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Aliases for C11orf73 Gene

Aliases for C11orf73 Gene

  • Chromosome 11 Open Reading Frame 73 2 3 5
  • Lethal, Chr 7, Rinchik 6 3
  • HSPC138 3
  • HSPC179 3
  • Hikeshi 3
  • HLD13 3
  • L7RN6 3
  • OPI10 3

External Ids for C11orf73 Gene

Previous GeneCards Identifiers for C11orf73 Gene

  • GC11P085691
  • GC11P086013
  • GC11P082301

Summaries for C11orf73 Gene

Entrez Gene Summary for C11orf73 Gene

  • This gene encodes an evolutionarily conserved nuclear transport receptor that mediates heat-shock-induced nuclear import of 70 kDa heat-shock proteins (Hsp70s) through interactions with FG-nucleoporins. The protein mediates transport of the ATP form but not the ADP form of Hsp70 proteins under conditions of heat shock stress. Structural analyses demonstrate that the protein forms an asymmetric homodimer and that the N-terminal domain consists of a jelly-roll/beta-sandwich fold structure that contains hydrophobic pockets involved in FG-nucleoporin recognition. Reduction of RNA expression levels in HeLa cells using small interfering RNAs results in inhibition of heat shock-induced nuclear accumulation of Hsp70s, indicating a role for this gene in regulation of Hsp70 nuclear import during heat shock stress. [provided by RefSeq, Apr 2016]

GeneCards Summary for C11orf73 Gene

C11orf73 (Chromosome 11 Open Reading Frame 73) is a Protein Coding gene. Among its related pathways are Cellular response to heat stress and Cellular Senescence. GO annotations related to this gene include protein transporter activity and Hsp70 protein binding.

UniProtKB/Swiss-Prot for C11orf73 Gene

  • Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.

Gene Wiki entry for C11orf73 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C11orf73 Gene

Genomics for C11orf73 Gene

Regulatory Elements for C11orf73 Gene

Enhancers for C11orf73 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around C11orf73 on UCSC Golden Path with GeneCards custom track

Promoters for C11orf73 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around C11orf73 on UCSC Golden Path with GeneCards custom track

Genomic Location for C11orf73 Gene

Chromosome:
11
Start:
86,302,211 bp from pter
End:
86,345,943 bp from pter
Size:
43,733 bases
Orientation:
Plus strand

Genomic View for C11orf73 Gene

Genes around C11orf73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C11orf73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C11orf73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C11orf73 Gene

Proteins for C11orf73 Gene

  • Protein details for C11orf73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53FT3-HIKES_HUMAN
    Recommended name:
    Protein Hikeshi
    Protein Accession:
    Q53FT3
    Secondary Accessions:
    • Q8WVE8
    • Q9NVQ2
    • Q9NZZ1
    • Q9P022
    • Q9P0N1

    Protein attributes for C11orf73 Gene

    Size:
    197 amino acids
    Molecular mass:
    21628 Da
    Quaternary structure:
    • Interacts with ATP-bound HSP70 proteins. Interacts with NUP62 and NUP153 (via F-X-F-G repeats).
    Miscellaneous:
    • Hikeshi is a traditional Japanese compound word used for a firefighter, smokejumper, or troubleshooter.
    SequenceCaution:
    • Sequence=AAF29102.1; Type=Frameshift; Positions=62, 68; Evidence={ECO:0000305}; Sequence=AAF29142.1; Type=Frameshift; Positions=9, 57; Evidence={ECO:0000305}; Sequence=AAF36168.1; Type=Frameshift; Positions=67; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for C11orf73 Gene

neXtProt entry for C11orf73 Gene

Proteomics data for C11orf73 Gene at MOPED

Post-translational modifications for C11orf73 Gene

  • Ubiquitination at Lys 196
  • Modification sites at PhosphoSitePlus

Other Protein References for C11orf73 Gene

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for C11orf73

No data available for DME Specific Peptides for C11orf73 Gene

Domains & Families for C11orf73 Gene

Protein Domains for C11orf73 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q53FT3

UniProtKB/Swiss-Prot:

HIKES_HUMAN :
  • Belongs to the OPI10 family.
Family:
  • Belongs to the OPI10 family.
genes like me logo Genes that share domains with C11orf73: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for C11orf73 Gene

Function for C11orf73 Gene

Molecular function for C11orf73 Gene

UniProtKB/Swiss-Prot Function:
Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.
UniProtKB/Swiss-Prot Induction:
Following heat-shock treatment.

Phenotypes for C11orf73 Gene

genes like me logo Genes that share phenotypes with C11orf73: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C11orf73 Gene

Localization for C11orf73 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C11orf73 Gene

Cytoplasm, cytosol. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for C11orf73 Gene COMPARTMENTS Subcellular localization image for C11orf73 gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 5
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for C11orf73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0030054 cell junction IDA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with C11orf73: view

Pathways & Interactions for C11orf73 Gene

genes like me logo Genes that share pathways with C11orf73: view

Pathways by source for C11orf73 Gene

Interacting Proteins for C11orf73 Gene

Gene Ontology (GO) - Biological Process for C11orf73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034605 cellular response to heat IDA,TAS 22541429
genes like me logo Genes that share ontologies with C11orf73: view

No data available for SIGNOR curated interactions for C11orf73 Gene

Drugs & Compounds for C11orf73 Gene

No Compound Related Data Available

Transcripts for C11orf73 Gene

Unigene Clusters for C11orf73 Gene

Chromosome 11 open reading frame 73:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for C11orf73 Gene

No ASD Table

Relevant External Links for C11orf73 Gene

GeneLoc Exon Structure for
C11orf73
ECgene alternative splicing isoforms for
C11orf73

Expression for C11orf73 Gene

mRNA expression in normal human tissues for C11orf73 Gene

Protein differential expression in normal tissues from HIPED for C11orf73 Gene

This gene is overexpressed in Bone (11.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for C11orf73 Gene



SOURCE GeneReport for Unigene cluster for C11orf73 Gene Hs.283322

genes like me logo Genes that share expression patterns with C11orf73: view

Protein tissue co-expression partners for C11orf73 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for C11orf73 Gene

Orthologs for C11orf73 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for C11orf73 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C29H11orf73 35
  • 96.11 (n)
  • 97.97 (a)
C29H11orf73 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C21H11orf73 35
  • 96.95 (n)
  • 98.48 (a)
C11orf73 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia l7Rn6 35
  • 93.06 (n)
  • 96.95 (a)
l7Rn6 16
l7Rn6 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C11H11orf73 35
  • 99.83 (n)
  • 100 (a)
C11H11ORF73 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia l7Rn6 35
  • 92.83 (n)
  • 96.84 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia C11orf73 36
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1H11ORF73 35
  • 80.88 (n)
  • 88.32 (a)
C1H11ORF73 36
  • 88 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C11orf73 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c11orf73 35
  • 76.31 (n)
  • 88.32 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6804 35
zebrafish
(Danio rerio)
Actinopterygii wufj34d09 35
zgc:110091 35
  • 66.5 (n)
  • 71.07 (a)
C1H11orf73 36
  • 72 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1040 35
African malaria mosquito
(Anopheles gambiae)
Insecta OPI10_ANOGA 35
  • 52.18 (n)
  • 52.36 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13926 35
  • 49.38 (n)
  • 50.26 (a)
CG13926 36
  • 48 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F42A6.6 36
  • 31 (a)
OneToOne
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC21H7.06c 35
  • 53.73 (n)
  • 46.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6719 36
  • 42 (a)
OneToOne
Species with no ortholog for C11orf73:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C11orf73 Gene

ENSEMBL:
Gene Tree for C11orf73 (if available)
TreeFam:
Gene Tree for C11orf73 (if available)

Paralogs for C11orf73 Gene

Pseudogenes.org Pseudogenes for C11orf73 Gene

genes like me logo Genes that share paralogs with C11orf73: view

No data available for Paralogs for C11orf73 Gene

Variants for C11orf73 Gene

Sequence variations from dbSNP and Humsavar for C11orf73 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs11539213 - 86,306,353(+) CATTT(C/G)CTGAG intron-variant, nc-transcript-variant, reference, missense
rs591791 -- 86,328,279(-) tccat(C/T)tcaaa intron-variant
rs603761 -- 86,315,311(+) CCAGG(A/G)AAAAT intron-variant
rs636653 -- 86,334,860(-) aagtt(C/T)gagac intron-variant
rs662648 -- 86,333,693(+) tattt(A/C/G/T)ggaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for C11orf73 Gene

Variant ID Type Subtype PubMed ID
nsv832223 CNV Loss 17160897
nsv508643 CNV Loss 20534489
nsv519914 CNV Loss 19592680
nsv518588 CNV Loss 19592680

Variation tolerance for C11orf73 Gene

Residual Variation Intolerance Score: 49.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.30; 6.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for C11orf73 Gene

HapMap Linkage Disequilibrium report
C11orf73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C11orf73 Gene

Disorders for C11orf73 Gene

Relevant External Links for C11orf73

Genetic Association Database (GAD)
C11orf73
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
C11orf73

No disorders were found for C11orf73 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C11orf73 Gene

Publications for C11orf73 Gene

  1. Hikeshi, a nuclear import carrier for hsp70s, protects cells from heat shock-induced nuclear damage. (PMID: 22541429) Kose S. … Imamoto N. (Cell 2012) 2 3 4 67
  2. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 2 3
  3. Leukoencephalopathy and early death associated with an Ashkenazi-Jewish founder mutation in the Hikeshi gene. (PMID: 26545878) Edvardson S. … Elpeleg O. (J. Med. Genet. 2016) 3
  4. Structural Biology and Regulation of Protein Import into the Nucleus. (PMID: 26523678) Christie M. … Kobe B. (J. Mol. Biol. 2015) 3
  5. Structural and functional analysis of Hikeshi, a new nuclear transport receptor of Hsp70s. (PMID: 25760597) Song J. … Lee S.J. (Acta Crystallogr. D Biol. Crystallogr. 2015) 3

Products for C11orf73 Gene

Sources for C11orf73 Gene

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