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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C11orf80 Gene

protein-coding   GIFtS: 38
GCID: GC11P066512

Chromosome 11 Open Reading Frame 80

  Search for C11orf80
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chromosome 11 Open Reading Frame 801 2
Putative Uncharacterized Protein C11orf802

External Ids:    HGNC: 261971   Entrez Gene: 797032   Ensembl: ENSG000001737157   UniProtKB: Q8N6T03   

Export aliases for C11orf80 gene to outside databases

Previous GC identifers: GC11P066269 GC11P062840


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for C11orf80 Gene: 
C11orf80 (chromosome 11 open reading frame 80) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C11orf80 gene promoter:
         GR   Spz1   AP-4   LCR-F1   AP-2beta   Sox9   GR-alpha   AP-2alpha   AP-2alphaA   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for C11orf80

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf80


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.2   Ensembl cytogenetic band:  11q13.2   HGNC cytogenetic band: 11q13.2

C11orf80 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf80 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P066512:  view genomic region     (about GC identifiers)

Start:
66,511,922 bp from pter      End:
66,610,987 bp from pter
Size:
99,066 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CK080_HUMAN, Q8N6T0 (See protein sequence)
Recommended Name: Putative uncharacterized protein C11orf80 precursor  
Size: 677 amino acids; 74636 Da
Sequence caution: Sequence=AAH28240.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB15387.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q9H677
Alternative splicing: 2 isoforms:  Q8N6T0-1   Q8N6T0-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for C11orf80: NX_Q8N6T0

Explore proteomics data for C11orf80 at MOPED 

C11orf80 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

C11orf80 Protein Expression

REFSEQ proteins: NP_078926.3  
ENSEMBL proteins: 
 ENSP00000437319   ENSP00000434960   ENSP00000432039   ENSP00000431578   ENSP00000444319  
 ENSP00000437143   ENSP00000434804   ENSP00000434648   ENSP00000435512   ENSP00000433869  
 ENSP00000432775   ENSP00000433032   ENSP00000354227   ENSP00000317408  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8N6T0


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for C11orf80 
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miRNA
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C11orf80

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for C11orf80 (Q8N6T03 ENSP000003542274) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
TSC22D4Q9Y3Q83I2D: score=1 
UBCENSP000003448184STRING: ENSP00000344818
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C11orf80 (CK080)

Search CenterWatch for drugs/clinical trials and news about C11orf80 / CK080

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C11orf80 gene: 
NM_024650.3  

Unigene Cluster for C11orf80:

Chromosome 11 open reading frame 80
Hs.292088  [show with all ESTs]
Unigene Representative Sequence: NM_024650
18/19 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 19):
ENST00000534325 ENST00000524551 ENST00000525908 ENST00000527634 ENST00000527368
ENST00000540737 ENST00000531400 ENST00000532565 ENST00000525449 ENST00000532727
ENST00000532089 ENST00000526260 ENST00000527352 ENST00000533143 ENST00000526718
ENST00000531415 ENST00000526270 ENST00000360962(uc021qmd.1 uc010rpl.2 uc001ojj.3)

miRNA
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Inhib. RNA
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Clone
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Sirion Biotech Customized lentivirus for stable overexpression of C11orf80 
                     Customized lentivirus expression plasmids for stable overexpression of C11orf80 
Primer
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SABiosciences RT2 qPCR Primer Assay in human, mouse, rat C11orf80
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C11orf80

Additional mRNA sequence: 

AK026184.1 AK225435.1 AK302025.1 BC028240.1 NR_048553.1 

15 DOTS entries:

DT.441833  DT.97845283  DT.97845282  DT.430291  DT.100785433  DT.95273956  DT.99972836  DT.91857956 
DT.92437820  DT.95273957  DT.100785429  DT.100843086  DT.40221608  DT.92437817  DT.95148582 

24/222 AceView cDNA sequences (see all 222):

AI285045 BF436853 AL537953 CA487579 AW135477 AA910288 AL713740 BU543442 
BF001690 BU517086 AI292099 CR626111 BM928167 BX109301 BX107454 AK026184 
BM554707 BE856459 AA872430 AA593730 AA639800 BM701935 AA428315 BE675162 

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for C11orf80 (see all 8)    About this scheme

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1:        -                       -                       -                                                               
SP2:        -                       -                       -                       -     -                                 
SP3:        -                       -                       -                                                               
SP4:                                                                                                                        
SP5:                                                                                                                        


ECgene alternative splicing isoforms for C11orf80

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C11orf80 expression in normal human tissues (normalized intensities)      C11orf80 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGAGGTGAAG
C11orf80 Expression
About this image


C11orf80 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/2 selected tissues (see all 2) fully expand
 
 Blood (Cardiovascular System)    fully expand to see all 2 entries
         Double Positive Thymocytes Thymus
         plasma cells   
 
 Thymus (Hematopoietic System)
         Double Positive Thymocytes Thymus

See C11orf80 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C11orf80

SOURCE GeneReport for Unigene cluster: Hs.292088
    SABiosciences Custom PCR Arrays for C11orf80
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Products:
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C11orf80
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf80

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for C11orf80 gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Gm9601 , 5 predicted gene 9601, 5 75.96(n)1
63.06(a)1
  19 (4.08 cM)5
3811961  NM_001033447.31  NP_001028619.21 
 46258415 
zebrafish
(Danio rerio)
Actinopterygii zgc:1952121 zgc:195212 40.71(n)
25.18(a)
  100189619  NM_001135145.1  NP_001128617.1 


ENSEMBL Gene Tree for C11orf80 (if available)
TreeFam Gene Tree for C11orf80 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for C11orf80 gene
18/43 SIMAP similar genes for C11orf80 using alignment to 13 protein entries:     CK080_HUMAN (see all proteins) (see all similar genes):
IK    TNNT1    ARL6IP5    SH2B3    C12orf76    RBP7
ZNF257    RHBG    COQ5    NLN    RRM2B    TUBA1C
DPP9    LOC100996577    ZNF429    VPS33A    ZNF799    pp12301

C11orf80 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1641 SNPs in C11orf80 are shown (see all 1641)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1823507031,2
--66510361(+) CAGGCA/GTGAGC 2 -- us2k10--------
rs1158897511,2
--66510382(+) GGCCAA/CGATGG 2 -- us2k10--------
rs344482371,2
C,H--66510448(+) ACGATA/CACAAT 2 -- us2k13Minor allele frequency- C:0.01NS NA 102
rs1176013411,2
C,F--66510510(+) GGGTCC/TGACAA 2 -- us2k11Minor allele frequency- T:0.02EA 120
rs1878471051,2
--66510751(+) ATGGGA/GAGGAA 2 -- us2k10--------
rs1920843211,2
--66510765(+) GGAGGA/GGCGCT 2 -- us2k10--------
rs1420006531,2
--66510907(+) GCTGGA/GGTGGA 2 -- us2k10--------
rs1508527281,2
C--66511025(+) TCACCA/GGCAGT 2 -- us2k10--------
rs780449431,2
F--66511807(+) CCCGCC/TGCAGA 2 -- us2k11Minor allele frequency- T:0.03WA 118
rs1839777881,2
C--66512011(+) CGCTCA/CCCTCC 2 -- us2k10--------

HapMap Linkage Disequilibrium report for C11orf80 (66511922 - 66610987 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/13 variations for C11orf80 (see all 13):    About this table     
Variant IDTypeSubtypePubMed ID
esv2744640CNV Deletion23290073
esv2665794CNV Deletion23128226
esv2744642CNV Deletion23290073
nsv364CNV Insertion18451855
dgv1191n71CNV Loss21882294
nsv897794CNV Loss21882294
nsv897791CNV Loss21882294
nsv508638CNV Loss20534489
nsv468602CNV Loss19166990
nsv897790CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C11orf80 for disorders           About MalaCards

C11orf80 for disorders           About GeneDecksing

Genetic Association Database (GAD): C11orf80

Export disorders for C11orf80 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C11orf80 gene integrated from 9 sources:
(articles sorted by number of sources associating them with C11orf80)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Large-scale genome-wide association analysis of bipol ar disorder identifies a new susceptibility locus near ODZ4. (PubMed id 21926972)1, 4 Sklar P....Purcell S.M. (2011)
  2. The molecular basis of the folate-sensitive fragile site FRA11A at 11q13. (PubMed id 18160775)1, 3 Debacker K....Kooy F. (2007)
  3. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
  4. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 79703 HGNC: 26197 AceView: RCE1andFLJ22531 Ensembl:ENSG00000173715 euGenes: HUgn79703
ECgene: C11orf80 H-InvDB: C11orf80

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for C11orf80 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for C11orf80 gene:
Search GeneIP for patents involving C11orf80

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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