerio)
Actinopterygii C25H12orf73 34
  • 71 (a)
OneToOne
si:ch211-68a17.7 33
  • 68.78 (n)
Species where no ortholog for C12orf73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C12orf73 Gene

ENSEMBL:
Gene Tree for C12orf73 (if available)
TreeFam:
Gene Tree for C12orf73 (if available)

Paralogs for C12orf73 Gene

Pseudogenes.org Pseudogenes for C12orf73 Gene

genes like me logo Genes that share paralogs with C12orf73: view

No data available for Paralogs for C12orf73 Gene

Variants for C12orf73 Gene

Sequence variations from dbSNP and Humsavar for C12orf73 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000180615 -- 103,961,528(+) TAATA(C/G)TGTTT intron-variant
rs1000377654 -- 103,965,028(+) TGAAG(A/G)TTTGG intron-variant, upstream-variant-2KB
rs1000385508 -- 103,955,962(+) ATTGA(A/G)TGTCT intron-variant, utr-variant-5-prime
rs1000733591 -- 103,960,353(+) ACAGG(C/G)ATGAG intron-variant
rs1000935131 -- 103,966,489(+) TGCGG(C/T)TTCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C12orf73 Gene

Variant ID Type Subtype PubMed ID
nsv560039 CNV gain 21841781

Variation tolerance for C12orf73 Gene

Gene Damage Index Score: 5.49; 71.76% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C12orf73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C12orf73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf73 Gene

Disorders for C12orf73 Gene

Relevant External Links for C12orf73

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C12orf73

No disorders were found for C12orf73 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf73 Gene

Publications for C12orf73 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  3. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for C12orf73 Gene

Sources for C12orf73 Gene

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