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Aliases for C12orf56 Gene

Aliases for C12orf56 Gene

  • Chromosome 12 Open Reading Frame 56 2 3

External Ids for C12orf56 Gene

Previous GeneCards Identifiers for C12orf56 Gene

  • GC12M062948
  • GC12M064661
  • GC12M061713

Summaries for C12orf56 Gene

GeneCards Summary for C12orf56 Gene

C12orf56 (Chromosome 12 Open Reading Frame 56) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf56 Gene

Genomics for C12orf56 Gene

Regulatory Elements for C12orf56 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for C12orf56 Gene

64,264,762 bp from pter
64,391,192 bp from pter
126,431 bases
Minus strand

Genomic View for C12orf56 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C12orf56 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf56 Gene

Proteins for C12orf56 Gene

  • Protein details for C12orf56 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C12orf56
    Protein Accession:

    Protein attributes for C12orf56 Gene

    622 amino acids
    Molecular mass:
    71046 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C12orf56 Gene


neXtProt entry for C12orf56 Gene

Proteomics data for C12orf56 Gene at MOPED

Post-translational modifications for C12orf56 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C12orf56 Gene

No data available for DME Specific Peptides for C12orf56 Gene

Domains & Families for C12orf56 Gene

Protein Domains for C12orf56 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C12orf56: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C12orf56 Gene

Function for C12orf56 Gene

Phenotypes for C12orf56 Gene

GenomeRNAi human phenotypes for C12orf56:
genes like me logo Genes that share phenotypes with C12orf56: view

Animal Model Products

CRISPR Products

miRNA for C12orf56 Gene

miRTarBase miRNAs that target C12orf56

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for C12orf56 Gene

Localization for C12orf56 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C12orf56 Gene

Pathways & Interactions for C12orf56 Gene

SuperPathways for C12orf56 Gene

No Data Available

Interacting Proteins for C12orf56 Gene

Gene Ontology (GO) - Biological Process for C12orf56 Gene


No data available for Pathways by source and SIGNOR curated interactions for C12orf56 Gene

Drugs & Compounds for C12orf56 Gene

No Compound Related Data Available

Transcripts for C12orf56 Gene

Unigene Clusters for C12orf56 Gene

Chromosome 12 open reading frame 56:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C12orf56

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf56 Gene

No ASD Table

Relevant External Links for C12orf56 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C12orf56 Gene

mRNA expression in normal human tissues for C12orf56 Gene

mRNA differential expression in normal tissues according to GTEx for C12orf56 Gene

This gene is overexpressed in Testis (x14.0), Nerve - Tibial (x6.1), Vagina (x5.8), and Esophagus - Mucosa (x5.8).

Protein differential expression in normal tissues from HIPED for C12orf56 Gene

This gene is overexpressed in Pancreatic juice (63.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C12orf56 Gene

SOURCE GeneReport for Unigene cluster for C12orf56 Gene Hs.535190

genes like me logo Genes that share expression patterns with C12orf56: view

Protein tissue co-expression partners for C12orf56 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C12orf56 Gene

Orthologs for C12orf56 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C12orf56 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C5H12orf56 35
  • 87.58 (n)
  • 84.03 (a)
C12orf56 36
  • 63 (a)
(Canis familiaris)
Mammalia C10H12orf56 35
  • 86.23 (n)
  • 80.39 (a)
C12orf56 36
  • 60 (a)
(Mus musculus)
Mammalia D930020B18Rik 35
  • 79.67 (n)
  • 75.73 (a)
D930020B18Rik 16
D930020B18Rik 36
  • 59 (a)
(Pan troglodytes)
Mammalia C12H12orf56 35
  • 99.21 (n)
  • 98.81 (a)
C12orf56 36
  • 98 (a)
(Rattus norvegicus)
Mammalia RGD1561648 35
  • 79.01 (n)
  • 75.04 (a)
(Danio rerio)
Actinopterygii si:ch211-258f14.2 35
  • 49.43 (n)
  • 37.21 (a)
C4H12orf56 36
  • 26 (a)
Species with no ortholog for C12orf56:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C12orf56 Gene

Gene Tree for C12orf56 (if available)
Gene Tree for C12orf56 (if available)

Paralogs for C12orf56 Gene

No data available for Paralogs for C12orf56 Gene

Variants for C12orf56 Gene

Sequence variations from dbSNP and Humsavar for C12orf56 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1002392 -- 64,275,310(+) AAGAC(A/C)AGAAG reference, synonymous-codon, missense, nc-transcript-variant
rs1046624 -- 64,267,137(-) TTAAT(C/T)AAGAG utr-variant-3-prime, nc-transcript-variant
rs1162974 -- 64,265,865(-) TACTA(C/T)ATTTT nc-transcript-variant
rs1162975 -- 64,267,657(+) TAGAA(C/G)TCATC intron-variant, nc-transcript-variant
rs1162976 -- 64,268,557(+) aggag(A/C)atatg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C12orf56 Gene

Variant ID Type Subtype PubMed ID
nsv469456 CNV Loss 19166990
nsv517246 CNV Loss 19592680
esv1457683 CNV Deletion 17803354
esv2745987 CNV Deletion 23290073

Variation tolerance for C12orf56 Gene

Residual Variation Intolerance Score: 80.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.35; 96.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C12orf56 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf56 Gene

Disorders for C12orf56 Gene

Relevant External Links for C12orf56

Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C12orf56: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf56 Gene

Publications for C12orf56 Gene

  1. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  3. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for C12orf56 Gene

Sources for C12orf56 Gene

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