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Aliases for C11orf74 Gene

Aliases for C11orf74 Gene

  • Chromosome 11 Open Reading Frame 74 2 3 5
  • Protein HEPIS 4
  • HEPIS 3

External Ids for C11orf74 Gene

Previous GeneCards Identifiers for C11orf74 Gene

  • GC11P036318

Summaries for C11orf74 Gene

Entrez Gene Summary for C11orf74 Gene

  • This gene encodes a protein that was identified as a cellular interacting partner of non-structural protein 10 of the severe acute respiratory syndrome coronavirus (SARS-CoV). The encoded protein may function as a negative regulator of transcription. There is a pseudogene for this gene on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

GeneCards Summary for C11orf74 Gene

C11orf74 (Chromosome 11 Open Reading Frame 74) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf74 Gene

Genomics for C11orf74 Gene

Regulatory Elements for C11orf74 Gene

Enhancers for C11orf74 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C11orf74 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf74 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C11orf74 on UCSC Golden Path with GeneCards custom track

Genomic Location for C11orf74 Gene

Chromosome:
11
Start:
36,594,229 bp from pter
End:
36,659,291 bp from pter
Size:
65,063 bases
Orientation:
Plus strand

Genomic View for C11orf74 Gene

Genes around C11orf74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf74 Gene

Proteins for C11orf74 Gene

  • Protein details for C11orf74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VG3-CK074_HUMAN
    Recommended name:
    Uncharacterized protein C11orf74
    Protein Accession:
    Q86VG3
    Secondary Accessions:
    • D3DR18
    • Q96DD6

    Protein attributes for C11orf74 Gene

    Size:
    221 amino acids
    Molecular mass:
    25407 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C11orf74 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C11orf74 Gene

Proteomics data for C11orf74 Gene at MOPED

Post-translational modifications for C11orf74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C11orf74 Gene

Domains & Families for C11orf74 Gene

Protein Domains for C11orf74 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C11orf74 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C11orf74: view

No data available for Gene Families and UniProtKB/Swiss-Prot for C11orf74 Gene

Function for C11orf74 Gene

genes like me logo Genes that share phenotypes with C11orf74: view

Animal Model Products

CRISPR Products

miRNA for C11orf74 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C11orf74 Gene

Localization for C11orf74 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C11orf74 Gene COMPARTMENTS Subcellular localization image for C11orf74 gene
Compartment Confidence
cytosol 3
nucleus 3
extracellular 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C11orf74 Gene

Pathways & Interactions for C11orf74 Gene

SuperPathways for C11orf74 Gene

No Data Available

Interacting Proteins for C11orf74 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000334848%0d%0a9606.ENSP00000216540%0d%0a9606.ENSP00000267064%0d%0a
Selected Interacting proteins: ENSP00000334848 for C11orf74 Gene via STRING

Gene Ontology (GO) - Biological Process for C11orf74 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C11orf74 Gene

Drugs & Compounds for C11orf74 Gene

No Compound Related Data Available

Transcripts for C11orf74 Gene

Unigene Clusters for C11orf74 Gene

Chromosome 11 open reading frame 74:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf74 Gene

No ASD Table

Relevant External Links for C11orf74 Gene

GeneLoc Exon Structure for
C11orf74
ECgene alternative splicing isoforms for
C11orf74

Expression for C11orf74 Gene

mRNA expression in normal human tissues for C11orf74 Gene

Protein differential expression in normal tissues from HIPED for C11orf74 Gene

This gene is overexpressed in Fetal gut (61.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for C11orf74 Gene



SOURCE GeneReport for Unigene cluster for C11orf74 Gene Hs.159376

genes like me logo Genes that share expression patterns with C11orf74: view

Protein tissue co-expression partners for C11orf74 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C11orf74 Gene

Orthologs for C11orf74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C11orf74 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C15H11orf74 35
  • 80.03 (n)
  • 68.4 (a)
C15H11ORF74 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C18H11orf74 35
  • 79.76 (n)
  • 67.58 (a)
C11orf74 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia B230118H07Rik 35
  • 77.29 (n)
  • 67.63 (a)
B230118H07Rik 16
B230118H07Rik 36
  • 59 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf74 35
  • 98.34 (n)
  • 96.38 (a)
C11orf74 36
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1309730 35
  • 76.19 (n)
  • 64.04 (a)
oppossum
(Monodelphis domestica)
Mammalia C11orf74 36
  • 37 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf74 36
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves C11orf74 36
  • 24 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C25H11orf74 36
  • 23 (a)
OneToOne
Species with no ortholog for C11orf74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C11orf74 Gene

ENSEMBL:
Gene Tree for C11orf74 (if available)
TreeFam:
Gene Tree for C11orf74 (if available)

Paralogs for C11orf74 Gene

Pseudogenes.org Pseudogenes for C11orf74 Gene

genes like me logo Genes that share paralogs with C11orf74: view

No data available for Paralogs for C11orf74 Gene

Variants for C11orf74 Gene

Sequence variations from dbSNP and Humsavar for C11orf74 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs728875 -- 36,635,692(-) TTTTC(A/C)TTTTA intron-variant
rs868613 -- 36,618,923(+) AAAAT(A/G)GAAAG intron-variant
rs869206 -- 36,637,064(-) ATGAC(C/T)ACCTA intron-variant
rs869207 -- 36,637,023(-) ACCAA(A/G)CCTCC intron-variant
rs871912 -- 36,636,225(+) CTCCT(A/G)AGACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf74 Gene

Variant ID Type Subtype PubMed ID
esv2422305 CNV Duplication 17116639
nsv467791 CNV Gain 19166990
nsv832123 CNV Gain 17160897
nsv467792 CNV Gain 19166990
nsv518415 CNV Loss 19592680
esv29188 CNV Loss 19812545
esv2674800 CNV Deletion 23128226
esv27238 CNV Loss 19812545

Variation tolerance for C11orf74 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.48; 43.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf74 Gene

HapMap Linkage Disequilibrium report
C11orf74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf74 Gene

Disorders for C11orf74 Gene

Relevant External Links for C11orf74

Genetic Association Database (GAD)
C11orf74
Human Genome Epidemiology (HuGE) Navigator
C11orf74
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C11orf74

No disorders were found for C11orf74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf74 Gene

Publications for C11orf74 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 67
  2. Identification of a novel transcriptional repressor (HEPIS) that interacts with nsp-10 of SARS coronavirus. (PMID: 18433331) Hong M. … Li Q. (Viral Immunol. 2008) 3 23
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M. … da Cruz e Silva E.F. (Biochem. Pharmacol. 2011) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for C11orf74 Gene

Sources for C11orf74 Gene

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