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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

C11orf82 Gene

protein-coding GIFtS: 41
GCID: GC11P082612

chromosome 11 open reading frame 82

Explore 1 disease affiliated with
C11orf82 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chromosome 11 Open Reading Frame 82¹ ²
Noxin¹
FLJ25416¹
FLJ38838¹
Nitric Oxide-Inducible Gene Protein²

External Ids:	HGNC: 26351¹	Entrez Gene: 220042²	Ensembl: ENSG00000165490⁷	UniProtKB: Q8IXT1³

Export aliases for C11orf82 gene to outside databases

Previous GC identifers: GC11P082291 GC11P078910

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NOXIN_HUMAN, Q8IXT1

Function: Acts as an anti-apoptotic factor and its absence increases cell death under normal and stress conditions. Can

induce cell cycle arrest in the G1 or early S phase and this activity is independent of p53/TP53 (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the C11orf82 gene promoter:
GR Sox5 Tal-1 AML1a GR-beta HNF-1A PPAR-alpha HNF-1 SEF-1 (1) GR-alpha
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for C11orf82

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf82

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.1 Ensembl cytogenetic band: 11q14.1 HGNC cytogenetic band: 11q14.1

C11orf82 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf82 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P082612: view genomic region (about GC identifiers)

Start:	82,611,017 bp from pter	End:	82,669,319 bp from pter
Size:	58,303 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: NOXIN_HUMAN, Q8IXT1 (See protein sequence)

Recommended Name: Nitric oxide-inducible gene protein

Size: 998 amino acids; 111616 Da

Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Accumulates in the nucleus in response

to stress (By similarity)

Sequence caution: Sequence=BAB14764.1; Type=Erroneous initiation;

Secondary accessions: Q96LK6 Q9H856

Alternative splicing: 2 isoforms: Q8IXT1-1 Q8IXT1-2

Explore the universe of human proteins at neXtProt for C11orf82: NX_Q8IXT1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8IXT1

C11orf82 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_659455.3

ENSEMBL proteins:

ENSP00000433306 ENSP00000436241 ENSP00000431234 ENSP00000435424 ENSP00000435421

ENSP00000431206 ENSP00000434427 ENSP00000436611 ENSP00000432871 ENSP00000414687

ENSP00000329930

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--

C11orf82 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C11orf82 for domains About GeneDecksing

2 InterPro domains/families:

IPR012340 NA-bd_OB-fold

IPR013955 Rep_factor-A_C

Graphical View of Domain Structure for InterPro Entry Q8IXT1

ProtoNet protein and cluster: Q8IXT1

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: NOXIN_HUMAN, Q8IXT1

Function: Acts as an anti-apoptotic factor and its absence increases cell death under normal and stress conditions. Can

induce cell cycle arrest in the G1 or early S phase and this activity is independent of p53/TP53 (By similarity)

Phenotypes:
1 GenomeRNAi human phenotype for C11orf82:

Decreased influenza A virus in

Animal Models:

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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for C11orf82

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	IEA	--
GO:0007050	cell cycle arrest	--	--
GO:0007286	spermatid development	IEA	--
GO:0030097	hemopoiesis	IEA	--
GO:0033554	cellular response to stress	IEA	--

C11orf82 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for C11orf82 gene:

NM_145018.3

Unigene Cluster for C11orf82:

Chromosome 11 open reading frame 82

Hs.165607 [show with all ESTs]

Unigene Representative Sequence: NM_145018

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000532277 ENST00000524921 ENST00000528759(uc010rss.2) ENST00000525361(uc009yvd.2)

ENST00000533655(uc001ozt.3 uc010rsr.2) ENST00000532764 ENST00000532589

ENST00000528189 ENST00000525388 ENST00000528262 ENST00000533750 ENST00000430323

ENST00000329143

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		hsa-miR-142-5p hsa-miR-20a hsa-miR-519d hsa-miR-125a-3p hsa-miR-106a hsa-miR-106b hsa-miR-93 hsa-miR-20b

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Additional cDNA sequence:

AK023998.1 AK058145.1 AK096157.1 AK292399.1 AK297366.1 AK299581.1 BC039268.1

7 DOTS entries:

DT.91846921 DT.442170 DT.95191334 DT.100777136 DT.95149443 DT.120742517 DT.120742542

24/53 AceView cDNA sequences (see all 53):

AK058145 AW664845 BU431639 AW872975 BF478106 CR613676 AA946869 AA781175

AA992090 AA477171 CA441300 AI766808 AI654796 BX365621 BX370517 AW515075

BG743904 BM829262 NM_145018 BF343258 AU253903 AL705883 AI376202 AU142737

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for C11orf82 (see all 6) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	·	8d
SP1:							-				-
SP2:			-								-
SP3:			-		-		-				-
SP4:
SP5:			-		-		-				-		-		-

ECgene alternative splicing isoforms for C11orf82

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C11orf82 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image

C11orf82 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

PureStem™ progenitor E44 (Embryonic Progenitor Cell)

PureStem™ progenitor F15 (Embryonic Progenitor Cell)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See C11orf82 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C11orf82

SOURCE GeneReport for Unigene cluster: Hs.165607

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C11orf82 gene from 4/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	4632434I11Rik^{1 , 5}	RIKEN cDNA 4632434I11 gene^{1, 5}	73.55(n)¹ 55.19(a)¹		7 (51.64 cM)⁵ 74041¹ NM_001080995.1¹ NP_001074464.1¹ 92857529⁵
chicken (Gallus gallus)	Aves	C11orf82⁶	Uncharacterized protein	38(a)	1 ↔ 1	1(193403817-193409109)
lizard (Anolis carolinensis)	Reptilia	C11orf82⁶	--	58(a)	1 ↔ 1	3(202240803-202241881)
zebrafish (Danio rerio)	Actinopterygii	si:ch73-115d3.4⁶	si:ch73-115d3.4	24(a)	1 ↔ 1	21(21987708-21992855)

ENSEMBL Gene Tree for C11orf82 (if available)
TreeFam Gene Tree for C11orf82 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs181782880^1,2		--	82613597(+)	`TCTTTA/TACATG`	1	--	int¹		0	--	--	--	--
rs185084284^1,2		--	82613707(+)	`GCACTA/GTCCTC`	1	--	int¹		0	--	--	--	--
rs151032077^1,2		--	82613897(+)	`TGCTAA/GGTACT`	1	--	int¹		0	--	--	--	--
rs189548797^1,2	C	--	82613989(+)	`AAACTA/GTGTGA`	1	--	int¹		0	--	--	--	--
rs183168858^1,2		--	82614008(+)	`GGTCTA/GAGAAG`	1	--	int¹		0	--	--	--	--
rs141106036^1,2		--	82614242(+)	`AGACCA/GGATCA`	1	--	int¹		0	--	--	--	--
rs144898212^1,2		--	82614385(+)	`GTGTGA/TTGTGG`	1	--	int¹		0	--	--	--	--
rs186525881^1,2		--	82614465(+)	`GTACCA/GTTTAC`	1	--	int¹		0	--	--	--	--
rs76147775^1,2	F	--	82614538(+)	`GTATCG/ATACTA`	1	--	int¹		2		WA NA	238
rs147932749^1,2		--	82614746(+)	`AGTATC/GTGCCA`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for C11orf82 (82611017 - 82669319 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for C11orf82
1 CNV: 6945

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C11orf82 for disorders About GeneDecksing

1 disease for C11orf82: About MalaCards

carcinoma

Export disorders for C11orf82 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for C11orf82 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C11orf82)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
noxin, a novel stress-induced gene involved in cell cycle and apoptosis. (PubMed id 17515607)¹ Nakaya N....Enikolopov G. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 220042	HGNC: 26351	AceView: FLJ25416	Ensembl:ENSG00000165490	euGenes: HUgn220042
ECgene: C11orf82	H-InvDB: C11orf82

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for C11orf82	Pharmacogenomics, SNPs, Pathways

Intellectual Property for C11orf82 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for C11orf82 gene:
Search GeneIP for patents involving C11orf82

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf82

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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 27 Apr 2013 , 14 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes C11orf82 gene at Home site.

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C11orf82 Gene

chromosome 11 open reading frame 82

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C11orf82 Gene

chromosome 11 open reading frame 82

Aliasesfor C11orf82 gene

Summariesfor C11orf82 gene

Genomic Viewsfor C11orf82 gene

Proteinsfor C11orf82 gene

Protein Domains /Familiesfor C11orf82 gene

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for C11orf82 gene

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for C11orf82 gene

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