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Aliases for C11orf88 Gene

Aliases for C11orf88 Gene

  • Chromosome 11 Open Reading Frame 88 2 3 5
  • Hypothetical Gene Supported By BC039505 2

External Ids for C11orf88 Gene

Previous GeneCards Identifiers for C11orf88 Gene

  • GC11P110903
  • GC11P110904
  • GC11P110907
  • GC11P111386
  • GC11P107309
  • GC11P111387
  • GC11P111392
  • GC11P111398
  • GC11P111404
  • GC11P111515
  • GC11P111518
  • GC11P111521
  • GC11P111524

Summaries for C11orf88 Gene

GeneCards Summary for C11orf88 Gene

C11orf88 (Chromosome 11 Open Reading Frame 88) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf88 Gene

Genomics for C11orf88 Gene

Regulatory Elements for C11orf88 Gene

Enhancers for C11orf88 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F111357 1.6 FANTOM5 Ensembl ENCODE 9.2 -149.9 -149881 15.7 HDGF PKNOX1 MLX WRNIP1 ZFP64 ARID4B YBX1 FEZF1 DMAP1 ZNF2 COLCA2 COLCA1 LAYN BTG4 C11orf88 MIR34B MIR34C POU2AF1 MIR4491 RNU2-60P
GH11F111697 1.4 FANTOM5 Ensembl ENCODE 9.7 +184.0 183978 2.6 PKNOX1 ATF1 ARNT CREB3L1 CHAMP1 GATA2 SMARCA5 JUNB CEBPB ZEB2 PPP2R1B BTG4 C11orf88 MIR34B MIR34C SIK2 RN7SKP273 PIR48599
GH11F111445 1.2 Ensembl ENCODE 10 -68.3 -68286 1.4 HDGF ELF3 PKNOX1 WRNIP1 ARID4B ZBTB40 ZNF2 RAD21 EGR1 ZNF366 BTG4 C11orf88 MIR34B MIR34C LAYN ENSG00000254980 DIXDC1 LOC644277 POU2AF1
GH11F111413 1.2 Ensembl ENCODE 9.9 -98.1 -98087 6.6 HDGF ELF3 TBP PKNOX1 TBL1XR1 WRNIP1 ARID4B YBX1 BMI1 RAD21 COLCA1 RNU2-60P COLCA2 BTG4 C11orf88 MIR34B MIR34C LOC100132078 BCO2 GC11M111399
GH11F111776 1.2 Ensembl ENCODE 9.8 +263.1 263095 2.7 HDGF TBP PKNOX1 ATF1 ARID4B SIN3A DMAP1 THRB ZSCAN9 RAD21 PPP2R1B SIK2 LOC644277 POU2AF1 MIR34B MIR34C BTG4 C11orf88 ENSG00000254980 ENSG00000254990
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around C11orf88 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf88 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001772164 15 401 CTCF RFX1 PRDM10 BMI1

Genomic Location for C11orf88 Gene

Chromosome:
11
Start:
111,514,785 bp from pter
End:
111,537,031 bp from pter
Size:
22,247 bases
Orientation:
Plus strand

Genomic View for C11orf88 Gene

Genes around C11orf88 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf88 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf88 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf88 Gene

Proteins for C11orf88 Gene

  • Protein details for C11orf88 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PI97-CK088_HUMAN
    Recommended name:
    UPF0722 protein C11orf88
    Protein Accession:
    Q6PI97
    Secondary Accessions:
    • E9PAN0
    • Q6ZRL3

    Protein attributes for C11orf88 Gene

    Size:
    169 amino acids
    Molecular mass:
    19340 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH39505.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for C11orf88 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C11orf88 Gene

Post-translational modifications for C11orf88 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf88 Gene

No data available for DME Specific Peptides for C11orf88 Gene

Domains & Families for C11orf88 Gene

Protein Domains for C11orf88 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C11orf88 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6PI97

UniProtKB/Swiss-Prot:

CK088_HUMAN :
  • Belongs to the UPF0722 family.
Family:
  • Belongs to the UPF0722 family.
genes like me logo Genes that share domains with C11orf88: view

No data available for Gene Families for C11orf88 Gene

Function for C11orf88 Gene

genes like me logo Genes that share phenotypes with C11orf88: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C11orf88 Gene

Localization for C11orf88 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C11orf88 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf88 Gene

Pathways & Interactions for C11orf88 Gene

SuperPathways for C11orf88 Gene

No Data Available

Interacting Proteins for C11orf88 Gene

Gene Ontology (GO) - Biological Process for C11orf88 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0048741 NOT skeletal muscle fiber development IBA --
genes like me logo Genes that share ontologies with C11orf88: view

No data available for Pathways by source and SIGNOR curated interactions for C11orf88 Gene

Transcripts for C11orf88 Gene

mRNA/cDNA for C11orf88 Gene

Unigene Clusters for C11orf88 Gene

Chromosome 11 open reading frame 88:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf88 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2:

Relevant External Links for C11orf88 Gene

GeneLoc Exon Structure for
C11orf88
ECgene alternative splicing isoforms for
C11orf88

Expression for C11orf88 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C11orf88 Gene

mRNA differential expression in normal tissues according to GTEx for C11orf88 Gene

This gene is overexpressed in Testis (x11.3), Cervix - Endocervix (x6.9), Fallopian Tube (x6.2), Brain - Caudate (basal ganglia) (x6.0), and Brain - Hypothalamus (x5.5).

Protein differential expression in normal tissues from HIPED for C11orf88 Gene

This gene is overexpressed in Blymphocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C11orf88 Gene



Protein tissue co-expression partners for C11orf88 Gene

NURSA nuclear receptor signaling pathways regulating expression of C11orf88 Gene:

C11orf88

SOURCE GeneReport for Unigene cluster for C11orf88 Gene:

Hs.411600
genes like me logo Genes that share expression patterns with C11orf88: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C11orf88 Gene

Orthologs for C11orf88 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf88 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf88 34
  • 98.81 (n)
C11orf88 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C15H11orf88 34
  • 80.26 (n)
C11orf88 35
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C5H11orf88 34
  • 78.44 (n)
C11orf88 35
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4833427G06Rik 34 16 35
  • 76.79 (n)
rat
(Rattus norvegicus)
Mammalia LOC100359479 34
  • 74.27 (n)
oppossum
(Monodelphis domestica)
Mammalia C11orf88 35
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves C11orf88 35
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C5H11orf88 35
  • 38 (a)
OneToOne
Species where no ortholog for C11orf88 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf88 Gene

ENSEMBL:
Gene Tree for C11orf88 (if available)
TreeFam:
Gene Tree for C11orf88 (if available)

Paralogs for C11orf88 Gene

No data available for Paralogs for C11orf88 Gene

Variants for C11orf88 Gene

Sequence variations from dbSNP and Humsavar for C11orf88 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10569744 -- 111,531,302(+) CTCAA(-/TCAAT)TCAAT intron-variant
rs10599570 -- 111,515,220(+) CATAT(-/AA)GTTTC intron-variant
rs111247821 -- 111,514,809(+) AAGAA(C/G)CTAGC reference, missense
rs111406491 -- 111,514,252(+) TAAAG(A/G)ATTCA upstream-variant-2KB
rs111753393 -- 111,530,765(+) CCTTA(C/T)TAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf88 Gene

Variant ID Type Subtype PubMed ID
nsv976515 CNV deletion 23825009
nsv832268 CNV loss 17160897
nsv1119912 CNV deletion 24896259

Variation tolerance for C11orf88 Gene

Residual Variation Intolerance Score: 85.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.24; 52.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf88 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C11orf88

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf88 Gene

Disorders for C11orf88 Gene

Relevant External Links for C11orf88

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C11orf88

No disorders were found for C11orf88 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf88 Gene

Publications for C11orf88 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for C11orf88 Gene

Sources for C11orf88 Gene

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