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Aliases for C11orf85 Gene

Aliases for C11orf85 Gene

  • Chromosome 11 Open Reading Frame 85 2 3 5
  • MAJIN 3 4
  • Uncharacterized Protein C11orf85 3

External Ids for C11orf85 Gene

Previous GeneCards Identifiers for C11orf85 Gene

  • GC11M064463
  • GC11M064705
  • GC11M061032

Summaries for C11orf85 Gene

GeneCards Summary for C11orf85 Gene

C11orf85 (Chromosome 11 Open Reading Frame 85) is a Protein Coding gene.

UniProtKB/Swiss-Prot for C11orf85 Gene

  • Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf85 Gene

Genomics for C11orf85 Gene

Regulatory Elements for C11orf85 Gene

Promoters for C11orf85 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C11orf85 on UCSC Golden Path with GeneCards custom track

Genomic Location for C11orf85 Gene

Chromosome:
11
Start:
64,937,517 bp from pter
End:
64,972,112 bp from pter
Size:
34,596 bases
Orientation:
Minus strand

Genomic View for C11orf85 Gene

Genes around C11orf85 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf85 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf85 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf85 Gene

Proteins for C11orf85 Gene

  • Protein details for C11orf85 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3KP22-MAJIN_HUMAN
    Recommended name:
    Membrane-anchored junction protein
    Protein Accession:
    Q3KP22
    Secondary Accessions:
    • B3KS99
    • E9PPE5

    Protein attributes for C11orf85 Gene

    Size:
    176 amino acids
    Molecular mass:
    20078 Da
    Quaternary structure:
    • Component of the MAJIN-TERB1-TERB2 complex, composed of MAJIN, TERB1 and TERB2.

    Alternative splice isoforms for C11orf85 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C11orf85 Gene

Proteomics data for C11orf85 Gene at MOPED

Post-translational modifications for C11orf85 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C11orf85 Gene

Antibody Products

No data available for DME Specific Peptides for C11orf85 Gene

Domains & Families for C11orf85 Gene

Protein Domains for C11orf85 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C11orf85 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3KP22

UniProtKB/Swiss-Prot:

MAJIN_HUMAN :
  • Belongs to the MAJIN family.
Family:
  • Belongs to the MAJIN family.
genes like me logo Genes that share domains with C11orf85: view

No data available for Gene Families for C11orf85 Gene

Function for C11orf85 Gene

Molecular function for C11orf85 Gene

UniProtKB/Swiss-Prot Function:
Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane.

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C11orf85 Gene

Localization for C11orf85 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C11orf85 Gene

Nucleus inner membrane; Single-pass membrane protein. Chromosome, telomere. Note=In leptotene spermatocytes, localizes to telomeres that localize to the nucleus inner membrane. {ECO:0000250 UniProtKB:Q9D992}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C11orf85 Gene COMPARTMENTS Subcellular localization image for C11orf85 gene
Compartment Confidence
nucleus 5
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for C11orf85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005639 integral component of nuclear inner membrane ISS --
genes like me logo Genes that share ontologies with C11orf85: view

Pathways & Interactions for C11orf85 Gene

SuperPathways for C11orf85 Gene

No Data Available

Interacting Proteins for C11orf85 Gene

Gene Ontology (GO) - Biological Process for C11orf85 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045141 meiotic telomere clustering ISS --
genes like me logo Genes that share ontologies with C11orf85: view

No data available for Pathways by source and SIGNOR curated interactions for C11orf85 Gene

Drugs & Compounds for C11orf85 Gene

No Compound Related Data Available

Transcripts for C11orf85 Gene

Unigene Clusters for C11orf85 Gene

Chromosome 11 open reading frame 85:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf85 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1:
SP2: - - - - -
SP3:

Relevant External Links for C11orf85 Gene

GeneLoc Exon Structure for
C11orf85
ECgene alternative splicing isoforms for
C11orf85

Expression for C11orf85 Gene

mRNA expression in normal human tissues for C11orf85 Gene

mRNA differential expression in normal tissues according to GTEx for C11orf85 Gene

This gene is overexpressed in Testis (x40.1).

Protein differential expression in normal tissues from HIPED for C11orf85 Gene

This gene is overexpressed in Plasma (67.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C11orf85 Gene



SOURCE GeneReport for Unigene cluster for C11orf85 Gene Hs.567793

genes like me logo Genes that share expression patterns with C11orf85: view

Protein tissue co-expression partners for C11orf85 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for C11orf85 Gene

Orthologs for C11orf85 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C11orf85 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C29H11orf85 35
  • 83.33 (n)
  • 80.59 (a)
C11orf85 36
  • 54 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C18H11orf85 35
  • 86.86 (n)
  • 82.94 (a)
C11orf85 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700123I01Rik 35
  • 75 (n)
  • 65.38 (a)
1700123I01Rik 16
1700123I01Rik 36
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC499306 35
  • 81.59 (n)
  • 75 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf85 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C11orf85 36
  • 100 (a)
OneToOne
Species with no ortholog for C11orf85:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C11orf85 Gene

ENSEMBL:
Gene Tree for C11orf85 (if available)
TreeFam:
Gene Tree for C11orf85 (if available)

Paralogs for C11orf85 Gene

No data available for Paralogs for C11orf85 Gene

Variants for C11orf85 Gene

Sequence variations from dbSNP and Humsavar for C11orf85 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs240565 -- 64,963,577(-) TACAG(G/T)CGTGA intron-variant
rs240566 -- 64,962,905(-) GGGTG(A/G)TCTGC intron-variant
rs240567 -- 64,962,213(-) GTACA(A/G)CACAT intron-variant
rs240568 -- 64,961,562(-) ggagg(C/T)ggagc intron-variant
rs240569 -- 64,966,206(-) ATATT(C/T)TCTCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf85 Gene

Variant ID Type Subtype PubMed ID
dgv1173n71 CNV Loss 21882294
nsv526181 CNV Gain 19592680

Variation tolerance for C11orf85 Gene

Residual Variation Intolerance Score: 47.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.65; 13.96% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf85 Gene

HapMap Linkage Disequilibrium report
C11orf85

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf85 Gene

Disorders for C11orf85 Gene

Relevant External Links for C11orf85

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C11orf85

No disorders were found for C11orf85 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf85 Gene

Publications for C11orf85 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for C11orf85 Gene

Sources for C11orf85 Gene

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