C12orf43 Gene
protein-coding GIFtS: 43
GCID: GC12M121440 (predicted)
|
|
chromosome 12 open reading frame 43
| |
Aliases
for C12orf43 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chromosome 12 Open Reading Frame 431 2 | | FLJ124481 | | Uncharacterized Protein C12orf432 |
Export aliases for C12orf43 gene to outside databasesPrevious GC identifers: GC12M119904 GC12M118449 |
Summaries
for C12orf43 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Gene Wiki entry for C12orf43
|
Genomic Views
for C12orf43 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_009775.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the C12orf43 gene promoter:
STAT1 RFX1 STAT1beta CUTL1 STAT5A STAT1alpha Gfi-1 Ik-2 Zic1
Other transcription factors
Search SABiosciences Chromatin IP Primers for C12orf43
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C12orf43 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q Ensembl cytogenetic band: 12q24.31 HGNC cytogenetic band: 12q24.31C12orf43 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M121440: view genomic region
(about GC identifiers)
Start:
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121,440,243 bp from pter |
End:
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121,454,305 bp from pter |
Size:
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14,063 bases |
Orientation:
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minus strand |
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Proteins
for C12orf43 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CL043_HUMAN, Q96C57 (See
protein sequence)Recommended Name: Uncharacterized protein C12orf43 Size: 262 amino acids; 28171 Da
Secondary accessions: Q53HF0 Q9H9Z7Explore the universe of human proteins at neXtProt for C12orf43: NX_Q96C57
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96C57
C12orf43 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_075046.1
ENSEMBL proteins: ENSP00000409788 ENSP00000442224 ENSP00000437546 ENSP00000443642 ENSP00000437803 ENSP00000442041 ENSP00000438856 ENSP00000439393 ENSP00000288757 ENSP00000444399
Human Recombinant Protein Products:
C12orf43 Antibody Products:
Assay Products for C12orf43: |
Protein
Domains /
Families
for C12orf43 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
C12orf43 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96C57ProtoNet protein and cluster: Q96C57 |
Function
for C12orf43 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf43 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf43
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: C12orf43 (NM_022895) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C12orf43 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf43 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C12orf43 |
1 GenomeRNAi human phenotype for C12orf43:
|
Pathways & Interactions
for C12orf43 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C12orf43
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for C12orf43 (ENSP000002887574) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for C12orf43 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for C12orf43
Search CenterWatch for drugs/clinical trials and news about C12orf43 / CL043
|
Transcripts
for C12orf43 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for C12orf43 gene: NM_022895.1 Unigene Cluster for C12orf43: Chromosome 12 open reading frame 43 Hs.528671 [show with all ESTs]Unigene Representative Sequence: BC01466112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000445832 ENST00000502891 ENST00000537817 ENST00000536407 ENST00000546272
ENST00000539736 ENST00000538296 ENST00000535367 ENST00000539088 ENST00000508193
ENST00000288757(uc001tzh.1 uc009zxa.1 uc010szo.1 uc010szp.1 uc001tzi.1)
ENST00000366211
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf43 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf43
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: C12orf43 (NM_022895) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C12orf43 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf43 |
Additional cDNA sequence: AK022510.1 AK222630.1 AK225162.1 AK299170.1 AK301566.1 AK307971.1 BC009736.1 BC014661.1 5 DOTS entries: DT.423415 DT.95360079 DT.100785095 DT.97772304 DT.100785094 24/110 AceView cDNA sequences (see all 110): BM685927 CR604606 AI696291 CB068818 BE382680 CR618697 AW261897 BM704982 BG033395 BF970208 BU734570 AA307302 BM724029 BM663470 BU190005 AI289448 BP870746 BC014661 BG685157 BQ221045 AK022510 BM847867 BG325487 BG763053
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for C12orf43 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|
|
| SP1: | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | - | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for C12orf43
|
Expression
for C12orf43 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| C12orf43 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCGAGACCCC
About this image
See C12orf43 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C12orf43
SOURCE GeneReport for Unigene cluster: Hs.528671
SABiosciences Custom PCR Arrays for C12orf43
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C12orf43
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C12orf43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C12orf43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C12orf43 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C12orf43 |
Orthologs
for C12orf43 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for C12orf43 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for C12orf43 (if available)
TreeFam Gene Tree for C12orf43 (if available) |
Paralogs
for C12orf43 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for C12orf43 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for C12orf43 (121440243 - 121454305 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C12orf43
1 CNV: 3899 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C12orf43 |
|
Disorders
/ Diseases
for C12orf43 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 C12orf43 for disorders About MalaCards
C12orf43 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: C12orf43 (2 documents)
Export disorders for C12orf43 gene to outside databases
|
Publications
for C12orf43 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for C12orf43 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with C12orf43) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1, 3 Yu W.... Gibbs R.A. (1997)
- A "double adaptor" method for improved shotgun library construction. (PubMed id 8619474)1, 3 Andersson B.... Gibbs R.A. (1996)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genome-wide YFP fluorescence complementation screen id entifies new regulators for telomere signaling in human cells. (PubMed id 21044950)1 Lee O.H....Songyang Z. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Genomics meets glycomics-the first GWAS study of huma n N-Glycome identifies HNF1I+ as a master regulator of plasma protein fucosylati on. (PubMed id 21203500)1 Lauc G....Rudan I. (2010)
- New susceptibility locus for coronary artery disease on chromosome 3q22.3. (PubMed id 19198612)1 Erdmann J....Schunkert H. (2009)
|
External Searches for C12orf43 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing C12orf43 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing C12orf43 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing C12orf43 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for C12orf43 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for C12orf43 gene:
Search GeneIP for patents involving C12orf43
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for C12orf43 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for C12orf43 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C12orf43 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for C12orf43 | | | OriGene Protein Over-expression Lysate for C12orf43 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for C12orf43 | | OriGene 3'-UTR Clone for C12orf43 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf43 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for C12orf43 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for C12orf43 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C12orf43 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C12orf43 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C12orf43 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C12orf43 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C12orf43 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C12orf43 |
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 | | | C12orf43 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C12orf43 |
|  |  |  | | | | Search ThermoFisher Antibodies for C12orf43 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C12orf43 |
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