Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



C11orf73 Gene

protein-coding   GIFtS: 48
GCID: GC11P086013

Chromosome 11 Open Reading Frame 73

  Search for C11orf73
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 11 Open Reading Frame 731 2     OPI102
HSPC1792     Lethal, Chr 7, Rinchik 62
Hikeshi2     Protein Hikeshi2
L7RN62     HIKESHI5

External Ids:    HGNC: 269381   Entrez Gene: 515012   Ensembl: ENSG000001491967   OMIM: 6149085   UniProtKB: Q53FT33   
ORGUL members:         

Export aliases for C11orf73 gene to outside databases

Previous GC identifers: GC11P085691 GC11P082301


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for C11orf73 Gene:
C11orf73 (chromosome 11 open reading frame 73) is a protein-coding gene. GO annotations related to this gene include protein transporter activity and Hsp70 protein binding.

UniProtKB/Swiss-Prot: HIKES_HUMAN, Q53FT3
Function: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by
mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins
import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into
the nucleus

Gene Wiki entry for C11orf73 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000011.10  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the C11orf73 gene promoter:
         ER-alpha   AML1a   Lmo2   Nkx2-5   Cdc5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC11orf73 promoter sequence
   Search Chromatin IP Primers for C11orf73

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C11orf73


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.2   Ensembl cytogenetic band:  11q14.2   HGNC cytogenetic band: 11q14.2

C11orf73 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf73 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P086013:  view genomic region     (about GC identifiers)

Start:
86,013,253 bp from pter      End:
86,056,985 bp from pter
Size:
43,733 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for C11orf73

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: HIKES_HUMAN, Q53FT3 (See protein sequence)
Recommended Name: Protein Hikeshi  
Size: 197 amino acids; 21628 Da
Subunit: Interacts with ATP-bound HSP70 proteins. Interacts with NUP62 and NUP153 (via F-X-F-G repeats)
Miscellaneous: 'Hikeshi' is a traditional Japanese compound word used for a firefighter, smokejumper, or
troubleshooter (PubMed:22541429)
Sequence caution: Sequence=AAF29102.1; Type=Frameshift; Positions=62, 68; Sequence=AAF29142.1; Type=Frameshift;
Positions=9, 57; Sequence=AAF36168.1; Type=Frameshift; Positions=67;
Secondary accessions: Q8WVE8 Q9NVQ2 Q9NZZ1 Q9P022 Q9P0N1

Explore the universe of human proteins at neXtProt for C11orf73: NX_Q53FT3

Explore proteomics data for C11orf73 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys196

  • See C11orf73 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057485.2  
    ENSEMBL proteins: 
     ENSP00000432699   ENSP00000278483   ENSP00000433815  

    C11orf73 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for C11orf73
    OriGene Protein Over-expression Lysate for C11orf73
    OriGene MassSpec for C11orf73
    OriGene Custom Protein Services for C11orf73
    GenScript Custom Purified and Recombinant Proteins Services for C11orf73
    Novus Biologicals C11orf73 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for C11orf73

     
    Search eBioscience for Proteins for C11orf73 

    C11orf73 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for C11orf73
    Novus Biologicals C11orf73 Antibodies
    Abcam antibodies for C11orf73
    Cloud-Clone Corp. Antibodies for C11orf73
    ThermoFisher Antibody for C11orf73
    LSBio Antibodies in human, mouse, rat for C11orf73

    C11orf73 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for C11orf73
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for C11orf73
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for C11orf73
    Cloud-Clone Corp. CLIAs for C11orf73
    Search eBioscience for ELISAs for C11orf73 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    1 InterPro protein domain:
     IPR008493 DUF775

    Graphical View of Domain Structure for InterPro Entry Q53FT3

    ProtoNet protein and cluster: Q53FT3

    UniProtKB/Swiss-Prot: HIKES_HUMAN, Q53FT3
    Similarity: Belongs to the OPI10 family


    Find genes that share domains with C11orf73           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: HIKES_HUMAN, Q53FT3
    Function: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by
    mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins
    import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into
    the nucleus
    Induction: Following heat-shock treatment

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008565protein transporter activity IDA--
    GO:0030544Hsp70 protein binding IDA--
         
    Find genes that share ontologies with C11orf73           About GenesLikeMe


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for l7Rn6):
     homeostasis/metabolism  mortality/aging  respiratory system 

    Find genes that share phenotypes with C11orf73           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C11orf73
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C11orf73

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for C11orf73
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for C11orf73

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat C11orf73 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate C11orf73
    SwitchGear 3'UTR luciferase reporter plasmidC11orf73 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for C11orf73
    Predesigned siRNA for gene silencing in human, mouse, rat C11orf73

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for C11orf73

    Clone
    Products:
         
    OriGene clones in human, mouse for C11orf73 (see all 7)
    OriGene ORF clones in mouse, rat for C11orf73
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C11orf73 (NM_016401)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C11orf73
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf73

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for C11orf73
    Browse ESI BIO Cell Lines and PureStem Progenitors for C11orf73 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf73


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    HIKES_HUMAN, Q53FT3: Cytoplasm, cytosol. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    nucleus5
    extracellular1
    golgi apparatus1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IDA--
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm ----
    GO:0005829cytosol IDA--
    GO:0030054cell junction IDA--

    Find genes that share ontologies with C11orf73           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for C11orf73
    Interactions:

        Search GeneGlobe Interaction Network for C11orf73

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for C11orf73 (ENSP000002784834) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ENSG00000237724ENSP000004063594STRING: ENSP00000406359
    HSPA8ENSP000002273784STRING: ENSP00000227378
    NUP62ENSP000003055034STRING: ENSP00000305503
    ZC3H14ENSP000002510384STRING: ENSP00000251038
    COPS5ENSP000003505124STRING: ENSP00000350512
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006606protein import into nucleus IDA--
    GO:0007030Golgi organization IEA--
    GO:0015031protein transport IDA--
    GO:0030324lung development IEA--
    GO:0034605cellular response to heat IDA--

    Find genes that share ontologies with C11orf73           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for C11orf73 (HIKES)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for C11orf73 gene: 
    NM_016401.3  

    Unigene Cluster for C11orf73:

    Chromosome 11 open reading frame 73
    Hs.283322  [show with all ESTs]
    Unigene Representative Sequence: AK298763
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000533986 ENST00000278483(uc010rto.2 uc001pbu.3 uc010rtp.2 uc001pbv.3)
    ENST00000531485 ENST00000528004 ENST00000532270 ENST00000530208 ENST00000529405

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat C11orf73 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate C11orf73
    SwitchGear 3'UTR luciferase reporter plasmidC11orf73 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for C11orf73
    Predesigned siRNA for gene silencing in human, mouse, rat C11orf73
    Clone
    Products:
         
    OriGene clones in human, mouse for C11orf73 (see all 7)
    OriGene ORF clones in mouse, rat for C11orf73
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: C11orf73 (NM_016401)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for C11orf73
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf73
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for C11orf73
    OriGene qSTAR qPCR primer pairs in human, mouse for C11orf73
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C11orf73
      QuantiTect SYBR Green Assays in human, mouse, rat C11orf73
      QuantiFast Probe-based Assays in human, mouse, rat C11orf73

    Additional mRNA sequence: 

    AF151082.1 AF161487.1 AF161527.1 AK001447.1 AK223198.1 AK298763.1 BC001677.2 BC006476.2 
    BC015991.2 BC018080.1 BC021621.1 NR_024596.1 NR_024597.1 NR_024598.1 

    13 DOTS entries:

    DT.444127  DT.120740755  DT.100027362  DT.91756052  DT.102830686  DT.120740771  DT.120740772  DT.95214431 
    DT.100794210  DT.75102643  DT.95214432  DT.100794211  DT.95214430 

    Selected AceView cDNA sequences (see all 194):

    BE858273 BU957169 CD674095 BU633297 BC001677 AI677832 BM505179 AW169153 
    AU150866 N57511 AU128604 AA426226 D81067 BC006476 AI080402 NM_016401 
    AI867484 BE396840 BU173904 CA306008 BE894379 AW665110 BG471763 CK824958 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    C11orf73 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTGAAGAT
    C11orf73 Expression
    About this image

    C11orf73 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    C11orf73 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.283322
        Custom PCR Arrays for C11orf73
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for C11orf73
    OriGene qSTAR qPCR primer pairs in human, mouse for C11orf73
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C11orf73
    QuantiTect SYBR Green Assays in human, mouse, rat C11orf73
    QuantiFast Probe-based Assays in human, mouse, rat C11orf73
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf73

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for C11orf73 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia l7Rn61 , 5 lethal, Chr 7, Rinchik 61, 5 93.06(n)1
    96.95(a)1
      7 (50.40 cM)5
    676691  NM_026304.21  NP_080580.11 
     899175295 
    chicken
    (Gallus gallus)
    Aves C1H11ORF731 chromosome 1 open reading frame, human C11orf73 80.88(n)
    88.32(a)
      427034  NM_001031412.1  NP_001026583.1 
    lizard
    (Anolis carolinensis)
    Reptilia C11orf736
    chromosome 11 open reading frame 73
    86(a)
    1 ↔ 1
    3(200389320-200400617)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.68042 Xenopus laevis transcribed sequence with weak similarity more 77.7(n)    CD254315.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufj34d092 Transcribed sequence with moderate similarity to protein more 72.3(n)    57074612 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG139261 CG13926 49.38(n)
    50.26(a)
      38192  NM_139376.3  NP_647633.1 
    worm
    (Caenorhabditis elegans)
    Secernentea F42A6.66
    Protein F42A6.6, isoform c
    31(a)
    1 ↔ 1
    IV(3334084-3336854) WBGene00018328


    ENSEMBL Gene Tree for C11orf73 (if available)
    TreeFam Gene Tree for C11orf73 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for C11orf73 gene

    Find genes that share paralogs with C11orf73           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for C11orf73
    PGOHUM00000234494 PGOHUM00000245588 PGOHUM00000249285 PGOHUM00000241665


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for C11orf73 (see all 1035)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37588811,2
    C,F,A,H--86011256(-) ACTTAC/TGGAAA 3 -- us2k19Minor allele frequency- T:0.27NS EA NA WA 778
    rs748725951,2
    C,F--86011273(+) AACAAC/TGTAAG 3 -- us2k11Minor allele frequency- T:0.50WA 2
    rs2912371,2
    C,F,A,H--86011298(+) GGTTAA/CAATAT 3 -- us2k117Minor allele frequency- C:0.23NS EA NA WA CSA 798
    rs1872742251,2
    --86011307(+) ATCAAC/TGTGAA 3 -- us2k10--------
    rs1466703881,2
    --86011318(+) TAGGAA/GCATTC 3 -- us2k10--------
    rs788657981,2
    C,F--86011432(+) TGCCCG/ACAGAA 3 -- us2k11Minor allele frequency- A:0.01NA 120
    rs37588791,2
    C,F,H--86011457(-) TGTACA/GTACAG 3 -- us2k19Minor allele frequency- G:0.12NS EA NA WA 786
    rs1916824661,2
    --86011535(+) ACTCTC/TTGTAC 3 -- us2k10--------
    rs1827980721,2
    --86011618(+) ATTAAA/TAAACA 3 -- us2k10--------
    rs766697541,2
    C,F--86011623(+) TAAACG/ATCATC 3 -- us2k11Minor allele frequency- A:0.50WA 2

    HapMap Linkage Disequilibrium report for C11orf73 (86013253 - 86056985 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for C11orf73:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508643CNV Loss20534489
    nsv519914CNV Loss19592680
    nsv832223CNV Loss17160897
    nsv518588CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing C11orf73
    DNA2.0 Custom Variant and Variant Library Synthesis for C11orf73

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 614908    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for C11orf73:
    Crescentic glomerulonephritis

    Find genes that share disorders with C11orf73           About GenesLikeMe

    Genetic Association Database (GAD): C11orf73

    Export disorders for C11orf73 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for C11orf73 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with C11orf73)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hikeshi, a nuclear import carrier for hsp70s, protects cells from heat shock-induced nuclear damage. (PubMed id 22541429)1, 2, 3 Kose S.... Imamoto N. (Cell 2012)
    2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (Genome Res. 2000)
    3. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PubMed id 19734545)1, 4 Need A.C....Goldstein D.B. (Hum. Mol. Genet. 2009)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. N-terminal acetylome analyses and functional insights of the N- terminal acetyltransferase NatB. (PubMed id 22814378)2 Van Damme P....Aldabe R. (Proc. Natl. Acad. Sci. U.S.A. 2012)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51501 HGNC: 26938 AceView: HSPC138 Ensembl:ENSG00000149196 euGenes: HUgn51501
    ECgene: C11orf73 H-InvDB: C11orf73

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for C11orf73 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for C11orf73 gene:
    Search GeneIP for patents involving C11orf73

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for C11orf73  
     OriGene qPCR primer pairs and template standards for C11orf73   OriGene Protein Over-expression Lysate for C11orf73  
     OriGene MassSpec something-or-other for C11orf73   OriGene clones in human, mouse for C11orf73  
     OriGene qSTAR qPCR primer pairs in human, mouse for C11orf73   OriGene Purified Protein for C11orf73  
     OriGene ORF clones in mouse, rat for C11orf73   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for C11orf73   OriGene Custom Protein Services for C11orf73  

     
     
     Block miRNA regulation of human, mouse, rat C11orf73 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing C11orf73
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat C11orf73 Predesigned siRNA for gene silencing in human, mouse, rat C11orf73
     QuantiFast Probe-based Assays in human, mouse, rat C11orf73 QuantiTect SYBR Green Assays in human, mouse, rat C11orf73
     Custom PCR Arrays for C11orf73 Search Chromatin IP Primers for C11orf73
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat C11orf73  Search GeneGlobe Interaction Network for C11orf73
     Regulatory tfbs in C11orf73 promoter
     GenScript Custom Purified and Recombinant Proteins Services for C11orf73 GenScript cDNA clones with any tag delivered in your preferred vector for C11orf73
     GenScript Custom Assay Services for C11orf73 GenScript Custom overexpressing Cell Line Services for C11orf73
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for C11orf73 (HIKES)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     C11orf73 antibodies
     C11orf73 lysates
     Antibodies for C11orf73
     See all of Abcam's Antibodies, Kits and Proteins for C11orf73
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for C11orf73
     Antibodies for C11orf73
     ELISAs for C11orf73
     CLIAs for C11orf73



     Browse ESI BIO Cell Lines and PureStem Progenitors for C11orf73
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf73
     SwitchGear 3'UTR luciferase reporter plasmids for C11orf73
     SwitchGear Promoter luciferase reporter plasmids for C11orf73
     ThermoFisher Antibody for C11orf73
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat C11orf73
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for C11orf73
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for C11orf73
     LSBio Antibodies in human, mouse, rat for C11orf73
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for C11orf73
      Search eBioscience for proteins for C11orf73
      Search eBioscience for elisas for C11orf73
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      C11orf73 gene at Home site.
    Version: 3.12.202 14 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4