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Aliases for C11orf74 Gene

Aliases for C11orf74 Gene

  • Chromosome 11 Open Reading Frame 74 2 3 5
  • Uncharacterized Protein C11orf74 3
  • Protein HEPIS 4
  • HEPIS 3

External Ids for C11orf74 Gene

Previous GeneCards Identifiers for C11orf74 Gene

  • GC11P036318

Summaries for C11orf74 Gene

Entrez Gene Summary for C11orf74 Gene

  • This gene encodes a protein that was identified as a cellular interacting partner of non-structural protein 10 of the severe acute respiratory syndrome coronavirus (SARS-CoV). The encoded protein may function as a negative regulator of transcription. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

GeneCards Summary for C11orf74 Gene

C11orf74 (Chromosome 11 Open Reading Frame 74) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf74 Gene

Genomics for C11orf74 Gene

Regulatory Elements for C11orf74 Gene

Enhancers for C11orf74 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around C11orf74 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf74 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C11orf74 on UCSC Golden Path with GeneCards custom track

Genomic Location for C11orf74 Gene

36,594,229 bp from pter
36,659,291 bp from pter
65,063 bases
Plus strand

Genomic View for C11orf74 Gene

Genes around C11orf74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf74 Gene

Proteins for C11orf74 Gene

  • Protein details for C11orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C11orf74
    Protein Accession:
    Secondary Accessions:
    • D3DR18
    • Q96DD6

    Protein attributes for C11orf74 Gene

    221 amino acids
    Molecular mass:
    25407 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C11orf74 Gene


neXtProt entry for C11orf74 Gene

Post-translational modifications for C11orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for C11orf74 Gene

Domains & Families for C11orf74 Gene

Protein Domains for C11orf74 Gene


Suggested Antigen Peptide Sequences for C11orf74 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf74: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C11orf74 Gene

Function for C11orf74 Gene

genes like me logo Genes that share phenotypes with C11orf74: view

Animal Model Products

CRISPR Products

miRNA for C11orf74 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf74 Gene

Localization for C11orf74 Gene

Subcellular locations from

Jensen Localization Image for C11orf74 Gene COMPARTMENTS Subcellular localization image for C11orf74 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf74 Gene

Pathways & Interactions for C11orf74 Gene

SuperPathways for C11orf74 Gene

No Data Available

Interacting Proteins for C11orf74 Gene

Gene Ontology (GO) - Biological Process for C11orf74 Gene


No data available for Pathways by source and SIGNOR curated interactions for C11orf74 Gene

Drugs & Compounds for C11orf74 Gene

No Compound Related Data Available

Transcripts for C11orf74 Gene

Unigene Clusters for C11orf74 Gene

Chromosome 11 open reading frame 74:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf74 Gene

No ASD Table

Relevant External Links for C11orf74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C11orf74 Gene

mRNA expression in normal human tissues for C11orf74 Gene

Protein differential expression in normal tissues from HIPED for C11orf74 Gene

This gene is overexpressed in Fetal gut (61.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C11orf74 Gene

Protein tissue co-expression partners for C11orf74 Gene

NURSA nuclear receptor signaling pathways regulating expression of C11orf74 Gene:


SOURCE GeneReport for Unigene cluster for C11orf74 Gene:

genes like me logo Genes that share expression patterns with C11orf74: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C11orf74 Gene

Orthologs for C11orf74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf74 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia C15H11orf74 34
  • 80.03 (n)
  • 68.4 (a)
C15H11ORF74 35
  • 61 (a)
(Canis familiaris)
Mammalia C18H11orf74 34
  • 79.76 (n)
  • 67.58 (a)
C11orf74 35
  • 61 (a)
(Mus musculus)
Mammalia B230118H07Rik 34
  • 77.29 (n)
  • 67.63 (a)
B230118H07Rik 16
B230118H07Rik 35
  • 59 (a)
(Pan troglodytes)
Mammalia C11H11orf74 34
  • 98.34 (n)
  • 96.38 (a)
C11orf74 35
  • 96 (a)
(Rattus norvegicus)
Mammalia RGD1309730 34
  • 76.19 (n)
  • 64.04 (a)
(Monodelphis domestica)
Mammalia C11orf74 35
  • 37 (a)
(Ornithorhynchus anatinus)
Mammalia C11orf74 35
  • 45 (a)
(Gallus gallus)
Aves C11orf74 35
  • 24 (a)
(Danio rerio)
Actinopterygii C25H11orf74 35
  • 23 (a)
Species where no ortholog for C11orf74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf74 Gene

Gene Tree for C11orf74 (if available)
Gene Tree for C11orf74 (if available)

Paralogs for C11orf74 Gene Pseudogenes for C11orf74 Gene

genes like me logo Genes that share paralogs with C11orf74: view

No data available for Paralogs for C11orf74 Gene

Variants for C11orf74 Gene

Sequence variations from dbSNP and Humsavar for C11orf74 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1105593 -- 36,620,823(+) ATACA(C/T)ATAAA intron-variant
rs1353715 -- 36,617,549(-) CCTAA(A/G)TCAGT intron-variant
rs1391542 -- 36,622,526(-) CTGAA(C/T)CCAAG intron-variant
rs1391543 -- 36,610,989(-) TTTTC(A/G)TGTAA intron-variant
rs1472438 -- 36,609,186(-) ATCTC(C/T)CACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf74 Gene

Variant ID Type Subtype PubMed ID
esv2422305 CNV duplication 17116639
esv2674800 CNV deletion 23128226
esv27238 CNV loss 19812545
esv29188 CNV loss 19812545
esv3625963 CNV loss 21293372
nsv1042014 CNV loss 25217958
nsv467791 CNV gain 19166990
nsv467792 CNV gain 19166990
nsv518415 CNV loss 19592680
nsv554003 CNV gain 21841781
nsv554004 CNV gain 21841781
nsv554005 CNV gain 21841781
nsv554006 CNV loss 21841781
nsv832123 CNV gain 17160897
nsv976512 CNV deletion 23825009

Variation tolerance for C11orf74 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf74 Gene

Disorders for C11orf74 Gene

Relevant External Links for C11orf74

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for C11orf74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf74 Gene

Publications for C11orf74 Gene

  1. Identification of a novel transcriptional repressor (HEPIS) that interacts with nsp-10 of SARS coronavirus. (PMID: 18433331) Hong M. … Li Q. (Viral Immunol. 2008) 3 22 65
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 65
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 65
  5. A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network. (PMID: 22228203) Aslibekyan S. … Arnett D.K. (Pharmacogenet. Genomics 2012) 46 65

Products for C11orf74 Gene

Sources for C11orf74 Gene