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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

C11orf73 Gene

protein-coding   GIFtS: 45
GCID: GC11P086013

chromosome 11 open reading frame 73

 Explore 2 diseases affiliated with
C11orf73 via our new
 Human Malady Compendium 
Biological research products
for C11orf73
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Chromosome 11 Open Reading Frame 731 2     L7RN62
HSPC1791 2     Lethal, Chr 7, Rinchik 62
Hikeshi1 2     Protein Hikeshi2
HSPC1381     

External Ids:    HGNC: 269381   Entrez Gene: 515012   Ensembl: ENSG000001491967   OMIM: 6149085   UniProtKB: Q53FT33   
ORGUL members:         
NONCODE:n407096 n407097 n407095    

Export aliases for C11orf73 gene to outside databases

Previous GC identifers: GC11P085691 GC11P082301


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: HIKES_HUMAN, Q53FT3
Function: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating
the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is
required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus

Gene Wiki entry for C11orf73


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.1  NT_167190.1  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the C11orf73 gene promoter:
         ER-alpha   AML1a   Lmo2   Nkx2-5   Cdc5   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidC11orf73 promoter sequence
   Search SABiosciences Chromatin IP Primers for C11orf73

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat C11orf73


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.2   Ensembl cytogenetic band:  11q14.2   HGNC cytogenetic band: 11q14.2

C11orf73 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
C11orf73 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P086013:  view genomic region     (about GC identifiers)

Start:
86,013,253 bp from pter      End:
86,056,985 bp from pter
Size:
43,733 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

  • n407096
  • n407097
  • n407095
86013252 86035119 86056985 chr11

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: HIKES_HUMAN, Q53FT3 (See protein sequence)
Recommended Name: Protein Hikeshi  
Size: 197 amino acids; 21628 Da
Subunit: Interacts with ATP-bound HSP70 proteins. Interacts with NUP62 and NUP153 (via F-X-F-G repeats)
Subcellular location: Cytoplasm, cytosol. Nucleus
Miscellaneous: 'Hikeshi' is a traditional Japanese compound word used for a firefighter, smokejumper, or troubleshooter
(PubMed:22541429)
Sequence caution: Sequence=AAF29102.1; Type=Frameshift; Positions=62, 68; Sequence=AAF29142.1; Type=Frameshift;
Positions=9, 57; Sequence=AAF36168.1; Type=Frameshift; Positions=67;
Secondary accessions: Q8WVE8 Q9NVQ2 Q9NZZ1 Q9P022 Q9P0N1

Explore the universe of human proteins at neXtProt for C11orf73: NX_Q53FT3

C11orf73 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_057485.2  
ENSEMBL proteins: 
 ENSP00000432699   ENSP00000278483   ENSP00000433815  

Human Recombinant Protein Products: 
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Browse ProSpec Recombinant Proteins
Uscn Proteins for C11orf73

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular IDA--
GO:0005634nucleus IDA--
GO:0005737cytoplasm ----
GO:0005829cytosol IDA--


C11orf73 for ontologies           About GeneDecksing



C11orf73 Antibody Products: 
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Uscn ELISAs and CLIAs for C11orf73


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

C11orf73 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR008493 DUF775

Graphical View of Domain Structure for InterPro Entry Q53FT3

ProtoNet protein and cluster: Q53FT3

UniProtKB/Swiss-Prot: HIKES_HUMAN, Q53FT3
Similarity: Belongs to the OPI10 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: HIKES_HUMAN, Q53FT3
Function: Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating
the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is
required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus
Induction: Following heat-shock treatment

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidC11orf73 3' UTR sequence
Inhib. RNA
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C11orf73 (see all 7)
OriGene shRNA RFP: C11orf73
OriGene siRNA: C11orf73
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C11orf73

Gene Editing
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Clone
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Cell Line
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In Situ Assay
Products:
   

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf73

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008565protein transporter activity IDA--
GO:0030544Hsp70 protein binding IDA--


C11orf73 for ontologies           About GeneDecksing


Animal Models:
     3 MGI mutant phenotypes (inferred from 1 allele(MGI details for l7Rn6):
 homeostasis/metabolism  mortality/aging  respiratory system 

C11orf73 for phenotypes           About GeneDecksing


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for C11orf73

STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

4 Interacting proteins for C11orf73 (ENSP000002784834) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
HSPA8ENSP000002273784STRING: ENSP00000227378
NUP62ENSP000003055034STRING: ENSP00000305503
COPS5ENSP000003505124STRING: ENSP00000350512
--ENSP000004063594STRING: ENSP00000406359
About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006606protein import into nucleus IDA--
GO:0007030Golgi organization IEA--
GO:0015031protein transport IDA--
GO:0030324lung development IEA--
GO:0034605cellular response to heat IDA--


C11orf73 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for C11orf73
Search CenterWatch for drugs/clinical trials and news about C11orf73 / HIKES 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for C11orf73 gene: 
NM_016401.3  

Unigene Cluster for C11orf73:

Chromosome 11 open reading frame 73
Hs.283322  [show with all ESTs]
Unigene Representative Sequence: AK298763
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000533986 ENST00000278483(uc010rto.2 uc001pbu.3 uc010rtp.2 uc001pbv.3)
ENST00000531485 ENST00000528004 ENST00000532270 ENST00000524519 ENST00000530208
ENST00000529405

miRNA
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SwitchGear 3'UTR luciferase reporter plasmidC11orf73 3' UTR sequence
Inhib. RNA
Products:
     
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OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for C11orf73 (see all 7)
OriGene shRNA RFP: C11orf73
OriGene siRNA: C11orf73
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat C11orf73
Clone
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Primer
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  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat C11orf73
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C11orf73

Additional cDNA sequence: 

AF151082.1 AF161487.1 AF161527.1 AK001447.1 AK223198.1 AK298763.1 BC001677.2 BC006476.2 
BC015991.2 BC018080.1 BC021621.1 NR_024596.1 NR_024597.1 NR_024598.1 

13 DOTS entries:

DT.444127  DT.120740755  DT.100027362  DT.91756052  DT.102830686  DT.120740771  DT.120740772  DT.95214431 
DT.100794210  DT.75102643  DT.95214432  DT.100794211  DT.95214430 

24/194 AceView cDNA sequences (see all 194):

BM505179 NM_016401 AW665110 N47744 BU173904 BU957169 AW248839 AI207722 
D81067 BU633297 AU150866 BQ268888 CR606835 AA426226 BU619988 BC015991 
AW572629 AI677832 BG471763 BE858273 BX332668 AI720406 CK824958 CR592099 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

C11orf73 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTGAAGAT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image

C11orf73 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
Gut TubeVentral Foregut EndodermGut Tube
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See C11orf73 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for C11orf73

SOURCE GeneReport for Unigene cluster: Hs.283322
    SABiosciences Custom PCR Arrays for C11orf73
Primer
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat C11orf73
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for C11orf73

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for C11orf73 gene from 7/24 species (see all 24)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia l7Rn61 , 5 lethal, Chr 7, Rinchik 61, 5 93.06(n)1
96.95(a)1
  7 (50.40 cM)5
676691  NM_026304.21  NP_080580.11 
 899175295 
chicken
(Gallus gallus)
Aves C1H11orf731 chromosome 1 open reading frame, human C11orf73 80.88(n)
88.32(a)
  427034  NM_001031412.1  NP_001026583.1 
lizard
(Anolis carolinensis)
Reptilia C11orf736
--
86(a)
1 ↔ 1
3(200391840-200399954)
African clawed frog
(Xenopus laevis)
Amphibia Xl.68042 Xenopus laevis transcribed sequence with weak similarity more 77.7(n)    CD254315.1 
zebrafish
(Danio rerio)
Actinopterygii wufj34d092 Transcribed sequence with moderate similarity to protein more 72.3(n)    57074612 
fruit fly
(Drosophila melanogaster)
Insecta CG139261 CG13926 49.56(n)
50.26(a)
  38192  NM_139376.2  NP_647633.1 
worm
(Caenorhabditis elegans)
Secernentea F42A6.66
Protein F42A6.6
30(a)
1 ↔ 1
IV(3335991-3336851)


ENSEMBL Gene Tree for C11orf73 (if available)
TreeFam Gene Tree for C11orf73 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for C11orf73 gene

C11orf73 for paralogs           About GeneDecksing


4 Pseudogenes.org Pseudogenes for C11orf73
PGOHUM00000234494 PGOHUM00000245588 PGOHUM00000249285 PGOHUM00000241665


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/902 NCBI SNPs in C11orf73 are shown (see all 902    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs37588811,2
C,F,A,H,--86011256(-) ACTTAC/TGGAAA 3 -- us2k19Minor allele frequency- T:0.27NS EA NA WA 778
rs748725951,2
C,--86011273(+) AACAAC/TGTAAG 3 -- us2k11Minor allele frequency- T:0.50WA 2
rs2912371,2
C,F,A,H,--86011298(+) GGTTAA/CAATAT 3 -- us2k117Minor allele frequency- C:0.23NS EA NA WA CSA 798
rs1872742251,2
--86011307(+) ATCAAC/TGTGAA 3 -- us2k10--------
rs1466703881,2
--86011318(+) TAGGAA/GCATTC 3 -- us2k10--------
rs788657981,2
--86011432(+) TGCCCG/ACAGAA 3 -- us2k11Minor allele frequency- A:0.01NA 120
rs37588791,2
C,F,H,--86011457(-) TGTACA/GTACAG 3 -- us2k19Minor allele frequency- G:0.12NS EA NA WA 786
rs1916824661,2
--86011535(+) ACTCTC/TTGTAC 3 -- us2k10--------
rs1827980721,2
--86011618(+) ATTAAA/TAAACA 3 -- us2k10--------
rs766697541,2
C,--86011623(+) TAAACG/ATCATC 3 -- us2k11Minor allele frequency- A:0.50WA 2

HapMap Linkage Disequilibrium report for C11orf73 (86013253 - 86056985 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for C11orf73: --

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing C11orf73
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

C11orf73 for disorders           About GeneDecksing

OMIM gene information: 614908    OMIM disorders: --

2 diseases for C11orf73:    About MalaCards
crescentic glomerulonephritis    glomerulonephritis

1 disease from the University of Copenhagen DISEASES database for C11orf73:
Crescentic glomerulonephritis

Export disorders for C11orf73 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for C11orf73 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with C11orf73)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Hikeshi, a nuclear import carrier for hsp70s, protects cells from heat shock-induced nuclear damage. (PubMed id 22541429)1, 2, 3 Kose S.... Imamoto N. (2012)
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2, 3 Zhang Q.-H.... Chen Z. (2000)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
  6. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
  7. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
  8. A genome-wide study of common SNPs and CNVs in cognit ive performance in the CANTAB. (PubMed id 19734545)1 Need A.C....Goldstein D.B. (2009)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. Generation and analysis of 280,000 human expressed sequence tags. (PubMed id 8889549)1 Hillier L.D....Marra M. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 51501 HGNC: 26938 AceView: HSPC138 Ensembl:ENSG00000149196 euGenes: HUgn51501
ECgene: C11orf73 H-InvDB: C11orf73

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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PharmGKB entry for C11orf73 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for C11orf73 gene:
Search GeneIP for patents involving C11orf73

GeneCards and IP:
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