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C11orf84 Gene

protein-coding   GIFtS: 39
GCID: GC11P063581          (predicted)

Chromosome 11 Open Reading Frame 84

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromosome 11 Open Reading Frame 841 2
Hypothetical Protein BC0075402
Uncharacterized Protein C11orf842

External Ids:    HGNC: 251151   Entrez Gene: 1440972   Ensembl: ENSG000001680057   UniProtKB: Q9BUA33   

Export aliases for C11orf84 gene to outside databases

Previous GC identifers: GC11P063338 GC11P059909


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for C11orf84 Gene:
C11orf84 (chromosome 11 open reading frame 84) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C11orf84 gene promoter:
         USF1   Elk-1   USF2   USF-1:USF-2   E47   CREB   PPAR-gamma1   deltaCREB   USF-1   PPAR-gamma2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for C11orf84

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C11orf84


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.1   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

C11orf84 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf84 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P063581:  view genomic region     (about GC identifiers)

Start:
63,580,860 bp from pter      End:
63,595,190 bp from pter
Size:
14,331 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CK084_HUMAN, Q9BUA3 (See protein sequence)
Recommended Name: Uncharacterized protein C11orf84  
Size: 381 amino acids; 41037 Da
Secondary accessions: Q68CV7 Q6PHS2 Q96IH0

Explore the universe of human proteins at neXtProt for C11orf84: NX_Q9BUA3

Explore proteomics data for C11orf84 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See C11orf84 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_612480.1  
    ENSEMBL proteins: 
     ENSP00000294244   ENSP00000445256   ENSP00000443715  

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    antibodies-online proteins for C11orf84 (2 products) 

     
    Search antibodies-online for peptides for C11orf84

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9BUA3


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C11orf84
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    hsa-mir-1307-3p (MIRT035817), hsa-mir-296-3p (MIRT038504)

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    Selected qRT-PCR Assays for microRNAs that regulate C11orf84 (see all 19):
    hsa-miR-3910 hsa-let-7d hsa-let-7c hsa-let-7g hsa-miR-124 hsa-let-7a hsa-miR-506 hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidC11orf84 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    plasma membrane1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C11orf84
    Interactions:

        Search GeneGlobe Interaction Network for C11orf84

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    4 Interacting proteins for C11orf84 (Q9BUA33 ENSP000002942444) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ARRB2P321213I2D: score=1 
    YWHAEP622583I2D: score=1 
    GRB2ENSP000003390074STRING: ENSP00000339007
    SUMO2ENSP000004059654STRING: ENSP00000405965
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C11orf84 (CK084)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for C11orf84 gene: 
    NM_138471.1  

    Unigene Cluster for C11orf84:

    Chromosome 11 open reading frame 84
    Hs.502793  [show with all ESTs]
    Unigene Representative Sequence: AK091493
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000294244(uc001nxt.3) ENST00000540893 ENST00000535820
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate C11orf84 (see all 19):
    hsa-miR-3910 hsa-let-7d hsa-let-7c hsa-let-7g hsa-miR-124 hsa-let-7a hsa-miR-506 hsa-miR-4273
    SwitchGear 3'UTR luciferase reporter plasmidC11orf84 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat C11orf84
      QuantiFast Probe-based Assays in human, mouse, rat C11orf84

    Additional mRNA sequence: 

    AK091493.1 AK092098.1 BC002782.2 BC007540.1 BC056402.1 CR749697.1 

    9 DOTS entries:

    DT.409823  DT.100761028  DT.100776062  DT.40114613  DT.65287857  DT.91759675  DT.91759676  DT.95160771 
    DT.95126734 

    Selected AceView cDNA sequences (see all 109):

    CR749697 AA678817 CR602254 CR597472 CA976178 AW272855 BU619979 BC007540 
    BM903854 AA643577 BC002782 BQ009932 BQ071899 CR622295 BQ893891 AI612823 
    BE256102 AA723034 BM463482 BC056402 BM925859 AK091493 BM050422 BX393946 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for C11orf84    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6
    SP1:                                                  -         
    SP2:                                                            
    SP3:                                -     -                     


    ECgene alternative splicing isoforms for C11orf84

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    C11orf84 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    C11orf84 Expression
    About this image


    C11orf84 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Eye (Sensory Organs)
             Retina
    C11orf84 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C11orf84 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.502793
        Custom PCR Arrays for C11orf84
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf84

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for C11orf84 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia AI8461481 , 5 expressed sequence AI8461481, 5 82.02(n)1
    82.63(a)1
      19 (5.32 cM)5
    682291  NM_001033139.31  NP_001028311.21 
     73564645 


    ENSEMBL Gene Tree for C11orf84 (if available)
    TreeFam Gene Tree for C11orf84 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for C11orf84 (see all 419)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs118241931,2
    H--63578928(+) tttttC/Tttttt 1 -- us2k1 tfbs3 trp30--------
    rs118271181,2
    H--63578929(+) ttttcC/Tttttt 1 -- us2k1 tfbs3 trp30--------
    rs1461117961,2
    C--63579075(+) CACTT-/TAAG  
            
    TATTG
    1 -- us2k10--------
    rs1917163951,2
    --63579172(+) AGAGAA/GAGGCA 1 -- us2k10--------
    rs1827695051,2
    --63579181(+) CAGTAC/TAGAGA 1 -- us2k10--------
    rs122838981,2
    C,F,H--63579191(+) actggC/Aaaaag 1 -- us2k19Minor allele frequency- A:0.10NS NA WA 1118
    rs1392888181,2
    C--63579265(+) CAGGGA/GCATGG 1 -- us2k10--------
    rs1432217981,2
    --63579270(+) GCATGC/GATCAT 1 -- us2k10--------
    rs1875037771,2
    --63579354(+) TGTCAC/TCTGAG 1 -- us2k10--------
    rs2019365171,2
    --63579376(+) GAGAG-/AAAGAGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for C11orf84 (63580860 - 63595190 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for C11orf84:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv33730CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C11orf84
    DNA2.0 Custom Variant and Variant Library Synthesis for C11orf84

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for C11orf84 gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with C11orf84)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    2. The HECT type ubiquitin ligase NEDL2 is degraded by anaphase-promoting complex/cyclosome (APC/C)-Cdh1, and its tight regulation maintains the metaphase to anaphase transition. (PubMed id 24163370)1 Lu L....Zhang L. (J. Biol. Chem. 2013)
    3. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. (PubMed id 23246001)1 Xu Y....Ye Y. (Cell Rep 2012)
    4. Family-based genome-wide association study of frontal I, oscillations identifies potassium channel gene KCNJ6. (PubMed id 22554406)1 Kang S.J....Porjesz B. (Genes Brain Behav. 2012)
    5. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    6. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    7. Purification and identification of endogenous polySUMO conjugates. (PubMed id 21252943)1 Bruderer R....Hay R.T. (EMBO Rep. 2011)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. 14-3-3 epsilon dynamically interacts with key components of mitogen-activated protein kinase signal module for selective modulation of the TNF-alpha-induced time course-dependent NF-kappaB activity. (PubMed id 20462248)1 Zuo S....Chen X. (J. Proteome Res. 2010)
    10. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (Anal. Chem. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 144097 HGNC: 25115 AceView: LOC144097 Ensembl:ENSG00000168005 euGenes: HUgn144097
    ECgene: C11orf84 H-InvDB: C11orf84

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for C11orf84 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for C11orf84 gene:
    Search GeneIP for patents involving C11orf84

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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