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C11orf95 Gene

protein-coding   GIFtS: 38
GCID: GC11M063527          (predicted)

Chromosome 11 Open Reading Frame 95

  See C11orf95-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 11 Open Reading Frame 951 2
Uncharacterized Protein C11orf952

External Ids:    HGNC: 284491   Entrez Gene: 659982   Ensembl: ENSG000001880707   OMIM: 6156995   UniProtKB: C9JLR93   

Export aliases for C11orf95 gene to outside databases

Previous GC identifers: GC11M063285 GC11M059857


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C11orf95 Gene:
C11orf95 (chromosome 11 open reading frame 95) is a protein-coding gene. Diseases associated with C11orf95 include ependymoma, and chondroid lipoma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for C11orf95
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C11orf95

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C11orf95


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13

C11orf95 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf95 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M063527:  view genomic region     (about GC identifiers)

Start:
63,527,364 bp from pter      End:
63,536,113 bp from pter
Size:
8,750 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CK095_HUMAN, C9JLR9 (See protein sequence)
Recommended Name: Uncharacterized protein C11orf95  
Size: 678 amino acids; 73197 Da
Sequence caution: Sequence=BAE46893.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: A6NLS7 Q3C1V4

Explore the universe of human proteins at neXtProt for C11orf95: NX_C9JLR9

Explore proteomics data for C11orf95 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C11orf95 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001138408.1  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR015880 Znf_C2H2-like

    Graphical View of Domain Structure for InterPro Entry C9JLR9

    ProtoNet protein and cluster: C9JLR9


    Find genes that share domains with C11orf95           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C11orf95
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C11orf95
    Interactions:

        Search GeneGlobe Interaction Network for C11orf95

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C11orf95 (CK095)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C11orf95 gene: 
    NM_001144936.1  

    Unigene Cluster for C11orf95:

    Chromosome 11 open reading frame 95
    Hs.191073  [show with all ESTs]
    Unigene Representative Sequence: NM_001144936
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000338498(lincRNA) ENST00000458348(lincRNA) ENST00000445014(lincRNA) ENST00000433688(lincRNA)(uc001nxs.3 uc010rmv.2)

    miRNA
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    hsa-miR-548j hsa-miR-607 hsa-miR-642a hsa-miR-520e hsa-miR-188-5p hsa-miR-4272 hsa-miR-106a hsa-miR-200a
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    Additional mRNA sequence: 

    AB231750.1 AB231752.1 AK096306.1 BC000572.2 BC021866.1 BC033262.1 BC065479.1 

    9 DOTS entries:

    DT.446077  DT.120741071  DT.120741114  DT.92052134  DT.70104627  DT.91821576  DT.40284721  DT.99932426 
    DT.100774581 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C11orf95 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACTTAGTG
    C11orf95 Expression
    About this image


    C11orf95 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    C11orf95 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C11orf95 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.191073
        Custom PCR Arrays for C11orf95
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf95

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for C11orf95 gene from Selected species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia 2700081O15Rik1 , 5 RIKEN cDNA 2700081O15 gene1, 5 88.18(n)1
    87.48(a)1
      19 (5.32 cM)5
    1088991  NM_175381.61  NP_780590.31 
     74176255 


    ENSEMBL Gene Tree for C11orf95 (if available)
    TreeFam Gene Tree for C11orf95 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C11orf95 (see all 145)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1884120651,2
    --63527893(+) TTTTTA/TAAATG 1 -- ut310--------
    rs1174608751,2
    F--63527924(+) AAATAC/GGCATA 1 -- ut311Minor allele frequency- G:0.01EA 120
    rs1818439141,2
    --63528143(+) AGGCCA/GTAACT 1 -- ut310--------
    rs778878071,2
    C,F--63528150(+) AACTTC/TCATCA 1 -- ut311Minor allele frequency- T:0.05NA 120
    rs745468151,2
    C,F--63528207(+) GTGCCC/TGGCAC 1 -- ut311Minor allele frequency- T:0.02WA 118
    rs1872951451,2
    --63528304(+) CCCAAG/TAATTT 1 -- ut310--------
    rs1916814401,2
    --63528398(+) GTAAAG/TATGTC 1 -- ut310--------
    rs1834695151,2
    --63528410(+) ACTCTC/GCTGAG 1 -- ut310--------
    rs1863116081,2
    C--63528436(+) CGGAGA/C/GGGGGG 2 -- ut310--------
    rs785461431,2
    C,F--63528440(+) GGGGGG/TGGAAT 1 -- ut313Minor allele frequency- T:0.13NA CSA 124

    HapMap Linkage Disequilibrium report for C11orf95 (63527364 - 63536113 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for C11orf95:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv24244CNV Loss19812545
    nsv832183CNV Loss17160897
    esv33170CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing C11orf95
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 615699    OMIM disorders: --

    2 diseases for C11orf95:    
    About MalaCards
    ependymoma    chondroid lipoma

    3 diseases from the University of Copenhagen DISEASES database for C11orf95:
    Lipoma     Extraskeletal myxoid chondrosarcoma     Liposarcoma

    Find genes that share disorders with C11orf95           About GenesLikeMe


    Export disorders for C11orf95 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C11orf95 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with C11orf95)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. (PubMed id 20607705)1, 3 Huang D....Bridge J.A. (amp 2010)
    2. Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases. (PubMed id 23672313)1 Flucke U....Mentzel T. (Histopathology 2013)
    3. Contributions of cytogenetics and molecular cytogenetics to the diagnosis of adipocytic tumors. (PubMed id 21274402)1 Nishio J. (amp 2011)
    4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (Nature 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 65998 HGNC: 28449 Ensembl:ENSG00000188070 euGenes: HUgn65998 ECgene: C11orf95
    H-InvDB: C11orf95

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C11orf95 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C11orf95 gene:
    Search GeneIP for patents involving C11orf95

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse SwitchGear 3'UTR luciferase reporter plasmids for C11orf95
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     Search ThermoFisher Antibodies for C11orf95
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat C11orf95
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C11orf95
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     LSBio Antibodies in human, mouse, rat for C11orf95
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     Search Addgene for plasmids for C11orf95
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    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

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