Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C11orf73 Gene

Aliases for C11orf73 Gene

  • Chromosome 11 Open Reading Frame 73 2 3
  • Hikeshi 3 6
  • Lethal, Chr 7, Rinchik 6 3
  • Protein Hikeshi 3
  • HSPC138 3
  • HSPC179 3
  • L7RN6 3
  • OPI10 3

External Ids for C11orf73 Gene

Previous GeneCards Identifiers for C11orf73 Gene

  • GC11P085691
  • GC11P086013
  • GC11P082301

Summaries for C11orf73 Gene

GeneCards Summary for C11orf73 Gene

C11orf73 (Chromosome 11 Open Reading Frame 73) is a Protein Coding gene. GO annotations related to this gene include protein transporter activity and Hsp70 protein binding.

UniProtKB/Swiss-Prot for C11orf73 Gene

  • Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.

Gene Wiki entry for C11orf73 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf73 Gene

Genomics for C11orf73 Gene

Regulatory Elements for C11orf73 Gene

Genomic Location for C11orf73 Gene

Start:
86,302,211 bp from pter
End:
86,345,943 bp from pter
Size:
43,733 bases
Orientation:
Plus strand

Genomic View for C11orf73 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for C11orf73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf73 Gene

Proteins for C11orf73 Gene

  • Protein details for C11orf73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53FT3-HIKES_HUMAN
    Recommended name:
    Protein Hikeshi
    Protein Accession:
    Q53FT3
    Secondary Accessions:
    • Q8WVE8
    • Q9NVQ2
    • Q9NZZ1
    • Q9P022
    • Q9P0N1

    Protein attributes for C11orf73 Gene

    Size:
    197 amino acids
    Molecular mass:
    21628 Da
    Quaternary structure:
    • Interacts with ATP-bound HSP70 proteins. Interacts with NUP62 and NUP153 (via F-X-F-G repeats).
    Miscellaneous:
    • Hikeshi is a traditional Japanese compound word used for a firefighter, smokejumper, or troubleshooter.
    SequenceCaution:
    • Sequence=AAF29102.1; Type=Frameshift; Positions=62, 68; Evidence={ECO:0000305}; Sequence=AAF29142.1; Type=Frameshift; Positions=9, 57; Evidence={ECO:0000305}; Sequence=AAF36168.1; Type=Frameshift; Positions=67; Evidence={ECO:0000305};

neXtProt entry for C11orf73 Gene

Proteomics data for C11orf73 Gene at MOPED

Post-translational modifications for C11orf73 Gene

  • Ubiquitination at Lys196
  • Modification sites at PhosphoSitePlus

Other Protein References for C11orf73 Gene

No data available for DME Specific Peptides for C11orf73 Gene

Domains for C11orf73 Gene

Protein Domains for C11orf73 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q53FT3

UniProtKB/Swiss-Prot:

HIKES_HUMAN :
  • Q53FT3
Family:
  • Belongs to the OPI10 family.
genes like me logo Genes that share domains with C11orf73: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for C11orf73 Gene

Function for C11orf73 Gene

Molecular function for C11orf73 Gene

UniProtKB/Swiss-Prot Function: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
UniProtKB/Swiss-Prot Induction: Following heat-shock treatment.

Gene Ontology (GO) - Molecular Function for C11orf73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008565 protein transporter activity IDA 22541429
GO:0030544 Hsp70 protein binding IDA 22541429
genes like me logo Genes that share ontologies with C11orf73: view

Phenotypes for C11orf73 Gene

genes like me logo Genes that share phenotypes with C11orf73: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for C11orf73 Gene

Localization for C11orf73 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C11orf73 Gene

Cytoplasm, cytosol. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C11orf73 Gene COMPARTMENTS Subcellular localization image for C11orf73 gene
Compartment Confidence
cytosol 5
nucleus 5
extracellular 1
golgi apparatus 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C11orf73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IDA 22541429
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with C11orf73: view

Pathways for C11orf73 Gene

SuperPathways for C11orf73 Gene

No Data Available

Interacting Proteins for C11orf73 Gene

Gene Ontology (GO) - Biological Process for C11orf73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IDA 22541429
GO:0007030 Golgi organization IEA --
GO:0015031 protein transport IDA 22541429
GO:0030324 lung development IEA --
GO:0034605 cellular response to heat TAS --
genes like me logo Genes that share ontologies with C11orf73: view

No data available for Pathways by source for C11orf73 Gene

Transcripts for C11orf73 Gene

Unigene Clusters for C11orf73 Gene

Chromosome 11 open reading frame 73:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf73 Gene

No ASD Table

Relevant External Links for C11orf73 Gene

GeneLoc Exon Structure for
C11orf73
ECgene alternative splicing isoforms for
C11orf73

Expression for C11orf73 Gene

mRNA expression in normal human tissues for C11orf73 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for C11orf73 Gene

SOURCE GeneReport for Unigene cluster for C11orf73 Gene Hs.283322

genes like me logo Genes that share expressions with C11orf73: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C11orf73 Gene

Orthologs for C11orf73 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C11orf73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf73 35
  • 99.83 (n)
  • 100 (a)
C11H11ORF73 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C29H11orf73 35
  • 96.11 (n)
  • 97.97 (a)
C29H11orf73 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C11orf73 36
  • 98 (a)
OneToOne
C21H11orf73 35
  • 96.95 (n)
  • 98.48 (a)
mouse
(Mus musculus)
Mammalia l7Rn6 35
  • 93.06 (n)
  • 96.95 (a)
l7Rn6 16
l7Rn6 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf73 36
  • 87 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia l7Rn6 35
  • 92.83 (n)
  • 96.84 (a)
chicken
(Gallus gallus)
Aves C1H11ORF73 35
  • 80.88 (n)
  • 88.32 (a)
C1H11ORF73 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf73 36
  • 86 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.6804 35
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf73 35
  • 76.31 (n)
  • 88.32 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1040 35
zebrafish
(Danio rerio)
Actinopterygii C1H11orf73 36
  • 72 (a)
OneToOne
wufj34d09 35
zgc:110091 35
  • 66.5 (n)
  • 71.07 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta OPI10_ANOGA 35
  • 52.18 (n)
  • 52.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13926 35
  • 49.38 (n)
  • 50.26 (a)
CG13926 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F42A6.6 36
  • 31 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC21H7.06c 35
  • 53.73 (n)
  • 46.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6719 36
  • 42 (a)
OneToOne
Species with no ortholog for C11orf73:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C11orf73 Gene

ENSEMBL:
Gene Tree for C11orf73 (if available)
TreeFam:
Gene Tree for C11orf73 (if available)

Paralogs for C11orf73 Gene

Pseudogenes.org Pseudogenes for C11orf73 Gene

genes like me logo Genes that share paralogs with C11orf73: view

No data available for Paralogs for C11orf73 Gene

Variants for C11orf73 Gene

Sequence variations from dbSNP and Humsavar for C11orf73 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs167086 -- 86,324,339(-) GATGA(A/G)AAACA intron-variant
rs167087 -- 86,305,467(+) ccgca(A/G)cctct intron-variant
rs167088 -- 86,307,091(+) TATGT(A/G)TAATA intron-variant
rs167089 -- 86,307,105(+) atcat(A/G)tatca intron-variant
rs169729 -- 86,307,125(+) tatgt(A/G)taata intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf73 Gene

Variant ID Type Subtype PubMed ID
nsv832223 CNV Loss 17160897
nsv508643 CNV Loss 20534489
nsv519914 CNV Loss 19592680
nsv518588 CNV Loss 19592680

Relevant External Links for C11orf73 Gene

HapMap Linkage Disequilibrium report
C11orf73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf73 Gene

Disorders for C11orf73 Gene

(1) University of Copenhagen DISEASES for C11orf73 Gene

Relevant External Links for C11orf73

Genetic Association Database (GAD)
C11orf73
genes like me logo Genes that share disorders with C11orf73: view

No data available for UniProtKB/Swiss-Prot for C11orf73 Gene

Publications for C11orf73 Gene

  1. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3 4
  2. Hikeshi, a nuclear import carrier for hsp70s, protects cells from heat shock-induced nuclear damage. (PMID: 22541429) Kose S. … Imamoto N. (Cell 2012) 2 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB. (PMID: 19734545) Need A.C. … Goldstein D.B. (Hum. Mol. Genet. 2009) 3 48

Products for C11orf73 Gene

Sources for C11orf73 Gene

Back to Top

Content