Aliases for C11orf85 Gene
External Ids for C11orf85 Gene
Previous GeneCards Identifiers for C11orf85 Gene
GeneCards Summary for C11orf85 Gene
C11orf85 (Chromosome 11 Open Reading Frame 85) is a Protein Coding gene.
UniProtKB/Swiss-Prot for C11orf85 Gene
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.