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Aliases for C12orf49 Gene

Aliases for C12orf49 Gene

  • Chromosome 12 Open Reading Frame 49 2 3

External Ids for C12orf49 Gene

Summaries for C12orf49 Gene

GeneCards Summary for C12orf49 Gene

C12orf49 (Chromosome 12 Open Reading Frame 49) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf49 Gene

Genomics for C12orf49 Gene

Genomic Location for C12orf49 Gene

Start:
116,710,185 bp from pter
End:
116,738,070 bp from pter
Size:
27,886 bases
Orientation:
Minus strand

Genomic View for C12orf49 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C12orf49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf49 Gene

Regulatory Elements for C12orf49 Gene

Proteins for C12orf49 Gene

  • Protein details for C12orf49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H741-CL049_HUMAN
    Recommended name:
    UPF0454 protein C12orf49
    Protein Accession:
    Q9H741
    Secondary Accessions:
    • Q53GE8

    Protein attributes for C12orf49 Gene

    Size:
    205 amino acids
    Molecular mass:
    23594 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C12orf49 Gene

Proteomics data for C12orf49 Gene at MOPED

Post-translational modifications for C12orf49 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn67 and Thr185

Other Protein References for C12orf49 Gene

No data available for DME Specific Peptides for C12orf49 Gene

Domains for C12orf49 Gene

Protein Domains for C12orf49 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CL049_HUMAN
Family:
  • Belongs to the UPF0454 family.:
    • Q9H741
genes like me logo Genes that share domains with C12orf49: view

No data available for Gene Families for C12orf49 Gene

Function for C12orf49 Gene

Gene Ontology (GO) - Molecular Function for C12orf49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C12orf49: view

Phenotypes for C12orf49 Gene

GenomeRNAi human phenotypes for C12orf49:
genes like me logo Genes that share phenotypes with C12orf49: view

miRNA for C12orf49 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for C12orf49 Gene

Localization for C12orf49 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C12orf49 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C12orf49 Gene COMPARTMENTS Subcellular localization image for C12orf49 gene
Compartment Confidence
extracellular 3
mitochondrion 2
cytoskeleton 1
cytosol 1
golgi apparatus 1
lysosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C12orf49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C12orf49: view

Pathways for C12orf49 Gene

SuperPathways for C12orf49 Gene

No Data Available

Interacting Proteins for C12orf49 Gene

Gene Ontology (GO) - Biological Process for C12orf49 Gene

None

No data available for Pathways by source for C12orf49 Gene

Transcripts for C12orf49 Gene

Unigene Clusters for C12orf49 Gene

Chromosome 12 open reading frame 49:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf49 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c
SP1:
SP2: - -
SP3: - -

Relevant External Links for C12orf49 Gene

GeneLoc Exon Structure for
C12orf49
ECgene alternative splicing isoforms for
C12orf49

Expression for C12orf49 Gene

mRNA expression in normal human tissues for C12orf49 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C12orf49 Gene

SOURCE GeneReport for Unigene cluster for C12orf49 Gene Hs.592011

genes like me logo Genes that share expressions with C12orf49: view

Orthologs for C12orf49 Gene

This gene was present in the common ancestor of animals.

Orthologs for C12orf49 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C12H12orf49 36
  • 99.67 (n)
  • 99.51 (a)
C12orf49 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C12orf49 37
  • 96 (a)
OneToOne
C9H12orf49 36
  • 90.41 (n)
  • 96.1 (a)
dog
(Canis familiaris)
Mammalia -- 37
  • 55 (a)
OneToMany
-- 37
  • 32 (a)
OneToMany
-- 37
  • 95 (a)
OneToMany
LOC102153143 36
  • 91.54 (n)
  • 94.63 (a)
mouse
(Mus musculus)
Mammalia 2410131K14Rik 36
  • 85.53 (n)
  • 92.68 (a)
2410131K14Rik 16
2410131K14Rik 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C12orf49 37
  • 69 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1562310 36
  • 85.37 (n)
  • 92.2 (a)
chicken
(Gallus gallus)
Aves C15H12ORF49 36
  • 80.81 (n)
  • 83.9 (a)
C15H12ORF49 37
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C12orf49 37
  • 74 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4670 36
tropical clawed frog
(Silurana tropicalis)
Amphibia c12orf49 36
  • 72.41 (n)
  • 81.28 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.554 36
zebrafish
(Danio rerio)
Actinopterygii C5H12orf49 37
  • 79 (a)
OneToOne
Dr.15241 36
zgc:110063 36
  • 74.24 (n)
  • 79.8 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000855 36
  • 52.18 (n)
  • 45.55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG15643 36
  • 56.52 (n)
  • 46.74 (a)
CG15643 37
  • 42 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 46 (a)
OneToOne
Species with no ortholog for C12orf49:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C12orf49 Gene

ENSEMBL:
Gene Tree for C12orf49 (if available)
TreeFam:
Gene Tree for C12orf49 (if available)

Paralogs for C12orf49 Gene

genes like me logo Genes that share paralogs with C12orf49: view

No data available for Paralogs for C12orf49 Gene

Variants for C12orf49 Gene

Sequence variations from dbSNP and Humsavar for C12orf49 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs180304 -- 116,726,583(-) TCCCA(A/G)GGCTC intron-variant
rs180305 -- 116,726,942(-) AACGC(A/G)TTGAA intron-variant
rs182889 -- 116,726,608(-) TGCAC(C/T)TAAGT intron-variant
rs339448 -- 116,726,341(-) TACAG(A/G)TGGTA intron-variant
rs339449 -- 116,725,488(-) CCCAA(A/G)ATGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C12orf49 Gene

Variant ID Type Subtype PubMed ID
nsv832523 CNV Gain+Loss 17160897

Relevant External Links for C12orf49 Gene

HapMap Linkage Disequilibrium report
C12orf49

Disorders for C12orf49 Gene

No disorders were found for C12orf49 Gene.

No data available for UniProtKB/Swiss-Prot for C12orf49 Gene

Publications for C12orf49 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for C12orf49 Gene

Sources for C12orf49 Gene

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