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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C11orf95 Gene

protein-coding GIFtS: 36
GCID: GC11M063527 (predicted)

chromosome 11 open reading frame 95

Explore 3 diseases affiliated with
C11orf95 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 11 Open Reading Frame 95¹ ²
MGC3032¹
Uncharacterized Protein C11orf95²

External Ids:	HGNC: 28449¹	Entrez Gene: 65998²	Ensembl: ENSG00000188070⁷	UniProtKB: C9JLR9³

Export aliases for C11orf95 gene to outside databases

Previous GC identifers: GC11M063285 GC11M059857

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for C11orf95
Other transcription factors

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf95

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13

C11orf95 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf95 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M063527: view genomic region (about GC identifiers)

Start:	63,527,364 bp from pter	End:	63,536,113 bp from pter
Size:	8,750 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CK095_HUMAN, C9JLR9 (See protein sequence)

Recommended Name: Uncharacterized protein C11orf95

Size: 678 amino acids; 73197 Da

Sequence caution: Sequence=BAE46893.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;

Secondary accessions: A6NLS7 Q3C1V4

Explore the universe of human proteins at neXtProt for C11orf95: NX_C9JLR9

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_C9JLR9

C11orf95 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001138408.1
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--

C11orf95 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C11orf95 for domains About GeneDecksing

1 InterPro domain/family:

IPR015880 Znf_C2H2-like

Graphical View of Domain Structure for InterPro Entry C9JLR9

ProtoNet protein and cluster: C9JLR9

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008270	zinc ion binding	IEA	--

C11orf95 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C11orf95

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

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Search CenterWatch for drugs/clinical trials and news about C11orf95 / CK095

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for C11orf95 gene:

NM_001144936.1

Unigene Cluster for C11orf95:

Chromosome 11 open reading frame 95

Hs.191073 [show with all ESTs]

Unigene Representative Sequence: NM_001144936

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000539233 ENST00000338498 ENST00000458348 ENST00000445014 ENST00000433688(uc001nxs.3 uc010rmv.2)

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Additional cDNA sequence:

AB231750.1 AB231752.1 AK096306.1 BC000572.2 BC021866.1 BC033262.1 BC065479.1

9 DOTS entries:

DT.446077 DT.120741071 DT.120741114 DT.92052134 DT.70104627 DT.91821576 DT.40284721 DT.99932426

DT.100774581

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C11orf95 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTACTTAGTG

About this image

C11orf95 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Neural Tube

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C11orf95 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C11orf95

SOURCE GeneReport for Unigene cluster: Hs.191073

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C11orf95 gene from 2/5 species (see all 5) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	2700081O15Rik^{1 , 5}	RIKEN cDNA 2700081O15 gene^{1, 5}	89.67(n)¹ 90.01(a)¹		19 (5.32 cM)⁵ 108899¹ NM_175381.6¹ NP_780590.3¹ 7417625⁵
zebrafish (Danio rerio)	Actinopterygii	LOC793997¹	uncharacterized protein C11orf95 homolog	51.41(n) 41.33(a)		793997 XM_001333840.3 XP_001333876.2

ENSEMBL Gene Tree for C11orf95 (if available)
TreeFam Gene Tree for C11orf95 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs188412065^1,2		--	63527893(+)	`TTTTTA/TAAATG`	1	--	ut3¹		0	--	--	--	--
rs117460875^1,2		--	63527924(+)	`AAATAC/GGCATA`	1	--	ut3¹		1		EA	120
rs181843914^1,2		--	63528143(+)	`AGGCCA/GTAACT`	1	--	ut3¹		0	--	--	--	--
rs77887807^1,2	C,F,	--	63528150(+)	`NNNNTC/TCATCA`	1	--	ut3¹		1		NA	120
rs74546815^1,2	C,F,	--	63528207(+)	`GTGCCC/TGGCAC`	1	--	ut3¹		1		WA	118
rs187295145^1,2		--	63528304(+)	`CCCAAG/TAATTT`	1	--	ut3¹		0	--	--	--	--
rs191681440^1,2		--	63528398(+)	`GTAAAG/TATGTC`	1	--	ut3¹		0	--	--	--	--
rs183469515^1,2		--	63528410(+)	`ACTCTC/GCTGAG`	1	--	ut3¹		0	--	--	--	--
rs186311608^1,2		--	63528436(+)	`CGGAGA/GGGGGG`	1	--	ut3¹		0	--	--	--	--
rs78546143^1,2	C,F,	--	63528440(+)	`NNNNGG/TGGAAT`	1	--	ut3¹		3		NA CSA	124

HapMap Linkage Disequilibrium report for C11orf95 (63527364 - 63536113 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for C11orf95
1 CNV: 71338
1 Indel: 11055

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C11orf95 for disorders About GeneDecksing

3 diseases for C11orf95: About MalaCards

chondroid lipoma lipoma liposarcoma

3 diseases from the University of Copenhagen DISEASES database for C11orf95:

Lipoma Extraskeletal myxoid chondrosarcoma Liposarcoma

Export disorders for C11orf95 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C11orf95 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C11orf95)

Utopia: connect your pdf to the dynamic
world of online information

C11orf95-MKL2 is the resulting fusion oncogene of t(1 1;16)(q13;p13) in chondroid lipoma. (PubMed id 20607705)^{1, 3} Huang D....Bridge J.A. (2010)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 65998	HGNC: 28449	Ensembl:ENSG00000188070	euGenes: HUgn65998	ECgene: C11orf95
H-InvDB: C11orf95

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C11orf95	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C11orf95 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C11orf95 gene:
Search GeneIP for patents involving C11orf95

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C11orf95 gene at Home site.

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C11orf95 Gene

chromosome 11 open reading frame 95

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for C11orf95 gene

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C11orf95 Gene

chromosome 11 open reading frame 95

Aliasesfor C11orf95 gene

Summariesfor C11orf95 gene

Genomic Viewsfor C11orf95 gene

Proteinsfor C11orf95 gene

Protein Domains /Familiesfor C11orf95 gene

Functionfor C11orf95 gene

Pathways & Interactionsfor C11orf95 gene

Drugs & Compoundsfor C11orf95 gene

Transcriptsfor C11orf95 gene

Expression for C11orf95 gene

Orthologsfor C11orf95 gene

Paralogsfor C11orf95 gene

Genomic Variantsfor C11orf95 gene

Disorders / Diseasesfor C11orf95 gene

Publicationsfor C11orf95 gene

External Searches for C11orf95 gene

Genome Databases showing C11orf95 gene

Other Databases showing C11orf95 gene

Specialized Databases showing C11orf95 gene

Intellectual Propertyfor C11orf95 gene

Productsfor C11orf95 gene

View Random Gene

Aliases
for C11orf95 gene

Summaries
for C11orf95 gene

Genomic Views
for C11orf95 gene

Proteins
for C11orf95 gene

Protein Domains /
Families
for C11orf95 gene

Function
for C11orf95 gene

Pathways & Interactions
for C11orf95 gene

Drugs & Compounds
for C11orf95 gene

Transcripts
for C11orf95 gene

Expression
for C11orf95 gene

Orthologs
for C11orf95 gene

Paralogs
for C11orf95 gene

Genomic Variants
for C11orf95 gene

Disorders / Diseases
for C11orf95 gene

Publications
for C11orf95 gene

Intellectual Property
for C11orf95 gene

Products
for C11orf95 gene