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Aliases for C12orf43 Gene

Aliases for C12orf43 Gene

  • Chromosome 12 Open Reading Frame 43 2 3

External Ids for C12orf43 Gene

Previous GeneCards Identifiers for C12orf43 Gene

  • GC12M119904
  • GC12M121440
  • GC12M118449

Summaries for C12orf43 Gene

GeneCards Summary for C12orf43 Gene

C12orf43 (Chromosome 12 Open Reading Frame 43) is a Protein Coding gene.

Gene Wiki entry for C12orf43 Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf43 Gene

Genomics for C12orf43 Gene

Regulatory Elements for C12orf43 Gene

Genomic Location for C12orf43 Gene

121,000,486 bp from pter
121,016,502 bp from pter
16,017 bases
Minus strand

Genomic View for C12orf43 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C12orf43 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf43 Gene

Proteins for C12orf43 Gene

  • Protein details for C12orf43 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C12orf43
    Protein Accession:
    Secondary Accessions:
    • Q53HF0
    • Q9H9Z7

    Protein attributes for C12orf43 Gene

    262 amino acids
    Molecular mass:
    28171 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C12orf43 Gene

Proteomics data for C12orf43 Gene at MOPED

Post-translational modifications for C12orf43 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C12orf43 Gene

Domains & Families for C12orf43 Gene

Protein Domains for C12orf43 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C12orf43: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C12orf43 Gene

Function for C12orf43 Gene

genes like me logo Genes that share phenotypes with C12orf43: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C12orf43 Gene

Localization for C12orf43 Gene

Subcellular locations from

Jensen Localization Image for C12orf43 Gene COMPARTMENTS Subcellular localization image for C12orf43 gene
Compartment Confidence
nucleus 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C12orf43 Gene

Pathways & Interactions for C12orf43 Gene

SuperPathways for C12orf43 Gene

No Data Available

Interacting Proteins for C12orf43 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000288757 for C12orf43 Gene via STRING

Gene Ontology (GO) - Biological Process for C12orf43 Gene


No data available for Pathways by source and SIGNOR curated interactions for C12orf43 Gene

Drugs & Compounds for C12orf43 Gene

No Compound Related Data Available

Transcripts for C12orf43 Gene

Unigene Clusters for C12orf43 Gene

Chromosome 12 open reading frame 43:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf43 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - - -
SP6: - -

Relevant External Links for C12orf43 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C12orf43 Gene

mRNA expression in normal human tissues for C12orf43 Gene

Protein differential expression in normal tissues from HIPED for C12orf43 Gene

This gene is overexpressed in Lung (28.8), Pancreas (13.5), and CD8 Tcells (12.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C12orf43 Gene

SOURCE GeneReport for Unigene cluster for C12orf43 Gene Hs.528671

genes like me logo Genes that share expression patterns with C12orf43: view

Protein tissue co-expression partners for C12orf43 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C12orf43 Gene

Orthologs for C12orf43 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C12orf43 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C17H12orf43 35
  • 77.07 (n)
  • 70.51 (a)
C12orf43 36
  • 72 (a)
(Canis familiaris)
Mammalia C26H12orf43 35
  • 76.59 (n)
  • 70.99 (a)
OASL2 36
  • 72 (a)
(Mus musculus)
Mammalia 2210016L21Rik 35
  • 72.46 (n)
  • 67.19 (a)
2210016L21Rik 16
2210016L21Rik 36
  • 66 (a)
(Pan troglodytes)
Mammalia C12H12orf43 35
  • 99.62 (n)
  • 100 (a)
C12ORF43 36
  • 100 (a)
(Rattus norvegicus)
Mammalia RGD1311899 35
  • 73.33 (n)
  • 67.06 (a)
(Monodelphis domestica)
Mammalia C12orf43 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia C12orf43 36
  • 45 (a)
(Gallus gallus)
Aves C12orf43 36
  • 48 (a)
(Danio rerio)
Actinopterygii C8H12orf43 36
  • 36 (a)
Species with no ortholog for C12orf43:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C12orf43 Gene

Gene Tree for C12orf43 (if available)
Gene Tree for C12orf43 (if available)

Paralogs for C12orf43 Gene

No data available for Paralogs for C12orf43 Gene

Variants for C12orf43 Gene

Sequence variations from dbSNP and Humsavar for C12orf43 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1169279 -- 121,018,070(-) atgga(A/G)tcact upstream-variant-2KB
rs1169280 -- 121,017,735(-) TTTTA(C/T)GGTGT upstream-variant-2KB
rs1169281 -- 121,017,103(-) ggtct(C/T)gaact upstream-variant-2KB
rs1169312 -- 121,003,658(+) TCTGT(G/T)AAGTC utr-variant-3-prime, nc-transcript-variant
rs1169313 -- 121,004,867(+) GCTCA(A/C/T)GATTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C12orf43 Gene

Variant ID Type Subtype PubMed ID
nsv521928 CNV Gain 19592680
nsv899559 CNV Gain 21882294
dgv1496n71 CNV Gain 21882294
dgv529e1 CNV Complex 17122850
nsv832531 CNV Gain 17160897

Variation tolerance for C12orf43 Gene

Residual Variation Intolerance Score: 53.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C12orf43 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf43 Gene

Disorders for C12orf43 Gene

Relevant External Links for C12orf43

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with C12orf43: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf43 Gene

Publications for C12orf43 Gene

  1. Large-scale concatenation cDNA sequencing. (PMID: 9110174) Yu W. … Gibbs R.A. (Genome Res. 1997) 2 67
  2. A "double adaptor" method for improved shotgun library construction. (PMID: 8619474) Andersson B. … Gibbs R.A. (Anal. Biochem. 1996) 2 67
  3. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre R.N. … Friedlander Y. (J. Lipid Res. 2015) 67
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  5. New variants including ARG1 polymorphisms associated with C-reactive protein levels identified by genome-wide association and pathway analysis. (PMID: 24763700) Vinayagamoorthy N. … Chung Y.J. (PLoS ONE 2014) 67

Products for C12orf43 Gene

Sources for C12orf43 Gene

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