C12orf57 Gene
protein-coding GIFtS: 38
GCID: GC12P007094
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chromosome 12 open reading frame 57
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Aliases
for C12orf57 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 12 Open Reading Frame 571 2 | | C101 2 3 | | GRCC101 2 | | Likely Ortholog Of Mouse Gene Rich Cluster, C102 | | Protein C102 |
Export aliases for C12orf57 gene to outside databasesPrevious GC identifers: GC12P006927 GC12P006929 GC12P006932 GC12P006934 GC12P006937 GC12P006939 GC12P007053 GC12P007057 GC12P007059 GC12P007062 |
Summaries
for C12orf57 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C12orf57 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009759.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C12orf57 gene promoter:
Bach1 GATA-3 AP-1 ATF-2 c-Jun NF-kappaB NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C12orf57
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C12orf57 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12p13.31 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13.31C12orf57 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12P007094: view genomic region
(about GC identifiers)
Start:
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7,052,141 bp from pter |
End:
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7,055,166 bp from pter |
Size:
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3,026 bases |
Orientation:
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plus strand |
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Proteins
for C12orf57 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: C10_HUMAN, Q99622 (See
protein sequence)Recommended Name: Protein C10 Size: 126 amino acids; 13178 Da
Secondary accessions: B2R4Q6Explore the universe of human proteins at neXtProt for C12orf57: NX_Q99622
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q99622
C12orf57 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612434.1
ENSEMBL proteins: ENSP00000440602 ENSP00000440937 ENSP00000229281
Human Recombinant Protein Products:
C12orf57 Antibody Products:
Assay Products for C12orf57: |
Protein
Domains /
Families
for C12orf57 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C12orf57 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q99622ProtoNet protein and cluster: Q99622 UniProtKB/Swiss-Prot: C10_HUMAN, Q99622Similarity: Belongs to the UPF0456 family |
Function
for C12orf57 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf57 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf57
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: C12orf57 (NM_138425) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C12orf57 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf57 |
|
Pathways & Interactions
for C12orf57 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C12orf57
|
Drugs & Compounds
for C12orf57 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C12orf57
Search CenterWatch for drugs/clinical trials and news about C12orf57 / C10
|
Transcripts
for C12orf57 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C12orf57 gene: NM_138425.2 Unigene Cluster for C12orf57: Chromosome 12 open reading frame 57 Hs.405913 [show with all ESTs]Unigene Representative Sequence: BM5483627 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000538392(uc009zfj.1) ENST00000542222 ENST00000545581 ENST00000544681
ENST00000537087 ENST00000229281(uc001qrz.3) ENST00000540506
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf57 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf57
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C12orf57 (NM_138425) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C12orf57 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf57 |
Additional cDNA sequence: AK074416.1 AK310266.1 AK311912.1 BC009925.2 24 DOTS entries: DT.119456 DT.40261371 DT.101962210 DT.121157962 DT.121157526 DT.95183102 DT.121157428 DT.121157255 DT.121157585 DT.91796877 DT.121157900 DT.95183084 DT.99974672 DT.121157453 DT.100876961 DT.121157333 DT.100876960 DT.121157267 DT.97859182 DT.100876963 DT.121157538 DT.100876954 DT.100876965 DT.100032994 3 AceView cDNA sequences: BC009925 CR620372 NM_138425
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for C12orf57 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b |
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| SP1: | | | | | | | | | - | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C12orf57
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Expression
for C12orf57 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C12orf57 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See C12orf57 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C12orf57
SOURCE GeneReport for Unigene cluster: Hs.405913
SABiosciences Custom PCR Arrays for C12orf57
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C12orf57
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C12orf57 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C12orf57 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C12orf57 |
Orthologs
for C12orf57 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for C12orf57 gene from 5/14 species (see all 14) About this table
ENSEMBL Gene Tree for C12orf57 (if available)
TreeFam Gene Tree for C12orf57 (if available) |
Paralogs
for C12orf57 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C12orf57 gene
C12orf57 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for C12orf57
PGOHUM00000244319
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Genomic Variants
for C12orf57 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C12orf57 (7052141 - 7055166 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C12orf57
1 Indel: 60076
Human Gene Mutation Database (HGMD): C12orf57
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C12orf57 |
|
Disorders
/ Diseases
for C12orf57 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C12orf57 for disorders About MalaCards
C12orf57 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: C12orf57 (1 document)
Export disorders for C12orf57 gene to outside databases
|
Publications
for C12orf57 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C12orf57 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with C12orf57) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. (PubMed id 9445485)1, 3 Ansari-Lari M.A....Gibbs R.A. (1998)
- Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. (PubMed id 9074930)1, 2 Ansari-Lari M.A....Gibbs R.A. (1997)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease. (PubMed id 19204726)1 Chapuis J....Lambert J.C. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for C12orf57 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C12orf57 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C12orf57 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C12orf57 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C12orf57 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C12orf57 gene:
Search GeneIP for patents involving C12orf57
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C12orf57 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C12orf57 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C12orf57 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C12orf57 | | | OriGene Protein Over-expression Lysate for C12orf57 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C12orf57 | | OriGene 3'-UTR Clone for C12orf57 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf57 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf57 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C12orf57 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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 | | | C12orf57 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for C12orf57 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf57 |
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