Aliases for C12orf60 Gene
External Ids for C12orf60 Gene
- HGNC: 28726
- Entrez Gene: 144608
- Ensembl: ENSG00000182993
- UniProtKB: Q5U649
Previous GeneCards Identifiers for C12orf60 Gene
- GC12P014848
- GC12P014956
- GC12P014725
Summaries for C12orf60 Gene
GeneCards Summary for C12orf60 Gene
C12orf60 (Chromosome 12 Open Reading Frame 60) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf60 Gene
Genomics for C12orf60 Gene
Regulatory Elements for C12orf60 Gene
Enhancers for C12orf60 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C12orf60 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the C12orf60 gene promoter:
Regulatory Element Products
Genomic Location for C12orf60 Gene
- Chromosome:
- 12
- Start:
- 14,785,217 bp from pter
- End:
- 14,906,586 bp from pter
- Size:
- 121,370 bases
- Orientation:
- Plus strand
Genomic View for C12orf60 Gene
Genes around C12orf60 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p12.3 by Ensembl
- 12p13.1-p12.3 by Entrez Gene
- 12p12.3 by HGNC
C12orf60 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C12orf60 Gene
Proteins for C12orf60 Gene
-
Protein details for C12orf60 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q5U649-CL060_HUMAN
- Recommended name:
- Uncharacterized protein C12orf60
- Protein Accession:
- Q5U649
- A8K1M7
- Q5XKK8
- Q8IXY2
Protein attributes for C12orf60 Gene
- Size:
- 245 amino acids
- Molecular mass:
- 27626 Da
- Quaternary structure:
- No Data Available
Protein Expression for C12orf60 Gene
Post-translational modifications for C12orf60 Gene
Other Protein References for C12orf60 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C12orf60
- Invitrogen Antibodies for C12orf60
- Search GeneTex for Antibodies for C12orf60
Protein Products
-
OriGene Purified Proteins for C12orf60
- Search Origene for MassSpec and Protein Over-expression Lysates for C12orf60
- Origene Custom Protein Services for C12orf60
- Search GeneTex for Proteins for C12orf60
Assay Products
No data available for DME Specific Peptides for C12orf60 Gene
Domains & Families for C12orf60 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C12orf60 Gene
Function for C12orf60 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C12orf60
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C12orf60 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf60 gene
- Search ViGene Biosciences for C12orf60
CRISPR Products
-
OriGene CRISPR knockouts for C12orf60
-
Santa Cruz Biotechnology (SCBT) CRISPR for C12orf60
- GenScript: Design CRISPR guide RNA sequences for C12orf60
miRNA for C12orf60 Gene
- miRTarBase miRNAs that target C12orf60
miRNA Products
- Search ViGene Biosciences for C12orf60
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C12orf60
- Browse OriGene Inhibitory RNA Products For C12orf60
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf60 gene
Clone Products
-
OriGene ORF clones in human for C12orf60
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C12orf60
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf60
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C12orf60
-
ViGene Biosciences adenoviral particle packaged cDNA for C12orf60 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C12orf60 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf60 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C12orf60 Gene
Localization for C12orf60 Gene
| Compartment | Confidence |
|---|---|
| cytosol | 3 |
| plasma membrane | 1 |
| extracellular | 1 |
| mitochondrion | 1 |
| nucleus | 1 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C12orf60 Gene
Pathways & Interactions for C12orf60 Gene
No Data Available
Interacting Proteins for C12orf60 Gene
| Symbol | External ID(s) | Details |
|---|---|---|
| BMP4 |
No data available for Pathways by source and SIGNOR curated interactions for C12orf60 Gene
Transcripts for C12orf60 Gene
mRNA/cDNA for C12orf60 Gene
- (8) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (39) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C12orf60 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C12orf60
-
Santa Cruz Biotechnology (SCBT) CRISPR for C12orf60
- GenScript: Design CRISPR guide RNA sequences for C12orf60
miRNA Products
- Search ViGene Biosciences for C12orf60
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C12orf60
- Browse OriGene Inhibitory RNA Products For C12orf60
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf60 gene
Clone Products
-
OriGene ORF clones in human for C12orf60
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C12orf60
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf60
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for C12orf60 Gene
mRNA differential expression in normal tissues according to GTEx for C12orf60 Gene
This gene is overexpressed in Testis (x8.3).
This gene is overexpressed in Pancreas (63.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C12orf60 Gene
NURSA nuclear receptor signaling pathways regulating expression of C12orf60 Gene:
C12orf60SOURCE GeneReport for Unigene cluster for C12orf60 Gene:
Hs.659951Primer Products
-
OriGene qPCR primer pairs for C12orf60
-
OriGene qPCR primer pairs and template standards for C12orf60
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C12orf60 Gene
Orthologs for C12orf60 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C12H12orf60 34 |
|
||
| C12orf60 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C5H12orf60 34 |
|
||
| C12orf60 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C27H12orf60 34 |
|
||
| C12orf60 35 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | BC049715 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC500354 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | C12orf60 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | C12orf60 35 |
|
OneToOne |
- Species where no ortholog for C12orf60 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C12orf60 Gene
No data available for Paralogs for C12orf60 Gene
Variants for C12orf60 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1057519441 | Pathogenic | 14,683,243(-) | AGAAT(C/T)GAGCT | intron-variant, reference, missense | |
| rs587776871 | Pathogenic | 14,622,087(+) | GGGTG(A/C)TGTAT | intron-variant, reference, missense | |
| rs587776905 | Pathogenic | 14,672,883(+) | TGGTG(C/T)CCACA | intron-variant, reference, missense | |
| rs587784572 | Pathogenic | 14,641,142(-) | TCATC(A/G)CACAG | intron-variant, reference, missense | |
| rs587784573 | Pathogenic | 14,619,304(-) | GTCCC(C/T)GTGCT | nc-transcript-variant, reference, missense |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2745588 | CNV | deletion | 23290073 |
Residual Variation Intolerance Score:
90% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.36;
88.41% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C12orf60 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C12orf60
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf60 Gene
Disorders for C12orf60 Gene
Relevant External Links for C12orf60
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- C12orf60
No disorders were found for C12orf60 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf60 Gene
Publications for C12orf60 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity. (PMID: 23449627) Cousminer D.L. … WidAcn E. (Hum. Mol. Genet. 2013) 3 64
Products for C12orf60 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
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- Browse Peptides
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- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for C12orf60
- Search Origene for MassSpec and Protein Over-expression Lysates for C12orf60
- Origene Custom Protein Services for C12orf60
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C12orf60
- Browse OriGene Inhibitory RNA Products For C12orf60
- OriGene qPCR primer pairs and template standards for C12orf60
- OriGene qPCR primer pairs for C12orf60
- OriGene CRISPR knockouts for C12orf60
- OriGene ORF clones in human for C12orf60
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For C12orf60
- GenScript: Next-day shipping cDNA ORF clone for C12orf60 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for C12orf60
- GenScript Custom Assay Services for C12orf60
- GenScript Custom overexpressing Cell Line Services for C12orf60
- GenScript: Design CRISPR guide RNA sequences for C12orf60
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for C12orf60
- Novus Biologicals proteins and lysates for C12orf60
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for C12orf60 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C12orf60 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C12orf60 gene
- Search ViGene Biosciences for C12orf60
- Horizon Cell Lines for C12orf60
- Cyagen custom Knockout/knockin (KOKI) mouse models for C12orf60
- VectorBuilder custom plasmid, inducible vectors for C12orf60
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf60
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C12orf60 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer