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Aliases for C11orf95 Gene

Aliases for C11orf95 Gene

  • Chromosome 11 Open Reading Frame 95 2 3 5

External Ids for C11orf95 Gene

Previous GeneCards Identifiers for C11orf95 Gene

  • GC11M063285
  • GC11M063527
  • GC11M059857

Summaries for C11orf95 Gene

GeneCards Summary for C11orf95 Gene

C11orf95 (Chromosome 11 Open Reading Frame 95) is a Protein Coding gene. Diseases associated with C11orf95 include Ependymoma and Chondroid Lipoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf95 Gene

Genomics for C11orf95 Gene

Regulatory Elements for C11orf95 Gene

Enhancers for C11orf95 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F064183 1.4 FANTOM5 ENCODE 11.4 -416.9 -416899 4.4 PKNOX1 ARNT CREB3L1 MLX WRNIP1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 C11orf84 TRPT1 IMMP1LP1 ENSG00000269038 FERMT3 C11orf95 ENSG00000257086 PLCB3 ENSG00000256341 SNX15
GH11F064501 1.2 ENCODE 10.1 -733.4 -733446 1.9 HDGF PKNOX1 ARNT CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 C11orf84 ENSG00000237410 NEAT1 NRXN2 SLC22A11 SLC22A12 MIR1237 LOC100996455 C11orf95 FAU
GH11F064267 1.2 ENCODE 10.1 -501.9 -501925 7.2 HDGF PKNOX1 CREB3L1 WRNIP1 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF143 ZFPL1 TRMT112 PLCB3 POLA2 LOC102723878 FAU MRPL49 TRPT1 ENSG00000257086 C11orf84
GH11F063760 1.1 ENCODE 0.8 +3.3 3315 9.8 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 FOS ATL3 TRMT112 RTN3 C11orf95 GC11M063761
GH11F063778 0.5 ENCODE 0.4 -10.2 -10238 1.0 GATA3 NRF1 CEBPB C11orf84 RNU6-1306P C11orf95 RN7SL596P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C11orf95 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf95 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001570734 75 3001 ATF1 SIN3A ZNF48 YY1 ZNF766 GLIS2 GATA2 ZNF143 KLF13 SP3
ENSR00001769129 1875 201 GATAD2A ZFP69B KLF1 ZNF692 SAP130 SP5 ARID4B SMAD4

Genomic Location for C11orf95 Gene

Chromosome:
11
Start:
63,759,892 bp from pter
End:
63,768,775 bp from pter
Size:
8,884 bases
Orientation:
Minus strand

Genomic View for C11orf95 Gene

Genes around C11orf95 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf95 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf95 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf95 Gene

Proteins for C11orf95 Gene

  • Protein details for C11orf95 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9JLR9-CK095_HUMAN
    Recommended name:
    Uncharacterized protein C11orf95
    Protein Accession:
    C9JLR9
    Secondary Accessions:
    • A6NLS7
    • Q3C1V4

    Protein attributes for C11orf95 Gene

    Size:
    678 amino acids
    Molecular mass:
    73197 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAE46893.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

neXtProt entry for C11orf95 Gene

Post-translational modifications for C11orf95 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf95 Gene

No data available for DME Specific Peptides for C11orf95 Gene

Domains & Families for C11orf95 Gene

Protein Domains for C11orf95 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf95: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C11orf95 Gene

Function for C11orf95 Gene

Phenotypes for C11orf95 Gene

GenomeRNAi human phenotypes for C11orf95:
genes like me logo Genes that share phenotypes with C11orf95: view

Animal Model Products

miRNA for C11orf95 Gene

miRTarBase miRNAs that target C11orf95

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf95 Gene

Localization for C11orf95 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for C11orf95 Gene

Pathways & Interactions for C11orf95 Gene

SuperPathways for C11orf95 Gene

No Data Available

Interacting Proteins for C11orf95 Gene

Gene Ontology (GO) - Biological Process for C11orf95 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf95 Gene

Transcripts for C11orf95 Gene

mRNA/cDNA for C11orf95 Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C11orf95 Gene

Chromosome 11 open reading frame 95:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf95 Gene

No ASD Table

Relevant External Links for C11orf95 Gene

GeneLoc Exon Structure for
C11orf95
ECgene alternative splicing isoforms for
C11orf95

Expression for C11orf95 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C11orf95 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C11orf95 Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C11orf95 Gene



Protein tissue co-expression partners for C11orf95 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C11orf95 Gene:

C11orf95

SOURCE GeneReport for Unigene cluster for C11orf95 Gene:

Hs.191073
genes like me logo Genes that share expression patterns with C11orf95: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C11orf95 Gene

Orthologs for C11orf95 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C11orf95 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf95 34
  • 97.92 (n)
cow
(Bos Taurus)
Mammalia C29H11orf95 34
  • 91.36 (n)
dog
(Canis familiaris)
Mammalia C18H11orf95 34
  • 88.51 (n)
mouse
(Mus musculus)
Mammalia 2700081O15Rik 34 16
  • 88.18 (n)
rat
(Rattus norvegicus)
Mammalia RGD1560108 34
  • 87.98 (n)
Species where no ortholog for C11orf95 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C11orf95 Gene

ENSEMBL:
Gene Tree for C11orf95 (if available)
TreeFam:
Gene Tree for C11orf95 (if available)

Paralogs for C11orf95 Gene

No data available for Paralogs for C11orf95 Gene

Variants for C11orf95 Gene

Sequence variations from dbSNP and Humsavar for C11orf95 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1059708 -- 63,759,636(+) ACCTT(C/T)TGCAG nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1059763 -- 63,759,813(+) GTAGC(A/C)CCTAA nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs111546471 -- 63,770,145(+) GGAAA(C/T)CTGTC upstream-variant-2KB
rs111714159 -- 63,767,269(+) TCATT(C/G)TCCCA intron-variant
rs112074795 -- 63,769,639(+) GGCAC(C/G)TGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for C11orf95 Gene

Variant ID Type Subtype PubMed ID
nsv975941 CNV duplication 23825009
nsv832183 CNV loss 17160897
nsv555180 CNV loss 21841781
nsv1143684 CNV deletion 24896259
nsv1136128 CNV deletion 24896259
nsv1070464 CNV deletion 25765185
esv33170 CNV gain 17666407
esv24244 CNV loss 19812545

Relevant External Links for C11orf95 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf95

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for C11orf95 Gene

Disorders for C11orf95 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C11orf95 Gene - From: Orphanet and GeneCards

Disorder Aliases PubMed IDs
ependymoma
  • cellular ependymoma
chondroid lipoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

CK095_HUMAN
  • Note=A chromosomal aberration involving MKL2 is found in 3 chondroid lipomas. Translocation t(11;16)(q13;p13) with MKL2 produces a C11orf95-MKL2 fusion protein (PubMed:20607705). {ECO:0000269 PubMed:20607705}.
  • Note=A chromosomal aberration involving RELA is found in more than two-thirds of supratentorial ependymomas. Translocation with RELA produces a C11orf95-RELA fusion protein. C11orf95-RELA translocations are potent oncogenes that probably transform neural stem cells by driving an aberrant NF-kappa-B transcription program (PubMed:24553141). {ECO:0000269 PubMed:24553141}.

Relevant External Links for C11orf95

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C11orf95
genes like me logo Genes that share disorders with C11orf95: view

No data available for Genatlas for C11orf95 Gene

Publications for C11orf95 Gene

  1. C11orf95-MKL2 is the resulting fusion oncogene of t(11;16)(q13;p13) in chondroid lipoma. (PMID: 20607705) Huang D. … Bridge J.A. (Genes Chromosomes Cancer 2010) 2 3 4 64
  2. Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-I_B signaling pathway. (PMID: 24562983) Pietsch T. … Klein-Hitpass L. (Acta Neuropathol. 2014) 3 64
  3. C11orf95-RELA fusions drive oncogenic NF-kappaB signalling in ependymoma. (PMID: 24553141) Parker M. … Gilbertson R.J. (Nature 2014) 4 64
  4. C11orf95-RELA fusion present in a primary supratentorial ependymoma and recurrent sarcoma. (PMID: 25388523) Cachia D. … Aldape K.D. (Brain Tumor Pathol 2014) 3 64
  5. Presence of C11orf95-MKL2 fusion is a consistent finding in chondroid lipomas: a study of eight cases. (PMID: 23672313) Flucke U. … Mentzel T. (Histopathology 2013) 3 64

Products for C11orf95 Gene

Sources for C11orf95 Gene

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