Aliases for C12orf54 Gene
Aliases for C12orf54 Gene
External Ids for C12orf54 Gene
- HGNC: 28553
- Entrez Gene: 121273
- Ensembl: ENSG00000177627
- UniProtKB: Q6X4T0
Previous GeneCards Identifiers for C12orf54 Gene
- GC12P047164
- GC12P048877
- GC12P045910
- GC12P048482
Summaries for C12orf54 Gene
GeneCards Summary for C12orf54 Gene
C12orf54 (Chromosome 12 Open Reading Frame 54) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf54 Gene
Genomics for C12orf54 Gene
Regulatory Elements for C12orf54 Gene
Enhancers for C12orf54 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G048488 | 0.9 | ENCODE | 26.5 | +33.6 | 33649 | 1.7 | HDGF FOXA2 SIN3A ZNF48 YY1 GATA2 CBX5 SP3 SP5 JUNB | C12orf54 RPL37P19 RPS10P20 ENSG00000258121 |
| GH12G048307 | 0.6 | FANTOM5 | 31.8 | -148.1 | -148080 | 0.1 | TFDP1 PKNOX1 PHF8 IRF2 PBX2 | H1FNT C12orf54 PFKM SENP1 LOC105369753 ENSG00000275228 |
| GH12G048409 | 0.8 | ENCODE | 12.2 | -45.6 | -45554 | 0.8 | CTCF HDAC1 LEF1 PKNOX1 KLF1 ATF1 RB1 ETV1 ZNF121 NCOR1 | C12orf54 ANP32D OR8S21P OR5BJ1P |
| GH12G048421 | 1 | FANTOM5 | 9 | -34.2 | -34155 | 0.2 | HDGF ATF1 PKNOX1 CREB3L1 ARID4B SIN3A GLI4 ZNF2 GLIS2 ELK1 | DDX23 CCNT1 KANSL2 SENP1 LOC390314 RPAP3 C12orf54 CCDC184 ZNF641 PFKM |
| GH12G047867 | 1.4 | Ensembl ENCODE dbSUPER | 4.7 | -587.5 | -587523 | 1.3 | ATF1 TBL1XR1 NFIB ARNT FOS RELB IKZF2 CREM EGR2 ZNF263 | HDAC7 VDR TMEM106C RAPGEF3 SLC48A1 ASB8 CCDC184 C12orf54 ENSG00000205537 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C12orf54 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for C12orf54 Gene
- Chromosome:
- 12
- Start:
- 48,455,581 bp from pter
- End:
- 48,496,514 bp from pter
- Size:
- 40,934 bases
- Orientation:
- Plus strand
Genomic View for C12orf54 Gene
Genes around C12orf54 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.11 by Ensembl
- 12q13.11 by Entrez Gene
- 12q13.11 by HGNC
C12orf54 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C12orf54 Gene
Proteins for C12orf54 Gene
-
Protein details for C12orf54 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6X4T0-CL054_HUMAN
- Recommended name:
- Uncharacterized protein C12orf54
- Protein Accession:
- Q6X4T0
- Q6X4S9
- Q8N5S2
Protein attributes for C12orf54 Gene
- Size:
- 127 amino acids
- Molecular mass:
- 14485 Da
- Quaternary structure:
- No Data Available
Protein Expression for C12orf54 Gene
Post-translational modifications for C12orf54 Gene
Other Protein References for C12orf54 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C12orf54
- Invitrogen Antibodies for C12orf54
- Search GeneTex for Antibodies for C12orf54
Protein Products
-
OriGene Purified Proteins for C12orf54
- Search Origene for MassSpec and Protein Over-expression Lysates for C12orf54
- Origene Custom Protein Services for C12orf54
- Search GeneTex for Proteins for C12orf54
Assay Products
No data available for DME Specific Peptides for C12orf54 Gene
Domains & Families for C12orf54 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C12orf54 Gene
Function for C12orf54 Gene
Phenotypes for C12orf54 Gene
- GenomeRNAi human phenotypes for C12orf54:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C12orf54
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C12orf54 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf54 gene
- Search ViGene Biosciences for C12orf54
CRISPR Products
-
OriGene CRISPR knockouts for C12orf54
-
Santa Cruz Biotechnology (SCBT) CRISPR for C12orf54
- GenScript: Design CRISPR guide RNA sequences for C12orf54
miRNA Products
- Search ViGene Biosciences for C12orf54
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C12orf54
- Browse OriGene Inhibitory RNA Products For C12orf54
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf54 gene
Clone Products
-
OriGene ORF clones in human for C12orf54
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C12orf54
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf54
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for C12orf54
-
ViGene Biosciences adenoviral particle packaged cDNA for C12orf54 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C12orf54 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf54 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C12orf54 Gene
Localization for C12orf54 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C12orf54 Gene
Pathways & Interactions for C12orf54 Gene
No Data Available
Interacting Proteins for C12orf54 Gene
No data available for Pathways by source and SIGNOR curated interactions for C12orf54 Gene
Transcripts for C12orf54 Gene
mRNA/cDNA for C12orf54 Gene
- (4) REFSEQ mRNAs :
- (3) Additional mRNA sequences :
- (24) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C12orf54 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C12orf54
-
Santa Cruz Biotechnology (SCBT) CRISPR for C12orf54
- GenScript: Design CRISPR guide RNA sequences for C12orf54
miRNA Products
- Search ViGene Biosciences for C12orf54
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C12orf54
- Browse OriGene Inhibitory RNA Products For C12orf54
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf54 gene
Clone Products
-
OriGene ORF clones in human for C12orf54
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C12orf54
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf54
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for C12orf54 Gene
mRNA differential expression in normal tissues according to GTEx for C12orf54 Gene
This gene is overexpressed in Testis (x36.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C12orf54 Gene
NURSA nuclear receptor signaling pathways regulating expression of C12orf54 Gene:
C12orf54SOURCE GeneReport for Unigene cluster for C12orf54 Gene:
Hs.98202Primer Products
-
OriGene qPCR primer pairs for C12orf54
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C12orf54 Gene
Orthologs for C12orf54 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | C27H12orf54 34 |
|
||
| C12orf54 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C5H12orf54 34 35 |
|
- Species where no ortholog for C12orf54 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- mouse (Mus musculus)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rat (Rattus norvegicus)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C12orf54 Gene
No data available for Paralogs for C12orf54 Gene
Variants for C12orf54 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000005821 | -- | 48,439,869(+) | ATGTG(A/C)ACATG | intron-variant | |
| rs1000069556 | -- | 48,460,015(+) | GTCAA(A/C)CTGGT | intron-variant | |
| rs1000079048 | -- | 48,460,274(+) | CACTC(A/G)TTATA | intron-variant | |
| rs1000110506 | -- | 48,445,367(+) | TGGAC(A/G)GGTTT | intron-variant | |
| rs1000153605 | -- | 48,482,458(+) | CACAA(A/G)GTATT | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
81.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.01;
74.96% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C12orf54 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C12orf54
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf54 Gene
Disorders for C12orf54 Gene
Relevant External Links for C12orf54
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- C12orf54
No disorders were found for C12orf54 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf54 Gene
Publications for C12orf54 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
Products for C12orf54 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for C12orf54
- Search Origene for MassSpec and Protein Over-expression Lysates for C12orf54
- Origene Custom Protein Services for C12orf54
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C12orf54
- Browse OriGene Inhibitory RNA Products For C12orf54
- OriGene qPCR primer pairs for C12orf54
- OriGene CRISPR knockouts for C12orf54
- OriGene ORF clones in human for C12orf54
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For C12orf54
- GenScript: Next-day shipping cDNA ORF clone for C12orf54 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for C12orf54
- GenScript Custom Assay Services for C12orf54
- GenScript Custom overexpressing Cell Line Services for C12orf54
- GenScript: Design CRISPR guide RNA sequences for C12orf54
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
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- Browse Sino Biological cDNA Clones
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- Sino Biological Antibodies
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- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for C12orf54
- Novus Biologicals proteins and lysates for C12orf54
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for C12orf54 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C12orf54 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C12orf54 gene
- Search ViGene Biosciences for C12orf54
- Horizon Cell Lines for C12orf54
- Cyagen custom Knockout/knockin (KOKI) mouse models for C12orf54
- VectorBuilder custom plasmid, inducible vectors for C12orf54
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf54
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C12orf54 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer