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Aliases for C12orf66 Gene

Aliases for C12orf66 Gene

  • Chromosome 12 Open Reading Frame 66 2 3 5

External Ids for C12orf66 Gene

Previous GeneCards Identifiers for C12orf66 Gene

  • GC12M062867
  • GC12M064581
  • GC12M061638

Summaries for C12orf66 Gene

GeneCards Summary for C12orf66 Gene

C12orf66 (Chromosome 12 Open Reading Frame 66) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf66 Gene

Genomics for C12orf66 Gene

Regulatory Elements for C12orf66 Gene

Enhancers for C12orf66 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C12orf66 on UCSC Golden Path with GeneCards custom track

Genomic Location for C12orf66 Gene

64,186,312 bp from pter
64,237,341 bp from pter
51,030 bases
Minus strand

Genomic View for C12orf66 Gene

Genes around C12orf66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C12orf66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C12orf66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf66 Gene

Proteins for C12orf66 Gene

  • Protein details for C12orf66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0536 protein C12orf66
    Protein Accession:
    Secondary Accessions:
    • C9JX54
    • Q8IYA0

    Protein attributes for C12orf66 Gene

    445 amino acids
    Molecular mass:
    50415 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C12orf66 Gene

Post-translational modifications for C12orf66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C12orf66 Gene

No data available for DME Specific Peptides for C12orf66 Gene

Domains & Families for C12orf66 Gene

Protein Domains for C12orf66 Gene


Suggested Antigen Peptide Sequences for C12orf66 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0536 family.
  • Belongs to the UPF0536 family.
genes like me logo Genes that share domains with C12orf66: view

No data available for Gene Families for C12orf66 Gene

Function for C12orf66 Gene

genes like me logo Genes that share phenotypes with C12orf66: view

Animal Models for C12orf66 Gene

MGI Knock Outs for C12orf66:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C12orf66 Gene

Localization for C12orf66 Gene

Subcellular locations from

Jensen Localization Image for C12orf66 Gene COMPARTMENTS Subcellular localization image for C12orf66 gene
Compartment Confidence
cytoskeleton 5
extracellular 4
cytosol 2
nucleus 2
peroxisome 2

Gene Ontology (GO) - Cellular Components for C12orf66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015630 microtubule cytoskeleton IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with C12orf66: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C12orf66 Gene

Pathways & Interactions for C12orf66 Gene

SuperPathways for C12orf66 Gene

No Data Available

Interacting Proteins for C12orf66 Gene

Selected Interacting proteins: Q96MD2-CL066_HUMAN for C12orf66 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C12orf66 Gene


No data available for Pathways by source and SIGNOR curated interactions for C12orf66 Gene

Drugs & Compounds for C12orf66 Gene

No Compound Related Data Available

Transcripts for C12orf66 Gene

Unigene Clusters for C12orf66 Gene

Chromosome 12 open reading frame 66:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf66 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5
SP1: - - -
SP2: - -
SP3: -

Relevant External Links for C12orf66 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C12orf66 Gene

mRNA expression in normal human tissues for C12orf66 Gene

Protein differential expression in normal tissues from HIPED for C12orf66 Gene

This gene is overexpressed in Liver, secretome (43.2), Peripheral blood mononuclear cells (15.1), and Adipocyte (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C12orf66 Gene

NURSA nuclear receptor signaling pathways regulating expression of C12orf66 Gene:


SOURCE GeneReport for Unigene cluster for C12orf66 Gene:

genes like me logo Genes that share expression patterns with C12orf66: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for C12orf66 Gene

Orthologs for C12orf66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C12orf66 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C5H12orf66 34
  • 92.96 (n)
  • 97.53 (a)
C5H12orf66 35
  • 97 (a)
(Canis familiaris)
Mammalia C10H12orf66 34
  • 92.88 (n)
  • 97.3 (a)
C12orf66 35
  • 97 (a)
(Mus musculus)
Mammalia BC048403 34
  • 89.21 (n)
  • 94.83 (a)
BC048403 16
BC048403 35
  • 94 (a)
(Pan troglodytes)
Mammalia C12H12orf66 34
  • 99.78 (n)
  • 99.33 (a)
C12orf66 35
  • 94 (a)
(Rattus norvegicus)
Mammalia RGD1565498 34
  • 89.51 (n)
  • 94.83 (a)
(Monodelphis domestica)
Mammalia C12orf66 35
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia C12orf66 35
  • 82 (a)
(Gallus gallus)
Aves C1H12ORF66 34
  • 83.3 (n)
  • 93.71 (a)
C12orf66 35
  • 93 (a)
(Anolis carolinensis)
Reptilia C12orf66 35
  • 88 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c12orf66 34
  • 75.27 (n)
  • 84.02 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23915 34
(Danio rerio)
Actinopterygii si:ch211-125a15.1 34
  • 71.94 (n)
  • 77.29 (a)
C4H12orf66 35
  • 74 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10480 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 27 (a)
Species where no ortholog for C12orf66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C12orf66 Gene

Gene Tree for C12orf66 (if available)
Gene Tree for C12orf66 (if available)

Paralogs for C12orf66 Gene

No data available for Paralogs for C12orf66 Gene

Variants for C12orf66 Gene

Sequence variations from dbSNP and Humsavar for C12orf66 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs2335390 - 64,215,782(-) GAGAT(A/G)GCAGA reference, missense
rs699638 - 64,193,853(+) TTTGG(A/C)TCCAG reference, missense
rs1657050 -- 64,233,279(-) AAATA(C/T)CAAAA intron-variant
rs1657051 -- 64,203,973(+) GGACA(A/C/T)GGATG intron-variant
rs1657053 -- 64,216,146(-) ATGAT(A/T)ATCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C12orf66 Gene

Variant ID Type Subtype PubMed ID
esv1536875 CNV insertion 17803354
esv3629769 CNV loss 21293372
nsv1111074 CNV tandem duplication 24896259
nsv1129161 CNV insertion 24896259
nsv1141213 CNV duplication 24896259

Variation tolerance for C12orf66 Gene

Residual Variation Intolerance Score: 28.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.52; 29.60% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C12orf66 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf66 Gene

Disorders for C12orf66 Gene

Relevant External Links for C12orf66

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C12orf66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf66 Gene

Publications for C12orf66 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. (PMID: 24483146) Li L. … Wang L. (BMC Genomics 2014) 3 65
  5. A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities. (PMID: 24104479) Vizeacoumar F.J. … Moffat J. (Mol. Syst. Biol. 2013) 3 65

Products for C12orf66 Gene

Sources for C12orf66 Gene

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