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Aliases for C11orf80 Gene

Aliases for C11orf80 Gene

  • Chromosome 11 Open Reading Frame 80 2 3

External Ids for C11orf80 Gene

Summaries for C11orf80 Gene

GeneCards Summary for C11orf80 Gene

C11orf80 (Chromosome 11 Open Reading Frame 80) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf80 Gene

Genomics for C11orf80 Gene

Genomic Location for C11orf80 Gene

Start:
66,744,451 bp from pter
End:
66,843,516 bp from pter
Size:
99,066 bases
Orientation:
Plus strand

Genomic View for C11orf80 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C11orf80 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf80 Gene

Regulatory Elements for C11orf80 Gene

Proteins for C11orf80 Gene

  • Protein details for C11orf80 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6T0-CK080_HUMAN
    Recommended name:
    Uncharacterized protein C11orf80
    Protein Accession:
    Q8N6T0
    Secondary Accessions:
    • Q9H677

    Protein attributes for C11orf80 Gene

    Size:
    677 amino acids
    Molecular mass:
    74636 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Expansion of a polymorphic CGG repeat within the 5-UTR of this gene may be the cause of folate-sensitive fragile site FRA11A. The expansion is identified in the 15-year-old proband with mental retardation as well as in phenotypically normal members of the family.
    SequenceCaution:
    • Sequence=AAH28240.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB15387.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C11orf80 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C11orf80 Gene

Proteomics data for C11orf80 Gene at MOPED

Post-translational modifications for C11orf80 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C11orf80 Gene

Domains for C11orf80 Gene

Protein Domains for C11orf80 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C11orf80: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C11orf80 Gene

Function for C11orf80 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C11orf80 Gene

Localization for C11orf80 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C11orf80 Gene COMPARTMENTS Subcellular localization image for C11orf80 gene
Compartment Confidence
nucleus 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for C11orf80 Gene

Pathways for C11orf80 Gene

SuperPathways for C11orf80 Gene

No Data Available

Interacting Proteins for C11orf80 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000354227%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000354227 Q8N6T0-CK080_HUMAN for C11orf80 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for C11orf80 Gene

None

No data available for Pathways by source for C11orf80 Gene

Transcripts for C11orf80 Gene

Unigene Clusters for C11orf80 Gene

Chromosome 11 open reading frame 80:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf80 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4:
SP5:
SP6: -
SP7: - - -
SP8:

Relevant External Links for C11orf80 Gene

GeneLoc Exon Structure for
C11orf80
ECgene alternative splicing isoforms for
C11orf80

Expression for C11orf80 Gene

mRNA expression in normal human tissues for C11orf80 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for C11orf80 Gene

SOURCE GeneReport for Unigene cluster for C11orf80 Gene Hs.292088

mRNA Expression by UniProt/SwissProt for C11orf80 Gene

Q8N6T0-CK080_HUMAN
Tissue specificity: Detected in lung, spleen,colon and in skeletal muscle.
genes like me logo Genes that share expressions with C11orf80: view

Orthologs for C11orf80 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf80 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf80 36
  • 99.02 (n)
  • 98.74 (a)
C11orf80 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11orf80 37
  • 72 (a)
OneToOne
C29H11orf80 36
  • 82.45 (n)
  • 73.28 (a)
dog
(Canis familiaris)
Mammalia C11orf80 37
  • 75 (a)
OneToOne
C18H11orf80 36
  • 80.87 (n)
  • 70.81 (a)
mouse
(Mus musculus)
Mammalia Gm960 36
  • 74.64 (n)
  • 62.13 (a)
Gm960 16
Gm960 37
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf80 37
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C14H11orf80 37
  • 19 (a)
OneToOne
zgc:195212 36
  • 40.67 (n)
  • 25.06 (a)
Species with no ortholog for C11orf80:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf80 Gene

ENSEMBL:
Gene Tree for C11orf80 (if available)
TreeFam:
Gene Tree for C11orf80 (if available)

Paralogs for C11orf80 Gene

genes like me logo Genes that share paralogs with C11orf80: view

No data available for Paralogs for C11orf80 Gene

Variants for C11orf80 Gene

Sequence variations from dbSNP and Humsavar for C11orf80 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs487975 -- 66,802,423(-) gtaat(C/T)tcagc intron-variant
rs488577 -- 66,769,848(+) ccatt(C/T)tcctg intron-variant
rs493328 -- 66,811,721(+) ctggc(A/G)atccc intron-variant
rs494771 -- 66,769,409(+) GCTTC(A/C)AAAGA intron-variant
rs499448 -- 66,771,182(+) ttttt(A/T)aaaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf80 Gene

Variant ID Type Subtype PubMed ID
nsv897789 CNV Gain 21882294
nsv897790 CNV Loss 21882294
nsv897791 CNV Loss 21882294
nsv468602 CNV Loss 19166990
dgv1191n71 CNV Loss 21882294
nsv516087 CNV Gain 19592680
esv2744640 CNV Deletion 23290073
esv2665794 CNV Deletion 23128226
nsv508638 CNV Loss 20534489
nsv897794 CNV Loss 21882294
nsv364 CNV Insertion 18451855
nsv897795 CNV Loss 21882294
esv2744642 CNV Deletion 23290073

Relevant External Links for C11orf80 Gene

HapMap Linkage Disequilibrium report
C11orf80

Disorders for C11orf80 Gene

Relevant External Links for C11orf80

Genetic Association Database (GAD)
C11orf80
genes like me logo Genes that share disorders with C11orf80: view

No data available for UniProtKB/Swiss-Prot for C11orf80 Gene

Publications for C11orf80 Gene

  1. The molecular basis of the folate-sensitive fragile site FRA11A at 11q13. (PMID: 18160775) Debacker K. … Kooy F. (Cytogenet. Genome Res. 2007) 2 3 4
  2. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) (Nat. Genet. 2011) 3 49
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  5. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4

Products for C11orf80 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate C11orf80
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for C11orf80
    • Block miRNA regulation of C11orf80 using miScript Target Protectors

    Sources for C11orf80 Gene

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