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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C11orf87 Gene

protein-coding   GIFtS: 37
GCID: GC11P109292

Chromosome 11 Open Reading Frame 87

  Search for C11orf87
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 11 Open Reading Frame 871 2
LOH11CR1A2
Uncharacterized Protein C11orf872

External Ids:    HGNC: 337881   Entrez Gene: 3999472   Ensembl: ENSG000001857427   UniProtKB: Q6NUJ23   

Export aliases for C11orf87 gene to outside databases

Previous GC identifers: GC11P108799 GC11P105218


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C11orf87 Gene: 
C11orf87 (chromosome 11 open reading frame 87) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C11orf87 gene promoter:
         C/EBPbeta   HNF-4alpha2   Nkx2-5   C/EBPalpha   HNF-4alpha1   POU2F1   HSF2   POU2F1a   Cart-1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C11orf87

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf87


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3   Ensembl cytogenetic band:  11q22.3   HGNC cytogenetic band: 11q22.3

C11orf87 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf87 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P109292:  view genomic region     (about GC identifiers)

Start:
109,292,846 bp from pter      End:
109,299,893 bp from pter
Size:
7,048 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CK087_HUMAN, Q6NUJ2 (See protein sequence)
Recommended Name: Uncharacterized protein C11orf87 precursor  
Size: 197 amino acids; 20623 Da
Subcellular location: Membrane; Single-pass type I membrane protein (Potential)
Secondary accessions: B4E169

Explore the universe of human proteins at neXtProt for C11orf87: NX_Q6NUJ2

Explore proteomics data for C11orf87 at MOPED 

C11orf87 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

C11orf87 Protein Expression

REFSEQ proteins: NP_997528.2  
ENSEMBL proteins: 
 ENSP00000331581  

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Cloud-Clone Corp. Proteins for C11orf87 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

C11orf87 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6NUJ2


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for C11orf87:
 Increased gamma-H2AX phosphory 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for C11orf87 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C11orf87

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C11orf87 (CK087)

Search CenterWatch for drugs/clinical trials and news about C11orf87 / CK087

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C11orf87 gene: 
NM_207645.3  

Unigene Cluster for C11orf87:

Chromosome 11 open reading frame 87
Hs.172982  [show with all ESTs]
Unigene Representative Sequence: NM_207645
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000327419(uc010rwb.2)
miRNA
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SwitchGear 3'UTR luciferase reporter plasmidC11orf87 3' UTR sequence
Inhib. RNA
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Additional mRNA sequence: 

AB096240.1 AK091086.1 AK303693.1 BC035798.1 BC068577.1 

2 DOTS entries:

DT.99993323  DT.120694697 

24/37 AceView cDNA sequences (see all 37):

AI753016 CR623612 AI570560 BC035798 BU102027 AK091086 BX428120 AB096240 
T65416 F09412 BX116521 BI917697 N51928 M78723 AI470042 N53742 
BM548498 F11752 BC068577 CK005437 NM_207645 H25216 AA633992 AW896256 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C11orf87 expression in normal human tissues (normalized intensities)      C11orf87 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
C11orf87 Expression
About this image


C11orf87 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/11 selected tissues (see all 11) fully expand
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Postnatal Endothelial Cells Blood Brain Barrier
         Cerebral Cortex
         posterior singulate   
 
 Eye (Sensory Organs)    fully expand to see all 2 entries
         Glycinergic Amacrine Cells Inner Nuclear Layer
 
 Fibroblast
         BH2 Dermal Fibroblasts   
 
 Dermis (Uncategorized)    fully expand to see all 2 entries
         BH2 Dermal Fibroblasts   
 
 Blood Brain Barrier (Nervous System)
         Postnatal Endothelial Cells Blood Brain Barrier

See C11orf87 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C11orf87

SOURCE GeneReport for Unigene cluster: Hs.172982
    SABiosciences Custom PCR Arrays for C11orf87
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf87

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C11orf87 gene from 4/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia AI5934421 , 5 expressed sequence AI5934421, 5 87.93(n)1
88.27(a)1
  9 (29.12 cM)5
3309411  NM_178906.41  NP_849237.21 
 526730445 
chicken
(Gallus gallus)
Aves C1H11orf871 chromosome 1 open reading frame, human C11orf87 75.11(n)
72.08(a)
  418964  XM_417157.3  XP_417157.1 
lizard
(Anolis carolinensis)
Reptilia C11ORF876
Uncharacterized protein
58(a)
1 ↔ 1
3(186102058-186102540)
zebrafish
(Danio rerio)
Actinopterygii wu:fj46d111 wu:fj46d11 66.3(n)
58.7(a)
  795516  XM_001333231.3  XP_001333267.1 


ENSEMBL Gene Tree for C11orf87 (if available)
TreeFam Gene Tree for C11orf87 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/165 SNPs in C11orf87 are shown (see all 165)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1892588281,2
--109290848(+) CCAGGC/TTGGAG 1 -- us2k10--------
rs1813025591,2
--109290951(+) TGCCTC/GTCACC 1 -- us2k10--------
rs1426513951,2
--109290954(+) CTGTCA/CCCATG 1 -- us2k10--------
rs1459487931,2
--109290962(+) ATGCCC/TGGCTT 1 -- us2k10--------
rs2012768591,2
--109290965(+) CCGGC-/TTTT  
        
TTTTA
1 -- us2k10--------
rs108909941,2
C,F,A,H--109290970(+) CTTTTT/ATTTAT 1 -- us2k1 tfbs33Minor allele frequency- A:0.50NA 8
rs1997322061,2
--109290970(+) CTTTT-/ATTTAT 1 -- us2k10--------
rs1858504371,2
--109291002(+) TATTTA/TTTTAT 1 -- us2k10--------
rs1886003341,2
--109291003(+) ATTTAG/TTTATT 1 -- us2k10--------
rs1817137231,2
--109291037(+) CAGGGA/TTTCAC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for C11orf87 (109292846 - 109299893 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for C11orf87: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing C11orf87
DNA2.0 Custom Variant and Variant Library Synthesis for C11orf87

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C11orf87 for disorders           About MalaCards

C11orf87 for disorders           About GeneDecksing

Genetic Association Database (GAD): C11orf87
Human Genome Epidemiology (HuGE) Navigator: C11orf87 (1 document)

Export disorders for C11orf87 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C11orf87 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C11orf87)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  3. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (2007)
  4. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PubMed id 17903300)4 Fox C.S....Atwood L.D. (2007)
  5. Genome-wide association with select biomarker traits in the Framingham Heart Study. (PubMed id 17903293)4 Benjamin E.J....Vasan R.S. (2007)
  6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  7. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
  8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 399947 HGNC: 33788 AceView: LOC399947 Ensembl:ENSG00000185742 euGenes: HUgn399947
ECgene: C11orf87 H-InvDB: C11orf87

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C11orf87 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C11orf87 gene:
Search GeneIP for patents involving C11orf87

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Regulatory tfbs in C11orf87 promoter
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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