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Aliases for C12orf10 Gene

Aliases for C12orf10 Gene

  • Chromosome 12 Open Reading Frame 10 2 3 5
  • Melanocyte Proliferating Gene 1 2 3
  • Melanocyte Related Gene 2
  • Melanocyte Related 3
  • MSTP024 3
  • MST024 3
  • Gamm1 3
  • MYG1 3
  • MYG 3

External Ids for C12orf10 Gene

Previous GeneCards Identifiers for C12orf10 Gene

  • GC12M054008
  • GC12M053803
  • GC12P053411
  • GC12P051979
  • GC12P053693
  • GC12P050734

Summaries for C12orf10 Gene

GeneCards Summary for C12orf10 Gene

C12orf10 (Chromosome 12 Open Reading Frame 10) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C12orf10 Gene

Genomics for C12orf10 Gene

Regulatory Elements for C12orf10 Gene

Promoters for C12orf10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C12orf10 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the C12orf10 gene promoter:

Genomic Location for C12orf10 Gene

Chromosome:
12
Start:
53,299,686 bp from pter
End:
53,307,181 bp from pter
Size:
7,496 bases
Orientation:
Plus strand

Genomic View for C12orf10 Gene

Genes around C12orf10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C12orf10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C12orf10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C12orf10 Gene

Proteins for C12orf10 Gene

  • Protein details for C12orf10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9HB07-MYG1_HUMAN
    Recommended name:
    UPF0160 protein MYG1, mitochondrial
    Protein Accession:
    Q9HB07

    Protein attributes for C12orf10 Gene

    Size:
    376 amino acids
    Molecular mass:
    42449 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C12orf10 Gene

Proteomics data for C12orf10 Gene at MOPED

Post-translational modifications for C12orf10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C12orf10 Gene

No data available for DME Specific Peptides for C12orf10 Gene

Domains & Families for C12orf10 Gene

Protein Domains for C12orf10 Gene

Graphical View of Domain Structure for InterPro Entry

Q9HB07

UniProtKB/Swiss-Prot:

MYG1_HUMAN :
  • Belongs to the UPF0160 (MYG1) family.
Family:
  • Belongs to the UPF0160 (MYG1) family.
genes like me logo Genes that share domains with C12orf10: view

No data available for Gene Families for C12orf10 Gene

Function for C12orf10 Gene

genes like me logo Genes that share phenotypes with C12orf10: view

Animal Models for C12orf10 Gene

MGI Knock Outs for C12orf10:

Animal Model Products

CRISPR Products

miRNA for C12orf10 Gene

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C12orf10 Gene

Localization for C12orf10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C12orf10 Gene

Nucleus. Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C12orf10 Gene COMPARTMENTS Subcellular localization image for C12orf10 gene
Compartment Confidence
extracellular 5
mitochondrion 5
nucleus 5
chloroplast 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for C12orf10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with C12orf10: view

Pathways & Interactions for C12orf10 Gene

SuperPathways for C12orf10 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C12orf10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035641 locomotory exploration behavior IEA --
genes like me logo Genes that share ontologies with C12orf10: view

No data available for Pathways by source and SIGNOR curated interactions for C12orf10 Gene

Drugs & Compounds for C12orf10 Gene

No Compound Related Data Available

Transcripts for C12orf10 Gene

Unigene Clusters for C12orf10 Gene

Chromosome 12 open reading frame 10:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C12orf10 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b
SP1: - - - - -
SP2: - - - - - -
SP3: - - - -
SP4: - - - -
SP5: -
SP6: -
SP7: - - - - - -
SP8:

Relevant External Links for C12orf10 Gene

GeneLoc Exon Structure for
C12orf10
ECgene alternative splicing isoforms for
C12orf10

Expression for C12orf10 Gene

mRNA expression in normal human tissues for C12orf10 Gene

Protein differential expression in normal tissues from HIPED for C12orf10 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C12orf10 Gene



SOURCE GeneReport for Unigene cluster for C12orf10 Gene Hs.655988

mRNA Expression by UniProt/SwissProt for C12orf10 Gene

Q9HB07-MYG1_HUMAN
Tissue specificity: Ubiquitously expressed, with highest levels in testis.
genes like me logo Genes that share expression patterns with C12orf10: view

Protein tissue co-expression partners for C12orf10 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for C12orf10 Gene

Orthologs for C12orf10 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for C12orf10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C5H12orf10 35
  • 86.99 (n)
  • 88.62 (a)
C5H12orf10 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C27H12orf10 35
  • 88.99 (n)
  • 91.3 (a)
C12orf10 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Myg1 35
  • 86.94 (n)
  • 88.38 (a)
mouse
(Mus musculus)
Mammalia Myg1 16
Myg1 36
  • 85 (a)
OneToOne
Myg1 35
  • 85.51 (n)
  • 88.04 (a)
chimpanzee
(Pan troglodytes)
Mammalia C12orf10 36
  • 99 (a)
OneToOne
C12H12orf10 35
  • 99.38 (n)
  • 99.2 (a)
chicken
(Gallus gallus)
Aves C12ORF10 35
  • 66.89 (n)
  • 69.15 (a)
lizard
(Anolis carolinensis)
Reptilia C12orf10 36
  • 66 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c12orf10 35
  • 63.73 (n)
  • 67.35 (a)
Str.20255 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.24401 35
zebrafish
(Danio rerio)
Actinopterygii wufa14e09 35
zgc:136866 35
  • 60.62 (n)
  • 59.63 (a)
C11H12orf10 36
  • 53 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4414 35
fruit fly
(Drosophila melanogaster)
Insecta CG11980 37
  • 41 (a)
CG11980 35
  • 51.78 (n)
  • 44.95 (a)
CG11980 36
  • 41 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002408 35
  • 53.59 (n)
  • 48.5 (a)
worm
(Caenorhabditis elegans)
Secernentea C27H6.8 35
  • 53.06 (n)
  • 49.05 (a)
C27H6.8 36
  • 45 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGR145C 35
  • 54.54 (n)
  • 46.75 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11671g 35
  • 48.46 (n)
  • 46.91 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YER156C 35
  • 52.15 (n)
  • 45.71 (a)
-- 36
  • 43 (a)
OneToOne
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G41970 35
  • 54.71 (n)
  • 52.06 (a)
rice
(Oryza sativa)
Liliopsida Os.47398 35
Os02g0686600 35
  • 54.88 (n)
  • 52.87 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.7612 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4262 35
bread mold
(Neurospora crassa)
Ascomycetes NCU03859 35
  • 57.64 (n)
  • 52.23 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPAC694.04c 35
  • 51.53 (n)
  • 50.33 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
CSA.2613 36
  • 49 (a)
OneToMany
Species with no ortholog for C12orf10:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for C12orf10 Gene

ENSEMBL:
Gene Tree for C12orf10 (if available)
TreeFam:
Gene Tree for C12orf10 (if available)

Paralogs for C12orf10 Gene

(1) SIMAP similar genes for C12orf10 Gene using alignment to 6 proteins:

Pseudogenes.org Pseudogenes for C12orf10 Gene

genes like me logo Genes that share paralogs with C12orf10: view

No data available for Paralogs for C12orf10 Gene

Variants for C12orf10 Gene

Sequence variations from dbSNP and Humsavar for C12orf10 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
VAR_059854 -
rs1045181 -- 53,306,922(+) GAGAA(A/C/G)GCTGC intron-variant
rs1801674 -- 53,306,812(-) CCACT(G/T)TCCAG reference, missense
rs2030901 -- 53,304,349(+) GGCAC(A/G)ATCTC intron-variant
rs2279025 -- 53,305,709(+) GTGAT(C/G)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C12orf10 Gene

Variant ID Type Subtype PubMed ID
nsv517066 CNV Loss 19592680

Variation tolerance for C12orf10 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.80; 33.98% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C12orf10 Gene

HapMap Linkage Disequilibrium report
C12orf10
Human Gene Mutation Database (HGMD)
C12orf10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C12orf10 Gene

Disorders for C12orf10 Gene

Relevant External Links for C12orf10

Human Genome Epidemiology (HuGE) Navigator
C12orf10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C12orf10

No disorders were found for C12orf10 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C12orf10 Gene

Publications for C12orf10 Gene

  1. Characterization of MYG1 gene and protein: subcellular distribution and function. (PMID: 19014353) Philips M.-A. … Nielsen F.C. (Biol. Cell 2009) 3 4 23 67
  2. Promoter polymorphism -119C/G in MYG1 (C12orf10) gene is related to vitiligo susceptibility and Arg4Gln affects mitochondrial entrance of Myg1. (PMID: 20377893) Philips M.A. … KA/ks S. (BMC Med. Genet. 2010) 3 23
  3. MYG1, novel melanocyte related gene, has elevated expression in vitiligo. (PMID: 16996721) Kingo K. … KA/ks S. (J. Dermatol. Sci. 2006) 2 3
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3

Products for C12orf10 Gene

Sources for C12orf10 Gene

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