C11orf75 Gene
protein-coding GIFtS : 44 GCID: GC11 M093211
chromosome 11 open reading frame 75
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Aliasesfor C11orf75 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Chromosome 11 Open Reading Frame 75 1 2 FN51 2 3 UPF0443 Protein C11orf752 Protein FN53
Export aliases for C11orf75 gene to outside databases Previous GC identifers: GC11M092852 GC11M089289
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Summariesfor C11orf75 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section
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Genomic Viewsfor C11orf75 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000011.9 NC_018922.1 NT_167190.1 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the C11orf75 gene promoter:Nkx3-1 ISGF-3 Nkx3-1 v4 AP-1 AML1a Pax-6 Nkx3-1 v1 GATA-1 Nkx3-1 v2 Nkx3-1 v3 Other transcription factors Search SABiosciences Chromatin IP Primers for C11orf75 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 11q21 Ensembl cytogenetic band: 11q21 HGNC cytogenetic band: 11q21 C11orf75 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 11 GeneLoc Exon Structure
GeneLoc location for GC11M093211: view genomic region
(about GC identifiers )
Start: 93,211,638 bp from pter End:
93,276,674 bp from pter
Size: 65,037 bases Orientation:
minus strand
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Proteinsfor C11orf75 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CK075_HUMAN, Q9NRQ5 See
protein sequence )Recommended Name: Size : 59 amino acids; 6738 DaSubcellular location : Membrane; Single-pass membrane protein (Potential)Explore the universe of human proteins at neXtProt for C11orf75: NX_Q9NRQ5 C11orf75 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_064564.1 ENSEMBL proteins: ENSP00000431781 ENSP00000298966 ENSP00000433555 ENSP00000432581 ENSP00000435827 Human Recombinant Protein Products for C11orf75: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005575 cellular_component
ND -- GO:0016021 integral to membrane
IEA --
About GeneDecksing C11orf75 Antibody Products: Assay Products for C11orf75:
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Protein
Domains /for C11orf75 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: Q9NRQ5
UniProtKB/Swiss-Prot: CK075_HUMAN, Q9NRQ5 Similarity : Belongs to the UPF0443 family
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Functionfor C11orf75 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003674 molecular_function
ND --
About GeneDecksing Phenotypes: 2 GenomeRNAi human phenotypes for C11orf75 :Animal Models: Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C11orf75 (NM_020179 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C11orf75 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat C11orf75
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf75
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Pathways & Interactionsfor C11orf75 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C11orf75 1 Interacting protein for C11orf75 (Q9NRQ5 3 via UniProtKB, MINT, STRING, and/or I2D About this table Gene Ontology (GO): 1 biological process term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0008150 biological_process
ND --
About GeneDecksing
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Drugs & Compoundsfor C11orf75 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for C11orf75 C11orf75 / CK075
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Transcriptsfor C11orf75 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
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QIAGEN
)About This Section REFSEQ mRNAs for C11orf75 gene: NM_020179.2 Unigene Cluster for C11orf75:
Chromosome 11 open reading frame 75 Hs.438064 [show with all ESTs ] Unigene Representative Sequence: BM911813 5 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000525141 ENST00000298966 (uc001pds.4 ) ENST00000527149 ENST00000529714 ENST00000526869 Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 2 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: C11orf75 (NM_020179 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for C11orf75 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat C11orf75
Additional cDNA sequence: AF197137.1 BC031564.1
8 DOTS entries : DT.98131890 DT.92474815
DT.95273436 DT.95344395 DT.100656641 DT.120713915 DT.91755096 DT.100727163 24/67 AceView cDNA sequences (see all 67 ):
BI091033 BG698163 BG676605 AA384878 CR624699 BF846816 BF849191 BX487934 AW152094 NM_020179 T36056 BQ674950 W95754 BU855610 AW440429 AA485088 BC031564 BQ049161 AW512036 AI952281 CD370631 AV752109 AI815614 T25513 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for C11orf75 About this scheme ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c SP1 : SP2 : - -
ECgene alternative splicing isoforms for C11orf75
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Expression for C11orf75 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section C11orf75 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CCTCTTTCCAAbout this image C11orf75 expression in embryonic tissues and stem cells About this table
1 LifeMap In Vivo Development Anatomical Compartment/CellTissue Category (developmental path) Limb Limb Bud Limb Bud Mesenchyme Cells Mesoderm Expression: Experimental details:
In-situ hybridization
See C11orf75 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for C11orf75 SOURCE GeneReport for Unigene cluster: Hs.438064 SABiosciences Custom PCR Arrays for C11orf75 Primer Browse OriGene genome-wide validated SYBR primer pairs Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf75
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Orthologsfor C11orf75 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for C11orf75 gene from 6/12 species (see all 12 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
mouse Mammalia BC0176121 5
cDNA sequence BC0176121, 5
89.27(n) 1 96.61(a) 1
9 (4.95 cM) 5 170748 1 NM_133214.2 1 NP_573477.2 1 15505487 5
chicken Aves C1H11orf751
chromosome 1 open reading frame, human C11orf75
76.84(n) 94.92(a)
772206 NM_001164340.1 NP_001157812.1
lizard Reptilia C11orf756
--
95(a)
1 ↔ 1
3(196298673-196298849)
African clawed frog Amphibia AW634164.12
--
83.73(n)
AW634164.1
rainbow trout Actinopterygii Omy.11102
Oncorhynchus mykiss transcribed sequence with moderate more
79.58(n)
BX078254.1
fruit fly Insecta CG331696
--
55(a)
1 ↔ 1
3L(22856964-22857596)
ENSEMBL Gene Tree for C11orf75 (if available)TreeFam Gene Tree for C11orf75 (if available)
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Paralogsfor C11orf75 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section
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Genomic Variantsfor C11orf75 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 11 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for C11orf75 (93211638 - 93276674 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 3 variations for C11orf75 3 CNVs 48918 48919 4991
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor C11orf75 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 609477
OMIM disorders : --1 : About MalaCards neurofibromatosis Export disorders for C11orf75 gene to outside databases
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Publicationsfor C11orf75 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for C11orf75 gene integrated from 9 sources :(articles sorted by number of sources associating them with C11orf75) Utopia : connect your pdf to the dynamic
Characterization of the Fugu rubripes NLK and FN5 genes flanking the NF1 (Neurofibromatosis type 1) gene in the 5' direction and mapping of the human counterparts. (PubMed id 10863097) 1 , 2 , 3(2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 (2004) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 (2007) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 (2002)
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External Searches for C11orf75 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing C11orf75 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing C11orf75 gene
(According to HUGE )
About This Section --
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Specialized Databases showing C11orf75 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description PharmGKB entry for C11orf75 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for C11orf75 gene: C11orf75 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor C11orf75 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for C11orf75 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat Browse OriGene genome-wide validated SYBR primer pairs OriGene Protein Over-expression Lysate for C11orf75 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for C11orf75 OriGene 3'-UTR Clone for C11orf75 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for C11orf75 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for C11orf75 OriGene Custom Protein Services for C11orf75 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat C11orf75 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
C11orf75 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf75
Search ThermoFisher Antibodies for C11orf75
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse rat C11orf75
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Browse Tocris compounds for 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Anatomical Compartment 
Negative
Selective marker
Microarrays
In-situ hybridization
