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Aliases for C12orf60 Gene

Aliases for C12orf60 Gene

  • Chromosome 12 Open Reading Frame 60 2 3 5

External Ids for C12orf60 Gene

Previous GeneCards Identifiers for C12orf60 Gene

  • GC12P014848
  • GC12P014956
  • GC12P014725

Summaries for C12orf60 Gene

GeneCards Summary for C12orf60 Gene

C12orf60 (Chromosome 12 Open Reading Frame 60) is a Protein Coding gene. Diseases associated with C12orf60 include li-fraumeni syndrome.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf60 Gene

Genomics for C12orf60 Gene

Regulatory Elements for C12orf60 Gene

Genomic Location for C12orf60 Gene

Chromosome:
12
Start:
14,785,217 bp from pter
End:
14,906,586 bp from pter
Size:
121,370 bases
Orientation:
Plus strand

Genomic View for C12orf60 Gene

Genes around C12orf60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C12orf60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C12orf60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf60 Gene

Proteins for C12orf60 Gene

  • Protein details for C12orf60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5U649-CL060_HUMAN
    Recommended name:
    Uncharacterized protein C12orf60
    Protein Accession:
    Q5U649
    Secondary Accessions:
    • A8K1M7
    • Q5XKK8
    • Q8IXY2

    Protein attributes for C12orf60 Gene

    Size:
    245 amino acids
    Molecular mass:
    27626 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C12orf60 Gene

Proteomics data for C12orf60 Gene at MOPED

Post-translational modifications for C12orf60 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C12orf60 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C12orf60 Gene

Domains & Families for C12orf60 Gene

Protein Domains for C12orf60 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C12orf60: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C12orf60 Gene

Function for C12orf60 Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C12orf60 Gene

Localization for C12orf60 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C12orf60 Gene COMPARTMENTS Subcellular localization image for C12orf60 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C12orf60 Gene

Pathways & Interactions for C12orf60 Gene

SuperPathways for C12orf60 Gene

No Data Available

Interacting Proteins for C12orf60 Gene

Gene Ontology (GO) - Biological Process for C12orf60 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C12orf60 Gene

Drugs & Compounds for C12orf60 Gene

No Compound Related Data Available

Transcripts for C12orf60 Gene

Unigene Clusters for C12orf60 Gene

Chromosome 12 open reading frame 60:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf60 Gene

No ASD Table

Relevant External Links for C12orf60 Gene

GeneLoc Exon Structure for
C12orf60
ECgene alternative splicing isoforms for
C12orf60

Expression for C12orf60 Gene

mRNA expression in normal human tissues for C12orf60 Gene

mRNA differential expression in normal tissues according to GTEx for C12orf60 Gene

This gene is overexpressed in Testis (x8.3).

Protein differential expression in normal tissues from HIPED for C12orf60 Gene

This gene is overexpressed in Pancreas (63.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C12orf60 Gene



SOURCE GeneReport for Unigene cluster for C12orf60 Gene Hs.659951

genes like me logo Genes that share expression patterns with C12orf60: view

Protein tissue co-expression partners for C12orf60 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C12orf60 Gene

Orthologs for C12orf60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C12orf60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf60 35
  • 98.49 (n)
  • 96.28 (a)
C12orf60 36
  • 96 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C12orf60 36
  • 67 (a)
OneToOne
C5H12orf60 35
  • 80.39 (n)
  • 68.49 (a)
dog
(Canis familiaris)
Mammalia C27H12orf60 35
  • 79.61 (n)
  • 64.88 (a)
C12orf60 36
  • 65 (a)
OneToOne
mouse
(Mus musculus)
Mammalia BC049715 16
BC049715 36
  • 54 (a)
OneToOne
BC049715 35
  • 69.27 (n)
  • 55.14 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia C12orf60 36
  • 18 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC500354 35
  • 69.14 (n)
  • 51.44 (a)
lizard
(Anolis carolinensis)
Reptilia C12orf60 36
  • 27 (a)
OneToOne
Species with no ortholog for C12orf60:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C12orf60 Gene

ENSEMBL:
Gene Tree for C12orf60 (if available)
TreeFam:
Gene Tree for C12orf60 (if available)

Paralogs for C12orf60 Gene

No data available for Paralogs for C12orf60 Gene

Variants for C12orf60 Gene

Sequence variations from dbSNP and Humsavar for C12orf60 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs17853860 - 14,823,087(+) TGTGA(A/G)AAACA reference, missense
rs7304054 - 14,823,129(+) GCTCA(A/G/T)AATTT reference, missense
rs7307438 - 14,823,244(+) ACCAA(A/T)GTAGA reference, missense
rs7312579 -- 14,817,071(+) ATGCC(C/T)GGcca intron-variant
rs7963528 -- 14,785,797(+) TGTGT(A/G)TATGT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for C12orf60 Gene

Variant ID Type Subtype PubMed ID
nsv898817 CNV Gain 21882294
esv2745588 CNV Deletion 23290073

Variation tolerance for C12orf60 Gene

Residual Variation Intolerance Score: 90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.36; 88.41% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C12orf60 Gene

HapMap Linkage Disequilibrium report
C12orf60

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf60 Gene

Disorders for C12orf60 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C12orf60 Gene - From: DISEASES

Disorder Aliases PubMed IDs
li-fraumeni syndrome
  • sarcoma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for C12orf60

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C12orf60
genes like me logo Genes that share disorders with C12orf60: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C12orf60 Gene

Publications for C12orf60 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (PMID: 23449627) Cousminer D.L. … WidAcn E. (Hum. Mol. Genet. 2013) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for C12orf60 Gene

Sources for C12orf60 Gene

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