C12orf49 Gene
protein-coding GIFtS: 41
GCID: GC12M117153 (predicted)
|
|
chromosome 12 open reading frame 49
| |
Aliases
for C12orf49 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 12 Open Reading Frame 491 2 | | FLJ214151 | | UPF0454 Protein C12orf492 |
Export aliases for C12orf49 gene to outside databasesPrevious GC identifers: GC12M115617 GC12M114163 |
Summaries
for C12orf49 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for C12orf49 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C12orf49 gene promoter:
p53 SREBP-1c CBF-C SREBP-1b Egr-4 CBF-B SREBP-1a CBF-A SEF-1 (1) Msx-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C12orf49
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C12orf49 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q24.22 Ensembl cytogenetic band: 12q24.22 HGNC cytogenetic band: 12q24.22C12orf49 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M117153: view genomic region
(about GC identifiers)
Start:
|
117,153,593 bp from pter |
End:
|
117,175,875 bp from pter |
Size:
|
22,283 bases |
Orientation:
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minus strand |
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Proteins
for C12orf49 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CL049_HUMAN, Q9H741 (See
protein sequence)Recommended Name: UPF0454 protein C12orf49 precursor Size: 205 amino acids; 23594 Da
Subcellular location: Secreted (Potential)
Secondary accessions: Q53GE8Explore the universe of human proteins at neXtProt for C12orf49: NX_Q9H741
C12orf49 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_079014.1
ENSEMBL proteins: ENSP00000261318 ENSP00000446478 ENSP00000449151 ENSP00000447722 ENSP00000442947
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
C12orf49 for ontologies About GeneDecksing
C12orf49 Antibody Products:
Assay Products for C12orf49: |
Protein
Domains /
Families
for C12orf49 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C12orf49 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H741ProtoNet protein and cluster: Q9H741 UniProtKB/Swiss-Prot: CL049_HUMAN, Q9H741Similarity: Belongs to the UPF0454 family |
Function
for C12orf49 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf49 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf49
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: C12orf49 (NM_024738) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C12orf49 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf49 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C12orf49 |
1 GenomeRNAi human phenotype for C12orf49:
Animal Models:
1 MGI phenotypic allele  for 2410131K14Rik (no phenotypes)
C12orf49 for phenotypes About GeneDecksing
|
Pathways & Interactions
for C12orf49 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C12orf49
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for C12orf49 (ENSP000002613184) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C12orf49 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C12orf49
Search CenterWatch for drugs/clinical trials and news about C12orf49 / CL049
|
Transcripts
for C12orf49 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C12orf49 gene: NM_024738.1 Unigene Cluster for C12orf49: Chromosome 12 open reading frame 49 Hs.592011 [show with all ESTs]Unigene Representative Sequence: AK0250685 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000261318(uc001tvz.1 uc009zwm.1) ENST00000547630 ENST00000548356
ENST00000547606 ENST00000536380
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf49 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf49
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C12orf49 (NM_024738) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C12orf49 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf49 |
Additional cDNA sequence: AK025068.1 AK222983.1 AK298857.1 AK309652.1 BC019843.1 6 DOTS entries: DT.209967 DT.100767181 DT.102823524 DT.95260076 DT.100695386 DT.100767178 24/164 AceView cDNA sequences (see all 164): AI356201 AI492878 BX389599 AI189976 AA514750 AA514509 BM981179 BQ009949 BF434458 CA394526 AA360709 AW183346 AA026236 BF590567 BQ437586 AA908183 AI016678 AA329614 AI018506 AI254333 CR625981 BX104590 BE763891 CD558287
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for C12orf49 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for C12orf49
|
Expression
for C12orf49 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C12orf49 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGCCTGCCCT
About this image
See C12orf49 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C12orf49
SOURCE GeneReport for Unigene cluster: Hs.592011
SABiosciences Custom PCR Arrays for C12orf49
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C12orf49
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C12orf49 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C12orf49 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C12orf49 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C12orf49 |
Orthologs
for C12orf49 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for C12orf49 gene from 8/23 species (see all 23) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
2410131K14Rik1 , 5 |
RIKEN cDNA 2410131K14 gene1, 5 |
85.53(n)1
92.68(a)1 |
|
5 (58.32 cM)5
767921 NM_001081236.11 NP_001074705.11
1182452275 |
chicken
(Gallus gallus) |
Aves |
C15H12orf491 |
chromosome 15 open reading frame, human C12orf49 |
80.88(n)
84.31(a) |
|
417026 NM_001007841.1 NP_001007842.1 |
lizard
(Anolis carolinensis) |
Reptilia |
C12orf496 |
-- |
74(a) |
1 ↔ 1 |
LGb(2290688-2295074) |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.46702 |
Xenopus laevis transcribed sequences |
73.29(n) |
|
AW643959.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.152412 |
Transcribed sequence with moderate similarity to protein more |
78.35(n) |
|
BQ074323.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG156431 |
CG15643 |
56.16(n)
46.74(a) |
|
32489 NM_176736.1 NP_788909.1 |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
AT3G593906 |
uncharacterized protein |
17(a) |
1 ↔ 1 |
3(21946118-21948372) |
rice
(Oryza sativa) |
Liliopsida |
-- |
expressed protein |
19(a) |
1 ↔ 1 |
11(9173414-9178805) |
ENSEMBL Gene Tree for C12orf49 (if available)
TreeFam Gene Tree for C12orf49 (if available) |
Paralogs
for C12orf49 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for C12orf49 gene
C12orf49 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for C12orf49
PGOHUM00000238756 PGOHUM00000259015 PGOHUM00000249521 PGOHUM00000260539 PGOHUM00000242010
|
Genomic Variants
for C12orf49 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C12orf49 (117153593 - 117175875 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C12orf49
1 CNV: 4788 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C12orf49 |
|
Disorders
/ Diseases
for C12orf49 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for C12orf49 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C12orf49 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C12orf49) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
|
External Searches for C12orf49 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C12orf49 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C12orf49 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C12orf49 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C12orf49 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C12orf49 gene:
Search GeneIP for patents involving C12orf49
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C12orf49 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C12orf49 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C12orf49 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C12orf49 | | | OriGene Protein Over-expression Lysate for C12orf49 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C12orf49 | | OriGene 3'-UTR Clone for C12orf49 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf49 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf49 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| |
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 | | | C12orf49 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C12orf49 |
|  |  |  | | | | Search ThermoFisher Antibodies for C12orf49 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf49 |
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