Aliases for C12orf45 Gene
External Ids for C12orf45 Gene
- HGNC: 28628
- Entrez Gene: 121053
- Ensembl: ENSG00000151131
- UniProtKB: Q8N5I9
Previous GeneCards Identifiers for C12orf45 Gene
- GC12P103883
- GC12P105380
- GC12P102439
Summaries for C12orf45 Gene
GeneCards Summary for C12orf45 Gene
C12orf45 (Chromosome 12 Open Reading Frame 45) is a Protein Coding gene.
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf45 Gene
Genomics for C12orf45 Gene
Regulatory Elements for C12orf45 Gene
Enhancers for C12orf45 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH12G104957 | 1.1 | ENCODE | 19.4 | -27.3 | -27266 | 3.0 | HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 FEZF1 YY1 ZNF766 FOS | C12orf45 SLC41A2 KRT18P20 |
| GH12G104944 | 0.8 | ENCODE | 17.7 | -41.7 | -41700 | 0.9 | MAX RAD21 YY1 ZNF121 ZNF366 HNF4G KLF8 GFI1B CEBPB TSHZ1 | C12orf45 GC12M104943 GC12M104883 |
| GH12G105024 | 0.7 | ENCODE | 19.8 | +39.1 | 39087 | 2.5 | CTCF BHLHE40 RAD21 NR2F2 YY1 FOXA1 JUND PRDM6 SMARCA4 ZSCAN5C | C12orf45 SLC41A2 PIR40149 PIR45033 |
| GH12G104985 | 1 | ENCODE | 11.3 | +0.5 | 452 | 2.3 | HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF48 YY1 GTF3C2 | SLC41A2 NFYB C12orf45 ALDH1L2 RPL18AP3 LOC105369952 PIR60982 |
| GH12G104952 | 0.6 | ENCODE | 10.7 | -32.9 | -32894 | 1.2 | RNF2 NR3C1 ZNF366 GATA2 HNF4A PRDM1 KLF8 ZBTB20 | C12orf45 SLC41A2 GC12M104943 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around C12orf45 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the C12orf45 gene promoter:
Regulatory Element Products
Genomic Location for C12orf45 Gene
- Chromosome:
- 12
- Start:
- 104,986,310 bp from pter
- End:
- 105,074,197 bp from pter
- Size:
- 87,888 bases
- Orientation:
- Plus strand
Genomic View for C12orf45 Gene
Genes around C12orf45 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q23.3 by Ensembl
- 12q23.3 by Entrez Gene
- 12q23.3 by HGNC
C12orf45 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C12orf45 Gene
Proteins for C12orf45 Gene
-
Protein details for C12orf45 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8N5I9-CL045_HUMAN
- Recommended name:
- Uncharacterized protein C12orf45
- Protein Accession:
- Q8N5I9
Protein attributes for C12orf45 Gene
- Size:
- 185 amino acids
- Molecular mass:
- 20123 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAH32326.1; Type=Frameshift; Positions=185; Evidence={ECO:0000305};
Protein Expression for C12orf45 Gene
Post-translational modifications for C12orf45 Gene
Other Protein References for C12orf45 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C12orf45
- Invitrogen Antibodies for C12orf45
- Search GeneTex for Antibodies for C12orf45
Protein Products
-
OriGene Purified Proteins for C12orf45
- Search Origene for MassSpec and Protein Over-expression Lysates for C12orf45
- Origene Custom Protein Services for C12orf45
- Search GeneTex for Proteins for C12orf45
Assay Products
No data available for DME Specific Peptides for C12orf45 Gene
Domains & Families for C12orf45 Gene
Graphical View of Domain Structure for InterPro Entry
No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C12orf45 Gene
Function for C12orf45 Gene
Phenotypes for C12orf45 Gene
- GenomeRNAi human phenotypes for C12orf45:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C12orf45
-
-
ViGene Biosciences lentiviral particle packaged cDNA for C12orf45 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf45 gene
- Search ViGene Biosciences for C12orf45
CRISPR Products
-
OriGene CRISPR knockouts for C12orf45
-
Santa Cruz Biotechnology (SCBT) CRISPR for C12orf45
- GenScript: Design CRISPR guide RNA sequences for C12orf45
miRNA Products
- Search ViGene Biosciences for C12orf45
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C12orf45
- Browse OriGene Inhibitory RNA Products For C12orf45
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf45 gene
Clone Products
-
OriGene ORF clones in human for C12orf45
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C12orf45
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf45
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for C12orf45 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for C12orf45 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf45 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C12orf45 Gene
Localization for C12orf45 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 3 |
| cytosol | 2 |
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C12orf45 Gene
Pathways & Interactions for C12orf45 Gene
No Data Available
No data available for Pathways by source and SIGNOR curated interactions for C12orf45 Gene
Transcripts for C12orf45 Gene
mRNA/cDNA for C12orf45 Gene
- (1) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (75) Selected AceView cDNA sequences:
- (6) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for C12orf45 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C12orf45
-
Santa Cruz Biotechnology (SCBT) CRISPR for C12orf45
- GenScript: Design CRISPR guide RNA sequences for C12orf45
miRNA Products
- Search ViGene Biosciences for C12orf45
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for C12orf45
- Browse OriGene Inhibitory RNA Products For C12orf45
-
ViGene Biosciences ready-to-package AAV shRNAs for C12orf45 gene
Clone Products
-
OriGene ORF clones in human for C12orf45
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for C12orf45
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf45
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for C12orf45 Gene
This gene is overexpressed in Lung (40.1) and Peripheral blood mononuclear cells (21.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C12orf45 Gene
NURSA nuclear receptor signaling pathways regulating expression of C12orf45 Gene:
C12orf45SOURCE GeneReport for Unigene cluster for C12orf45 Gene:
Hs.295563Primer Products
-
OriGene qPCR primer pairs for C12orf45
-
OriGene qPCR primer pairs and template standards for C12orf45
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C12orf45 Gene
Orthologs for C12orf45 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C12H12orf45 34 |
|
||
| C12orf45 35 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C10H12orf45 34 |
|
||
| C12orf45 35 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C5H12orf45 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | D10Wsu102e 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | RGD1563365 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | C12orf45 35 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | C12orf45 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC100857517 34 |
|
||
| C12orf45 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | C12orf45 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | c12orf45 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:dkey-48p11.3 34 |
|
||
| C4H12orf45 35 |
|
OneToOne |
- Species where no ortholog for C12orf45 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for C12orf45 Gene
Pseudogenes.org Pseudogenes for C12orf45 Gene
No data available for Paralogs for C12orf45 Gene
Variants for C12orf45 Gene
| SNP ID | Clin | Chr 12 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000137193 | -- | 104,984,950(+) | CCTAC(A/G)ACTCA | intron-variant, upstream-variant-2KB | |
| rs1000268560 | -- | 104,989,869(+) | TCTAT(A/G)TTGTC | intron-variant | |
| rs1000304082 | -- | 104,988,471(+) | TGCTT(A/G)TGGGT | intron-variant | |
| rs1000358780 | -- | 104,994,405(+) | GTTCT(C/T)CCCAA | intron-variant | |
| rs1002241124 | -- | 104,990,093(+) | TATGG(A/T)TTATG | intron-variant |
Residual Variation Intolerance Score:
71.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.36;
76.85% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for C12orf45 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C12orf45
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf45 Gene
Disorders for C12orf45 Gene
Relevant External Links for C12orf45
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- C12orf45
No disorders were found for C12orf45 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf45 Gene
Publications for C12orf45 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3 64
- Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. (PMID: 24999758) Elzi D.J. … Shiio Y. (J. Proteome Res. 2014) 3 64
Products for C12orf45 Gene
- Browse R&D Systems for Antibodies
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- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
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- Custom Antibody Services
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- Custom Assay Services
- OriGene Purified Proteins for C12orf45
- Search Origene for MassSpec and Protein Over-expression Lysates for C12orf45
- Origene Custom Protein Services for C12orf45
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for C12orf45
- Browse OriGene Inhibitory RNA Products For C12orf45
- OriGene qPCR primer pairs and template standards for C12orf45
- OriGene qPCR primer pairs for C12orf45
- OriGene CRISPR knockouts for C12orf45
- OriGene ORF clones in human for C12orf45
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For C12orf45
- GenScript: Next-day shipping cDNA ORF clone for C12orf45 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for C12orf45
- GenScript Custom Assay Services for C12orf45
- GenScript Custom overexpressing Cell Line Services for C12orf45
- GenScript: Design CRISPR guide RNA sequences for C12orf45
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- CloneReady with Over 120,000 Genes
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- Novus Biologicals Antibodies for C12orf45
- Novus Biologicals proteins and lysates for C12orf45
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for C12orf45 gene
- ViGene Biosciences lentiviral particle packaged cDNA for C12orf45 gene
- ViGene Biosciences ready-to-package AAV shRNAs for C12orf45 gene
- Search ViGene Biosciences for C12orf45
- Cyagen custom Knockout/knockin (KOKI) mouse models for C12orf45
- VectorBuilder custom plasmid, inducible vectors for C12orf45
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for C12orf45
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for C12orf45 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer