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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C11orf87 Gene

protein-coding GIFtS: 37
GCID: GC11P109292

chromosome 11 open reading frame 87

Search for C11orf87
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 11 Open Reading Frame 87¹ ²
LOH11CR1A¹ ²
LOC399947¹
Uncharacterized Protein C11orf87²

External Ids:	HGNC: 33788¹	Entrez Gene: 399947²	Ensembl: ENSG00000185742⁷	UniProtKB: Q6NUJ2³

Export aliases for C11orf87 gene to outside databases

Previous GC identifers: GC11P108799 GC11P105218

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_033899.8

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C11orf87 gene promoter:
C/EBPbeta HNF-4alpha2 Nkx2-5 C/EBPalpha HNF-4alpha1 POU2F1 HSF2 POU2F1a Cart-1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf87

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q22.3 Ensembl cytogenetic band: 11q22.3 HGNC cytogenetic band: 11q22.3

C11orf87 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf87 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P109292: view genomic region (about GC identifiers)

Start:	109,292,846 bp from pter	End:	109,299,893 bp from pter
Size:	7,048 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CK087_HUMAN, Q6NUJ2 (See protein sequence)

Recommended Name: Uncharacterized protein C11orf87 precursor

Size: 197 amino acids; 20623 Da

Subcellular location: Membrane; Single-pass type I membrane protein (Potential)

Secondary accessions: B4E169

Explore the universe of human proteins at neXtProt for C11orf87: NX_Q6NUJ2

C11orf87 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_997528.2

ENSEMBL proteins:

ENSP00000331581

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

C11orf87 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q6NUJ2

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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1 GenomeRNAi human phenotype for C11orf87:

Increased gamma-H2AX phosphory

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C11orf87

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for C11orf87 gene:

NM_207645.3

Unigene Cluster for C11orf87:

Chromosome 11 open reading frame 87

Hs.172982 [show with all ESTs]

Unigene Representative Sequence: NM_207645

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000327419(uc010rwb.2)

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Additional cDNA sequence:

AB096240.1 AK091086.1 AK303693.1 BC035798.1 BC068577.1

2 DOTS entries:

DT.99993323 DT.120694697

24/37 AceView cDNA sequences (see all 37):

CR623612 BC035798 AI570560 AK091086 AI753016 BU102027 F11752 N53742

BX116521 BC068577 N51928 BM548498 NM_207645 T65416 AB096240 M78723

AI470042 BX428120 CK005437 BI917697 F09412 BG152604 AA633992 AW896256

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C11orf87 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

C11orf87 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

GABAergic Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

PureStem™ progenitor U31 (Embryonic Progenitor Cell)

See C11orf87 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C11orf87

SOURCE GeneReport for Unigene cluster: Hs.172982

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C11orf87 gene from 4/8 species (see all 8) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	AI593442^{1 , 5}	expressed sequence AI593442^{1, 5}	87.93(n)¹ 88.27(a)¹		9 (29.12 cM)⁵ 330941¹ NM_178906.4¹ NP_849237.2¹ 52673044⁵
chicken (Gallus gallus)	Aves	C1H11orf87¹	chromosome 1 open reading frame, human C11orf87	75.11(n) 72.08(a)		418964 XM_417157.3 XP_417157.1
lizard (Anolis carolinensis)	Reptilia	C11orf87⁶	--	59(a)	1 ↔ 1	3(186102058-186102540)
zebrafish (Danio rerio)	Actinopterygii	wu:fj46d11¹	wu:fj46d11	66.3(n) 58.7(a)		795516 XM_001333231.3 XP_001333267.1

ENSEMBL Gene Tree for C11orf87 (if available)
TreeFam Gene Tree for C11orf87 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs189258828^1,2		--	109290848(+)	`CCAGGC/TTGGAG`	1	--	us2k¹		0	--	--	--	--
rs181302559^1,2		--	109290951(+)	`TGCCTC/GTCACC`	1	--	us2k¹		0	--	--	--	--
rs142651395^1,2		--	109290954(+)	`CTGTCA/CCCATG`	1	--	us2k¹		0	--	--	--	--
rs145948793^1,2		--	109290962(+)	`ATGCCC/TGGCTT`	1	--	us2k¹		0	--	--	--	--
rs201276859^1,2		--	109290965(+)	`CCGGC-/TTTT TTTTA`	1	--	us2k¹		0	--	--	--	--
rs10890994^1,2	C,F,A,H,	--	109290970(+)	`CTTTTT/ATTTAT`	1	--	us2k¹ tfbs³		3		NA	8
rs199732206^1,2		--	109290970(+)	`CTTTT-/ATTTAT`	1	--	us2k¹		0	--	--	--	--
rs185850437^1,2		--	109291002(+)	`TATTTA/TTTTAT`	1	--	us2k¹		0	--	--	--	--
rs188600334^1,2		--	109291003(+)	`ATTTAG/TTTATT`	1	--	us2k¹		0	--	--	--	--
rs181713723^1,2		--	109291037(+)	`CAGGGA/TTTCAC`	1	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for C11orf87 (109292846 - 109299893 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for C11orf87: --

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C11orf87 for disorders About MalaCards

C11orf87 for disorders About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: C11orf87 (1 document)

Export disorders for C11orf87 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C11orf87 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C11orf87)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 399947	HGNC: 33788	AceView: LOC399947	Ensembl:ENSG00000185742	euGenes: HUgn399947
ECgene: C11orf87	H-InvDB: C11orf87

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C11orf87	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C11orf87 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C11orf87 gene:
Search GeneIP for patents involving C11orf87

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf87

	SwitchGear 3'UTR luciferase reporter plasmids for C11orf87
	Browse SwitchGear Promoter luciferase reporter plasmids for C11orf87

Search ThermoFisher Antibodies for C11orf87

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf87

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C11orf87 gene at Home site.

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C11orf87 Gene

chromosome 11 open reading frame 87

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C11orf87 Gene

chromosome 11 open reading frame 87

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for C11orf87 gene

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for C11orf87 gene

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