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Aliases for C11orf74 Gene

Aliases for C11orf74 Gene

  • Chromosome 11 Open Reading Frame 74 2 3
  • Uncharacterized Protein C11orf74 3
  • Protein HEPIS 4
  • HEPIS 3

External Ids for C11orf74 Gene

Previous GeneCards Identifiers for C11orf74 Gene

  • GC11P036318

Summaries for C11orf74 Gene

Entrez Gene Summary for C11orf74 Gene

  • This gene encodes a protein that was identified as a cellular interacting partner of non-structural protein 10 of the severe acute respiratory syndrome coronavirus (SARS-CoV). The encoded protein may function as a negative regulator of transcription. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

GeneCards Summary for C11orf74 Gene

C11orf74 (Chromosome 11 Open Reading Frame 74) is a Protein Coding gene. Diseases associated with C11orf74 include severe acute respiratory syndrome.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf74 Gene

Genomics for C11orf74 Gene

Regulatory Elements for C11orf74 Gene

Genomic Location for C11orf74 Gene

36,594,432 bp from pter
36,673,273 bp from pter
78,842 bases
Plus strand

Genomic View for C11orf74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C11orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf74 Gene

Proteins for C11orf74 Gene

  • Protein details for C11orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C11orf74
    Protein Accession:
    Secondary Accessions:
    • D3DR18
    • Q96DD6

    Protein attributes for C11orf74 Gene

    221 amino acids
    Molecular mass:
    25407 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C11orf74 Gene


neXtProt entry for C11orf74 Gene

Proteomics data for C11orf74 Gene at MOPED

Post-translational modifications for C11orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for C11orf74 Gene

Domains for C11orf74 Gene

Protein Domains for C11orf74 Gene


Suggested Antigen Peptide Sequences for C11orf74 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf74: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C11orf74 Gene

Function for C11orf74 Gene

Phenotypes for C11orf74 Gene

GenomeRNAi human phenotypes for C11orf74:
genes like me logo Genes that share phenotypes with C11orf74: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C11orf74

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C11orf74 Gene

Localization for C11orf74 Gene

Subcellular locations from

Jensen Localization Image for C11orf74 Gene COMPARTMENTS Subcellular localization image for C11orf74 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf74 Gene

Pathways for C11orf74 Gene

SuperPathways for C11orf74 Gene

No Data Available

Interacting Proteins for C11orf74 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000334848 for C11orf74 Gene via STRING

Gene Ontology (GO) - Biological Process for C11orf74 Gene


No data available for Pathways by source for C11orf74 Gene

Transcripts for C11orf74 Gene

Unigene Clusters for C11orf74 Gene

Chromosome 11 open reading frame 74:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for C11orf74

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf74 Gene

No ASD Table

Relevant External Links for C11orf74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf74 Gene

mRNA expression in normal human tissues for C11orf74 Gene

Protein differential expression in normal tissues for C11orf74 Gene

This gene is overexpressed in Fetal gut (61.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C11orf74 Gene

SOURCE GeneReport for Unigene cluster for C11orf74 Gene Hs.159376

genes like me logo Genes that share expressions with C11orf74: view

Expression partners for C11orf74 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C11orf74 Gene

Orthologs for C11orf74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf74 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C15H11orf74 35
  • 80.03 (n)
  • 68.4 (a)
C15H11ORF74 36
  • 61 (a)
(Canis familiaris)
Mammalia C18H11orf74 35
  • 79.76 (n)
  • 67.58 (a)
C11orf74 36
  • 61 (a)
(Mus musculus)
Mammalia B230118H07Rik 35
  • 77.29 (n)
  • 67.63 (a)
B230118H07Rik 16
B230118H07Rik 36
  • 59 (a)
(Pan troglodytes)
Mammalia C11H11orf74 35
  • 98.34 (n)
  • 96.38 (a)
C11orf74 36
  • 96 (a)
(Rattus norvegicus)
Mammalia RGD1309730 35
  • 76.19 (n)
  • 64.04 (a)
(Monodelphis domestica)
Mammalia C11orf74 36
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia C11orf74 36
  • 45 (a)
(Gallus gallus)
Aves C11orf74 36
  • 24 (a)
(Danio rerio)
Actinopterygii C25H11orf74 36
  • 23 (a)
Species with no ortholog for C11orf74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf74 Gene

Gene Tree for C11orf74 (if available)
Gene Tree for C11orf74 (if available)

Paralogs for C11orf74 Gene Pseudogenes for C11orf74 Gene

genes like me logo Genes that share paralogs with C11orf74: view

No data available for Paralogs for C11orf74 Gene

Variants for C11orf74 Gene

Sequence variations from dbSNP and Humsavar for C11orf74 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs11033708 -- 36,601,252(+) ATTGT(A/G)TTGGA intron-variant
rs78775215 -- 36,665,094(+) AAGTT(C/T)GTTCT intron-variant
rs78858864 -- 36,670,673(+) TTTTT(G/T)TTTGA intron-variant
rs11033707 -- 36,601,043(+) CATGA(C/T)AGTGC intron-variant
rs11033706 -- 36,600,549(+) cactc(C/T)ggtcc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf74 Gene

Variant ID Type Subtype PubMed ID
esv2422305 CNV Duplication 17116639
nsv467791 CNV Gain 19166990
nsv832123 CNV Gain 17160897
nsv467792 CNV Gain 19166990
nsv518415 CNV Loss 19592680
esv29188 CNV Loss 19812545
esv2674800 CNV Deletion 23128226
esv27238 CNV Loss 19812545

Relevant External Links for C11orf74 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf74 Gene

Disorders for C11orf74 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for C11orf74 Gene in MalaCards »

(1) Disease for C11orf74 Gene

Relevant External Links for C11orf74

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with C11orf74: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for C11orf74 Gene

Publications for C11orf74 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Identification of a novel transcriptional repressor (HEPIS) that interacts with nsp-10 of SARS coronavirus. (PMID: 18433331) Hong M. … Li Q. (Viral Immunol. 2008) 3 23
  3. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  4. Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107413) Wistow G. … Peterson K. (Mol. Vis. 2002) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for C11orf74 Gene

Sources for C11orf74 Gene

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