Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C12orf5 Gene

protein-coding GIFtS: 50
GCID: GC12P004430

chromosome 12 open reading frame 5

Explore 3 diseases affiliated with
C12orf5 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 12 Open Reading Frame 5¹ ²		Fructose-2,6-Bisphosphate 2-Phosphatase²
TIGAR¹ ² ⁵		Probable Fructose-2,6-Bisphosphatase TIGAR²
TP53-Induced Glycolysis And Apoptosis Regulator² ³		Transactivated By NS3TP2 Protein²
FR2BP²		EC 3.1.3.46³
Fructose-2,6-Bisphosphatase TIGAR²

External Ids:	HGNC: 1185¹	Entrez Gene: 57103²	Ensembl: ENSG00000078237⁷	OMIM: 610775⁵	UniProtKB: Q9NQ88³

Export aliases for C12orf5 gene to outside databases

Previous GC identifers: GC12P004167 GC12P004322 GC12P004300

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for C12orf5:

This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to

the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by

blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also

protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced

apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. (provided by RefSeq, Jul

2008)

UniProtKB/Swiss-Prot: TIGAR_HUMAN, Q9NQ88

Function: Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Inhibits

glycolysis by reducing cellular levels of fructose-2,6-bisphosphate. May protect cells against reactive oxygen species

and against apoptosis induced by tp53

Gene Wiki entry for C12orf5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000012.11 NC_018923.1 NT_009759.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C12orf5 gene promoter:
E2F-4 E2F-3a E2F-5 p300 E2F-2 CBF-C E2F E2F-1 CP1A CP1C
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for C12orf5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C12orf5

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13.3 Ensembl cytogenetic band: 12p13.32 HGNC cytogenetic band: 12p13.32

C12orf5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C12orf5 gene location

GeneLoc information about chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P004430: view genomic region (about GC identifiers)

Start:	4,430,359 bp from pter	End:	4,469,194 bp from pter
Size:	38,836 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TIGAR_HUMAN, Q9NQ88 (See protein sequence)

Recommended Name: Fructose-2,6-bisphosphatase TIGAR

Size: 270 amino acids; 30063 Da

Subunit: Monomer (By similarity)

Caution: Not expected to have any kinase activity

1 PDB 3D structure from and Proteopedia for C12orf5:

3DCY (3D)

Secondary accessions: B2R840

Explore the universe of human proteins at neXtProt for C12orf5: NX_Q9NQ88

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9NQ88

C12orf5 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_065108.1

ENSEMBL proteins:

ENSP00000179259

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: C12orf5 OriGene Protein Over-expression Lysate: C12orf5 OriGene Custom Protein Services for C12orf5
	GenScript Custom Purified and Recombinant Proteins Services for C12orf5
	Novus Biologicals C12orf5 Proteins Novus Biologicals C12orf5 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for C12orf5

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IDA	--

C12orf5 for ontologies About GeneDecksing

C12orf5 Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of C12orf5
	R&D Systems Antibodies for C12orf5 (TIGAR/C12orf5)
	OriGene Antibodies (see all 2): C12orf5 OriGene Custom Antibody Services for C12orf5
	GenScript Custom Superior Antibodies Services for C12orf5
	Novus Biologicals C12orf5 Antibodies
	Abcam antibodies for C12orf5
	Uscn Antibodies for C12orf5
	ThermoFisher Antibodies for C12orf5

Assay Products for C12orf5:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for C12orf5
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for C12orf5

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C12orf5 for domains About GeneDecksing

2 InterPro domains/families:

IPR001345 PG/BPGM_mutase_AS

IPR013078 His_Pase_superF_clade-1

Graphical View of Domain Structure for InterPro Entry Q9NQ88

ProtoNet protein and cluster: Q9NQ88

1 Blocks protein family: IPB001345 Phosphoglycerate/bisphosphoglycerate mutase

UniProtKB/Swiss-Prot: TIGAR_HUMAN, Q9NQ88

Similarity: Belongs to the phosphoglycerate mutase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TIGAR_HUMAN, Q9NQ88

Function: Fructose-bisphosphatase hydrolyzing fructose-2,6-bisphosphate as well as fructose-1,6-bisphosphate. Inhibits

glycolysis by reducing cellular levels of fructose-2,6-bisphosphate. May protect cells against reactive oxygen species

and against apoptosis induced by tp53

Catalytic activity: Beta-D-fructose 2,6-bisphosphate + H(2)O = D-fructose 6-phosphate + phosphate

Induction: Rapidly up-regulated by p53/TP53

Enzyme Number (IUBMB): EC 3.1.3.46¹

miRNA Products:		OriGene 3'-UTR Clone: C12orf5 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C12orf5
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate C12orf5 (see all 14):
		hsa-miR-875-3p hsa-miR-188-5p hsa-miR-605 hsa-miR-410 hsa-miR-520a-5p hsa-miR-211 hsa-miR-144 hsa-miR-204

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C12orf5 (see all 4) OriGene shRNA RFP: C12orf5 OriGene siRNA: C12orf5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C12orf5

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for C12orf5

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf5 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf5 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: C12orf5 (NM_020375)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for C12orf5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf5

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for C12orf5
		Search LifeMap BioReagents cell lines for C12orf5

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C12orf5

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity	IEA	--

C12orf5 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out 9630033F20Rik^tm1.2Smat for C12orf5
     5 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for 9630033F20Rik):

cardiovascular system

cellular

homeostasis/metabolism

muscle

no phenotypic analysis

C12orf5 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Fructose and mannose metabolism

Fructose and mannose metabolism

1.00

Direct p53 effectors

Direct p53 effectors

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 BioSystems Pathway for C12orf5

Direct p53 effectors

1 Kegg Pathway (Kegg details for C12orf5):

Fructose and mannose metabolism

C12orf5 for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C12orf5

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/14 Interacting proteins for C12orf5 (ENSP00000179259⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FBP1	ENSP00000364475⁴	STRING: ENSP00000364475
FBP2	ENSP00000364486⁴	STRING: ENSP00000364486
HK2	ENSP00000290573⁴	STRING: ENSP00000290573
HK3	ENSP00000292432⁴	STRING: ENSP00000292432
HKDC1	ENSP00000346643⁴	STRING: ENSP00000346643

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C12orf5
Search CenterWatch for drugs/clinical trials and news about C12orf5 / TIGAR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C12orf5 gene:

NM_020375.2

Unigene Cluster for C12orf5:

Chromosome 12 open reading frame 5

Hs.504545 [show with all ESTs]

Unigene Representative Sequence: NM_020375

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000179259(uc001qmp.3) ENST00000539671 ENST00000537251

miRNA Products:		OriGene 3'-UTR Clone: C12orf5 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat C12orf5
		8/14 QIAGEN miScript miRNA Assays for microRNAs that regulate C12orf5 (see all 14):
		hsa-miR-875-3p hsa-miR-188-5p hsa-miR-605 hsa-miR-410 hsa-miR-520a-5p hsa-miR-211 hsa-miR-144 hsa-miR-204

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C12orf5 (see all 4) OriGene shRNA RFP: C12orf5 OriGene siRNA: C12orf5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C12orf5

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf5 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf5 (see all 2) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: C12orf5 (NM_020375)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for C12orf5
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C12orf5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat C12orf5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C12orf5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C12orf5

Additional cDNA sequence:

AJ272206.1 AK313226.1 AY425618.1 BC012340.1

5 DOTS entries:

DT.441019 DT.99960633 DT.100725881 DT.408307 DT.95161847

24/100 AceView cDNA sequences (see all 100):

BE906512 AI928246 AA897774 CK820201 BQ011607 BE463938 AI805174 BF061847

AA503851 AI968331 AW104400 CA434904 AW466953 AI376293 F09684 AI803333

CR613889 AI625405 AW236937 AI889011 AA903744 AI435416 AI949681 AI741732

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C12orf5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTATATTGA

About this image

C12orf5 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C12orf5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C12orf5

SOURCE GeneReport for Unigene cluster: Hs.504545

SABiosciences Custom PCR Arrays for C12orf5

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C12orf5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse / rat C12orf5
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C12orf5
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C12orf5

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C12orf5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C12orf5 gene from 3/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Details
mouse (Mus musculus)	Mammalia	9630033F20Rik^{1 , 5}	RIKEN cDNA 9630033F20 gene^{1, 5}	75.56(n)¹ 73.31(a)¹	6 (61.92 cM)⁵ 319801¹ NM_177003.5¹ NP_795977.1¹ 127085116⁵
chicken (Gallus gallus)	Aves	C1H12orf5¹	chromosome 1 open reading frame, human C12orf5	66.41(n) 59.54(a)	419040 XM_417232.3 XP_417232.1
zebrafish (Danio rerio)	Actinopterygii	tigarb¹	tp53-induced glycolysis and apoptosis regulator b	48.66(n) 42.74(a)	393160 NM_200191.1 NP_956485.1

ENSEMBL Gene Tree for C12orf5 (if available)
TreeFam Gene Tree for C12orf5 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 12 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7313134^1,2	C,F,	--	4428410(+)	`GTGATA/GTTACA`	1	--	us2k¹		6		NA CSA WA EA	363
rs144989968^1,2	C,	--	4428714(+)	`ATTTTC/TTTTTT`	1	--	us2k¹		0	--	--	--	--
rs9739906^1,2	C,A,H,	--	4428721(+)	`ttttaA/Gttctc`	1	--	us2k¹ tfbs³		4		NS EA	418
rs182970989^1,2		--	4428784(+)	`GTGAGC/TGCACA`	1	--	us2k¹		0	--	--	--	--
rs141945692^1,2		--	4428826(+)	`CCTGAC/TGCACG`	1	--	us2k¹		0	--	--	--	--
rs9737706^1,2	C,F,A,	--	4428845(+)	`gctgcT/Agtgta`	1	--	us2k¹		1		WA	118
rs186307476^1,2		--	4428907(+)	`TGATGA/GGGGTG`	1	--	us2k¹		0	--	--	--	--
rs190279359^1,2		--	4428923(+)	`TTTGGC/TGGGAA`	1	--	us2k¹		0	--	--	--	--
rs76214373^1,2	F	--	4428968(+)	`GGTGGC/AGTAGG`	1	--	us2k¹		2		NA CSA	4
rs182528365^1,2		--	4429228(+)	`GCAGGC/TGCCTG`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for C12orf5 (4430359 - 4469194 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C12orf5: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C12orf5

DNA2.0 Custom Variant and Variant Library Synthesis for C12orf5

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C12orf5 for disorders           About GeneDecksing

OMIM gene information: 610775    OMIM disorders: --

3 diseases for C12orf5:    About MalaCards

rickets lymphoblastic leukemia leukemia

Export disorders for C12orf5 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C12orf5 gene, integrated from 9 sources (see all 31):
(articles sorted by number of sources associating them with C12orf5)

Utopia: connect your pdf to the dynamic
world of online information

TIGAR, a p53-inducible regulator of glycolysis and apoptosis. (PubMed id 16839880)^{1, 2, 3} Bensaad K.... Vousden K.H. (2006)
Modulation of intracellular ROS levels by TIGAR contr ols autophagy. (PubMed id 19713938)^{1, 3} Bensaad K....Vousden K.H. (2009)
Identification of TIGAR in the equilibrative nucleosi de transporter 2-mediated response to fludarabine in chronic lymphocytic leukem ia cells. (PubMed id 18945750)^{1, 3} LA^pez-Guerra M....Pastor-Anglada M. (2008)
Identification of novel p53 target genes in ionizing radiation response. (PubMed id 16140933)^{1, 3} Jen K.Y. and Cheung V.G. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. (PubMed id 11062477)^{1, 2} White K.E.... Strom T.M. (2000)
SP1 plays a pivotal role for basal activity of TIGAR p romoter in liver cancer cell lines. (PubMed id 21761199)¹ Zou S....Fan Q. (2012)
A census of human soluble protein complexes. (PubMed id 22939629)¹ Havugimana P.C....Emili A. (2012)
Tp53-induced glycolysis and apoptosis regulator (TIGAR ) protects glioma cells from starvation-induced cell death by up-regulating resp iration and improving cellular redox homeostasis. (PubMed id 22887998)¹ Wanka C....Rieger J. (2012)
TIGAR induces p53-mediated cell-cycle arrest by regula tion of RB-E2F1 complex. (PubMed id 22782351)¹ Madan E....Mahdi A.A. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 57103	HGNC: 1185	AceView: C12orf5	Ensembl:ENSG00000078237	euGenes: HUgn57103
ECgene: C12orf5	Kegg: 57103	H-InvDB: C12orf5

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C12orf5	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C12orf5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C12orf5 gene:
Search GeneIP for patents involving C12orf5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	EMD Millipore Mono- and Polyclonal Antibodies for the study of C12orf5
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse Small Molecules at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for C12orf5 (TIGAR/C12orf5)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for C12orf5		OriGene shRNA RFP for C12orf5
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C12orf5		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C12orf5
	OriGene Protein Over-expression Lysate for C12orf5		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for C12orf5		OriGene 3'-UTR Clone for C12orf5
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf5		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf5
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for C12orf5		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for C12orf5		OriGene Custom Protein Services for C12orf5
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C12orf5
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C12orf5
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C12orf5
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C12orf5
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C12orf5
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C12orf5

	GenScript Custom Purified and Recombinant Proteins Services for C12orf5		GenScript cDNA clones with any tag delivered in your preferred vector for C12orf5
	GenScript Custom Assay Services for C12orf5		GenScript Custom Superior Antibodies Services for C12orf5
	GenScript Custom overexpressing Cell Line Services for C12orf5		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in C12orf5 promoter
	Search Chromatin IP Primers for C12orf5
	RT² qPCR Primer Assay in human, mouse / rat C12orf5
	Search GNC Networks for C12orf5
	SABiosciences Custom PCR Arrays for C12orf5

Search Tocris compounds for C12orf5

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	C12orf5 antibodies
	C12orf5 proteins
	C12orf5 lysates

	Antibodies for C12orf5
	See all of Abcam's Antibodies, Kits and Proteins for C12orf5
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

C12orf5 Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for C12orf5

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C12orf5

	Browse SwitchGear 3'UTR luciferase reporter plasmids for C12orf5
	Browse SwitchGear Promoter luciferase reporter plasmids for C12orf5

ThermoFisher Antibodies for C12orf5

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf5

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C12orf5 gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

C12orf5 Gene

chromosome 12 open reading frame 5

Aliases
for C12orf5 gene

Summaries
for C12orf5 gene

Genomic Views
for C12orf5 gene

Proteins
for C12orf5 gene

Protein Domains /
Families
for C12orf5 gene

Function
for C12orf5 gene

Pathways & Interactions
for C12orf5 gene

Drugs & Compounds
for C12orf5 gene

Transcripts
for C12orf5 gene

Expression
for C12orf5 gene

Orthologs
for C12orf5 gene

Paralogs
for C12orf5 gene

Genomic Variants
for C12orf5 gene

Disorders / Diseases
for C12orf5 gene

Publications
for C12orf5 gene

External Searches for C12orf5 gene

Genome Databases showing C12orf5 gene

Other Databases showing C12orf5 gene

Specialized Databases showing C12orf5 gene

Intellectual Property
for C12orf5 gene

Products
for C12orf5 gene

View Random Gene

Advanced Search

Export list of displayed genes

C12orf5 Gene

chromosome 12 open reading frame 5

Aliasesfor C12orf5 gene

Summariesfor C12orf5 gene

Genomic Viewsfor C12orf5 gene

Proteinsfor C12orf5 gene

Protein Domains /Familiesfor C12orf5 gene

Functionfor C12orf5 gene

Pathways & Interactionsfor C12orf5 gene

Drugs & Compoundsfor C12orf5 gene

Transcriptsfor C12orf5 gene

Expression for C12orf5 gene

Orthologsfor C12orf5 gene

Paralogsfor C12orf5 gene

Genomic Variantsfor C12orf5 gene

Disorders / Diseasesfor C12orf5 gene

Publicationsfor C12orf5 gene

External Searches for C12orf5 gene

Genome Databases showing C12orf5 gene

Other Databases showing C12orf5 gene

Specialized Databases showing C12orf5 gene

Intellectual Propertyfor C12orf5 gene

Productsfor C12orf5 gene

View Random Gene

Aliases
for C12orf5 gene

Summaries
for C12orf5 gene

Genomic Views
for C12orf5 gene

Proteins
for C12orf5 gene

Protein Domains /
Families
for C12orf5 gene

Function
for C12orf5 gene

Pathways & Interactions
for C12orf5 gene

Drugs & Compounds
for C12orf5 gene

Transcripts
for C12orf5 gene

Expression
for C12orf5 gene

Orthologs
for C12orf5 gene

Paralogs
for C12orf5 gene

Genomic Variants
for C12orf5 gene

Disorders / Diseases
for C12orf5 gene

Publications
for C12orf5 gene

Intellectual Property
for C12orf5 gene

Products
for C12orf5 gene